High versus standard clopidogrel loading in patients undergoing carotid artery stenting prior to cardiac surgery to assess the number of microemboli detected with transcranial Doppler: Results of the randomized IMPACT trial

Journal of Cardiovascular Surgery

Volumn 54, Issue 3, 2013, Pages 337-347

  Van Der Heyden, J ^a   Van Werkum, J ^a   Hackeng, C M ^a   Kelder, J C ^a   Breet, N J ^a   Deneer, V H M ^a   Ackerstaff, R G A ^a   Tromp, S C ^a   De Vries, J P P M ^a   Vos, J A ^a   Suttorp, M J ^a   Elsenberg, E H A ^a   Van Neerven, D ^a   Schonewille, W J ^a   Wolters, F ^a   Ten Berg, J M ^a  

^a ST ANTONIUS HOSPITAL   (Netherlands)

Author keywords

Cardiac surgical procedures; Carotid arteries; Stents

Indexed keywords

ACETYLSALICYLIC ACID; CLOPIDOGREL; ANTITHROMBOCYTIC AGENT; DRUG DERIVATIVE; TICLOPIDINE;

AGED; ARTICLE; BLOOD CLOTTING PARAMETERS; CAROTID ARTERY STENT; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; FOLLOW UP; HEART SURGERY; HUMAN; LOADING DRUG DOSE; MALE; MICROEMBOLISM; PLATELET REACTIVITY; PREDICTOR VARIABLE; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; THROMBOCYTE AGGREGATION; TRANSCRANIAL DOPPLER; TRANSIENT ISCHEMIC ATTACK; BRAIN EMBOLISM; CAROTID ARTERY OBSTRUCTION; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; DOPPLER ECHOGRAPHY; DOSE RESPONSE; DRUG ELUTING STENT; ECHOGRAPHY; HEART DISEASE; PROGNOSIS;

AGED; CARDIAC SURGICAL PROCEDURES; CAROTID STENOSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG-ELUTING STENTS; FEMALE; FOLLOW-UP STUDIES; HEART DISEASES; HUMANS; INTRACRANIAL EMBOLISM; ISCHEMIC ATTACK, TRANSIENT; MALE; PLATELET AGGREGATION INHIBITORS; PROGNOSIS; PROSPECTIVE STUDIES; TICLOPIDINE; ULTRASONOGRAPHY, DOPPLER, TRANSCRANIAL;

MLCS; MLOWN;

