Interobserver agreement of proliferation index (Ki-67) outperforms mitotic count in pulmonary carcinoids

Virchows Archiv

Volumn 462, Issue 5, 2013, Pages 507-513

  Warth, Arne ^a   Fink, Ludger ^b   Fisseler Eckhoff, Annette ^c   Jonigk, Danny ^d   Keller, Marius ^a   Ott, German ^e   Rieker, Ralf J ^f   Sinn, Peter ^a   Söder, Stephan ^f   Soltermann, Alex ^g   Willenbrock, Klaus ^c   Weichert, Wilko ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b Institute of Pathology and Cytology   (Germany)

^c DR HORST SCHMIDT KLINIKEN   (Germany)

^d HANNOVER MEDICAL SCHOOL   (Germany)

^e ROBERT BOSCH HOSPITAL   (Germany)

^f UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^g UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Interobserver agreement; Ki 67; Mitosis; Prognosis; Proliferation; Pulmonary carcinoids

Indexed keywords

EOSIN; HEMATOXYLIN; KI 67 ANTIGEN; TUMOR MARKER;

ALGORITHM; ARTICLE; CANCER PROGNOSIS; CARCINOID; CLINICAL ARTICLE; CLINICAL EVALUATION; CONTROLLED STUDY; CORRELATION COEFFICIENT; DATA ANALYSIS SOFTWARE; DIAGNOSTIC TEST; DIAGNOSTIC TEST ACCURACY STUDY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTERRATER RELIABILITY; LUNG RESECTION; LUNG TUMOR; MITOSIS; PATHOLOGIST; PREDICTIVE VALUE; PRIORITY JOURNAL; PULMONARY CARCINOID; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; TUMOR CLASSIFICATION; TUMOR GROWTH; TUMOR LOCALIZATION; TUMOR VOLUME; CANCER GRADING; CELL PROLIFERATION; COMPUTER ASSISTED DIAGNOSIS; METHODOLOGY; MITOSIS INDEX; OBSERVER VARIATION; PATHOLOGY;

ALGORITHMS; CARCINOID TUMOR; CELL PROLIFERATION; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; KI-67 ANTIGEN; LUNG NEOPLASMS; MITOTIC INDEX; NEOPLASM GRADING; OBSERVER VARIATION; TUMOR MARKERS, BIOLOGICAL;

MLCS; MLOWN;

EID: 84879288717     PISSN: 09456317     EISSN: 14322307     Source Type: Journal    
DOI: 10.1007/s00428-013-1408-2     Document Type: Article

References (36)

