Vaccination induced antibodies to recombinant avian influenza A virus M2 protein or synthetic M2e peptide do not bind to the M2 protein on the virus or virus infected cells

Virology Journal

Volumn 10, Issue , 2013, Pages

  Swinkels, Willem J C ^a   Hoeboer, Jeroen ^a   Sikkema, Reina ^a   Vervelde, Lonneke ^a,b   Koets, Ad P ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Chicken; Influenza; M2; Peptide Vaccination

Indexed keywords

HIS M2 PROTEIN; HSP STREPTAVIDIN VACCINE; IMMUNOLOGICAL ADJUVANT; M2E PEPTIDE; M2E STREPTAVIDINE VACCINE; PROTEIN M2; STIMUNE; STREPTAVIDIN; SUBUNIT VACCINE; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY DETECTION; ANTIBODY RESPONSE; ANTIGEN BINDING; ARTICLE; AVIAN INFLUENZA; AVIAN INFLUENZA VIRUS; BACTERIAL GROWTH; CHICKEN; CONTROLLED STUDY; DRUG CONJUGATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE SEQUENCE; IN VITRO STUDY; INFLUENZA VACCINATION; INFLUENZA VIRUS A H9N2; MDCK CELL; MOLECULAR CLONING; NATURAL HOST; NONHUMAN; POLYMERASE CHAIN REACTION; SEROCONVERSION; WESTERN BLOTTING;

ANIMALS; ANTIBODIES, VIRAL; ANTIGENS, VIRAL; CHICKENS; INFLUENZA A VIRUS; INFLUENZA VACCINES; PROTEIN BINDING; VACCINES, SYNTHETIC; VIRAL MATRIX PROTEINS;

ANIMALIA; AVES; GALLUS GALLUS; INFLUENZA A VIRUS; ORTHOMYXOVIRIDAE;

EID: 84879216215     PISSN: None     EISSN: 1743422X     Source Type: Journal    
DOI: 10.1186/1743-422X-10-206     Document Type: Article

References (32)

