Scrub Typhus Meningitis in South India - A Retrospective Study

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Viswanathan, Stalin ^a   Muthu, Vivekanandan ^a   Iqbal, Nayyar ^b   Remalayam, Bhavith ^b   George, Tarun ^b  

^a INDIRA GANDHI MEDICAL COLLEGE   (India)

^b PONDICHERRY INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DEAMINASE; BACTERIAL PROTEIN; CHLORAMPHENICOL; DOXYCYCLINE; IMMUNOGLOBULIN M; LACTATE DEHYDROGENASE; UREA;

ABDUCENS NERVE PARALYSIS; ACUTE PANCREATITIS; ADULT; ARTICLE; CEREBROSPINAL FLUID CYTOLOGY; CLINICAL EXAMINATION; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CONVALESCENCE; DISEASE SEVERITY; ENZYME BLOOD LEVEL; ENZYME LINKED IMMUNOSORBENT ASSAY; ESCHAR; FEMALE; FEVER; GLUCOSE BLOOD LEVEL; HEADACHE; HOSPITAL ADMISSION; HUMAN; INDIA; LACTATE DEHYDROGENASE BLOOD LEVEL; LENGTH OF STAY; LEUKOCYTE COUNT; LIMB WEAKNESS; LUMBAR PUNCTURE; MAJOR CLINICAL STUDY; MALE; MENINGITIS; PAPULAR RASH; PERICARDIAL EFFUSION; PLEURA EFFUSION; PROTEIN CEREBROSPINAL FLUID LEVEL; RESPIRATORY TRACT DISEASE; RETROSPECTIVE STUDY; RICKETTSIA; SCRUB TYPHUS; SCRUB TYPHUS MENINGITIS; SKIN DISEASE; THORAX RADIOGRAPHY; UREA BLOOD LEVEL;

ADULT; CEREBROSPINAL FLUID PROTEINS; FEMALE; GLUCOSE; HUMANS; INDIA; LYMPHOCYTE COUNT; MALE; MENINGITIS, BACTERIAL; MIDDLE AGED; RETROSPECTIVE STUDIES; SCRUB TYPHUS;

EID: 84879177910     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0066595     Document Type: Article

References (53)

