Astrocytes use a novel transporter to fill gliotransmitter vesicles with D-serine: Evidence for vesicular synergy

Journal of Neuroscience

Volumn 33, Issue 25, 2013, Pages 10193-10194

  Sild, Mari ^a   Van Horn, Marion R ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CELLUBREVIN; DEXTRO SERINE; GLIOTRANSMITTER; GLUTAMATE TRANSPORTER; GLUTAMIC ACID; NEUROTRANSMITTER; SYNAPTOBREVIN 2; UNCLASSIFIED DRUG;

ARTICLE; ASTROCYTE; EXOCYTOSIS; GLIA CELL; NERVE CELL PLASTICITY; PRIORITY JOURNAL;

ANIMALS; ASTROCYTES; FEMALE; MALE; NEUROGLIA; SERINE; SYNAPTIC TRANSMISSION; SYNAPTIC VESICLES;

EID: 84879188641     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1665-13.2013     Document Type: Article

References (11)

1. Agulhon C, Petravicz J, McMullen AB, Sweger EJ, Minton SK, Taves SR, Casper KB, Fiacco TA, McCarthy KD (2008) What is the role of astrocyte calcium in neurophysiology? Neuron 59:932-946. CrossRef Medline
2. Bergersen LH, Morland C, Ormel L, Rinholm JE, Larsson M, Wold JF, Røe AT, Stranna A, Santello M, Bouvier D, Ottersen OP, Volterra A, Gundersen V (2012) Immunogold detection of L-glutamate and D-serine in small synaptic like microvesicles in adult hippocampal astrocytes. Cereb Cortex 22:1690-1697. CrossRef Medline
3. Bezzi P, Gundersen V, Galbete JL, Seifert G, Steinhäuser C, Pilati E, Volterra A (2004) Astrocytes contain a vesicular compartment that is competent for regulated exocytosis of glutamate. Nat Neurosci 7:613-620. CrossRef Medline
4. Kang N, Peng H, Yu Y, Stanton PK, Guilarte TR, Kang J (2013) Astrocytes release d-serine by a large vesicle. Neuroscience 240:243-257. CrossRef Medline
5. Malarkey EB, Parpura V (2008) Mechanisms of glutamate release from astrocytes. Neurochem Int 52:142-154. CrossRef Medline
6. Martineau M, Shi T, Puyal J, Knolhoff AM, Dulong J, Gasnier B, Klingauf J, Sweedler JV, Jahn R, Mothet JP (2013) Storage and uptake of D-serine into astrocytic synaptic-like vesicles specify gliotransmission. J Neurosci 33:3413-3423. CrossRef Medline
7. Rosenberg D, Kartvelishvily E, Shleper M, Klinker CM, Bowser MT, Wolosker H (2010) Neuronal release of D-serine: a physiological pathway controlling extracellular D-serine concentration. FASEB J 24:2951-2961. CrossRef Medline
8. Rosenberg D, Artoul S, Segal AC, Kolodney G, Radzishevsky I, Dikopoltsev E, Foltyn VN, Inoue R, Mori H, Billard JM, Wolosker H (2013) Neuronal D-serine and glycine release via the Asc-1 transporter regulates NMDA receptor-dependent synaptic activity. J Neurosci 33:3533-3544. CrossRef Medline
9. Santello M, Calì C, Bezzi P (2012) Gliotransmission and the tripartite synapse. Adv Exp Med Biol 970:307-331. CrossRef Medline
10. Takano T, Kang J, Jaiswal JK, Simon SM, Lin JH, Yu Y, Li Y, Yang J, Dienel G, Zielke HR, Nedergaard M (2005) Receptor-mediated glutamate release from volume sensitive channels in astrocytes. Proc Natl Acad Sci U S A 102: 16466-16471. CrossRef Medline
11. Wolosker H (2011) Serine racemase and the serine shuttle between neurons and astrocytes. Biochim Biophys Acta 1814:1558-1566. CrossRef Medline