1. Evolution and ecology of influenza a viruses. Webster RG, Bean WJ, Gorman OT, Chambers TM, Kawaoka Y, Microbiol Rev 1992 56 152 179 1579108
2. Assembly and budding of influenza virus. Nayak DP, Hui EK, Barman S, Virus Res 2004 106 147 165 10.1016/j.virusres.2004.08.012 15567494
3. Potent immunogenicity and efficacy of a universal influenza vaccine candidate comprising a recombinant fusion protein linking influenza M2e to the TLR5 ligand flagellin. Huleatt JW, Nakaar V, Desai P, Huang Y, Hewitt D, Jacobs A, Tang J, McDonald W, Song L, Evans RK, et al. Vaccine 2008 26 201 214 10.1016/j.vaccine.2007.10.062 18063235
4. Universal influenza a vaccine: optimization of M2-based constructs. De Filette M, Min Jou W, Birkett A, Lyons K, Schultz B, Tonkyro A, Resch S, Fiers W, Virology 2005 337 149 161 10.1016/j.virol.2005.04.004 15914228
5. A universal influenza a vaccine based on the extracellular domain of the M2 protein. Neirynck S, Deroo T, Saelens X, Vanlandschoot P, Jou WM, Fiers W, Nat Med 1999 5 1157 1163 10.1038/13484 10502819
6. Preclinical study of influenza virus a M2 peptide conjugate vaccines in mice, ferrets, and rhesus monkeys. Fan J, Liang X, Horton MS, Perry HC, Citron MP, Heidecker GJ, Fu TM, Joyce J, Przysiecki CT, Keller PM, et al. Vaccine 2004 22 2993 3003 10.1016/j.vaccine.2004.02.021 15297047
7. Influenza a virus M2 protein: monoclonal antibody restriction of virus growth and detection of M2 in virions. Zebedee SL, Lamb RA, J Virol 1988 62 2762 2772 2455818
8. Identification of viral molecules recognized by influenza-specific human cytotoxic T lymphocytes. Gotch F, McMichael A, Smith G, Moss B, J Exp Med 1987 165 408 416 10.1084/jem.165.2.408 3029268
9. Influenza a virus infection engenders a poor antibody response against the ectodomain of matrix protein 2. Feng J, Zhang M, Mozdzanowska K, Zharikova D, Hoff H, Wunner W, Couch RB, Gerhard W, Virol J 2006 3 102 10.1186/1743-422X-3-102 17150104
10. Human cytotoxic T-lymphocyte repertoire to influenza a viruses. Jameson J, Cruz J, Ennis FA, J Virol 1998 72 8682 8689 9765409
11. Characterization of immunity induced by M2e of influenza virus. Wu F, Huang JH, Yuan XY, Huang WS, Chen YH, Vaccine 2007 25 8868 8873 10.1016/j.vaccine.2007.09.056 18061317
12. Protection of mice against influenza a virus challenge by vaccination with baculovirus-expressed M2 protein. Slepushkin VA, Katz JM, Black RA, Gamble WC, Rota PA, Cox NJ, Vaccine 1995 13 1399 1402 10.1016/0264-410X(95)92777-Y 8578816
13. Induction of influenza type a virus-specific resistance by immunization of mice with a synthetic multiple antigenic peptide vaccine that contains ectodomains of matrix protein 2. Mozdzanowska K, Feng J, Eid M, Kragol G, Cudic M, Otvos L Jr, Gerhard W, Vaccine 2003 21 2616 2626 10.1016/S0264-410X(03)00040- 9 12744898
14. Protective immunity against influenza a virus induced by immunization with DNA plasmid containing influenza M gene. Okuda K, Ihata A, Watabe S, Okada E, Yamakawa T, Hamajima K, Yang J, Ishii N, Nakazawa M, Okuda K, et al. Vaccine 2001 19 3681 3691 10.1016/S0264-410X(01)00078-0 11395202
15. Protection against influenza virus challenge by topical application of influenza DNA vaccine. Watabe S, Xin KQ, Ihata A, Liu LJ, Honsho A, Aoki I, Hamajima K, Wahren B, Okuda K, Vaccine 2001 19 4434 4444 10.1016/S0264-410X(01) 00194-3 11483269
16. Modified M2 proteins produce heterotypic immunity against influenza a virus. Frace AM, Klimov AI, Rowe T, Black RA, Katz JM, Vaccine 1999 17 2237 2244 10.1016/S0264-410X(99)00005-5 10403591
17. M2e-Based universal influenza a vaccine. Fiers W, De Filette M, El Bakkouri K, Schepens B, Roose K, Schotsaert M, Birkett A, Saelens X, Vaccine 2009 27 6280 6283 10.1016/j.vaccine.2009.07.007 19840661
18. Vaccination of pigs with a DNA construct expressing an influenza virus M2-nucleoprotein fusion protein exacerbates disease after challenge with influenza a virus. Heinen PP, Rijsewijk FA, de Boer-Luijtze EA, Bianchi AT, J Gen Virol 2002 83 1851 1859 12124449
19. Enhanced pneumonia and disease in pigs vaccinated with an inactivated human-like (delta-cluster) H1N2 vaccine and challenged with pandemic 2009 H1N1 influenza virus. Gauger PC, Vincent AL, Loving CL, Lager KM, Janke BH, Kehrli ME Jr, Roth JA, Vaccine 2011 29 2712 2719 10.1016/j.vaccine.2011.01.082 21310191
20. Swine influenza matrix 2 (M2) protein contributes to protection against infection with different H1 swine influenza virus (SIV) isolates. Kitikoon P, Vincent AL, Janke BH, Erickson B, Strait EL, Yu S, Gramer MR, Thacker EL, Vaccine 2009 28 2 523 531 10.1016/j.vaccine.2009.09.130 19837089
21. Contributions of the Avian Influenza Virus HA, NA and M2 Surface Proteins to the Induction of Neutralizing Antibodies and Protective Immunity. Nayak B, Kumar S, Dinapoli JM, Paldurai A, Perez DR, Collins PL, Samal SK, J Virol 2009 84 5 2408 2420 20032181
22. Fusion to chicken C3d enhances the immunogenicity of the M2 protein of avian influenza virus. Zhang Z, Li Y, Xu S, Chen F, Zhang L, Jiang B, Chen X, Virol J 2010 7 89 10.1186/1743-422X-7-89 20459691
23. Vaccination of chickens with recombinant Salmonella expressing M2e and CD154 epitopes increases protection and decreases viral shedding after low pathogenic avian influenza challenge. Layton SL, Kapczynski DR, Higgins S, Higgins J, Wolfenden AD, Liljebjelke KA, Bottje WG, Swayne D, Berghman LR, Kwon YM, et al. Poult Sci 2009 88 2244 2252 10.3382/ps.2009-00251 19834072
24. Influenza virus M2 protein is an integral membrane protein expressed on the infected-cell surface. Lamb RA, Zebedee SL, Richardson CD, Cell 1985 40 627 633 10.1016/0092-8674(85)90211-9 3882238
25. Development of an M2e-specific enzyme-linked immunosorbent assay for differentiating infected from vaccinated animals. Lambrecht B, Steensels M, Van Borm S, Meulemans G, van den Berg T, Avian Dis 2007 51 221 226 10.1637/7589-040206R.1 17494557
26. Influenza A vaccine based on the extracellular domain of M2: weak protection mediated via antibody-dependent NK cell activity. Jegerlehner A, Schmitz N, Storni T, Bachmann MF, J Immunol 2004 172 5598 5605 15100303
27. A one-size-fits-all flu vaccine? Kaiser J, Science 2006 312 380 382 10.1126/science.312.5772.380 16627732
28. Development and evaluation of an M2-293FT cell-based flow cytometric assay for quantification of antibody response to native form of matrix protein 2 of influenza a viruses. Zhong W, He J, Tang X, Liu F, Lu X, Zeng H, Vafai A, Fu TM, Katz JM, Hancock K, J Immunol Methods 2011 369 1-2 115 124 10.1016/j.jim.2011.04.010 21570401
29. Matrix protein 2 vaccination and protection against influenza viruses, including subtype H5N1. Tompkins SM, Zhao ZS, Lo CY, Misplon JA, Liu T, Ye Z, Hogan RJ, Wu Z, Benton KA, Tumpey TM, Epstein SL, Emerg Infect Dis 2007 13 426 435 10.3201/eid1303.061125 17552096
30. Comparative immunogenicity evaluations of influenza a virus M2 peptide as recombinant virus like particle or conjugate vaccines in mice and monkeys. Fu TM, Grimm KM, Citron MP, Freed DC, Fan J, Keller PM, Shiver JW, Liang X, Joyce JG, Vaccine 2009 27 1440 1447 10.1016/j.vaccine.2008.12.034 19146898
31. Role of immunostimulatory molecules in poultry vaccines. Kumar S, Koul M, Rai A, Recent Pat Biotechnol 2010 4 235 241 10.2174/187220810793611473 21171960
32. Hsp70 vaccination-induced antibodies recognize B cell epitopes in the cell wall of Mycobacterium avium subspecies paratuberculosis. Santema W, van Kooten P, Hoek A, Leeflang M, Overdijk M, Rutten V, Koets A, Vaccine 2011 29 1364 1373 10.1016/j.vaccine.2010.12.071 21199702