Management of initial bleeding or spotting after levonorgestrel-releasing intrauterine system placement: A Randomized Controlled Trial

Obstetrics and Gynecology

Volumn 121, Issue 5, 2013, Pages 934-941

  Sørdal, Terje ^a   Inki, Pirjo ^b   Draeby, John ^b   O'Flynn, Mary ^b   Schmelter, Thomas ^b  

^a Medicus   (Norway)

^b not available

Author keywords

[No Author keywords available]

Indexed keywords

LEVONORGESTREL; MEFENAMIC ACID; PLACEBO; TRANEXAMIC ACID;

ABDOMINAL DISTENSION; ABDOMINAL PAIN; ADULT; ARTICLE; BREAST TENDERNESS; CONNECTIVE TISSUE DISEASE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DYSMENORRHEA; ENDOMETRITIS; FATIGUE; FEMALE; HEADACHE; HUMAN; INFLUENZA; INTRAUTERINE CONTRACEPTIVE DEVICE; MAJOR CLINICAL STUDY; MENTAL DISEASE; MUSCULOSKELETAL DISEASE; NAUSEA; PATIENT SATISFACTION; PELVIS PAIN SYNDROME; PHASE 4 CLINICAL TRIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; SKIN DISEASE; SOFT TISSUE DISEASE; SPOTTING; SUBCUTANEOUS TISSUE DISORDER; UTERUS BLEEDING; VAGINA BLEEDING;

EID: 84879113824     PISSN: 00297844     EISSN: 1873233X     Source Type: Journal    
DOI: 10.1097/AOG.0b013e31828c65d8     Document Type: Article

References (11)

1. Suvisaari J, Lähteenmäki P. Detailed analysis of menstrual bleeding patterns after postmenstrual and postabortal insertion of a copper IUD or a levonorgestrel-releasing intrauterine system. Contraception 1996; 54: 201-8.
2. Warner P, Guttinger A, Glasier AF, Lee RJ, Nickerson S, Brenner RM, et al. Randomized placebo-controlled trial of CDB-2914 in new users of a levonorgestrel-releasing intrauterine system shows only short-lived amelioration of unscheduled bleeding. Hum Reprod 2010; 25: 345-53.
3. Lal S, Kriplani A, Kulshrestha V, Sharma M, Agarwal N. Efficacy of mifepristone in reducing intermenstrual vaginal bleeding in users of the levonorgestrel intrauterine system. Int J Gynaecol Obstet 2010; 109: 128-30.
4. National Institute for Health and Clinical Excellence. Heavy menstrual bleeding (NICE clinical guideline 44). London (UK): National Institute for Health and Clinical Excellence; 2007.
5. Senthong AJ, Taneepanichskul S. The effect of tranexamic acid for treatment irregular uterine bleeding secondary to DMPA use. J Med Assoc Thai 2009; 92: 461-5.
6. Phupong V, Sophonsritsuk A, Taneepanichskul S. The effect of tranexamic acid for treatment of irregular uterine bleeding secondary to Norplant use. Contraception 2006; 73: 253-6.
7. Lethaby A, Augood C, Duckitt K, Farquhar C. Nonsteroidal anti-inflammatory drugs for heavy menstrual bleeding. The Cochrane Database of Systematic Reviews 2007, Issue 4. Art. No: CD000400. DOI: 10.1002/14651858. CD000400.pub2.
8. Grimes DA, Hubacher D, Lopez LM, Schulz KF. Non-steroidal anti-inflammatory drugs for heavy bleeding or pain associated with intrauterine-device use. The Cochrane Database of Systematic Reviews 2011, Issue 10. Art. No.: CD006034. DOI: 10.1002/14651858.CD006034.pub2.
9. Madden T, Proehl S, Allsworth JE, Secura GM, Peipert JF. Naproxen or estradiol for bleeding and spotting with the levonorgestrel intrauterine system: a randomized controlled trial. Am J Obstet Gynecol 2012; 206: 129.e1-8.
10. Belsey EM, Machin D, d'Arcangues C. The analysis of vaginal bleeding patterns induced by fertility regulating methods. World Health Organization Special Programme of Research, Development and Research Training in Human Reproduction. Contraception 1986; 34: 253-60.
11. Gemzell-Danielsson K, Schellschmidt I, Apter D. A randomized, phase II study describing the efficacy, bleeding profile, and safety of two low-dose levonorgestrel-releasing intrauterine contraceptive systems and Mirena. Fertil Steril 2012; 97: 616-22.e1-3.