Angiogenesis and bone regeneration by allogeneic mesenchymal stem cell intravenous transplantation in rabbit model of avascular necrotic femoral head

Journal of Surgical Research

Volumn 183, Issue 1, 2013, Pages 193-203

  Li, Zhanghua ^a   Liao, Wen ^b   Zhao, Qiang ^c   Liu, Ming ^a   Xia, Wei ^c   Yang, Yi ^d   Shao, Ningsheng ^c  

^a RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

^b HEBEI UNIVERSITY   (China)

^c BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

^d WUHAN SPORTS UNIVERSITY   (China)

Author keywords

Avascular necrosis of femoral head (ANFH); Bone marrow mesenchymal stem cells (MSCs); Intravenous transplantation

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; COLLAGEN TYPE 1; COLLAGEN TYPE 3; MESSENGER RNA; OSTEOPONTIN; TRANSCRIPTION FACTOR RUNX2; VASCULOTROPIN;

ALLOGENEIC STEM CELL TRANSPLANTATION; ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AVASCULAR NECROSIS; BONE BIOPSY; BONE RADIOGRAPHY; BONE REGENERATION; BONE REMODELING; BONE STRUCTURE; COLLAGEN SYNTHESIS; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; EXPERIMENTAL RABBIT; FEASIBILITY STUDY; FEMUR HEAD NECROSIS; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; MESENCHYMAL STEM CELL TRANSPLANTATION; NONHUMAN; OSTEOCYTE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; STAINING; WESTERN BLOTTING; WOUND HEALING;

ANIMALS; BONE REGENERATION; COLLAGEN; DISEASE MODELS, ANIMAL; FEMUR HEAD NECROSIS; GENE EXPRESSION; INJECTIONS, INTRAVENOUS; MESENCHYMAL STEM CELL TRANSPLANTATION; NEOVASCULARIZATION, PHYSIOLOGIC; OSTEOCYTES; OSTEOGENESIS; RABBITS; RANDOM ALLOCATION; TRANSPLANTATION, HOMOLOGOUS; WOUND HEALING;

EID: 84879124031     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2012.11.031     Document Type: Article

References (28)

