-
1
-
-
0034623816
-
Efficient initiation of HCV RNA replication in cell culture
-
Blight K.J., Kolykhalov A.A., Rice C.M. Efficient initiation of HCV RNA replication in cell culture. Science 2000, 290:1972-1974.
-
(2000)
Science
, vol.290
, pp. 1972-1974
-
-
Blight, K.J.1
Kolykhalov, A.A.2
Rice, C.M.3
-
2
-
-
84857395452
-
Dual therapy with the nonstructural protein 5A inhibitor, daclatasvir, and the nonstructural protein 3 protease inhibitor, asunaprevir, in hepatitis C virus genotype 1b-infected null responders
-
Chayama K., Takahashi S., Toyota J., Karino Y., Ikeda K., Ishikawa H., Watanabe H., McPhee F., Hughes E., Kumada H. Dual therapy with the nonstructural protein 5A inhibitor, daclatasvir, and the nonstructural protein 3 protease inhibitor, asunaprevir, in hepatitis C virus genotype 1b-infected null responders. Hepatology 2012, 55:742-748.
-
(2012)
Hepatology
, vol.55
, pp. 742-748
-
-
Chayama, K.1
Takahashi, S.2
Toyota, J.3
Karino, Y.4
Ikeda, K.5
Ishikawa, H.6
Watanabe, H.7
McPhee, F.8
Hughes, E.9
Kumada, H.10
-
3
-
-
1442306648
-
Reactive oxygen species suppress hepatitis C virus RNA replication in human hepatoma cells
-
Choi J., Lee K.J., Zheng Y., Yamaga A.K., Lai M.M.C., Ou J.H. Reactive oxygen species suppress hepatitis C virus RNA replication in human hepatoma cells. Hepatology 2004, 3981-3989.
-
(2004)
Hepatology
, pp. 3981-3989
-
-
Choi, J.1
Lee, K.J.2
Zheng, Y.3
Yamaga, A.K.4
Lai, M.M.C.5
Ou, J.H.6
-
4
-
-
51749090448
-
Practical consequences of hepatitis C virus quasispecies for target-specific antivirals
-
Fanning L.J. Practical consequences of hepatitis C virus quasispecies for target-specific antivirals. J. Infect. Dis. 2008, 198:797-799.
-
(2008)
J. Infect. Dis.
, vol.198
, pp. 797-799
-
-
Fanning, L.J.1
-
5
-
-
84874030693
-
Combinations of interferon lambda with direct-acting antiviral agents are highly efficient in suppressing Hepatitis C virus replication
-
Friborg J., Levine S., Chen C., Sheaffer A.K., Chaniewski S., McPhee F. Combinations of interferon lambda with direct-acting antiviral agents are highly efficient in suppressing Hepatitis C virus replication. Antimicrob. Agents Chemother. 2013, 57:1312-1322.
-
(2013)
Antimicrob. Agents Chemother.
, vol.57
, pp. 1312-1322
-
-
Friborg, J.1
Levine, S.2
Chen, C.3
Sheaffer, A.K.4
Chaniewski, S.5
McPhee, F.6
-
6
-
-
77956116880
-
Resistance analysis of the hepatitis C virus NS5A inhibitor BMS-790052 in an in vitro replicon system
-
Fridell R.A., Qiu D., Wang C., Valera L., Gao M. Resistance analysis of the hepatitis C virus NS5A inhibitor BMS-790052 in an in vitro replicon system. Antimicrob. Agents Chemother. 2010, 54:3641-3650.
-
(2010)
Antimicrob. Agents Chemother.
, vol.54
, pp. 3641-3650
-
-
Fridell, R.A.1
Qiu, D.2
Wang, C.3
Valera, L.4
Gao, M.5
-
7
-
-
79960390342
-
Distinct functions of NS5A in hepatitis C virus RNA replication uncovered by studies with the NS5A inhibitor BMS-790052
-
Fridell R.A., Qiu D., Valera L., Wang C., Rose R.E., Gao M. Distinct functions of NS5A in hepatitis C virus RNA replication uncovered by studies with the NS5A inhibitor BMS-790052. J. Virol. 2011, 85:7312-7320.
-
(2011)
J. Virol.
, vol.85
, pp. 7312-7320
-
-
Fridell, R.A.1
Qiu, D.2
Valera, L.3
Wang, C.4
Rose, R.E.5
Gao, M.6
-
8
-
-
77952035218
-
Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect
-
Gao M., Nettles R.E., Belema M., Snyder L.B., Nguyen V.N., Fridell R.A., Serrano-Wu M.H., Langley D.R., Sun J.H., O'Boyle D.R., Lemm J.A., Wang C., Knipe J.O., Chien C., Colonno R.J., Grasela D.M., Meanwell N.A., Hamann L.G. Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect. Nature 2010, 465:96-100.