1. Sharma PK, Ramakrishnan R, Hutin YJ, Barui AK, Manickam P, et al. (2009) Scrub typhus in Darjeeling, India: opportunities for simple, practical prevention measures. Trans R Soc Trop Med Hyg 103: 1153-1158.
2. Harden VA, (1993) Typhus, Scrub (Tsutsugamushi). In: The Cambridge World History of Human Disease Kiple KF, editor. Cambridge University Press. 153: 355-356.
3. Parola P, Raoult D, (2006) Tropical rickettsioses. Clin Dermatol 24: 191-200.
4. Oaks JSC, Ridgway RL, Shirai A, Twartz JC, (1983) Scrub typhus. Bulletin No 21 United States Army Medical Research Unit, Institute for Medical Research, Malaysia pp. 1-107.
5. Jim WT, Chiu NC, Chan WT, Ho CS, Chang JH, et al. (2009) Clinical manifestations, laboratory findings and complications of pediatric scrub typhus in eastern Taiwan. Pediatr Neonatol 50: 96-101.
6. Lee CS, Hwang JH, Lee HB, Kwon KS, (2009) Risk factors leading to fatal outcome in scrub typhus patients. Am J Trop Med Hyg 81: 484-488.
7. Kim DM, Kim SW, Choi SH, Yun NR, (2010) Clinical and laboratory findings associated with severe scrub typhus. BMC Infect Dis 10: 108.
8. Saifudheen K, Kumar KG, Jose J, Veena V, Gafoor VA, (2012) First case of scrub typhus with meningoencephalitis from Kerala: An emerging infectious threat. Ann Indian Acad Neurol 15: 141-144.
9. Thakur JS, Mohindroo NK, Sharma DR, Soni K, Kaushal SS, (2011) Evoked response audiometry in scrub typhus: prospective, randomised, case-control study. J Laryngol Otol 125: 567-571.
10. Lai CH, Chen YH, Lin JN, Chang LL, Chen WF, et al. (2009) Acute Q fever and scrub typhus, southern Taiwan. Emerg Infect Dis 15: 1659-1661.
11. Suntharasaj T, Janjindamai W, Krisanapan S, (1997) Pregnancy with Scrub Typhus and Vertical Transmission: A Case Report. J Obstet Gynaecol Res 23: 75-77.
12. Liu YX, Feng D, Suo JJ, Xing YB, Liu G, et al. (2009) Clinical characteristics of the autumn-winter type scrub typhus cases in south of Shandong province, northern China. BMC Infect Dis 9: 82.
13. Seong SY, Choi MS, Kim IS, (2001) Orientia tsutsugamushi infection: overview and immune responses. Microbes Infect 3: 11-21.
14. Rajapakse S, Rodrigo C, Fernando D, (2012) Scrub typhus: pathophysiology, clinical manifestations and prognosis. Asian Pac J Trop Med 5: 261-264.
15. Sittiwangkul R, Pongprot Y, Silviliarat S, Oberdorfer P, Jittamala P, et al. (2008) Acute fulminant myocarditis in scrub typhus. Ann Trop Paediatr 28: 149-154.
16. Tsay RW, Chang FY, (2002) Acute respiratory distress syndrome in scrub typhus. QJM 95: 126-128.
17. Silpapojakul K, Ukkachoke C, Krisanapan S, (1991) Rickettsial meningitis and encephalitis. Arch Intern Med 151: 1753-1757.
18. Iqbal N, Viswanathan S, Remalayam B, George T, (2012) Pancreatitis and MODS due to scrub typhus and dengue co-infection. Tropical Medicine and Health 40.
19. Khan SA, Dutta P, Khan AM, Topno R, Borah J, et al. (2012) Re-emergence of scrub typhus in northeast India. Int J Infect Dis.
20. Boorugu H, Dinaker M, Roy ND, Jude JA, (2010) Reporting a case of scrub typhus from Andhra Pradesh. J Assoc Physicians India 58: 520.
21. Kamarasu K, Malathi M, Rajagopal V, Subramani K, Jagadeeshramasamy D, et al. (2007) Serological evidence for wide distribution of spotted fevers & typhus fever in Tamil Nadu. Indian J Med Res 126: 128-130.
22. Premaratna R, Chandrasena TG, Dassayake AS, Loftis AD, Dasch GA, et al. (2006) Acute hearing loss due to scrub typhus: a forgotten complication of a reemerging disease. Clin Infect Dis 42: e6-8.
23. Mathai E, Rolain JM, Verghese GM, Abraham OC, Mathai D, et al. (2003) Outbreak of scrub typhus in southern India during the cooler months. Ann N Y Acad Sci 990: 359-364.
24. Vivekanandan M, Mani A, Priya YS, Singh AP, Jayakumar S, et al. (2010) Outbreak of scrub typhus in Pondicherry. J Assoc Physicians India 58: 24-28.
25. Lin WR, Chen TC, Lin CY, Lu PL, Chen YH, (2011) Bilateral simultaneous facial palsy following scrub typhus meningitis: a case report and literature review. Kaohsiung J Med Sci 27: 573-576.
26. Lee CS, Min IS, Hwang JH, Kwon KS, Lee HB, (2010) Clinical significance of hypoalbuminemia in outcome of patients with scrub typhus. BMC Infect Dis 10: 216.
