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Volumn 14, Issue 3, 2013, Pages 218-226

Oral and intravenous acetylcysteine for treatment of acetaminophen toxicity: A systematic review and meta-analysis

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; PARACETAMOL;

EID: 84879160981     PISSN: 1936900X     EISSN: 19369018     Source Type: Journal    
DOI: 10.5811/westjem.2012.4.6885     Document Type: Article
Times cited : (96)

References (39)
  • 1
    • 79960731948 scopus 로고    scopus 로고
    • Characterization of acetaminophen overdose-related emergency department visits and hospitalizations in the United States
    • Manthripragada AD, Zhou EH, Budnitz DS, et al. Characterization of acetaminophen overdose-related emergency department visits and hospitalizations in the United States. Pharmacoepidemiol Drug Saf. 2011;20(8):819-826.
    • (2011) Pharmacoepidemiol Drug Saf , vol.20 , Issue.8 , pp. 819-826
    • Manthripragada, A.D.1    Zhou, E.H.2    Budnitz, D.S.3
  • 2
    • 0017654043 scopus 로고
    • Treatment of paracetamol (acetaminophen) poisoning with N-acetylcysteine
    • Prescott LF, Park J, Ballantyne A, et al. Treatment of paracetamol (acetaminophen) poisoning with N-acetylcysteine. Lancet. 1977;2(8035):432-434. (Pubitemid 8167941)
    • (1977) Lancet , vol.2 , Issue.8035 , pp. 432-434
    • Prescott, L.F.1    Park, J.2    Ballantyne, A.3
  • 3
    • 0024262737 scopus 로고
    • Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the National Multicenter Study (1976 to 1985)
    • Smilkstein MJ, Knapp GL, Kulig KW, et al. Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985). N Eng J Med. 1988;319(24):1557-1562. (Pubitemid 19003420)
    • (1988) New England Journal of Medicine , vol.319 , Issue.24 , pp. 1557-1562
    • Smilkstein, M.J.1    Knapp, G.L.2    Kulig, K.W.3    Rumack, B.H.4
  • 4
    • 78650932261 scopus 로고    scopus 로고
    • 2009 Annual Report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 27th Annual Report
    • Bronstein AC, Spyker DA, Cantilena LR, et al. 2009 Annual Report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 27th Annual Report. Clin Toxicol (Phila). 2010;48(10):979-1178.
    • (2010) Clin Toxicol (Phila) , vol.48 , Issue.10 , pp. 979-1178
    • Bronstein, A.C.1    Spyker, D.A.2    Cantilena, L.R.3
  • 5
    • 33745044739 scopus 로고    scopus 로고
    • Interventions for paracetamol (acetaminophen) overdose
    • Brok J, Buckley N, Gluud C. Interventions for paracetamol (acetaminophen) overdose. Cochrane Database Syst Rev. 2006 2006(2):CD003328.
    • (2006) Cochrane Database Syst Rev , vol.2006 , Issue.2
    • Brok, J.1    Buckley, N.2    Gluud, C.3
  • 6
    • 0032692511 scopus 로고    scopus 로고
    • Oral or intravenous N-acetylcysteine: Which is the treatment of choice for acetaminophen (paracetamol) poisoning?
    • Buckley NA, Whyte IM, O'Connell DL, et al. Oral or intravenous N-acetylcysteine: Which is the treatment of choice for acetaminophen (paracetamol) poisoning? J Toxicol Clin Toxicol. 1999;37(6):759-767.
    • (1999) J Toxicol Clin Toxicol , vol.37 , Issue.6 , pp. 759-767
    • Buckley, N.A.1    Whyte, I.M.2    O'Connell, D.L.3
  • 7
    • 70349139532 scopus 로고    scopus 로고
    • Comparison of the 20-hour intravenous and 72-hour oral acetylcysteine protocols for the treatment of acute acetaminophen poisoning
    • Yarema MC, Johnson DW, Berlin RJ, et al. Comparison of the 20-hour intravenous and 72-hour oral acetylcysteine protocols for the treatment of acute acetaminophen poisoning. Ann Emerg Med. 2009;54(4):606-614.