-
(2010)
Nature
, vol.465
, pp. 96-100
-
-
Gao, M.1
Nettles, R.E.2
Belema, M.3
Snyder, L.B.4
Nguyen, V.N.5
Fridell, R.A.6
Serrano-Wu, M.H.7
Langley, D.R.8
Sun, J.H.9
O'Boyle, D.R.10
Lemm, J.A.11
Wang, C.12
Knipe, J.O.13
Chien, C.14
Colonno, R.J.15
Grasela, D.M.16
Meanwell, N.A.17
Hamann, L.G.18
-
9
-
-
84894021640
-
BMS-766, a novel HCV NS5A inhibitor with enhanced resistance coverage
-
Gao M., Fridell R.A., Wang C., Sun J.-H., O'Boyle D.R., Valera L., Nower P.T., Monikowski A., Kirk M., Huang H., Ngo C., Fang H., Knox R., Wang Y.-K., Nguyen V., Wang F., Snyder L., Lavoie R., Bender J., Kadow J., Cockett M., Meanwell N.A., Belema M. BMS-766, a novel HCV NS5A inhibitor with enhanced resistance coverage. EASL Poster, 2011 2011.
-
(2011)
EASL Poster, 2011
-
-
Gao, M.1
Fridell, R.A.2
Wang, C.3
Sun, J.-H.4
O'Boyle, D.R.5
Valera, L.6
Nower, P.T.7
Monikowski, A.8
Kirk, M.9
Huang, H.10
Ngo, C.11
Fang, H.12
Knox, R.13
Wang, Y.-K.14
Nguyen, V.15
Wang, F.16
Snyder, L.17
Lavoie, R.18
Bender, J.19
Kadow, J.20
Cockett, M.21
Meanwell, N.A.22
Belema, M.23
more..
-
10
-
-
33845968083
-
Development of a novel dicistronic reporter-selectable hepatitis C virus replicon suitable for high-throughput inhibitor screening
-
Hao W., Herlihy K.J., Zhang N.J., Fuhrman S.A., Doan C., Patick A.K., Duggal R. Development of a novel dicistronic reporter-selectable hepatitis C virus replicon suitable for high-throughput inhibitor screening. Antimicrob. Agents Chemother. 2007, 51:95-102.
-
(2007)
Antimicrob. Agents Chemother.
, vol.51
, pp. 95-102
-
-
Hao, W.1
Herlihy, K.J.2
Zhang, N.J.3
Fuhrman, S.A.4
Doan, C.5
Patick, A.K.6
Duggal, R.7
-
11
-
-
79959438789
-
Telaprevir for previously untreated chronic hepatitis C virus infection
-
Jacobson I.M., McHutchison J.G., Dusheiko G., Di Bisceglie A.M., Reddy K.R., Bzowej N.H., Marcellin P., Muir A.J., Ferenci P., Flisiak R., George J., Rizzetto M., Shouval D., Sola R., Terg R.A., Yoshida E.M., Adda N., Bengtsson L., Sankoh A.J., Kieffer T.L., George S., Kauffman R.S., Zeuzem S. Telaprevir for previously untreated chronic hepatitis C virus infection. N. Engl. J. Med. 2011, 364:2405-2416.
-
(2011)
N. Engl. J. Med.
, vol.364
, pp. 2405-2416
-
-
Jacobson, I.M.1
McHutchison, J.G.2
Dusheiko, G.3
Di Bisceglie, A.M.4
Reddy, K.R.5
Bzowej, N.H.6
Marcellin, P.7
Muir, A.J.8
Ferenci, P.9
Flisiak, R.10
George, J.11
Rizzetto, M.12
Shouval, D.13
Sola, R.14
Terg, R.A.15
Yoshida, E.M.16
Adda, N.17
Bengtsson, L.18
Sankoh, A.J.19
Kieffer, T.L.20
George, S.21
Kauffman, R.S.22
Zeuzem, S.23
more..
-
12
-
-
77956268467
-
Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial
-
Kwo P.Y., Lawitz E.J., McCone J., Schiff E.R., Vierling J.M., Pound D., Davis M.N., Galati J.S., Gordon S.C., Ravendhran N., Rossaro L., Anderson F.H., Jacobson I.M., Rubin R., Koury K., Pedicone L.D., Brass C.A., Chaudhri E., Albrecht J.K. Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial. Lancet 2010, 376:705-716.