EID: 84879299046     PISSN: 00219509     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Roubin GS, New G, Iyer SS, Vitek JJ, Al-Mubarak N, Liu MW et al. Immediate and late clinical outcomes of carotid artery stenting in patients with symptomatic and asymptomatic carotid artery stenosis: a 5-year prospective analysis. Circulation 2001;103:532-7. (Pubitemid 32116237)
2. Yadav JS, Roubin GS, Iyer S, Vitek J, King P, Jordan WD et al. Elective stenting of the extracranial carotid arteries. Circulation 1997;95:376-81. (Pubitemid 27056202)
3. Wholey MH, Wholey M, Mathias K, Roubin GS, Diethrich EB, Henry M et al. Global experience in cervical carotid artery stent placement. Catheter Cardiovasc Interv 2000;50:160-7. (Pubitemid 30353838)
4. Yadav JS, Wholey MH, Kuntz RE, Fayad P, Katzen BT, Mishkel GJ et al. Protected carotid-artery stenting versus endanerectomy in high-risk patients. N Engl J Med 2004;351:1493-501.
5. Gurm HS, Yadav JS, Fayad P, Katzen BT, Mishkel GJ, Bajwa TK et al. SAPPHIRE Investigators. Long-term results of carotid stenting versus endarterectomy in high-risk patients. N Engl J Med 2008;358:1572-9. (Pubitemid 351519817)
6. Mas JL, Chatellier G, Beyssen B, Branchereau A, Moulin T, Becquemin JP et al. Endarterectomy versus stenting in patients with symptomatic severe carotid stenosis. N Engl J Med 2006;355:1660-71. (Pubitemid 44583956)
7. SPACE Collaborative Group, Ringleb PA, Allenberg J, Bruckmann H, Eckstein HH, Fraedrich G, Hartmann M et al. 30 day results from the SPACE trial of stent-protected angioplasty versus carotid endarterectomy in symptomatic patients: a randomised non-inferiority trial. Lancet 2006;368:1239-47.
8. International Carotid Stenting Study investigators, Ederle J, Dobson J, Featherstone RL, Bonati LH, van der Worp HB, de Borst GJ et al. Carotid artery stenting compared with endarterectomy in patients with symptomatic carotid stenosis (International Carotid Stenting Study): an interim analysis of a randomised controlled trial. Lancet 2010;375:985-97.
9. CREST. Silver FL, Mackey A, Clark WM, Brooks W, Timaran CH, Chiu D et al. Safety of stenting and endarterectomy by symptomatic status in the Carotid Revascularization Endarterectomy Versus Stenting Trial (CREST). Stroke 2011;42:675-80.
10. Topol EJ, Yadav JS. Recognition of the importance of embolization in atherosclerotic vascular disease. Circulation 2000;101:570-80. (Pubitemid 30080873)
11. Bertrand ME, Rupprecht HJ, Urban P, Gershlick AH; CLASSICS Investigators. Double blind study of the safety of clopidogrel with and without a loading dose in combination with aspirin compared with ticlopidine in combination with aspirin after coronary stenting: the Clopidogrel Aspirin Stent International Cooperative Study (CLASSICS). Circulation 2000;102:624-9. (Pubitemid 30640661)
12. Yadav JS. Management practices in carotid stenting. Cerebrovasc Dis 2001;11(Suppl 2):18-22.
13. McKevitt FM, Randall MS, Cleveland TJ, Gaines PA, Tan KT, Venables GS. The benefits of combined anti-platelet treatment in carotid artery stenting. Eur J Vasc Endovasc Surg 2005;29:522-7. (Pubitemid 40973849)
14. Serebruany VL, Steinhubl SR, Berger PB, Malinin AI, Bhatt DL, Topol EJ. Variability in platelet responsiveness to clopidogrel among 544 individuals. J Am Coll Cardiol 2005;45:246-51. (Pubitemid 40094733)
15. Gurbel PA, Bliden KP, Hiatt BL, O'Connor CM. Clopidogrel for coronary stenting: response variability, drug resistance, and the effect of pretreatment platelet reactivity. Circulation 2003;107:2908-13. (Pubitemid 36736631)
16. Breet NJ, van Werkum JW, Bouman HJ, Kelder JC, Ruven HJ, Bal ET et al. Comparison of platelet function tests in predicting clinical outcome in patients undergoing coronary stent implantation. JAMA 2010;303:754-62.
17. CURRENT-OASIS 7 Investigators, Mehta SR, Bassand JP, Chrolavicius S, Diaz R, Eikelboom JW, Fox KA et al. Dose comparisons of clopidogrel and aspirin in acute coronary syndromes. N Engl J Med 2010;363:930-42.
18. Transcranial Doppler monitoring in angioplasty and stenting of the carotid bifurcation. Antonius Carotid Endaterectomy, Angioplasty, and Stenting Study Group. J Endovasc Ther 2003;10:702-10.
19. Hellings WE, Ackerstaff RG, Pasterkamp G, De Vries JP, Moll FL. The carotid atherosclerotic plaque and microembolisation during carotid stenting. J Cardiovasc Surg (Torino) 2006;47:115-26.
20. Van der Heyden J, Lans HW, van Werkum JW, Schepens M, Ackerstaff RG, Suttorp MJ. Will carotid angioplasty become the preferred alternative to staged or synchronous carotid endarterectomy in patients undergoing cardiac surgery? Eur J Vasc Endovasc Surg 2008;36:379-84.
21. NASCET Steering Committee. North American Symptomatic Carotid Endarterectomy Trial. Methods, patient characteristics and progress. Stroke 1991;22:711-20.
22. Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. North American Symptomatic Carotid Endarterectomy Trial Collaborators N Engl J Med 1991;325:445-53.
23. Hyde DE, Fox AJ, Gulka I, Kalapos P, Lee DH, Pelz DM et al. Internal carotid artery stenosis measurement: comparison of 3D computed rotational angiography and conventional digital subtraction angiography. Stroke 2004;35:2776-81. (Pubitemid 39565170)
24. Chilcote WA, Modic MT, Pavlicek WA, Little JR, Furlan AJ, Duchesneau PM et al. Digital subtraction angiography of the carotid arteries: a comparative study in 100 patients. Radiology 1981;139:287-95. (Pubitemid 11112754)
25. Anzidei M, Napoli A, Zaccagna F, Di Paolo P, Saba L, Cavallo Marincola B et al. Diagnostic accuracy of colour Doppler ultrasonography, CT angiography and blood-pool-enhanced MR angiography in assessing carotid stenosis: a comparative study with DSA in 170 patients. Radiol Med 2011 [Epub ahead of print].
26. Rankin J. Cerebral vascular accidents in patients over the age of 60. II. Prognosis. Scott Med J 1957;2:200-15.
27. Van der Heyden J, Suttorp MJ, Bal ET, Ernst JM, Ackerstaff RG, Schaap J et al. Staged carotid angioplasty and stenting followed by cardiac surgery in patients with severe asymptomatic carotid artery stenosis: early and long-term results. Circulation 2007;116:2036-42. (Pubitemid 350023749)
28. Ringelstein EB, Droste DW, Babikian VL, Evans DH, Grosset DG, Kaps M et al. Consensus on microembolus detection by TCD. International Consensus Group on Microembolus Detection. Stroke 1998;29:725-9. (Pubitemid 28145805)
29. van Werkum JW, Kleibeuker M, Mieremet N, ten Berg JM, Hackeng CM. Evaluation of the platelet response to clopidogrel with light transmittance aggregometry: peak aggregation or late aggregation? J Thromb Haemost 2007;5:884-6. (Pubitemid 46563599)
30. Breet NJ, van Werkum JW, Bouman HJ, Kelder JC, Ten Berg JM, Hackeng CM. Both peak and late aggregation are capable of identifying patients at risk for atherothrombotic events. Thromb Haemost 2011;105:197-9.
31. van Werkum JW, van der Stelt CA, Seesing TH, Hackeng CM, ten Berg JM. A head-to-head comparison between the VerifyNow P2Y12 assay and light transmittance aggregometry for monitoring the individual platelet response to clopidogrel in patients undergoing elective percutaneous coronary intervention. J Thromb Haemost 2006;4:2516-8. (Pubitemid 44575456)
32. van Werkum JW, Harmsze AM, Elsenberg EH, Bouman HJ, ten Berg JM, Hackeng CM. The use of the Verify Now system to monitor antiplatelet therapy: a review of the current evidence. Platelets 2008;19:479-88.
33. Markus HS, Thomson N, Brown MM. Asymptomatic cerebral embolic signals in symptomatic and asymptomatic carotid artery disease. Brain 1995;118:1005-11.
34. Molloy J, Markus HS. Asymptomatic embolization predicts stroke and TIA risk in patients with carotid artery stenosis. Stroke 1999;30:1440-3. (Pubitemid 29296074)
35. Valton L, Larrue V, Arrue P, Geraud G, Bes A. Asymptomatic cerebral embolic signals in patients with carotid stenosis: correlation with the appearance of plaque ulceration on angiography. Stroke 1995;26:813-5.
36. Markus HS, King A, Shipley M, Topakian R, Cullinane M, Reihill S et al. Asymptomatic embolisation for prediction of stroke in the Asymptomatic Carotid Emboli Study (ACES): a prospective observational study. Lancet Neurol 2010;9:663-71.
37. Kaposzta Z, Martin JF, Markus HS. Switching off embolization from symptomatic carotid plaque using S-nitrosoglutathione. Circulation 2002;105:1480-4. (Pubitemid 34263281)
38. Kaposzta Z, Baskerville PA, Madge D, Fraser S, Martin JF, Markus HS. L-arginine and S-nitrosoglutathione reduce embolization in humans. Circulation 2001;103:2371-5. (Pubitemid 32448802)
39. Chaturvedi S, Yadav JS. The role of antiplatelet therapy in carotid stenting for ischemic stroke prevention. Stroke 2006;37;1572-7. (Pubitemid 44305747)
40. Steinhubl SR, Berger PB, Mann JT III, Fry ET, DeLago A, Wilmer C et al. Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: A randomized controlled trial. J Am Med Assoc 2002;288:2411-20. (Pubitemid 35340537)
41. Antiplatelet Trialists' Collaboration. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ 2002;324:71-86.
42. Hayes PD, Box H, Tull S, Bell PR, Goodall A, Naylor AR. Patients' thromboembolic potential after carotid endarterectomy is related to the platelets' sensitivity to adenosine diphosphate. J Vasc Surg 2003;38:1226-31. (Pubitemid 37517650)
43. Payne DA, Jones CI, Hayes PD, Thompson MM, London NJ, Bell PR et al. Beneficial effects of clopidogrel combined with aspirin in reducing cerebral emboli in patients undergoing carotid endarterectomy. Circulation 2004;109:1476-81. (Pubitemid 38420174)
44. Bhatt DL, Kapadia SR, Bajzer CT, Chew DP, Ziada KM, Mukherjee D et al. Dual antiplatelet therapy with clopidogrel and aspirin after carotid artery stenting. J Invasive Cardiol 2001;13:767-71. (Pubitemid 33759191)