NOEC and LOEC as merely concessive expedients: Two unambiguous alternatives and some criteria to maximize the efficiency of dose-response experimental designs

Science of the Total Environment

Volumn 461-462, Issue , 2013, Pages 576-586

  Murado, M A ^a   Prieto, M A ^a  

^a INSTITUTO DE INVESTIGACIONES MARINAS   (Spain)

Author keywords

ANOVA; Confidence intervals; Dose response models; Modeling; NOEC and LOEC; Parametric estimations

Indexed keywords

ALGEBRAIC EQUATIONS; CONFIDENCE INTERVAL; DOSE-RESPONSE MODELS; EFFECT CONCENTRATION; EXPERIMENTAL ERRORS; NOEC AND LOEC; PARAMETRIC ESTIMATION; SYSTEMATIC SIMULATION;

ANALYSIS OF VARIANCE (ANOVA); DESIGN OF EXPERIMENTS; ESTIMATION; MODELS; STATISTICS;

PARAMETER ESTIMATION;

CONCENTRATION (COMPOSITION); CONFIDENCE INTERVAL; DOSE-RESPONSE RELATIONSHIP; ECOTOXICOLOGY; EXPERIMENTAL DESIGN; NUMERICAL MODEL; PARAMETERIZATION; VARIANCE ANALYSIS;

ARTICLE; CONCENTRATION (PARAMETERS); CONFIDENCE INTERVAL; EXPERIMENTAL DESIGN; FEASIBILITY STUDY; LOWEST OBSERVED EFFECT CONCENTRATION; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; MEASUREMENT ACCURACY; MEASUREMENT ERROR; NO OBSERVED EFFECT CONCENTRATION; PARAMETRIC TEST; PRIORITY JOURNAL; SIMULATION;

ANOVA; CONFIDENCE INTERVALS; DOSE-RESPONSE MODELS; MODELING; NOEC AND LOEC; PARAMETRIC ESTIMATIONS;

ANALYSIS OF VARIANCE; COMPUTER SIMULATION; CONFIDENCE INTERVALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ECOTOXICOLOGY; MODELS, STATISTICAL; NO-OBSERVED-ADVERSE-EFFECT LEVEL;

EID: 84879196066     PISSN: 00489697     EISSN: 18791026     Source Type: Journal    
DOI: 10.1016/j.scitotenv.2013.04.098     Document Type: Article

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