-
(2010)
Lancet
, vol.376
, pp. 705-716
-
-
Kwo, P.Y.1
Lawitz, E.J.2
McCone, J.3
Schiff, E.R.4
Vierling, J.M.5
Pound, D.6
Davis, M.N.7
Galati, J.S.8
Gordon, S.C.9
Ravendhran, N.10
Rossaro, L.11
Anderson, F.H.12
Jacobson, I.M.13
Rubin, R.14
Koury, K.15
Pedicone, L.D.16
Brass, C.A.17
Chaudhri, E.18
Albrecht, J.K.19
-
13
-
-
83555174694
-
In vitro selection and characterization of HCV replicons resistant to multiple non-nucleoside polymerase inhibitors
-
Delang L., Vliegen I., Leyssen P., Neyts J. In vitro selection and characterization of HCV replicons resistant to multiple non-nucleoside polymerase inhibitors. J. Hepatol. 2012, 56:41-48.
-
(2012)
J. Hepatol.
, vol.56
, pp. 41-48
-
-
Delang, L.1
Vliegen, I.2
Leyssen, P.3
Neyts, J.4
-
14
-
-
84856159009
-
Preliminary study of two antiviral agents for hepatitis C genotype 1
-
Lok A.S., Gardiner D.F., Lawitz E., Martorell C., Everson G.T., Ghalib R., Reindollar R., Rustgi V., McPhee F., Wind-Rotolo M., Persson A., Zhu K., Dimitrova D.I., Eley T., Guo T., Grasela D.M., Pasquinelli C. Preliminary study of two antiviral agents for hepatitis C genotype 1. N. Engl. J. Med. 2012, 366:216-224.
-
(2012)
N. Engl. J. Med.
, vol.366
, pp. 216-224
-
-
Lok, A.S.1
Gardiner, D.F.2
Lawitz, E.3
Martorell, C.4
Everson, G.T.5
Ghalib, R.6
Reindollar, R.7
Rustgi, V.8
McPhee, F.9
Wind-Rotolo, M.10
Persson, A.11
Zhu, K.12
Dimitrova, D.I.13
Eley, T.14
Guo, T.15
Grasela, D.M.16
Pasquinelli, C.17
-
15
-
-
42949167169
-
The hepatitis C virus replicon presents a higher barrier to resistance to nucleoside analogs than to nonnucleoside polymerase or protease inhibitors
-
McCown M.F., Rajyaguru S., Le Pogam S., Ali S., Jiang W.R., Kang H., Symons J., Cammack N., Najera I. The hepatitis C virus replicon presents a higher barrier to resistance to nucleoside analogs than to nonnucleoside polymerase or protease inhibitors. Antimicrob. Agents Chemother. 2008, 52:1604-1612.
-
(2008)
Antimicrob. Agents Chemother.
, vol.52
, pp. 1604-1612
-
-
McCown, M.F.1
Rajyaguru, S.2
Le Pogam, S.3
Ali, S.4
Jiang, W.R.5
Kang, H.6
Symons, J.7
Cammack, N.8
Najera, I.9
-
16
-
-
16244415844
-
Development of a cell-based high-throughput specificity screen using a hepatitis C virus-bovine viral diarrhea virus dual replicon assay
-
O'Boyle D.R., Nower P.T., Lemm J.A., Valera L., Sun J.-H., Rigat K., Colonno R., Gao M. Development of a cell-based high-throughput specificity screen using a hepatitis C virus-bovine viral diarrhea virus dual replicon assay. Antimicrob. Agents Chemother. 2005, 49:1346-1353.
-
(2005)
Antimicrob. Agents Chemother.
, vol.49
, pp. 1346-1353
-
-
O'Boyle, D.R.1
Nower, P.T.2
Lemm, J.A.3
Valera, L.4
Sun, J.-H.5
Rigat, K.6
Colonno, R.7
Gao, M.8
-
17
-
-
84866315985
-
Effect on HCV replication by combinations of direct acting antivirals including NS5A inhibitor daclatasvir
-
Pelosi L.A., Voss S., Liu M., Gao M., Lemm J.A. Effect on HCV replication by combinations of direct acting antivirals including NS5A inhibitor daclatasvir. Antimicrob. Agents Chemother. 2012, 56:5230-5239.
-
(2012)
Antimicrob. Agents Chemother.
, vol.56
, pp. 5230-5239
-
-
Pelosi, L.A.1
Voss, S.2
Liu, M.3
Gao, M.4
Lemm, J.A.5
-
18
-
-
1642464020
-
Induced oxidative stress and activated expression of manganese superoxide dismutase during hepatitis C virus replication: role of JNK, p38 MAPK and AP-1
-
Qadri I., Iwahashi M., Capasso J.M., Hopken M.W., Flores S., Schaack J., Simon F.R. Induced oxidative stress and activated expression of manganese superoxide dismutase during hepatitis C virus replication: role of JNK, p38 MAPK and AP-1. Biochem. J. 2004, 378:919-928.
-
(2004)
Biochem. J.
