Platelet size for distinguishing between inherited thrombocytopenias and immune thrombocytopenia: A multicentric, real life study

British Journal of Haematology

Volumn 162, Issue 1, 2013, Pages 112-119

  Noris, Patrizia ^a   Klersy, Catherine ^a   Gresele, Paolo ^b   Giona, Fiorina ^c   Giordano, Paola ^d   Minuz, Pietro ^e   Loffredo, Giuseppe ^f   Pecci, Alessandro ^a   Melazzini, Federica ^a   Civaschi, Elisa ^a   Mezzasoma, Annamaria ^b   Piedimonte, Monica ^c   Semeraro, Fabrizio ^d   Veneri, Dino ^e   Menna, Francesco ^f   Ciardelli, Laura ^a   Balduini, Carlo L ^a  

^a FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

^b UNIVERSITY OF PERUGIA   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d UNIVERSITY OF BARI   (Italy)

^e UNIVERSITY HOSPITAL OF VERONA   (Italy)

^f SANTOBONO PAUSILIPON CHILDREN S HOSPITAL   (Italy)

Author keywords

Immune thrombocytopenia; Inherited thrombocytopenias; Platelet diameter; Platelet size; Platelet volume

Indexed keywords

ADOLESCENT; ADULT; AGED; ALLELE; ARTICLE; BERNARD SOULIER DISEASE; CELL SIZE; CHILD; CLINICAL EFFECTIVENESS; CLINICAL EVALUATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; FEMALE; GENE MUTATION; GENETIC DISORDER; HUMAN; IMMUNE THROMBOCYTOPENIA; INHERITED THROMBOCYTOPENIA; MAJOR CLINICAL STUDY; MALE; MICROSCOPY; MULTICENTER STUDY; PREDICTIVE VALUE; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SENSITIVITY AND SPECIFICITY; THROMBOCYTE COUNT; THROMBOCYTE VOLUME; THROMBOCYTOPENIA;

ADOLESCENT; ADULT; AGED; BLOOD PLATELETS; CELL SIZE; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; MALE; MIDDLE AGED; PLATELET COUNT; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; REFERENCE VALUES; SENSITIVITY AND SPECIFICITY; THROMBOCYTOPENIA; YOUNG ADULT;

EID: 84879114340     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/bjh.12349     Document Type: Article

References (17)

