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Mutations in PCSK9 cause autosomal dominant hypercholesterolemia
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Serum proprotein convertase subtilisin/kexin type 9 and cell surface low-density lipoprotein receptor: Evidence for a reciprocal regulation
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Serum levels of proprotein convertase subtilisin/kexin type 9 in subjects with familial hypercholesterolemia indicate that proprotein con-vertase subtilisin/kexin type 9 is cleared from plasma by low-density lipo-protein receptor-independent pathways
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Proprotein convertase subtilisin/kexin type 9 interacts with apolipoprotein B and prevents its intracellular degradation, irrespective of the low-density lipopro-tein receptor
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Sun H, Samarghandi A, Zhang N., Yao Z, Xiong M, Teng BB Proprotein convertase subtilisin/kexin type 9 interacts with apolipoprotein B and prevents its intracellular degradation, irrespective of the low-density lipopro-tein receptor. Arterioscler Thromb Vasc Biol. 2012;32:1585-1595.
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PCSK9 plays a significant role in cholesterol homeostasis and lipid transport in intestinal epithelial cells
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Effect of a monoclonal antibody to PCSK9, REGN727/ SAR236553, to reduce low-density lipoprotein cholesterol in patients with heterozygous familial hypercholesterolaemia on stable statin dose with or without ezetimibe therapy: A phase 2 randomised controlled trial
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Stein EA, Gipe D, Bergeron J., Gaudet D, Weiss R, Dufour R., Wu R, Pordy R. Effect of a monoclonal antibody to PCSK9, REGN727/ SAR236553, to reduce low-density lipoprotein cholesterol in patients with heterozygous familial hypercholesterolaemia on stable statin dose with or without ezetimibe therapy: a phase 2 randomised controlled trial. Lancet. 2012;380:29-36.
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Low-density lipoprotein cholesterol-lowering effects of AMG 145, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease in patients with heterozygous familial hypercholesterol-emia: The reduction of LDL-C with PCSK9 inhibition in heterozygous familial hypercholesterolemia disorder (RUTHERFORD) randomized trial
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