The CD4/CD8 ratio as a marker T-cell activation, senescence and activation/exhaustion in treated HIV-infected children and young adults

AIDS

Volumn 27, Issue 9, 2013, Pages 1513-1516

  Sainz, Talía ^a   Serrano Villar, Sergio ^b   Díaz, Laura ^a   Tome, María Isabel Gonzalez ^c   Gurbindo, María Dolores ^a   De José, María Isabel ^d   Mellado, María José ^d   Ramos, José T ^e   Zamora, Javier ^b   Moreno, Santiago ^b   Muñoz Fernández, María Angeles ^a  

^a HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^b HOSPITAL RAMÓN Y CAJAL   (Spain)

^c HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^d HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^e HOSPITAL UNIVERSITARIO DE GETAFE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN;

ARTICLE; CD4 CD8 RATIO; CD4+ T LYMPHOCYTE; DISEASE COURSE; EXHAUSTION; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; IMMUNOREACTIVITY; IMMUNOSTIMULATION; MEMORY; PATIENT IDENTIFICATION; PHENOTYPE; PRIORITY JOURNAL; SENESCENCE; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ADOLESCENT; AGING; ANTI-HIV AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; BIOLOGICAL MARKERS; CD4-CD8 RATIO; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL AGING; CHILD; HIV INFECTIONS; HUMANS; INFECTIOUS DISEASE TRANSMISSION, VERTICAL; LYMPHOCYTE ACTIVATION; REGRESSION ANALYSIS; VIRAL LOAD; YOUNG ADULT;

EID: 84879119636     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0b013e32835faa72     Document Type: Article

References (21)

1. Deeks SG, Phillips AN. HIV infection, antiretroviral treatment, ageing, and non-AIDS related morbidity. BMJ 2009; 338:a3172.
2. Hadrup SR, Strindhall J, Kollgaard T, Seremet T, Johansson B, Pawelec G, et al. Longitudinal studies of clonally expanded CD8 T-cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional cytomegalovirus-specific T-cells in the very elderly. J Immunol 2006; 176:2645-2653.
3. Wikby A, Johansson B, Ferguson F, Olsson J. Age-related changes in immune parameters in a very old population of Swedish people: a longitudinal study. Exp Gerontol 1994; 29:531-541.
4. Wikby A, Maxson P, Olsson J, Johansson B, Ferguson FG. Changes in CD8 and CD4 lymphocyte subsets, T-cell proliferation responses and nonsurvival in the very old: the Swedish longitudinal OCTO-immune study. Mech Ageing Dev 1998; 102:187-198.
5. Wikby A, Ferguson F, Forsey R, Thompson J, Strindhall J, Lofgren S, et al. An immune risk phenotype, cognitive impairment, and survival in very late life: impact of allostatic load in Swedish octogenarian and nonagenarian humans. J Gerontol A Biol Sci Med Sci 2005; 60:556-565.
6. Ferguson FG, Wikby A, Maxson P, Olsson J, Johansson B. Immune parameters in a longitudinal study of a very old population of Swedish people: a comparison between survivors and nonsurvivors. J Gerontol A Biol Sci Med Sci 1995; 50:B378-B382.
7. Ferrando-Martinez S, Romero-Sanchez MC, Solana R, Delgado J, de la Rosa R, Munoz-Fernandez MA, et al. Thymic function failure and C-reactive protein levels are independent predictors of all-cause mortality in healthy elderly humans. Age (Dordr) 2013; 35:251-259.
8. Appay V, Sauce D. Immunoactivation and inflammation in HIV-1 infection: causes and consequences. J Pathol 2008; 214:231-241.
9. Hsue PY, Deeks SG, Hunt PW. Immunologic basis of cardiovascular disease in HIV-infected adults. J Infect Dis 2012; 205 (Suppl 3):S375-S382.
10. Li T, Wu N, Dai Y, Qiu Z, Han Y, Xie J, et al. Reduced thymic output is a major mechanism of immune reconstitution failure in HIV-infected patients after long-term antiretroviral therapy. Clin Infect Dis 2011; 53:944-951.
11. Hong MS, Dan JM, Choi JY, Kang I. Age-associated changes in the frequency of naive, memory and effector CD8+ T-cells. Mech Ageing Dev 2004; 125:615-618.
12. Roederer M, Dubs JG, Anderson MT, Raju PA, Herzenberg LA, Herzenberg LA. CD8 naive T-cell counts decrease progressively in HIV-infected adults. J Clin Invest 1995; 95:2061-2066.
13. Wikby A, Mansson IA, Johansson B, Strindhall J, Nilsson SE. The immune risk profile is associated with age and gender: findings from three Swedish population studies of individuals 20-100 years of age. Biogerontology 2008; 9:299-308.
14. Denny T, Yogev R, Gelman R, Skuza C, Oleske J, Chadwick E, et al. Lymphocyte subsets in healthy children during the first 5 years of life. JAMA 1992; 267:1484-1488.
15. Taylor JM, Fahey JL, Detels R, Giorgi JV. CD4 percentage, CD4 number, and CD4:CD8 ratio in HIV infection: which to choose and how to use. J Acquir Immune Defic Syndr 1989; 2:114-124.
16. Lo J, Abbara S, Shturman L, Soni A, Wei J, Rocha-Filho JA, et al. Increased prevalence of subclinical coronary atherosclerosis detected by coronary computed tomography angiography in HIV-infected men. AIDS 2010; 24:243-253.
17. Serrano-Villar S, Gutiérrez C, Vallejo A, Hernández-Novoa B, Díaz L, Abad M, et al. The CD4/CD8 ratio in HIV-infected subjects is independently associated with T-cell activation despite long-term viral suppression. J Infect 2013; 66:57-66.
18. Hsue PY, Hunt PW, Schnell A, Kalapus SC, Hoh R, Ganz P, et al. Role of viral replication, antiretroviral therapy, and immunodeficiency in HIV-associated atherosclerosis. AIDS 2009; 23:1059-1067.
19. Kaplan RC, Sinclair E, Landay AL, Lurain N, Sharrett AR, Gange SJ, et al. T-cell activation and senescence predict subclinical carotid artery disease in HIV-infected women. J Infect Dis 2011; 203:452-463.
20. Sainz T, Diaz L, Álvarez M, Navarro ML, González- Tomé MI, de José MI, et al. Increased subclinical atherosclerosis and immunoactivation in HIVR children and adolescents: the Caro VIH study. [Abstract #971.] 19th Conference on Retroviruses and Opportunistic Infections Seattle, WA, 2012.
21. Serrano-Villar S, Moreno S, Fuentes-Ferrer M, Sánchez-Marcos C, Avila M, GP de Villar N et al. The CD4/CD8 ratio as a predictor of accelerated aging in virally suppressed HIV-infected patients with immunological recovery. [Abstract P-030.]. IV Congreso Nacional de GESIDA, Toledo (Spain), 2012. Formación en Investigacion Río Hortega) Espana