Born Germ-Free—Microbial Dependent

Gastrointestinal Microbiology

Volumn , Issue , 2006, Pages 273-284

  Norin, Elisabeth ^a   Midtvedt, Tore ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84879273418     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (52)

1. Nuttal GHF, Thierfelder H. Tierisches leben ohne Bakterien im Verdauungskanal. Hoppe Seyler’s Zeitsch Physiol Chemie 1896-1897; 33:62-73.
2. Gustafsson BE. Lightweight stainless steel systems for rearing germfree animals. Ann N Y Acad Sci 1959; 78:17-28.
3. Midtvedt T. Influence of antibiotics on biochemical intestinal microflora-associated characteristics in man and animals. In: Gillessen G, Opferkuch W, Peters G, Pulverer G, eds. The Influence of Antibiotics on the Host-Parasite Relationship III. Berlin, Heidelberg: Springer Verlag, 1989:209-215.
4. Midtvedt T, Björneklett A, Carlstedt-Duke B, et al. Germfree research; microflora control and its application to the biomedical sciences. In: Wostmann BS, Pleasants JR, Pollard M, Teah BA, Wagner M, eds. The Influence of Antibiotics Upon Microflora-Associated Characteristics in Man and Animals. New York: Alan R Liss Inc, 1985:241-244.
5. Collinder E, Björnhag G, Cardona M, Norin E, Rehbinder C, Midtvedt T. Gastrointestinal hostmicrobial interactions in mammals and fish. Comparative studies in man, mice, rats, pigs, horses, cows, elks, reindeers, salmon, and cod. Microb Ecol Health Dis 2003; 15:66-78.
6. Falk GP, Hooper LV, Midtvedt T, Gordon JI. Creating and maintaining the gastrointestinal ecosystem; what we know and need to know from gnotobiology. Microbiol Molecul Biol Rev 1998;1157-1170.
7. Hooper LV, Midtvedt T, Gordon JI. How host-microbial interactions shape the nutrient environment of the mammalian intestine. Ann Rev Nutr 2002; 22:283-307.
8. Midtvedt T. Probiotics, other nutritional factors, and intestinal microflora: microbial functional activities. In: Hansson LÅ, Yolken RH, eds. In: Nestlé Nutrition Workshop Series. Philadelphia: Lippincott-Raven Publishers, 1999:79-96.
9. Gustafsson BE. Vitamin K deficiency in germfree rats. Ann N Y Acad Sci 1959; 78:166-174.
10. Gustafsson BE, Draft FS, McDaniel EG, Smith JC, Fitzgerald RJ. Effects of vitamin K-active compounds and intestinal s in vitamin K deficient germfree rats. J Nutr 1962; 78:461-468.
11. Strandberg K, Sedvall G, Midtvedt T, Gustafsson BE. Effect of some biologically active amines on the cecum wall of germ-free rats. Proc Soc Exp Biol Med 1966; 121:699-702.
12. Gustafsson BE, Midtvedt T, Strandberg K. Effects of microbial contamination on the cecum enlargement of germ-free rats. Scand J Gastroent 1970; 5:309-314.
13. Banasaz M, Alam M, Norin E, Midtvedt T. Gender, age, and microbial status influence upon cell kinetics in a compartmentalised manner. An experimental study in germ-free and conventional rats. Microb Ecol Health Dis 2000; 12:208-218.
14. Banasaz M, Norin E, Midtvedt T. The role of gender, age, and microbial status on cell kinetics in the gastrointestinal tract of mice. An experimental study in germ-free and conventional mice. Microb Ecol Health Dis 2001; 13:135-142.
15. Banasaz M, Åkerlund T, Norin E, Burman L, Midtvedt T. Reduced mitotic activity of intestinal mucosal cells in germ-free rats mono-associated with toxin producing Clostridium difficile. Microb Ecol Health Dis 2003; 4:146-152.
