A Novel Laser-Doppler Flowmetry Assisted Murine Model of Acute Hindlimb Ischemia-Reperfusion for Free Flap Research

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Sönmez, Tolga Taha ^a   Al Sawaf, Othman ^a   Brandacher, Gerald ^b   Kanzler, Isabella ^a,c   Tuchscheerer, Nancy ^a   Tohidnezhad, Mersedeh ^a   Kanatas, Anastasios ^d   Knobe, Matthias ^a   Fragoulis, Athanassios ^a   Tolba, René ^a   Mitchell, David ^e   Pufe, Thomas ^a   Wruck, Christoph Jan ^a   Hölzle, Frank ^a   Liehn, Elisa Anamaria ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c GOETHE UNIVERSITY   (Germany)

^d LEEDS TEACHING HOSPITALS NHS TRUST   (United Kingdom)

^e MID YORKSHIRE HOSPITALS NHS TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; VASCULOTROPIN;

ADULT ANIMAL; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAPILLARY; CELL INFILTRATION; CONTROLLED STUDY; DOPPLER FLOWMETRY; EDEMA; FREE TISSUE GRAFT; HINDLIMB; HISTOPATHOLOGY; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; LIMB ISCHEMIA; MICROSURGERY; MOUSE; MUSCLE; MUSCLE CELL; MYOTUBE; NEUROMUSCULAR DISEASE; NONHUMAN; REPERFUSION INJURY; SKIN; STEM CELL; SWELLING; TISSUE INJURY; TISSUE REGENERATION; UPREGULATION;

ANIMALS; ANTIGENS, CD31; DISEASE MODELS, ANIMAL; FREE TISSUE FLAPS; HINDLIMB; LASER-DOPPLER FLOWMETRY; MICE; MICE, INBRED C57BL; MICROVESSELS; MUSCLE, SKELETAL; NEOVASCULARIZATION, PHYSIOLOGIC; REGENERATION; REPERFUSION INJURY; SKIN;

MURINAE; MUS;

EID: 84879251621     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0066498     Document Type: Article

References (21)

1. Holzle F, Wolff KD, Mohr C, (2008) Reconstructive oral and maxillofacial surgery. Dtsch Arztebl Int 105: 815-822.
2. Bui DT, Cordeiro PG, Hu QY, Disa JJ, Pusic A, et al. (2007) Free flap reexploration: indications, treatment, and outcomes in 1193 free flaps. Plast Reconstr Surg 119: 2092-2100.
3. Yassin MM, Harkin DW, Barros D'Sa AA, Halliday MI, Rowlands BJ, (2002) Lower limb ischemia-reperfusion injury triggers a systemic inflammatory response and multiple organ dysfunction. World J Surg 26: 115-121.
4. Koletsis E, Chatzimichalis A, Apostolakis E, Kokkinis K, Fotopoulos V, et al. (2006) In situ cooling in a lung hilar clamping model of ischemia-reperfusion injury. Exp Biol Med (Maywood) 231: 1410-1420.
5. Pipinos, II, Judge AR, Selsby JT, Zhu Z, Swanson SA, et al. (2008) The myopathy of peripheral arterial occlusive disease: Part 2. Oxidative stress, neuropathy, and shift in muscle fiber type. Vasc Endovascular Surg 42: 101-112.
6. Carroll WR, Esclamado RM, (2000) Ischemia/reperfusion injury in microvascular surgery. Head Neck 22: 700-713.
7. Honda HM, Korge P, Weiss JN, (2005) Mitochondria and ischemia/reperfusion injury. Ann N Y Acad Sci 1047: 248-258.
8. Hatoko M, Tanaka A, Kuwahara M, Yurugi S, Iioka H, et al. (2002) Difference of molecular response to ischemia-reperfusion of rat skeletal muscle as a function of ischemic time: study of the expression of p53, p21(WAF-1), Bax protein, and apoptosis. Ann Plast Surg 48: 68-74.
9. Crawford RS, Hashmi FF, Jones JE, Albadawi H, McCormack M, et al. (2007) A novel model of acute murine hindlimb ischemia. Am J Physiol Heart Circ Physiol 292: H830-837.
10. Bonheur JA, Albadawi H, Patton GM, Watkins MT, (2004) A noninvasive murine model of hind limb ischemia-reperfusion injury. J Surg Res 116: 55-63.
11. Mukundan C, Gurish MF, Austen KF, Hechtman HB, Friend DS, (2001) Mast cell mediation of muscle and pulmonary injury following hindlimb ischemia-reperfusion. J Histochem Cytochem 49: 1055-1056.
12. Yassin MM, Barros D'Sa AA, Parks G, Abdulkadir AS, Halliday I, et al. (1996) Mortality following lower limb ischemia-reperfusion: a systemic inflammatory response? World J Surg 20: 961-966; discussion 966-967.
13. Wakai A, Winter DC, Street JT, O'Sullivan RG, Wang JH, et al. (2001) Inosine attenuates tourniquet-induced skeletal muscle reperfusion injury. J Surg Res 99: 311-315.
14. Vignaud A, Hourde C, Medja F, Agbulut O, Butler-Browne G, et al. (2010) Impaired skeletal muscle repair after ischemia-reperfusion injury in mice. J Biomed Biotechnol 2010: 724914.
15. Rosenthal SM, (1943) Experimental chemotherapy of burns and shock. Public Health Rep 58: 1429-1436.
16. Kyriakides C, Austen WG Jr, Wang Y, Favuzza J, Moore FD Jr, et al. (2000) Neutrophil mediated remote organ injury after lower torso ischemia and reperfusion is selectin and complement dependent. J Trauma 48: 32-38.
17. Kyriakides C, Austen W Jr, Wang Y, Favuzza J, Kobzik L, et al. (1999) Skeletal muscle reperfusion injury is mediated by neutrophils and the complement membrane attack complex. Am J Physiol 277: C1263-1268.
18. Kuntscher MV, Schirmbeck EU, Menke H, Klar E, Gebhard MM, et al. (2002) Ischemic preconditioning by brief extremity ischemia before flap ischemia in a rat model. Plast Reconstr Surg 109: 2398-2404.
19. Brenes RA, Jadlowiec CC, Bear M, Hashim P, Protack CD, et al. (2012) Toward a mouse model of hind limb ischemia to test therapeutic angiogenesis. J Vasc Surg.
20. Kinnaird T, Stabile E, Burnett MS, Shou M, Lee CW, et al. (2004) Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms. Circulation 109: 1543-1549.
21. Pedowitz RA (1991) Tourniquet-induced neuromuscular injury. A recent review of rabbit and clinical experiments. Acta Orthop Scand Suppl 245: 1-33.