Hemorrhagic and ischemic outcomes after bivalirudin versus unfractionated heparin during carotid artery stenting a propensity score analysis from the NCDR

Circulation: Cardiovascular Interventions

Volumn 6, Issue 2, 2013, Pages 131-138

  Wayangankar, Siddharth A ^a   Abu Fadel, Mazen S ^a   Aronow, Herbert D ^b   Kennedy, Kevin F ^c   Gupta, Raghav ^a   Yeh, Robert W ^e   Gray, William A ^d   Rosenfield, Kenneth ^e   Hennebry, Thomas A ^f  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b Michigan Heart and Vascular Institute   (United States)

^c ST LUKE S HOSPITAL   (United States)

^d NewYork Presbyterian Hospital   (United States)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

^f Oklahoma Heart Hospital   (United States)

Author keywords

Bivalirudin; Bleeding; Carotid artery stenting; Heparin

Indexed keywords

ACETYLSALICYLIC ACID; CLOPIDOGREL; HEPARIN; HIRULOG; TICLOPIDINE;

ADULT; AGED; ANTICOAGULANT THERAPY; ARTICLE; BLEEDING; BRAIN HEMORRHAGE; CAROTID ARTERY STENTING; CEREBROVASCULAR ACCIDENT; COHORT ANALYSIS; ERYTHROCYTE TRANSFUSION; FEMALE; HEART DEATH; HEART INFARCTION; HEMATOMA; HUMAN; INCIDENCE; ISCHEMIA; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROPENSITY SCORE; TRANSIENT ISCHEMIC ATTACK;

AGED; AGED, 80 AND OVER; ANGIOPLASTY; ANTICOAGULANTS; ANTITHROMBINS; BRAIN ISCHEMIA; CAROTID STENOSIS; FEMALE; HEMORRHAGE; HEPARIN; HIRUDINS; HUMANS; INCIDENCE; MALE; MYOCARDIAL INFARCTION; PEPTIDE FRAGMENTS; RECOMBINANT PROTEINS; REGISTRIES; RISK FACTORS; STENTS; STROKE;

EID: 84879245647     PISSN: 19417640     EISSN: 19417632     Source Type: Journal    
DOI: 10.1161/CIRCINTERVENTIONS.112.974857     Document Type: Article

References (22)