16. Husebye E, Hellström PM, Midtvedt T. Intestinal microflora stimulates myoelectric activity of rat wall intestine by promoting cyclic initiation and abnormal propagation of migrating myoelectric complexes. Dig Dis Sci 1992;946-956.
17. Alam M, Midtvedt T. In: Hashimoto K, ed. Microflora and Gastrointestinal Peptides. Shiozawa, Japan: XII IGS Publishing Committee, 1996:409-412.
18. Bothin C, Okada M, Midtvedt T, Perbeck L. The intestinal flora influences adhesion formation around surgical anastomoses. Br J Surg 2001; 88:143-145.
19. Röd TO, Midtvedt T. The origin of intestinal b-glucuronidase in germfree, monocontaminated, and conventional rats. Acta Path Microbiol Scand Sect B 1977; 85:271-276.
20. Gadelle D, Raibaud P, Sacquet E. b-glucuronidase activities of intestinal bacteria determined both in vitro and in vivo in gnotobiotic rats. Appl Environ Microbiol 1985; 49:682-685.
21. Gustafsson BE, Swenander-Lanke L. Bilirubin, and urobilins in germ-free, ex-germ-free, and conventional rats. J Exp Med 1960; 112:975-981.
22. Midtvedt T, Gustafsson BE. Microbial conversion of bilirubin to urobilins in vitro and in vivo. Acta Pathol Microbiol Scand Sect B 1981; 89:57-60.
23. Midtvedt AC, Carlstedt-Duke B, Norin KE, Saxerholt H, Midtvedt T. Development of five metabolic activities associated with the intestinal microflora of healthy infants. J Pediatr Gastroenterol Nutr 1988; 7:559-567.
24. Benno P, Alam M, Collinder E, Norin E, Midtvedt T. Fecal tryptic activity and excretion of urobilinogens in 573 healthy subjects living in Sweden, Norway, and Scotland. Microb Ecol Health Dis 2003; 15:169-175.
25. Saxerholt H, Carlstedt-Duke B, Höverstad T, et al. Influence of antibiotics on the fecal excretion of bile pigments in healthy subjects. J Gastroenterol 1986; 2:991-996.
26. Midtvedt T. Metabolism of endogenous substances. In: Clercq De, ed. Frontiers in Microbiology. From Antibiotics to AIDS. Dordrecht/Boston/Lancaster: Martinus Nijhoff Publishers, 1987:79-87.
27. Danielsson H, Gustafsson BE. On serum-cholesterol levels and neutral fecal sterols in germfree rats. Bile acids and steroids59. Arch Biochem Biophys 1959; 83:482-485.
28. Gustafsson B, Carlstedt-Duke B. Intestinal water-soluble mucins in germfree, ex-germfree, and conventional animals. Acta Path Microbiol Immunol Scand Sect B 1984; 92:247-252.
29. Hoskins LC, Agustines M, McKee WB, Boulding ET, Kriaris M, Niedermeyer G. Mucin degradation in human colon ecosystems. Isolation and properties of fecal strains that degrade ABH blood group antigens and oligosacharrides from mucin glycoproteins. J Clin Invest 1985; 75:944-953.
30. Carlstedt-Duke B, Midtvedt T, Nord CE, Gustafsson BE. Isolation and characterization of a mucindegrading strain of Peptostreptococcus from rat intestinal tract. Acta Path Microbiol Immunol Scand Sec B 1986; 94:292-300.
31. Karlsson KA. Animal glucosphingolipids as membrane attachment sites for bacteria. Ann Rev Biochem 1989; 58:309-350.
32. Freitas M, Axelsson LG, Cayuela C, Midtvedt T, Trugnan G. Microbial-host interactions specifically control the glycosylation pattern in intestinal mouse mucosa. Histochem Cell Biol 2002; 118:149-161.
33. Bry L, Falk PG, Midtvedt T, Gordon JI. A model of host-microbial interactions in an open mammalian ecosystem. Science 1996; 6:1380-1383.
34. Carlstedt-Duke B, Høverstad T, Lingaas E, et al. Influence of antibiotics on intestinal mucin in healthy subjects. Eur J Clin Microbiol 1986; 5:634-638.
