PROP1 overexpression in corticotrophinomas: Evidence for the role of PROP1 in the maintenance of cells committed to corticotrophic differentiation

Clinics

Volumn 68, Issue 6, 2013, Pages 887-891

  Araujo, Ricardo V ^a   Chang, Claudia V ^a   Cescato, Valter A S ^a   Fragoso, Maria Candida B V ^a   Bronstein, Marcello D ^a   Mendonca, Berenice B ^a   Arnhold, Ivo J P ^a   Carvalho, Luciani R S ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Pituitary neoplasms; POU1F1; PROP1; TBX19

Indexed keywords

HOMEODOMAIN PROTEIN; MESSENGER RNA; POU1F1 PROTEIN, HUMAN; PROPHET OF PIT 1 PROTEIN; PROPHET OF PIT-1 PROTEIN; T BOX TRANSCRIPTION FACTOR; TBX19 PROTEIN, HUMAN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PIT 1; TUMOR PROTEIN;

ACTH SECRETING ADENOMA; ADENOMA; ADOLESCENT; ADULT; AGED; ARTICLE; CELL DIFFERENTIATION; FEMALE; GENETICS; HUMAN; HYPOPHYSIS; IMMUNOHISTOCHEMISTRY; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; SECRETION (PROCESS); YOUNG ADULT;

ACTH-SECRETING PITUITARY ADENOMA; ADENOMA; ADOLESCENT; ADULT; AGED; CELL DIFFERENTIATION; FEMALE; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; NEOPLASM PROTEINS; PITUITARY GLAND; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; T-BOX DOMAIN PROTEINS; TRANSCRIPTION FACTOR PIT-1; TRANSCRIPTION FACTORS; YOUNG ADULT;

EID: 84879315688     PISSN: 18075932     EISSN: None     Source Type: Journal    
DOI: 10.6061/clinics/2013(06)26     Document Type: Article

References (19)

1. Nakamura S, Ohtsuru A, Takamura N, Kitange G, Tokunaga Y, Yasunaga A, et al. Prop-1 gene expression in human pituitary tumors. J Clin Endocrinol Metab. 1999;84:2581-4, http://dx.doi.org/10.1210/jc.84.7.2581.
2. Evans CO, Moreno CS, Zhan X, McCabe MT, Vertino PM, Desiderio DM, et al. Molecular pathogenesis of human prolactinomas identified by gene expression profiling, RT-qPCR, and proteomic analyses. Pituitary. 2008;11(3):231-45, http://dx.doi.org/10.1007/s11102-007-0082-2.
3. Moreno CS, Evans CO, Zhan X, Okor M, Desiderio DM, Oyesiku NM. Novel molecular signaling and classification of human clinically nonfunctional pituitary adenomas identified by gene expression profiling and proteomic analyses. Cancer Res. 2005;65(22):10214-22, http://dx.doi.org/10.1158/0008-5472.CAN-05-0884.
4. Evans CO, Young AN, Brown MR, Brat DJ, Parks JS, Neish AS, et al. Novel patterns of gene expression in pituitary adenomas identified by complementary deoxyribonucleic acid microarrays and quantitative reverse transcription-polymerase chain reaction. J Clin Endocrinol Metab. 2001;86(7):3097-107, http://dx.doi.org/10.1210/jc.86.7.3097.
5. Melmed S. Mechanisms for pituitary tumorigenesis: the plastic pituitary. J Clin Invest. 2003;112(11):1603-18.
6. Turton JP, Mehta A, Raza J, Woods KS, Tiulpakov A, Cassar J, et al. Mutations within the transcription factor PROP1 are rare in a cohort of patients with sporadic combined pituitary hormone deficiency (CPHD). Clin Endocrinol (Oxf). 2005;63(1):10-8, http://dx.doi.org/10.1111/j.1365-2265.2005.02291.x.
7. Mendonca BB, Osorio MG, Latronico AC, Estefan V, Lo LS, Arnhold IJ. Longitudinal hormonal and pituitary imaging changes in two females with combined pituitary hormone deficiency due to deletion of A301,G302 in the PROP1 gene. J Clin Endocrinol Metab. 1999;84(3):942-5, http://dx.doi.org/10.1210/jc.84.3.942.
8. Cushman LJ, Watkins-Chow DE, Brinkmeier ML, Raetzman LT, Radak AL, Lloyd RV, et al. Persistent Prop1 expression delays gonadotrope differentiation and enhances pituitary tumor susceptibility. Hum Mol Genet. 2001;10(11):1141-53, http://dx.doi.org/10.1093/hmg/10.11.1141.
9. Roche C, Rasolonjanahary R, Thirion S, Goddard I, Fusco A, Figarella-Branger D, et al. Inactivation of transcription factor pit-1 to target tumoral somatolactotroph cells. Hum Gene Ther. 2012;23(1):104-14, http://dx.doi.org/10.1089/hum.2011.105.
10. Liu J, Lin C, Gleiberman A, Ohgi KA, Herman T, Huang HP, et al. Tbx19, a tissue-selective regulator of POMC gene expression. Proc Natl Acad Sci U S A. 2001;98:8674-9, http://dx.doi.org/10.1073/pnas.141234898.
11. Pulichino AM, Vallette-Kasic S, Tsai JP, Couture C, Gauthier Y, Drouin J. Tpit determines alternate fates during pituitary cell differentiation. Genes Dev. 2003;17(6):738-47, http://dx.doi.org/10.1101/gad.1065703.
12. Andersen B, Rosenfeld MG. POU domain factors in the neuroendocrine system: lessons from developmental biology provide insights into human disease. Endocr Rev. 2001;22(1):2-35, http://dx.doi.org/10.1210/er.22.1.2.
13. Rhodes SJ, DiMattia GE, Rosenfeld MG. Transcriptional mechanisms in anterior pituitary cell differentiation. Curr Opin Genet Dev. 1994;4(5):709-17, http://dx.doi.org/10.1016/0959-437X(94)90138-S.
14. Vankelecom H. Pituitary stem/progenitor cells: embryonic players in the adult gland? Eur J Neurosci. 2010;32(12):2063-81.
15. Savage JJ, Yaden BC, Kiratipranon P, Rhodes SJ. Transcriptional control during mammalian anterior pituitary development. Gene. 2003;319:1-19, http://dx.doi.org/10.1016/S0378-1119(03)00804-7
16. Asa SL, Puy LA, Lew AM, Sundmark VC, Elsholtz HP. Cell type-specific expression of the pituitary transcription activator pit-1 in the human pituitary and pituitary adenomas. J Clin Endocrinol Metab. 1993;77(5):1275-80, http://dx.doi.org/10.1210/jc.77.5.1275.
17. Lloyd RV, Jin L, Chandler WF, Horvath E, Stefaneanu L, Kovacs K. Pituitary specific transcription factor messenger ribonucleic expression in adenomatous and nontumorous human pituitary tissues. Lab Invest. 1993;69(5):570-5.
18. Tateno T, Izumiyama H, Doi M, Yoshimoto T, Shichiri M, Inoshita N, et al. Differential gene expression in ACTH -secreting and nonfunctioning pituitary tumors. Eur J Endocrinol. 2007;157(6):717-24.
19. Bottner A, Keller E, Kratzsch J, Stobbe H, Weigel JF, Keller A, et al. PROP1 mutations cause progressive deterioration of anterior pituitary function including adrenal insufficiency: a longitudinal analysis. J Clin Endocrinol Metab. 2004;89(10):5256-65, http://dx.doi.org/10.1210/jc.2004-0661.