    • (2009) Ann Emerg Med , vol.54 , Issue.4 , pp. 606-614
    • Yarema, M.C.1    Johnson, D.W.2    Berlin, R.J.3
  • 8
    • 58149529422 scopus 로고    scopus 로고
    • Hepatotoxicity despite early administration of intravenous N-acetylcysteine for acute acetaminophen overdose
    • 2009
    • Doyon S, Klein-Schwartz W. Hepatotoxicity despite early administration of intravenous N-acetylcysteine for acute acetaminophen overdose. Acad Emerg Med 2009 2009;16(1):34-39.
    • (2009) Acad Emerg Med , vol.16 , Issue.1 , pp. 34-39
    • Doyon, S.1    Klein-Schwartz, W.2
  • 9
    • 58149524459 scopus 로고    scopus 로고
    • Acetylcysteine for early presenting overdoses of acetaminophen combination products
    • Klein-Schwartz W, Doyon S. Acetylcysteine for early presenting overdoses of acetaminophen combination products. Clin Toxicol. 2007;45:346.
    • (2007) Clin Toxicol , vol.45 , pp. 346
    • Klein-Schwartz, W.1    Doyon, S.2
  • 11
    • 0019422847 scopus 로고
    • Treatment of severe acetaminophen poisoning with intravenous acetylcysteine
    • Prescott LF. Treatment of severe acetaminophen poisoning with intravenous acetylcysteine. Arch Intern Med. 1981;141(3 Spec No):386-389.
    • (1981) Arch Intern Med , vol.141 , Issue.3 SPEC NO , pp. 386-389
    • Prescott, L.F.1
  • 12
    • 0019430214 scopus 로고
    • Acetaminophen overdose. 662 cases with evaluation of oral acetylcysteine treatment
    • Rumack BH, Peterson RC, Koch GG, et al. Acetaminophen overdose. 662 cases with evaluation of oral acetylcysteine treatment. Arch Intern Med. 1981;141(3 Spec No):380-385.
    • (1981) Arch Intern Med , vol.141 , Issue.3 SPEC NO , pp. 380-385
    • Rumack, B.H.1    Peterson, R.C.2    Koch, G.G.3
  • 13
    • 0028222859 scopus 로고
    • A prospective evaluation of the effect of activated charcoal before oral N-acetylcysteine in acetaminophen overdose
    • Spiller HA, Krenzelok EP, Grande GA, et al. A prospective evaluation of the effect of activated charcoal before oral N-acetylcysteine in acetaminophen overdose. Ann Emerg Med. 1994;23(3):519-523. (Pubitemid 24097660)
    • (1994) Annals of Emergency Medicine , vol.23 , Issue.3 , pp. 519-523
    • Spiller, H.A.1    Krenzelok, E.P.2    Grande, G.A.3    Safir, E.F.4    Diamond, J.J.5
  • 14
    • 31144440242 scopus 로고    scopus 로고
    • Efficacy of activated charcoal administered more than four hours after acetaminophen overdose
    • DOI 10.1016/j.jemermed.2005.02.019, PII S0736467905003501
    • Spiller HA, Winter ML, Klein-Schwartz W, et al. Efficacy of activated charcoal administered more than four hours after acetaminophen overdose. J Emerg Med. 2006;30(1):1-5. (Pubitemid 43129870)
    • (2006) Journal of Emergency Medicine , vol.30 , Issue.1 , pp. 1-5
    • Spiller, H.A.1    Winter, M.L.2    Klein-Schwartz, W.3    Bangh, S.A.4
  • 15
    • 12344288216 scopus 로고    scopus 로고
    • Acute acetaminophen intoxication in Taiwan: Outcomes and risk factors
    • Tsai CL, Chang WT, Weng TI, et al. Acute acetaminophen intoxication in Taiwan: outcomes and risk factors. J Formos Med Assoc. 2004;103(11):830-835.