35. Carlstedt-Duke B, Alm L, Høverstad T, et al. Influence of clindamycin, administered together with or without lactobacilli, upon intestinal ecology in rats. FEMS Microbiol Ecol 1987; 45:251-259.
36. Norin KE, Midtvedt T, Gustafsson BE. Influence of the intestinal microflora on the tryptic activity during lactation. Lab Anim 1986; 20:234-237.
37. Norin KE. The regulatory and protective role of the normal microflora. In: Grubb R, Midtvedt T, Norin KE, eds. The Normal Microflora and Intestinal Enzymes. New York: Stockton Press, 1988:219-237.
38. Norin KE, Gustafsson BE, Midtvedt T. Strain differences in fecal tryptic activity of germfree and conventional rats. Lab Anim 1986; 20:67-69.
39. Ramare F, Hautefort I, Verhe F, Raibaud P, Iovanna J. Inactivation of tryptic activity by a human-derived strain of Bacteroides distasonis in the large intestines of gnotobiotic rats and mice. Appl Environ Microbiol 1996; 62:1434-1436.
40. Welling GW, Helmus G, de Vries-Hospers HG, et al. Germ-free research; microflora control, and its application to the biomedical sciences. In: Wostmann BS, Pleasants JR, Pollard M, Teah BA, Wagner M, eds. Rationale for Use of b-Aspartylglycine as Indicator of Colonization Resistance. New York: Alan R Liss Inc., 1985:155-158.
41. Welling GW, Groen G, Tuinte HM, et al. Biochemical effects on germ-free mice of association with several strains of anaerobic bacteria. J Gen Microbiol 1980; 117:57-63.
42. van der Waaij D, van der Waaij BD. The colonization resistance of the digestive tract in different animal species and in man: a comparative study. Epidemiology and Infections 1990; 105:237-243.
43. Høverstad T, Midtvedt T. Short-chain fatty acids in germ-free mice and rats. J Nutr 1986; 116:1772-1776.
44. Bottcher M, Norin EK, Sandin A, Midtvedt T, Björkstén B. Microflora associated characteristics in faeces from allergig and nonallergic infants. Clin Exp Allergy 2000; 30:1590-1596.
45. Høverstad T, Carlstedt-Duke B, Lingaas E, et al. Influence of ampicillin, clindamycin, and metronidazole on fecal excretion of short-chain fatty acids in healthy subjects. Scand J Gastroenterol 1986; 21:621-626.
46. Høverstad T, Carlstedt-Duke B, Lingaas E, et al. Influence of oral intake of seven different antibiotics on fecal of short-chain fatty acid excretion in healthy subjects. Scand J Gastroent 1986; 21:997-1003.
47. Siigur U, Norin KE, Allgood G, Schlagheck T, Midtvedt T. Effects of olestra on fecal water and short-chain fatty acids. Microb Ecol Health Dis 1996; 9:9-17.
48. Siigur U, Norin KE, Allgood G, Schlagheck T, Midtvedt T. Effect of olestra upon intestinal microecology as reflected by five microflora associated characteristics in man. Microb Ecol Health Dis 1996; 9:297-303.
49. Trippestad A, Midtvedt T. The phagocytic activity of polynuclear leucocytes from germfree and conventional rats. Acta Path Microbiol Scand Sect B 1971; 79:519-522.
50. Trippestad A, Midtvedt T. Chemotaxis of polymorphonuclear leucocytes from germfree rats and generation of chemotactic activity in germfree rat sera. Clin Exp Immunol 1971; 8:639-646.
51. Midtvedt T, Trippestad A. Specificity of opsonic and bactericidal response of gnotobiotic rat sera. Acta Path Microbiol Scand Sect B 1971; 79:291-296.
52. Brandtzaeg P, Halstensen TS, Kett K, et al. Immunobiology and immunopathology of human gut mucosa; humoral immun intraepithelial lymphocytes. Gastroenterology 1989; 97:1562-1584.