General method of synthesis for naloxone, naltrexone, nalbuphone, and nalbuphine by the reaction of grignard reagents with an oxazolidine derived from oxymorphone

Advanced Synthesis and Catalysis

Volumn 355, Issue 9, 2013, Pages 1869-1873

  Endoma Arias, Mary Ann A ^a   Cox, D Phillip ^b   Hudlicky, Tomas ^a  

^a BROCK UNIVERSITY   (Canada)

^b Noramco Inc   (United States)

Author keywords

morphinans; N demethylation; nucleophilic opening; oxazolidine; oxymorphone

Indexed keywords

EID: 84879228080     PISSN: 16154150     EISSN: 16154169     Source Type: Journal    
DOI: 10.1002/adsc.201300284     Document Type: Article

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