    • (2004) J Formos Med Assoc , vol.103 , Issue.11 , pp. 830-835
    • Tsai, C.L.1    Chang, W.T.2    Weng, T.I.3
  • 16
    • 18844424365 scopus 로고    scopus 로고
    • A patient-tailored N-acetylcysteine protocol for acute acetaminophen intoxication
    • DOI 10.1016/j.clinthera.2005.03.002, PII S0149291805000457
    • Tsai C-L, Chang W-T, Weng T-I, et al. A patient-tailored N-acetylcysteine protocol for acute acetaminophen intoxication. Clin. Ther. 2005;27(3):336-341. (Pubitemid 40692752)
    • (2005) Clinical Therapeutics , vol.27 , Issue.3 , pp. 336-341
    • Tsai, C.-L.1    Chang, W.-T.2    Weng, T.-I.3    Fang, C.-C.4    Walson, P.D.5
  • 17
    • 35649010961 scopus 로고    scopus 로고
    • Safety and efficacy of intravenous N-acetylcysteine for acetaminophen overdose: Analysis of the Hunter Area Toxicology Service (HATS) database
    • DOI 10.1185/030079907X219715
    • Whyte IM, Francis B, Dawson AH. Safety and efficacy of intravenous N-acetylcysteine for acetaminophen overdose: analysis of the Hunter Area Toxicology Service (HATS) database. Curr Med Res Opin. 2007;23(10):2359-2368. (Pubitemid 350033437)
    • (2007) Current Medical Research and Opinion , vol.23 , Issue.10 , pp. 2359-2368
    • Whyte, I.M.1    Francis, B.2    Dawson, A.H.3
  • 18
    • 0033902642 scopus 로고    scopus 로고
    • Shorter duration of oral N-acetylcysteine therapy for acute acetaminophen overdose
    • 2000
    • Woo OF, Mueller PD, Olson KR, et al. Shorter duration of oral N-acetylcysteine therapy for acute acetaminophen overdose. Ann. Emerg. Med. 2000 2000;35(4):363-368.
    • (2000) Ann. Emerg. Med. , vol.35 , Issue.4 , pp. 363-368
    • Woo, O.F.1    Mueller, P.D.2    Olson, K.R.3
  • 20
    • 70349139532 scopus 로고    scopus 로고
    • Comparison of the 20-Hour Intravenous and 72-Hour Oral Acetylcysteine Protocols for the Treatment of Acute Acetaminophen Poisoning
    • Yarema MC, Johnson DW, Berlin RJ, et al. Comparison of the 20-Hour Intravenous and 72-Hour Oral Acetylcysteine Protocols for the Treatment of Acute Acetaminophen Poisoning. Ann Emerg Med. 2009;54(4):606-614.
    • (2009) Ann Emerg Med , vol.54 , Issue.4 , pp. 606-614
    • Yarema, M.C.1    Johnson, D.W.2    Berlin, R.J.3
  • 21
    • 0038581620 scopus 로고    scopus 로고
    • A 20-hour treatment for acute acetaminophen overdose [7]
    • DOI 10.1056/NEJM200306123482422
    • Yip L, Dart RC. A 20-hour treatment for acute acetaminophen overdose. N Eng J Med. 2003;348(24):2471-2472. (Pubitemid 36682835)
    • (2003) New England Journal of Medicine , vol.348 , Issue.24 , pp. 2471-2472
    • Yip, L.1    Dart, R.C.2
  • 22
    • 24044433295 scopus 로고    scopus 로고
    • A risk quantification instrument for acute acetaminophen overdose patients treated with n-acetylcysteine
    • DOI 10.1016/j.annemergmed.2005.04.004, PII S0196064405004099
    • Sivilotti ML, Yarema MC, Juurlink DN, et al. A risk quantification instrument for acute acetaminophen overdose patients treated with N-acetylcysteine. Ann Emerg Med. 2005;46(3):263-271. (Pubitemid 41218716)
    • (2005) Annals of Emergency Medicine , vol.46 , Issue.3 , pp. 263-271
    • Sivilotti, M.L.A.1    Yarema, M.C.2    Juurlink, D.N.3    Good, A.M.4    Johnson, D.W.5
  • 23
    • 0028952622 scopus 로고
    • Renal failure is uncommon in Chinese patients with paracetamol (Acetaminophen) poisoning
    • Chan TYK, Critchley JAJH, Chan AYW. Renal failure is uncommon in Chinese patients with paracetamol (Acetaminophen) poisoning. Vet Hum Toxicol. 1995;37(2):154-156.
    • (1995) Vet Hum Toxicol , vol.37 , Issue.2 , pp. 154-156
    • Chan, T.Y.K.1    Critchley, J.A.J.H.2    Chan, A.Y.W.3
  • 24
    • 0025953515 scopus 로고
    • Acetaminophen overdose: A 48-hour intravenous N-acetylcysteine treatment protocol
    • Smilkstein MJ, Bronstein AC, Linden C, et al. Acetaminophen overdose: a 48-hour intravenous N-acetylcysteine treatment protocol. Ann Emerg Med. 1991;20(10):1058-1063.
