Systemic vascular hemodynamic changes due to 17-β-estradiol intranasal administration

Journal of Cardiovascular Pharmacology and Therapeutics

Volumn 18, Issue 4, 2013, Pages 354-358

  Ciccone, Marco Matteo ^a   Scicchitano, Pietro ^a   Gesualdo, Michele ^a   Fornarelli, Fara ^a   Pinto, Vincenzo ^b   Farinola, Giuseppe ^c   Lagioia, Rocco ^c   Sassara, Marco ^a   Zito, Annapaola ^a   Federici, Antonio ^a   Cicinelli, Ettore ^b  

^a UNIVERSITY OF BARI   (Italy)

^b UNIVERSITY OF BARI MEDICAL SCHOOL   (Italy)

^c IRCCS   (Italy)

Author keywords

cerebral circulation; estradiol; estrogen therapy; menopause; peripheral circulation

Indexed keywords

ESTRADIOL; SPREDIOL; UNCLASSIFIED DRUG;

ADULT; ARTERIAL CIRCULATION; ARTICLE; BRAIN CIRCULATION; BRAIN PERFUSION; CARDIOVASCULAR PARAMETERS; DIASTOLIC BLOOD PRESSURE; DRUG EFFECT; END DIASTOLIC VELOCITY; FEMALE; HEART RATE; HEMODYNAMICS; HUMAN; HUMAN EXPERIMENT; INTERNAL CAROTID ARTERY; MENOPAUSE; NORMAL HUMAN; PEAK SYSTOLIC VELOCITY; PERIPHERAL CIRCULATION; POSTMENOPAUSE; PRIORITY JOURNAL; SYSTOLIC BLOOD PRESSURE; TIBIAL ARTERY; VELOCITY TIME INTEGRAL;

CEREBRAL CIRCULATION; ESTRADIOL; ESTROGEN THERAPY; MENOPAUSE; PERIPHERAL CIRCULATION;

ADMINISTRATION, INTRANASAL; BLOOD FLOW VELOCITY; BLOOD PRESSURE; CAROTID ARTERY, INTERNAL; CEREBROVASCULAR CIRCULATION; ESTRADIOL; ESTROGENS; FEMALE; HEART RATE; HEMODYNAMICS; HUMANS; MIDDLE AGED; POSTMENOPAUSE; REGIONAL BLOOD FLOW; TIBIAL ARTERIES;

EID: 84879234713     PISSN: 10742484     EISSN: 19404034     Source Type: Journal    
DOI: 10.1177/1074248413484385     Document Type: Article

References (21)

1. Mendelsohn ME, Karas RH. The protective effects of estrogen on the cardiovascular system. N Engl J Med. 1999 ; 340 (23). 1801-1811
2. Barrett-Connor E. Sex differences in coronary heart disease: why are women so superior?. Circulation. 1997 ; 95 (1). 252-264
3. Clarkson TB, Anthony MS, Klein KP. Hormone replacement therapy and coronary artery atherosclerosis: the monkey model. Br J Obstet Gynaecol. 1996 ; 103 (suppl 13). 53-57
4. Hodgin JB, Krege JH, Reddick RL, Korach KS, Smithies O, Maeda N. Estrogen receptor alpha is a major mediator of 17beta-estradiol's atheroprotective effects on lesion size in Apoe-/- mice. J Clin Invest. 2001 ; 107 (3). 333-340
5. Maturana MA, Irigoyen MC, Spritzer PM. Menopause, estrogens, and endothelial dysfunction: current concepts. Clinics. 2007 ; 62 (1). 77-86
6. Arnal JF, Fontaine C, Billon-Galés A, et al. Estrogen receptors and endothelium. Arterioscler Thromb Vasc Biol. 2010 ; 30 (8). 1506-1512
7. Guetta V, Quyyumi AA, Prasad A, Panza JA, Waclawiw M, Cannon RO III. The role of nitric oxide in coronary vascular effects of estrogen in postmenopausal women. Circulation. 1997 ; 96 (9). 2795-2801
8. Han G, Yu X, Lu L, et al. Estrogen receptor alpha mediates acute potassium channel stimulation in human coronary artery smooth muscle cells. J Pharmacol Exp Ther. 2006 ; 316 (3). 1025-1230
9. Dooley M, Spencer CM, Ormrod D. Spotlight on estradiol-intranasal in the management of menopause. Treat Endocrinol. 2002 ; 1 (3). 191-194
10. Genazzani AR, Cappagli B, Ciaponi M. Aerodiol: the efficacy and tolerability of intranasal estrogen administration. An overview [in Italian]. Minerva Ginecol. 2003 ; 55 (3). 189-200
11. Cicinelli E, Cignarelli M, Sabatelli S, et al. Plasma concentrations of progesterone are higher in the uterine artery than in the radial artery after vaginal administration of micronized progesterone in an oil-based solution to postmenopausal women. Fertil Steril. 1998 ; 69 (3). 471-473
12. Einer-Jensen N, Cicinelli E, Galantino P, Pinto V, Barba B. Uterine first pass effect in postmenopausal women. Hum Reprod. 2002 ; 17 (12). 3060-3064
13. Tourgeman DE, Boostanfar R, Chang L, Lu J, Stanczyk FZ, Paulson RJ. Is there evidence for preferential delivery of ovarian estradiol to the endometrium?. Fertil Steril. 2001 ; 75 (6). 1156-1158
14. Dhuria SV, Hanson LR, Frey WH II. Intranasal delivery to the central nervous system: mechanisms and experimental considerations. J Pharm Sci. 2010 ; 99 (4). 1654-1673
15. Einer-Jensen N, Larsen L. Local transfer of diazepam, but not of cocaine, from the nasal cavities to the brain arterial blood in rats. Pharmacol Toxicol. 2000 ; 87 (6). 276-278
16. Krejza J, Mariak Z, Huba M, Wolczynski S, Lewko J. Effect of endogenous estrogen on blood flow through carotid arteries. Stroke. 2001 ; 32 (1). 30-36
17. Krejza J, Mariak Z, Nowacka A, Melhem ER, Babikian VL. Influence of 17-beta-estradiol on cerebrovascular impedance during menstrual cycle in women. J Neurol Sci. 2004 ; 221 (1-2). 61-67
18. Liu M, Dziennis S, Hurn PD, Alkayed NJ. Mechanisms of gender-linked ischemic brain injury. Restor Neurol Neurosci. 2009 ; 27 (3). 163-179
19. Mericlia M, Nadasyb GL, Szekeresb M, et al. Estrogen replacement therapy reverses changes in intramural coronary resistance arteries caused by female sex hormone depletion. Cardiovasc Res. 2004 ; 61 (2). 317-324
20. Traupe T, Stettler CD, Li H, et al. Distinct roles of estrogen receptors a and b mediating acute vasodilation of epicardial coronary arteries. Hypertension. 2007 ; 49 (6). 1364-1370
21. Yu X, Ma H, Barman SA, et al. Activation of G protein-coupled estrogen receptor induces endothelium-independent relaxation of coronary artery smooth muscle. Am J Physiol Endocrinol Metab. 2011 ; 301 (5). E882 - E888