1. Bader-Meunier, B., Proulle, V., Trichet, C., Debray, D., Gabolde, M., Yvart, J. & Dreyfus, M. (2003) Misdiagnosis of chronic thrombocytopenia in childhood. Journal of Pediatric Hematology/Oncology, 25, 548-552.
2. Balduini, C.L. & Savoia, A. (2012) Genetics of familial forms of thrombocytopenia. Human Genetics, 131, 1821-1832.
3. Balduini, C.L., Cattaneo, M., Fabris, F., Gresele, P., Iolascon, A., Pulcinelli, F.M. & Savoia, A. (2003) Inherited thrombocytopenias: a proposed diagnostic algorithm from the Italian Gruppo di Studio delle Piastrine. Haematologica, 88, 582-592.
4. Balduini, C.L., Pecci, A. & Savoia, A. (2011) Recent advances in the understanding and management of MYH9-related inherited thrombocytopenias. British Journal of Haematology, 154, 161-174.
5. England, J.M., Rowan, R.M., Bins, M., Bull, B.S., Coulter, W.H., Groner, W., Jones, A.R., Koepke, J.A., Lewis, S.M., Shinton, N.K., Thom, R., van Assendelft, O.W. & Verwilghen, R.L. (1988) Recommended methods for the visual determination of white cell and platelet counts. http://whqlibdoc.who.int/hq/1988/WHO_LAB_88.3.pdf.
6. Geddis, A.E. & Balduini, C.L. (2007) Diagnosis of immune thrombocytopenic purpura in children. Current Opinion in Hematology, 14, 520-525.
7. Gresele, P., Falcinelli, E., Giannini, S., D'Adamo, P., D'Eustacchio, A., Corazzi, T., Mezzasoma, A.M., Di Bari, F., Guglielmini, G., Cecchetti, L., Noris, P., Balduini, C.L. & Savoia, A. (2009) Dominant inheritance of a novel integrin beta3 mutation associated with a hereditary macrothrombocytopenia and platelet dysfunction in two Italian families. Haematologica, 94, 663-669.
8. Gunay-Aygun, M., Zivony-Elboum, Y., Gumruk, F., Geiger, D., Cetin, M., Khayat, M., Kleta, R., Kfir, N., Anikster, Y., Chezar, J., Arcos-Burgos, M., Shalata, A., Stanescu, H., Manaster, J., Arat, M., Edwards, H., Freiberg, A.S., Hart, P.S., Riney, L.C., Patzel, K., Tanpaiboon, P., Markello, T., Huizing, M., Maric, I., Horne, M., Kehrel, B.E., Jurk, K., Hansen, N.F., Cherukuri, P.F., Jones, M., Cruz, P., Mullikin, J.C., Nurden, A., White, J.G., Gahl, W.A. & Falik-Zaccai, T. (2010) Gray platelet syndrome: natural history of a large patient cohort and locus assignment to chromosome 3p. Blood, 116, 4990-5001.
9. Kunishima, S., Yamada, T., Hamaguchi, M. & Saito, H. (2006) Bernard-Soulier syndrome due to GPIX W127X mutation in Japan is frequently misdiagnosed as idiopathic thrombocytopenic purpura. International Journal of Hematotology, 83, 366-367.
10. Latger-Cannard, V., Hoarau, M., Salignac, S., Baumgart, D., Nurden, P. & Lecompte, T. (2012) Mean platelet volume: comparison of three analysers towards standardization of platelet morphological phenotype. International Journal of Laboratory Hematology, 34, 300-310.
11. Milton, J.G., Hutton, R.A., Tuddenham, E.G. & Frojmovic, M.M. (1985) Platelet size and shape in hereditary giant platelet syndromes on blood smear and in suspension: evidence for two types of abnormalities. Journal of Laboratory and Clinical Medicine, 106, 326-335.
12. Noris, P., Pecci, A., Di Bari, F., Di Stazio, M.T., Di Pumpo, M., Ceresa, I.F., Arezzi, N., Ambaglio, C., Savoia, A. & Balduini, C.L. (2004) Application of a diagnostic algorithm for inherited thrombocytopenias to 46 consecutive patients. Haematologica, 89, 1219-1225.
13. Noris, P., Klersy, C., Zecca, M., Arcaini, L., Pecci, A., Melazzini, F., Terulla, V., Bozzi, V., Ambaglio, C., Passamonti, F., Locatelli, F. & Balduini, C.L. (2009) Platelet size distinguishes between inherited macrothrombocytopenias and immune thrombocytopenia. Journal of Thrombosis and Haemostasis, 7, 2131-2136.
14. Noris, P., Perrotta, S., Seri, M., Pecci, A., Gnan, C., Loffredo, G., Pujol-Moix, N., Zecca, M., Scognamiglio, F., De Rocco, D., Punzo, F., Melazzini, F., Scianguetta, S., Casale, M., Marconi, C., Pippucci, T., Amendola, G., Notarangelo, L.D., Klersy, C., Civaschi, E., Balduini, C.L. & Savoia, A. (2011) Mutations in ANKRD26 are responsible for a frequent form of inherited thrombocytopenia: analysis of 78 patients from 21 families. Blood, 117, 6673-6680.
15. Noris, P., Perrotta, S., Bottega, R., Pecci, A., Melazzini, F., Civaschi, E., Russo, S., Magrin, S., Loffredo, G., Di Salvo, V., Russo, G., Casale, M., De Rocco, D., Grignani, C., Cattaneo, M., Baronci, C., Dragani, A., Albano, V., Jankovic, M., Scianguetta, S., Savoia, A. & Balduini, C.L. (2012) Clinical and laboratory features of 103 patients from 42 Italian families with inherited thrombocytopenia derived from the monoallelic Ala156Val mutation of GPIbα (Bolzano mutation). Haematologica, 97, 82-88.
16. Provan, D., Stasi, R., Newland, A.C., Blanchette, V.S., Bolton-Maggs, P., Bussel, J.B., Chong, B.H., Cines, D.B., Gernsheimer, T.B., Godeau, B., Grainger, J., Greer, I., Hunt, B.J., Imbach, P.A., Lyons, G., McMillan, R., Rodeghiero, F., Sanz, M.A., Tarantino, M., Watson, S., Young, J. & Kuter, D.J. (2010) International consensus report on the investigation and management of primary immune thrombocytopenia. Blood, 115, 168-186.
17. Savoia, A., Pastore, A., De Rocco, D., Civaschi, E., Di Stazio, M., Bottega, R., Melazzini, F., Bozzi, V., Pecci, A., Magrin, S., Balduini, C.L. & Noris, P. (2011) Clinical and genetic aspects of Bernard-Soulier syndrome: searching for genotype/phenotype correlations. Haematologica, 96, 417-423.