, vol.378
, pp. 919-928
-
-
Qadri, I.1
Iwahashi, M.2
Capasso, J.M.3
Hopken, M.W.4
Flores, S.5
Schaack, J.6
Simon, F.R.7
-
19
-
-
27144513392
-
Quantitative analysis of the hepatitis C virus replication complex
-
Quinkert D., Bartenschlager R., Lohmann V. Quantitative analysis of the hepatitis C virus replication complex. J. Virol. 2005, 79:13594-13605.
-
(2005)
J. Virol.
, vol.79
, pp. 13594-13605
-
-
Quinkert, D.1
Bartenschlager, R.2
Lohmann, V.3
-
20
-
-
84857659297
-
Screening of hepatitis C virus inhibitors using genotype 1a HCV replicon cell lines
-
(Chapter 1, Unit 17.7)
-
Robinson M., Tian Y., Pagratis N., Delaney W.E. Screening of hepatitis C virus inhibitors using genotype 1a HCV replicon cell lines. Curr. Protoc. Microbiol. 2011, (Chapter 1, Unit 17.7).
-
(2011)
Curr. Protoc. Microbiol.
-
-
Robinson, M.1
Tian, Y.2
Pagratis, N.3
Delaney, W.E.4
-
21
-
-
79959995313
-
Preexisting drug-resistance mutations reveal unique barriers to resistance for distinct antivirals
-
Robinson M., Tian Y., Delaney W.E., Greenstein A.E. Preexisting drug-resistance mutations reveal unique barriers to resistance for distinct antivirals. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:10290-10295.
-
(2011)
Proc. Natl. Acad. Sci. U.S.A.
, vol.108
, pp. 10290-10295
-
-
Robinson, M.1
Tian, Y.2
Delaney, W.E.3
Greenstein, A.E.4
-
22
-
-
79952296871
-
Recombinant HCV variants with NS5A from genotypes 1-7 have different sensitivities to an ns5a inhibitor but not interferon-α
-
Scheel T.K., Gottwein J.M., Mikkelsen L.S., Jensen T.B., Bukh J. Recombinant HCV variants with NS5A from genotypes 1-7 have different sensitivities to an ns5a inhibitor but not interferon-α. Gastroenterology 2011, 140:1032-1042.
-
(2011)
Gastroenterology
, vol.140
, pp. 1032-1042
-
-
Scheel, T.K.1
Gottwein, J.M.2
Mikkelsen, L.S.3
Jensen, T.B.4
Bukh, J.5
-
23
-
-
0033102304
-
Highly active antiretroviral therapy (HAART) for the treatment of infection with human immunodeficiency virus type 1
-
Shafer R.W., Vuitton D.A. Highly active antiretroviral therapy (HAART) for the treatment of infection with human immunodeficiency virus type 1. Biomed. Pharmacother. 1999, 53:73-86.
-
(1999)
Biomed. Pharmacother.
, vol.53
, pp. 73-86
-
-
Shafer, R.W.1
Vuitton, D.A.2
-
24
-
-
0141632671
-
Dynamics of subgenomic hepatitis C virus replicon RNA levels in Huh-7 cells after exposure to nucleoside antimetabolites
-
Stuyver L.J., McBrayer T.R., Tharnish P.M., Hassan A.E., Chu C.K., Pankiewicz K.W., Watanabe K.A., Schinazi R.F., Otto M.J. Dynamics of subgenomic hepatitis C virus replicon RNA levels in Huh-7 cells after exposure to nucleoside antimetabolites. J. Virol. 2003, 77:10689-10694.
-
(2003)
J. Virol.
, vol.77
, pp. 10689-10694
-
-
Stuyver, L.J.1
McBrayer, T.R.2
Tharnish, P.M.3
Hassan, A.E.4
Chu, C.K.5
Pankiewicz, K.W.6
Watanabe, K.A.7
Schinazi, R.F.8
Otto, M.J.9
-
25
-
-
84863148442
-
Hepatitis C virus RNA elimination and development of resistance in replicon cells treated with BMS-790052
-
Wang C., Huang H., Valera L., Sun J.-H., O'Boyle D.R., Nower P.T., Jia L., Qiu D., Huang X., Altaf A., Gao M., Fridell R.A. Hepatitis C virus RNA elimination and development of resistance in replicon cells treated with BMS-790052. Antimicrob. Agents Chemother. 2012, 56:1350-1358.
-
(2012)
Antimicrob. Agents Chemother.
, vol.56
, pp. 1350-1358
-
-
Wang, C.1
Huang, H.2
Valera, L.3
Sun, J.-H.4
O'Boyle, D.R.5
Nower, P.T.6
Jia, L.7
Qiu, D.8
Huang, X.9
Altaf, A.10
Gao, M.11
Fridell, R.A.12
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