Lin28 Mediates Radiation Resistance of Breast Cancer Cells via Regulation of Caspase, H2A.X and Let-7 Signaling

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Wang, Linbo ^a   Yuan, Chao ^a   Lv, Kezhen ^b   Xie, Shuduo ^a   Fu, Peifen ^b   Liu, Xiaojiao ^b   Chen, Yongxia ^a   Qin, Chuan ^a   Deng, Wuguo ^c,d   Hu, Wenxian ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY   (China)

^c DALIAN MEDICAL UNIVERSITY   (China)

^d SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CASPASE; GAMMA HISTONE H2AX; HISTONE H2AX; PROTEIN LET 7; PROTEIN LIN28; PROTEIN P21; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CELL STRAIN BCAP 37; CELL STRAIN MCF7; CELL STRAIN SK BR 3; CELL STRAIN T47D; COMPARATIVE STUDY; CONTROLLED STUDY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; RADIOSENSITIVITY; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

APOPTOSIS; BREAST NEOPLASMS; CELL SURVIVAL; CYCLIN-DEPENDENT KINASE INHIBITOR P21; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; HISTONES; HUMANS; MCF-7 CELLS; MICRORNAS; RADIATION TOLERANCE; RNA-BINDING PROTEINS; SIGNAL TRANSDUCTION;

EID: 84879261337     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0067373     Document Type: Article

References (21)

1. DeSantis C, Siegel R, Bandi P, Jemal A, (2011) Breast cancer statistics, 2011.CA Cancer J.Clin. 61: 409-418.
2. Darby S, McGale P, Correa C, Taylor C, Arriagada R, et al. (2011) Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10801 women in 17 randomised trials. Lancet 378: 1707-1716.
3. Whelan T, Olivotto I, Levine M, (2003) Clinical practice guidelines for the care and treatment of breast cancer: breast radiotherapy after breast-conserving surgery (summary of the 2003 update).CMAJ. 168: 437-439.
4. Yang X, Lin X, Zhong X, Kaur S, Li N, et al. (2010) Double-negative feedback loop between reprogramming factor LIN28 and microRNA let-7 regulates aldehyde dehydrogenase 1-positive cancer stem cells. Cancer Res. 70: 9463-9472.
5. Guo Y, Chen Y, Ito H, Watanabe A, Ge X, et al. (2006) Identification and characterization of lin-28 homolog B (LIN28B) in human hepatocellular carcinoma. Gene 384: 51-61.
6. Pan L, Gong Z, Zhong Z, Dong Z, Liu Q, et al. (2011) Lin-28 reactivation is required for let-7 repression and proliferation in human small cell lung cancer cells. Mol.Cell Biochem. 355: 257-263.
7. Xu B, Zhang K, Huang Y, (2009) Lin28 modulates cell growth and associates with a subset of cell cycle regulator mRNAs in mouse embryonic stem cells. RNA. 15: 357-361.
8. Oh JS, Kim JJ, Byun JY, Kim IA, (2010) Lin28-let7 modulates radiosensitivity of human cancer cells with activation of K-Ras. Int.J.Radiat.Oncol.Biol.Phys. 76: 5-8.
9. Duru N, Fan M, Candas D, Menaa C, Liu HC, et al. (2012) HER2-Associated Radioresistance of Breast Cancer Stem Cells Isolated from HER2-Negative Breast Cancer Cells. Clin.Cancer Res. [Epub ahead of print].
10. Viswanathan SR, Daley GQ, Gregory RI, et al. (2008) Selective blockade of microRNA processing by Lin28. Science 320: 97-100.
11. Lv K, Liu L, Wang L, Yu J, Liu X, et al. (2012) Lin28 mediates paclitaxel resistance by modulating p21, Rb and Let-7a miRNA in breast cancer cells. PLoS.One. 7: e40008.
12. Chakravarti A, Dicker A, Mehta M, (2004) The contribution of epidermal growth factor receptor (EGFR) signaling pathway to radioresistance in human gliomas: a review of preclinical and correlative clinical data. Int.J. Radiat.Oncol.Biol.Phys. 58: 927-931.
13. Bussink J, van der Kogel AJ, Kaanders JH, (2008) Activation of the PI3-K/AKT pathway and implications for radioresistance mechanisms in head and neck cancer. Lancet Oncol. 9: 288-296.
14. Fedrigo CA, Grivicich I, Schunemann DP, Chemale IM, dos Santos D, et al. (2011) Radioresistance of human glioma spheroids and expression of HSP70, p53 and EGFr. Radiat.Oncol. 6: 156.
15. Zhu Y, Zhao T, Itasaka S, Zeng L, Yeom CJ, et al. (2012) Involvement of decreased hypoxia-inducible factor 1 activity and resultant G(1)-S cell cycle transition in radioresistance of perinecrotic tumor cells. Oncogene. 223. [Epub ahead of print].
16. Park SH, Cho HN, Lee SJ, Kim TH, Lee Y, et al. (2000) Hsp25-induced radioresistance is associated with reduction of death by apoptosis: involvement of Bcl2 and the cell cycle. Radiat.Res. 154: 421-428.
17. Besancon R, Valsesia-Wittmann S, Puisieux A, Caron de Fromentel C, Maguer-Satta V, (2009) Cancer stem cells: the emerging challenge of drug targeting. Curr.Med.Chem. 16: 394-416.
18. Baumann M, Krause M, Hill R, (2008) Exploring the role of cancer stem cells in radioresistance. Nat.Rev.Cancer 8: 545-554.
19. Diehn M, Cho RW, Lobo NA, Kalisky T, Dorie MJ, et al. (2009) Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature 458: 780-783.
20. Liu ZL, Wang H, Liu J, Wang ZX (2012) MicroRNA-21 (miR-21) expression promotes growth, metastasis, and chemo- or radioresistance in non-small cell lung cancer cells by targeting PTEN. Mol.Cell Biochem. [Epub ahead of print].
21. Jiang P, Rao EY, Meng N, Zhao Y, Wang JJ, (2010) MicroRNA-17-92 significantly enhances radioresistance in human mantle cell lymphoma cells. Radiat.Oncol. 5: 100.