Cryptococcosis-IRIS is associated with lower cryptococcus-specific IFN-γ responses before antiretroviral therapy but not higher T-cell responses during therapy

Journal of Infectious Diseases

Volumn 208, Issue 6, 2013, Pages 898-906

  Chang, Christina C ^a,b,c   Lim, Andrew ^d   Omarjee, Saleha ^b,e   Levitz, Stuart M ^f   Gosnell, Bernadett I ^g   Spelman, Tim ^c   Elliott, Julian H ^a   Carr, William H ^b   Moosa, Mohamed Yunus S ^g   Ndung'U, Thumbi ^b,e   Lewin, Sharon R ^a,c   French, Martyn A ^d,h  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF KWAZULU NATAL   (South Africa)

^c BURNET INSTITUTE   (Australia)

^d UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^e UNIVERSITY OF KWAZULU NATAL   (South Africa)

^f UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^g KING EDWARD VIII HOSPITAL   (South Africa)

^h ROYAL PERTH HOSPITAL   (Australia)

Author keywords

antigen specific T cells; cryptococcal mannoprotein; cryptococcal meningitis; cryptococcosis associated immune reconstitution inflammatory syndrome; interferon gamma; whole blood assay

Indexed keywords

ANTIRETROVIRUS AGENT; CD134 ANTIGEN; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR ALPHA; MANNOPROTEIN;

ADULT; AGE DISTRIBUTION; ANTIVIRAL THERAPY; ARTICLE; CD4+ T LYMPHOCYTE; COMBINATION CHEMOTHERAPY; CRYPTOCOCCAL MENINGITIS; CRYPTOCOCCOSIS; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; DRUG EFFECT; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME; LYMPHOCYTE FUNCTION; MAJOR CLINICAL STUDY; MIXED INFECTION; PRIORITY JOURNAL; SURVIVAL TIME; T LYMPHOCYTE ACTIVATION; VIRUS LOAD;

ANTIGEN-SPECIFIC T CELLS; CRYPTOCOCCAL MANNOPROTEIN; CRYPTOCOCCAL MENINGITIS; CRYPTOCOCCOSIS-ASSOCIATED IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME; INTERFERON-GAMMA; WHOLE BLOOD ASSAY;

ADULT; AIDS-RELATED OPPORTUNISTIC INFECTIONS; ANTI-RETROVIRAL AGENTS; ANTIFUNGAL AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CD4-POSITIVE T-LYMPHOCYTES; CHEMOKINE CXCL10; CRYPTOCOCCUS; FUNGAL PROTEINS; HUMANS; IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME; INTERFERON-GAMMA; INTERLEUKIN-10; MEMBRANE GLYCOPROTEINS; MENINGITIS, CRYPTOCOCCAL; MULTIVARIATE ANALYSIS; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; RECOMBINANT PROTEINS; RISK FACTORS; SOUTH AFRICA;

EID: 84879300136     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jit271     Document Type: Article

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