1. Zahel T, Krysa S, Herpel E et al (2012) Phenotyping of pulmonary carcinoids and a Ki-67-based grading approach. Virchows Arch 460:299-308
2. Warth A, Krysa S, Zahel T et al (2010) S100 protein positive sustentacular cells in pulmonary carcinoids and thoracic paragangliomas: differential diagnostic and prognostic evaluation. Pathologe 31:379-384
3. Warth A, Herpel E, Krysa S et al (2009) Chromosomal instability is more frequent in metastasized than in non-metastasized pulmonary carcinoids but is not a reliable predictor of metastatic potential. Exp Mol Med 41:349-353
4. Rekhtman N (2010) Neuroendocrine tumors of the lung: an update. Arch Pathol Lab Med 134:1628-1638
5. Warren WH, Gould VE, Faber LP et al (1985) Neuroendocrine neoplasms of the bronchopulmonary tract. A classification of the spectrum of carcinoid to small cell carcinoma and intervening variants. J Thorac Cardiovasc Surg 89:819-825
6. Ducrocq X, Thomas P, Massard G et al (1998) Operative risk and prognostic factors of typical bronchial carcinoid tumors. Ann Thorac Surg 65:1410-1414
7. Fink G, Krelbaum T, Yellin A et al (2001) Pulmonary carcinoid: presentation, diagnosis, and outcome in 142 cases in Israel and review of 640 cases from the literature. Chest 119:1647-1651
8. Travis WD (2010) Advances in neuroendocrine lung tumors. Ann Oncol 21(Suppl 7):vii65-vii71
9. Hage R, de la Riviere AB, Seldenrijk CA et al (2003) Update in pulmonary carcinoid tumors: a review article. Ann Surg Oncol 10:697-704
10. Skov BG, Holm B, Erreboe A et al (2010) ERCC1 and Ki67 in small cell lung carcinoma and other neuroendocrine tumors of the lung: distribution and impact on survival. J Thorac Oncol 5:453-459
11. Rindi G, Falconi M, Klersy C et al (2012) TNM staging of neoplasms of the endocrine pancreas: results from a large international cohort study. J Natl Cancer Inst 104:764-777
12. Rindi G, Kloppel G, Alhman H et al (2006) TNM staging of foregut (neuro)endocrine tumors: a consensus proposal including a grading system. Virchows Arch 449:395-401
13. Santinelli A, Ranaldi R, Baccarini M et al (1999) Ploidy, proliferative activity, p53 and bcl-2 expression in bronchopulmonary carcinoids: relationship with prognosis. Pathol Res Pract 195:467-474
14. Bohm J, Koch S, Gais P et al (1996) Prognostic value of MIB-1 in neuroendocrine tumours of the lung. J Pathol 178:402-409
15. Granberg D, Wilander E, Oberg K et al (2000) Prognostic markers in patients with typical bronchial carcinoid tumors. J Clin Endocrinol Metab 85:3425-3430
16. Das-Neves-Pereira JC, Bagan P, Milanez-de-Campos JR, et al. (2008) Individual risk prediction of nodal and distant metastasis for patients with typical bronchial carcinoid tumors. Eur J Cardiothorac Surg 34:473-7; discussion 477-8
17. Grimaldi F, Muser D, Beltrami CA, et al. (2011) Partitioning of bronchopulmonary carcinoids in two different prognostic categories by ki-67 score. Front Endocrinol (Lausanne) 2:20
18. Walts AE, Ines D, Marchevsky AM (2012) Limited role of Ki-67 proliferative index in predicting overall short-term survival in patients with typical and atypical pulmonary carcinoid tumors. Mod Pathol 25:1258-1264
19. Hasegawa T, Yamamoto S, Nojima T et al (2002) Validity and reproducibility of histologic diagnosis and grading for adult soft-tissue sarcomas. Hum Pathol 33:111-115
20. Gunia S, Kakies C, Erbersdobler A et al (2012) Scoring the percentage of Ki67 positive nuclei is superior to mitotic count and the mitosis marker phosphohistone H3 (PHH3) in terms of differentiating flat lesions of the bladder mucosa. J Clin Pathol 65:715-720
21. Ladekarl M (1998) Objective malignancy grading: a review emphasizing unbiased stereology applied to breast tumors. APMIS Suppl 79:1-34
22. Barry M, Sinha SK, Leader MB et al (2001) Poor agreement in recognition of abnormal mitoses: requirement for standardized and robust definitions. Histopathology 38:68-72
23. Coindre JM, Trojani M, Contesso G et al (1986) Reproducibility of a histopathologic grading system for adult soft tissue sarcoma. Cancer 58:306-309
24. Silverberg SG (1976) Reproducibility of the mitosis count in the histologic diagnosis of smooth muscle tumors of the uterus. Hum Pathol 7:451-454
25. Montironi R, Collan Y, Scarpelli M et al (1988) Reproducibility of mitotic counts and identification of mitotic figures in malignant glial tumors. Appl Pathol 6:258-265
26. Gilles FH, Tavare CJ, Becker LE et al (2008) Pathologist interobserver variability of histologic features in childhood brain tumors: results from the CCG-945 study. Pediatr Dev Pathol 11:108-117
27. Svanholm H, Starklint H, Barlebo H et al (1990) Histological evaluation of prostatic cancer. (II): reproducibility of a histological grading system. APMIS 98:229-236
28. Tsuda H, Akiyama F, Kurosumi M et al (2000) Evaluation of the interobserver agreement in the number of mitotic figures of breast carcinoma as simulation of quality monitoring in the Japan National Surgical Adjuvant Study of Breast Cancer (NSAS-BC) protocol. Jpn J Cancer Res 91:451-457
29. van Diest PJ, Baak JP, Matze-Cok P et al (1992) Reproducibility of mitosis counting in 2,469 breast cancer specimens: results from the Multicenter Morphometric Mammary Carcinoma Project. Hum Pathol 23:603-607
30. Biesterfeld S (1997) Methodologic aspects of a standardized evaluation of mitotic activity in tumor tissues. Pathologe 18:439-444
31. Yadav KS, Gonuguntla S, Ealla KK et al (2012) Assessment of interobserver variability in mitotic figure counting in different histological grades of oral squamous cell carcinoma. J Contemp Dent Pract 13:339-344
32. Tapia C, Kutzner H, Mentzel T et al (2006) Two mitosis-specific antibodies, MPM-2 and phospho-histone H3 (Ser28), allow rapid and precise determination of mitotic activity. Am J Surg Pathol 30:83-89
33. Schimming TT, Grabellus F, Roner M et al (2012) pHH3 immunostaining improves interobserver agreement of mitotic index in thin melanomas. Am J Dermatopathol 34:266-269
34. Yamaguchi U, Hasegawa T, Sakurai S et al (2006) Interobserver variability in histologic recognition, interpretation of KIT immunostaining, and determining MIB-1 labeling indices in gastrointestinal stromal tumors and other spindle cell tumors of the gastrointestinal tract. Appl Immunohistochem Mol Morphol 14:46-51
35. Mengel M, von Wasielewski R, Wiese B et al (2002) Inter-laboratory and inter-observer reproducibility of immunohistochemical assessment of the Ki-67 labelling index in a large multi-centre trial. J Pathol 198:292-299
36. Hsu CY, Ho DM, Yang CF et al (2003) Interobserver reproducibility of MIB-1 labeling index in astrocytic tumors using different counting methods. Mod Pathol 16:951-957