27. Mahajan SK, Rolain JM, Kanga A, Raoult D, (2010) Scrub typhus involving central nervous system, India, 2004-2006. Emerg Infect Dis 16: 1641-1643.
28. Kim JH, Lee SA, Ahn TB, Yoon SS, Park KC, et al. (2008) Polyneuropathy and cerebral infarction complicating scrub typhus. J Clin Neurol 4: 36-39.
29. Yang SH, L.S W, Liang CC, Ho YH, Chang ET, et al. (2005) Scrub typhus complicated by intracranial hemorrhage - A case report. Tzu Chi Med J 17: 111-114.
30. Chen PH, Hung KH, Cheng SJ, Hsu KN, (2006) Scrub typhus-associated acute disseminated encephalomyelitis. Acta Neurol Taiwan 15: 251-254.
31. Remalayam B, Viswanathan S, Muthu V, Mookappan S, (2011) Altered sensorium in scrub typhus. J Postgrad Med 57: 262-263.
32. Jeong YJ, Kim S, Wook YD, Lee JW, Kim KI, et al. (2007) Scrub typhus: clinical, pathologic, and imaging findings. Radiographics 27: 161-172.
33. Kularatne SA, Weerakoon KG, Rajapakse RP, Madagedara SC, Nanayakkara D, et al. (2012) A case series of spotted fever rickettsiosis with neurological manifestations in Sri Lanka. Int J Infect Dis.
34. Papez JW, Bateman JF, (1949) Destruction of nerve cells by rickettsial organisms of tsutsugamushi fever. Arch Neurol Psychiatry 61: 545-557.
35. Kang JI, Kim DM, Lee J, (2009) Acute sensorineural hearing loss and severe otalgia due to scrub typhus. BMC Infect Dis 9: 173.
36. Hayakawa K, Oki M, Moriya Y, Mizuma A, Ohnuki Y, Yanagi H, et al. (2012) A case of scrub typhus with acalculous cholecystitis, aseptic meningitis and mononeuritis multiplex. J Med Microbiol 61: 291-4.
37. Ting KS, Lin JC, Chang MK, (1992) Brachial plexus neuropathy associated with scrub typhus: report of a case. J Formos Med Assoc 91: 110-2.
38. Lee KL, Lee JK, Yim YM, Lim OK, Bae KH, (2008) Acute transverse myelitis associated with scrub typhus: case report and a review of literatures. Diagn Microbiol Infect Dis 60: 237-239.
39. Garg RK, (2010) Tuberculous meningitis. Acta Neurol Scand 122: 75-90.
40. Silpapojakul K, Varachit B, (2004) Paediatric scrub typhus in Thailand: a study of 73 confirmed cases. Trans R Soc Trop Med Hyg 98: 354-359.
41. Murthy JM, (2010) Tuberculous meningitis: the challenges. Neurol India 58: 716-722.
42. Thwaites GE, Chau TT, Stepniewska K, Phu NH, Chuong LV, et al. (2002) Diagnosis of adult tuberculous meningitis by use of clinical and laboratory features. Lancet 360: 1287-1292.
43. Tuon FF, Higashino HR, Lopes MI, Litvoc MN, Atomiya AN, et al. (2010) Adenosine deaminase and tuberculous meningitis-a systematic review with meta-analysis. Scand J Infect Dis 42: 198-207.
44. Sun Q, Sha W, Xiao HP, Tian Q, Zhu H, (2012) Evaluation of Cerebrospinal Fluid Adenosine Deaminase Activity for the Differential Diagnosis of Tuberculous and Nontuberculous Meningitis. Am J Med Sci 344: 116-21.
45. Moghtaderi A, Alavi-Naini R, Izadi S, Cuevas LE, (2009) Diagnostic risk factors to differentiate tuberculous and acute bacterial meningitis. Scand J Infect Dis 41: 188-194.
46. Yum KS, Na SJ, Lee KO, Ko JH, (2011) Scrub typhus meningo-encephalitis with focal neurologic signs and associated brain MRI abnormal findings: literature review. Clin Neurol Neurosurg 113: 250-253.
47. Lee SH, Jung SI, Park KH, Choi SM, Park MS, et al. (2007) Guillain-Barre syndrome associated with scrub typhus. Scand J Infect Dis 39: 826-828.
48. Lee YH, Yun YJ, Jeong SH, (2010) Isolated abducens nerve palsy in a patient with scrub typhus. J AAPOS 14: 460-461.
49. Kim DM, Kim YS, Cho HY, Lee YB, (2011) Scrub typhus meningoencephalitis occurring during doxycycline therapy for Orientia tsutsugamushi. Diagn Microbiol Infect Dis 69: 271-274.
50. Isaac R, Varghese GM, Mathai E, J M, Joseph I, (2004) Scrub typhus: prevalence and diagnostic issues in rural Southern India. Clin Infect Dis 39: 1395-1396.
51. Liu YX, Cao WC, Gao Y, Zhang JL, Yang ZQ, et al. (2006) Orientia tsutsugamushi in eschars from scrub typhus patients. Emerg Infect Dis 12: 1109-1112.
52. Koh GC, Maude RJ, Paris DH, Newton PN, Blacksell SD, (2010) Diagnosis of scrub typhus. Am J Trop Med Hyg 82: 368-370.
53. Varghese GM, Abraham OC, Mathai D, Thomas K, Aaron R, et al. (2006) Scrub typhus among hospitalised patients with febrile illness in South India: magnitude and clinical predictors. J Infect 52: 56-60.