1. Yadav JS, Wholey MH, Kuntz RE, Fayad P, Katzen BT, Mishkel GJ, Bajwa TK, Whitlow P, Strickman NE, Jaff MR, Popma JJ, Snead DB, Cutlip DE, Firth BG, Ouriel K; Stenting and Angioplasty with Protection in Patients at High Risk for Endarterectomy Investigators. Protected carotidartery stenting versus endarterectomy in high-risk patients. N Engl J Med. 2004;351:1493-1501.
2. Brott TG, Hobson RW II, Howard G, Roubin GS, Clark WM, Brooks W, Mackey A, Hill MD, Leimgruber PP, Sheffet AJ, Howard VJ, Moore WS, Voeks JH, Hopkins LN, Cutlip DE, Cohen DJ, Popma JJ, Ferguson RD, Cohen SN, Blackshear JL, Silver FL, Mohr JP, Lal BK, Meschia JF; CREST Investigators. Stenting versus endarterectomy for treatment of carotid-artery stenosis. N Engl J Med. 2010;363:11-23.
3. Bates ER, Babb JD, Casey DE Jr, Cates CU, Duckwiler GR, Feldman TE, Gray WA, Ouriel K, Peterson ED, Rosenfield K, Rundback JH, Safian RD, Sloan MA, White CJ. Accf/scai/svmb/sir/asitn 2007 clinical expert consensus document on carotid stenting: a report of the american college of cardiology foundation task force on clinical expert consensus documents (accf/scai/svmb/sir/asitn clinical expert consensus document committee on carotid stenting). J Am Coll Cardiol. 2007;49:126-170.
4. Lepor NE. Anticoagulation for acute coronary syndromes: from heparin to direct thrombin inhibitors. Rev Cardiovasc Med. 2007;8 suppl 3:S9-S17.
5. Hirsh J, O'Donnell M, Eikelboom JW. Beyond unfractionated heparin and warfarin: current and future advances. Circulation. 2007;116: 552-560.
6. Gibson CM, Ten Y, Murphy SA, Ciaglo LN, Southard MC, Lincoff AM, Waksman R. Association of prerandomization anticoagulant switching with bleeding in the setting of percutaneous coronary intervention (A REPLACE- 2 analysis). Am J Cardiol. 2007;99:1687-1690.
7. Schulz S, Mehilli J, Ndrepepa G, Neumann FJ, Birkmeier KA, Kufner S, Richardt G, Berger PB, Schömig A, Kastrati A; Intracoronary Stenting and Antithrombotic Regimen: Rapid Early Action for Coronary Treatment (ISAR-REACT) 3 Trial Investigators. Bivalirudin vs. unfractionated heparin during percutaneous coronary interventions in patients with stable and unstable angina pectoris: 1-year results of the ISAR-REACT 3 trial. Eur Heart J. 2010;31:582-587.
8. Lopes RD, Alexander KP, Manoukian SV, Bertrand ME, Feit F, White HD, Pollack CV Jr, Hoekstra J, Gersh BJ, Stone GW, Ohman EM. Advanced age, antithrombotic strategy, and bleeding in non-ST-segment elevation acute coronary syndromes: results from the ACUITY (Acute Catheterization and Urgent Intervention Triage Strategy) trial. J Am Coll Cardiol. 2009;53:1021-1030.
9. Stone GW, Witzenbichler B, Guagliumi G, Peruga JZ, Brodie BR, Dudek D, Kornowski R, Hartmann F, Gersh BJ, Pocock SJ, Dangas G, Wong SC, Kirtane AJ, Parise H, Mehran R; HORIZONS-AMI Trial Investigators. Bivalirudin during primary PCI in acute myocardial infarction. N Engl J Med. 2008;358:2218-2230.
10. Schneider LM, Polena S, Roubin G, Iyer S, Vitek J, Panagopoulos G, Mussap CJ, Vitellas M, Mahdavi R, Brennan C. Carotid stenting and bivalirudin with and without vascular closure: 3-year analysis of procedural outcomes. Catheter Cardiovasc Interv. 2010;75:420-426.
11. Stabile E, Sorropago G, Tesorio T, Popusoi G, Ambrosini V, Mottola MT, Biamino G, Rubino P. Heparin versus bivalirudin for carotid artery stenting using proximal endovascular clamping for neuroprotection: results from a prospective randomized study. J Vasc Surg. 2010;52:1505-1510.
12. White CJ, Anderson HV, Brindis RG, Cates CU, Cohen DJ, Ho K, Hopkins LN, Jaff MR, Koroshetz WJ, Rosenfield KA. The Carotid Artery Revascularization and Endarterectomy (CARE) registry: objectives, design, and implications. Catheter Cardiovasc Interv. 2008;71:721-725.
13. Austin PC. Optimal caliper widths for propensity-score matching when estimating differences in means and differences in proportions in observational studies. Pharm Stat. 2011;10:150-161.
14. Lopes RD, Subherwal S, Holmes DN, Thomas L, Wang TY, Rao SV, Magnus Ohman E, Roe MT, Peterson ED, Alexander KP. The association of in-hospital major bleeding with short-, intermediate-, and long-term mortality among older patients with non-ST-segment elevation myocardial infarction. Eur Heart J. 2012;33:2044-2053.
15. Lindsey JB, Marso SP, Pencina M, Stolker JM, Kennedy KF, Rihal C, Barsness G, Piana RN, Goldberg SL, Cutlip DE, Kleiman NS, Cohen DJ; EVENT Registry Investigators. Prognostic impact of periprocedural bleeding and myocardial infarction after percutaneous coronary intervention in unselected patients: results from the EVENT (evaluation of drugeluting stents and ischemic events) registry. J Am Coll Cardiol Cardiovasc Interv. 2009;2:1074-1082.
16. Rao SV, Jollis JG, Harrington RA, Granger CB, Newby LK, Armstrong PW, Moliterno DJ, Lindblad L, Pieper K, Topol EJ, Stamler JS, Califf RM. Relationship of blood transfusion and clinical outcomes in patients with acute coronary syndromes. JAMA. 2004;292:1555-1562.
17. Dodson JA, Wang Y, Chaudhry SI, Curtis JP. Bleeding avoidance strategies and outcomes in patients /=80 years of age with st-elevation myocardial infarction undergoing primary percutaneous coronary intervention (from the ncdr cathpci registry). The Am J Cardiol. 2012;110:1-6.
18. Mehran R, Rao SV, Bhatt DL, Gibson CM, Caixeta A, Eikelboom J, Kaul S, Wiviott SD, Menon V, Nikolsky E, Serebruany V, Valgimigli M, Vranckx P, Taggart D, Sabik JF, Cutlip DE, Krucoff MW, Ohman EM, Steg PG, White H. Standardized bleeding definitions for cardiovascular clinical trials: a consensus report from the Bleeding Academic Research Consortium. Circulation. 2011;123:2736-2747.
19. Ndrepepa G, Schuster T, Hadamitzky M, Byrne RA, Mehilli J, Neumann FJ, Richardt G, Schulz S, Laugwitz KL, Massberg S, Schömig A, Kastrati A. Validation of the Bleeding Academic Research Consortium definition of bleeding in patients with coronary artery disease undergoing percutaneous coronary intervention. Circulation. 2012;125: 1424-1431.
20. Lin PH, Bush RL, Peden EK, Zhou W, Guerrero M, Henao EA, Kougias P, Mohiuddin I, Lumsden AB. Carotid artery stenting with neuroprotection: assessing the learning curve and treatment outcome. Am J Surg. 2005;190:850-857.
21. Cogar BD, Wayangankar SA, Abu-Fadel M, Hennebry TA, Ghani MK, Kipperman RM, Chrysant GS. Clinical safety of bivalirudin in patients undergoing carotid stenting. J Invasive Cardiol. 2012;24:202-205.
22. Geisbüsch P, Katzen BT, Peña C, Benenati JF, Uthoff H. Bivalirudin used as alternative anticoagulant in carotid artery stenting: a single center observational study. J Interv Cardiol. 2012;25:197-202.