    • (1991) Ann Emerg Med , vol.20 , Issue.10 , pp. 1058-1063
    • Smilkstein, M.J.1    Bronstein, A.C.2    Linden, C.3
  • 25
    • 0018069442 scopus 로고
    • Acetaminophen overdose: Incidence, diagnosis, and management in 416 patients
    • Rumack BH, Peterson RG. Acetaminophen overdose: incidence, diagnosis, and management in 416 patients. Pediatrics. 1978;62(5 Pt 2 Suppl):898-903. (Pubitemid 9009962)
    • (1978) Pediatrics , vol.62 , Issue.5 II SUPPL. , pp. 898-903
    • Rumack, B.H.1    Peterson, R.G.2
  • 26
    • 17844391545 scopus 로고    scopus 로고
    • The Australasian clinical toxicology investigators collaboration randomized trial of different loading infusion rates of N-acetylcysteine
    • DOI 10.1016/j.annemergmed.2004.08.040, PII S0196064404013265
    • Kerr F, Dawson A, Whyte IM, et al. The Australasian clinical toxicology investigators collaboration randomized trial of different loading infusion rates of N-acetylcysteine. Ann Emerg Med. 2005;45(4):402-408. (Pubitemid 43181007)
    • (2005) Annals of Emergency Medicine , vol.45 , Issue.4 , pp. 402-408
    • Kerr, F.1    Dawson, A.2    Whyte, I.M.3    Buckley, N.4    Murray, L.5    Graudins, A.6    Chan, B.7    Trudinger, B.8
  • 27
    • 34547890308 scopus 로고    scopus 로고
    • A Prospective Evaluation of Shortened Course Oral N-Acetylcysteine for the Treatment of Acute Acetaminophen Poisoning
    • DOI 10.1016/j.annemergmed.2006.11.010, PII S0196064406025339
    • Betten DP, Cantrell FL, Thomas SC, et al. A prospective evaluation of shortened course oral N-acetylcysteine for the treatment of acute acetaminophen poisoning. Ann Emerg Med. 2007;50(3):272-279. (Pubitemid 47259233)
    • (2007) Annals of Emergency Medicine , vol.50 , Issue.3 , pp. 272-279
    • Betten, D.P.1    Cantrell, F.L.2    Thomas, S.C.3    Williams, S.R.4    Clark, R.F.5
  • 28
    • 75349103219 scopus 로고    scopus 로고
    • A retrospective evaluation of shortened-duration oral N-acetylcysteine for the treatment of acetaminophen poisoning
    • Betten DP, Burner EE, Thomas SC, et al. A retrospective evaluation of shortened-duration oral N-acetylcysteine for the treatment of acetaminophen poisoning. J Med Toxicol. 2009;5(4):183-190.
    • (2009) J Med Toxicol , vol.5 , Issue.4 , pp. 183-190
    • Betten, D.P.1    Burner, E.E.2    Thomas, S.C.3
  • 29
    • 77954234433 scopus 로고    scopus 로고
    • A multicenter comparison of the safety of oral versus intravenous acetylcysteine for treatment of acetaminophen overdose
    • Bebarta VS, Kao L, Froberg B, et al. A multicenter comparison of the safety of oral versus intravenous acetylcysteine for treatment of acetaminophen overdose. Clin Toxicol (Phila). 2010;48(5):424-430.