1. C.W. DiGiovanni, A. Patel, and R. Calfee Osteonecrosis in the foot J Am Acad Orthop Surg 15 2007 208
2. P. Juery Avascular necrosis after a steroid injection CMAJ 176 2007 814 author reply 814
3. Y.C. Chao, S.J. Wang, and H.C. Chu Investigation of alcohol metabolizing enzyme genes in Chinese alcoholics with avascular necrosis of hip joint, pancreatitis and cirrhosis of the liver Alcohol Alcohol 38 2003 431
4. C.K. Lee, and H.R. Hansen Post-traumatic avascular necrosis of the humeral head in displaced proximal humeral fractures J Trauma 21 1981 788
5. A. Rajpura, A.C. Wright, and T.N. Board Medical management of osteonecrosis of the hip: a review Hip Int 21 2011 385
6. Z.H. Li, W. Liao, and X.L. Cui Intravenous transplantation of allogeneic bone marrow mesenchymal stem cells and its directional migration to the necrotic femoral head Int J Med Sci 8 2011 74
7. L. Zhang-hua, L. Wen, and C. Xi-long Effects of Cbfa1 on osteoanagenesis during avascular necrosis of femoral head Sci Res Essays 5 2010 2721
8. Y.D. Halvorsen, D. Franklin, and A.L. Bond Extracellular matrix mineralization and osteoblast gene expression by human adipose tissue-derived stromal cells Tissue Eng 7 2001 729
9. M. Kim, and S. Choe BMPs and their clinical potentials BMB Rep 44 2011 619
10. M.W. Stewart The expanding role of vascular endothelial growth factor inhibitors in ophthalmology Mayo Clin Proc 87 2012 77
11. E. Chung, and M.N. Rylander Response of preosteoblasts to thermal stress conditioning and osteoinductive growth factors Cell Stress Chaperones 17 2012 203
12. G.L. Lin, and K.D. Hankenson Integration of BMP, Wnt, and notch signaling pathways in osteoblast differentiation J Cell Biochem 112 2011 3491
13. J.H. Park, B.H. Park, and H.K. Kim Hypoxia decreases Runx2/Cbfa1 expression in human osteoblast-like cells Mol Cell Endocrinol 192 2002 197
14. G.M. Gordillo, and C.K. Sen Revisiting the essential role of oxygen in wound healing Am J Surg 186 2003 259
15. A. Salim, R.P. Nacamuli, and E.F. Morgan Transient changes in oxygen tension inhibit osteogenic differentiation and Runx2 expression in osteoblasts J Biol Chem 279 2004 40007
16. K.T. Suh, S.W. Kim, and H.L. Roh Decreased osteogenic differentiation of mesenchymal stem cells in alcohol-induced osteonecrosis Clin Orthop Relat Res 2005 220
17. B.L. Wang, W. Sun, and Z.C. Shi Decreased proliferation of mesenchymal stem cells in corticosteroid-induced osteonecrosis of femoral head Orthopedics 31 2008 444
18. J.S. Lee, H.L. Roh, and C.H. Kim Alterations in the differentiation ability of mesenchymal stem cells in patients with nontraumatic osteonecrosis of the femoral head: comparative analysis according to the risk factor J Orthop Res 24 2006 604
19. V. Gangji, J.P. Hauzeur, and C. Matos Treatment of osteonecrosis of the femoral head with implantation of autologous bone-marrow cells. A pilot study J Bone Joint Surg Am 86-A 2004 1153
20. W. Zhu, J. Chen, and X. Cong Hypoxia and serum deprivation-induced apoptosis in mesenchymal stem cells Stem Cells 24 2006 416
21. Z.Q. Yan, Y.S. Chen, and W.J. Li Treatment of osteonecrosis of the femoral head by percutaneous decompression and autologous bone marrow mononuclear cell infusion Chin J Traumatol 9 2006 3
22. H.M. Lazarus, S.E. Haynesworth, and S.L. Gerson Ex vivo expansion and subsequent infusion of human bone marrow-derived stromal progenitor cells (mesenchymal progenitor cells): implications for therapeutic use Bone Marrow Transplant 16 1995 557
23. K. Le Blanc, I. Rasmusson, and C. Götherström Mesenchymal stem cells inhibit the expression of CD25 (interleukin-2 receptor) and CD38 on phytohaemagglutin inactivated lymphocytes Scand J Immunol 60 2004 307
24. V. Gangji, and J.P. Hauzeur Treatment of osteonecrosis of the femoral head with implantation of autologous bone-marrow cells. Surgical technique J Bone Joint Surg Am 87 Suppl 1 2005 106
25. I. Müller, M. Vaegler, and C. Holzwarth Secretion of angiogenic proteins by human multipotent mesenchymal stromal cells and their clinical potential in the treatment of avascular osteonecrosis Leukemia 22 2008 2054
26. N. Noiseux, M. Gnecchi, and M. Lopez-Ilasaca Mesenchymal stem cells overexpressing Akt dramatically repair infarcted myocardium and improve cardiac function despite infrequent cellular fusion or differentiation Mol Ther 14 2006 840
27. T.T. Tang, B. Lu, and B. Yue Treatment of osteonecrosis of the femoral head with hBMP-2-gene-modified tissue-engineered bone in goats J Bone Joint Surg Br 89 2007 127
28. S.C. Hung, R.R. Pochampally, and S.C. Chen Angiogenic effects of human multipotent stromal cell conditioned medium activate the PI3K-Akt pathway in hypoxic endothelial cells to inhibit apoptosis, increase survival, and stimulate angiogenesis Stem Cells 25 2007 2363