Effects of icariin on β-amyloid and neurotrophic factors in brain of mitochondrial deficiency model rats

Zhongguo Zhongyao Zazhi

Volumn 38, Issue 9, 2013, Pages 1285-1289

  Zhang, Ru Yi ^a   Zhang, Li ^a   Ai, Hou Xi ^a   Zhang, Lan ^a   Li, Lin ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

amyloid; Alzheimer's disease; Icariin; Mitochondria; Neurotrophic factor; Rat; Sodium azide

Indexed keywords

AMYLOID BETA PROTEIN; BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; ICARIIN; NERVE GROWTH FACTOR; NEUROTROPHIC FACTOR; SODIUM AZIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME LINKED IMMUNOSORBENT ASSAY; HIPPOCAMPUS; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; NONHUMAN; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING;

AMYLOID; ANIMALS; BRAIN; BRAIN-DERIVED NEUROTROPHIC FACTOR; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLAVONOIDS; MITOCHONDRIA; MITOCHONDRIAL DISEASES; NERVE GROWTH FACTOR; NERVE GROWTH FACTORS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, TRKB;

EID: 84879157401     PISSN: 10015302     EISSN: None     Source Type: Journal    
DOI: 10.4268/cjcmm20130904     Document Type: Article

References (14)

1. Leuner K, Hauptmann S, Abdel-Kader R, et al. Mitochondrial dysfunction: the first domino in brain aging and Alzheimer's disease[J]. Antioxid Redox Signal, 2007, 9(10): 1659.
2. Müller W E, Eckert A, Kurz C, et al. Mitochondrial dysfunction: common final pathway in brain aging and Alzheimer's disease-therapeutic aspects[J]. Mol Neurobiol, 2010, 41(2/3): 159.
3. Kish S J, Bergeron C, Rajput A, et al. Brain cytochrome oxidase in Alzheimer's disease[J]. J Neurochem, 1992, 59(2): 776.
4. 2012, 31(4): 462.
5. 2003, 9(9): 536.
6. Bennett M C, Rose G M. Chronic sodium azide treatment impairs learning of the Morris water maze task[J]. Behav Neural Biol, 1992, 58(1): 72.
7. Morin C, Zini R, Simon N, et al. Dehydroepiandrosterone and alpha-estradiol limit the functional alterations of rat brain mitochondria submitted to different experimental stresses[J]. Neuroscience, 2002, 115(2): 415.
8. Tillement L, Lecanu L, Papadopoulos V. Alzheimer's disease: effects of β-amyloid on mitochondria[J]. Mitochondrion, 2011, 11(1): 13.
9. Nagahara A H, Tuszynski M H. Potential therapeutic uses of BDNF in neurological and psychiatric disorders[J]. Nat Rev Drug Discov, 2011, 10(3): 209.
10. Ye X, Tai W, Zhang D. The early events of Alzheimer's disease pathology: from mitochondrial dysfunction to BDNF axonal transport deficits[J]. Neurobiol Aging, 2012, 33(6): 1122.
11. Zeng Y, Zhao D, Xie C W. Neurotrophins enhance CaMKII activity and rescue amyloid-β-induced deficits in hippocampal synaptic plasticity[J]. J Alzheimer's Dis, 2010, 21(3): 823.
12. Arancibia S, Silhol M, Moulière F, et al. Protective effect of BDNF against beta-amyloid induced neurotoxicity in vitro and in vivo in rats[J]. Neurobiol Dis, 2008, 31(3): 316.
13. Schindowski K, Belarbi K, Buée L. Neurotrophic factors in Alzheimer's disease: role of axonal transport [J]. Genes Brain Behav, 2008, 7 (Suppl 1): 43.
14. 2005, 19(5): 331.