    • (2010) Clin Toxicol (Phila) , vol.48 , Issue.5 , pp. 424-430
    • Bebarta, V.S.1    Kao, L.2    Froberg, B.3
  • 30
    • 17844391545 scopus 로고    scopus 로고
    • The Australasian clinical toxicology investigators collaboration randomized trial of different loading infusion rates of N-acetylcysteine
    • DOI 10.1016/j.annemergmed.2004.08.040, PII S0196064404013265
    • Kerr F, Dawson A, Whyte IM, et al. The Australasian Clinical Toxicology Investigators Collaboration randomized trial of different loading infusion rates of N-acetylcysteine. Ann Emerg Med. 2005;45(4):402-408. (Pubitemid 43181007)
    • (2005) Annals of Emergency Medicine , vol.45 , Issue.4 , pp. 402-408
    • Kerr, F.1    Dawson, A.2    Whyte, I.M.3    Buckley, N.4    Murray, L.5    Graudins, A.6    Chan, B.7    Trudinger, B.8
  • 31
    • 34547890308 scopus 로고    scopus 로고
    • A Prospective Evaluation of Shortened Course Oral N-Acetylcysteine for the Treatment of Acute Acetaminophen Poisoning
    • DOI 10.1016/j.annemergmed.2006.11.010, PII S0196064406025339
    • Betten DP, Cantrell FL, Thomas SC, et al. A prospective evaluation of shortened course oral N-acetylcysteine for the treatment of acute acetaminophen poisoning. Ann Emerg Med. 2007;50(3):272-279. (Pubitemid 47259233)
    • (2007) Annals of Emergency Medicine , vol.50 , Issue.3 , pp. 272-279
    • Betten, D.P.1    Cantrell, F.L.2    Thomas, S.C.3    Williams, S.R.4    Clark, R.F.5
  • 34
    • 0021263980 scopus 로고
    • Acetaminophen overdose in young children. Treatment and effects of alcohol and other additional ingestants in 417 cases
    • Rumack BH. Acetaminophen overdose in young children. Treatment and effects of alcohol and other additional ingestants in 417 cases. Am J Dis Child. 1984;138(5):428-433. (Pubitemid 14137206)
    • (1984) American Journal of Diseases of Children , vol.138 , Issue.5 , pp. 428-433
    • Rumack, B.H.1
  • 35
    • 0025291687 scopus 로고
    • Improved outcome of paracetamol-induced fulminant hepatic failure by late administration of acetylcysteine
    • Harrison PM, Keays R, Bray GP, et al. Improved outcome of paracetamol-induced fulminant hepatic failure by late administration of acetylcysteine. Lancet. 30 1990;335(8705):1572-1573.
    • (1990) Lancet , vol.30 , Issue.8705 , pp. 1572-1573
    • Harrison, P.M.1    Keays, R.2    Bray, G.P.3
  • 36
    • 0036850974 scopus 로고    scopus 로고
    • Fatal anaphylactoid reaction to N-acetylcysteine: Caution in patients with asthma
    • Appelboam AV, Dargan PI, Knighton J. Fatal anaphylactoid reaction to N-acetylcysteine: caution in patients with asthma. Emerg Med J. 2002;19(6):594-595. (Pubitemid 35363397)
    • (2002) Emergency Medicine Journal , vol.19 , Issue.6 , pp. 594-595
    • Appelboam, A.V.1    Dargan, P.I.2    Knighton, J.3
  • 37
    • 47549090863 scopus 로고    scopus 로고
    • Acetylcysteine for acetaminophen poisoning
    • Heard KJ. Acetylcysteine for acetaminophen poisoning. N Engl J Med. 2008;359(3):285-292.
    • (2008) N Engl J Med , vol.359 , Issue.3 , pp. 285-292
    • Heard, K.J.1
  • 38
    • 72749093794 scopus 로고    scopus 로고
    • Managing acute acetaminophen poisoning with oral versus intravenous N-acetylcysteine: A provider-perspective cost analysis
    • Marchetti A, Rossiter R. Managing acute acetaminophen poisoning with oral versus intravenous N-acetylcysteine: a provider-perspective cost analysis. J Med Econ. 2009;12(4):384-391.
    • (2009) J Med Econ , vol.12 , Issue.4 , pp. 384-391
    • Marchetti, A.1    Rossiter, R.2
  • 39
    • 76749085174 scopus 로고    scopus 로고
    • Cost Minimization Analysis Comparing Enteral N-Acetylcysteine to Intravenous Acetylcysteine in the Management of Acute Acetaminophen Toxicity
    • Martello JL, Pummer TL, Krenzelok EP. Cost Minimization Analysis Comparing Enteral N-Acetylcysteine to Intravenous Acetylcysteine in the Management of Acute Acetaminophen Toxicity. Clin Toxicol (Phila). 2010;48(1):79-83.
    • (2010) Clin Toxicol (Phila) , vol.48 , Issue.1 , pp. 79-83
    • Martello, J.L.1    Pummer, T.L.2    Krenzelok, E.P.3


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