Scleromyxedema: A multicenter study of characteristics, comorbidities, course, and therapy in 30 patients

Journal of the American Academy of Dermatology

Volumn 69, Issue 1, 2013, Pages 66-72

  Rongioletti, Franco ^a   Merlo, Giulia ^a   Cinotti, Elisa ^a   Fausti, Valentina ^a   Cozzani, Emanuele ^a   Cribier, Bernard ^b   Metze, Dieter ^c   Calonje, Eduardo ^d   Kanitakis, Jean ^e   Kempf, Werner ^f   Stefanato, Catherine M ^d   Marinho, Eduardo ^g   Parodi, Aurora ^a  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITÉ DE STRASBOURG   (France)

^c UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^d ST THOMAS HOSPITAL   (United Kingdom)

^e EDOUARD HERRIOT HOSPITAL   (France)

^f UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^g Anatomie et Cytologie Pathologiques   (France)

Author keywords

dermatoneuro syndrome; intravenous immunoglobulin; monoclonal gammopathy; mucinoses; scleromyxedema

Indexed keywords

ALPHA2B INTERFERON; AZATHIOPRINE; CHLOROQUINE; CORTICOSTEROID; CYCLOPHOSPHAMIDE; CYCLOSPORIN; ETRETIN; ETRETINATE; HYDROXYCHLOROQUINE; IMMUNOGLOBULIN; ISOTRETINOIN; LENALIDOMIDE; MELPHALAN; METHOTREXATE; METHYLPREDNISOLONE; MUCIN; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISOLONE; PREDNISONE; STEROID; THALIDOMIDE;

ADULT; AGED; ALZHEIMER DISEASE; ARTHRALGIA; ARTHRITIS; ARTICLE; CARDIOMYOPATHY; CARPAL TUNNEL SYNDROME; CLINICAL ARTICLE; COMA; COMORBIDITY; CONGESTIVE CARDIOMYOPATHY; DEMOGRAPHY; DISEASE COURSE; DISEASE SEVERITY; DRUG MEGADOSE; DRUG WITHDRAWAL; ESOPHAGUS FUNCTION DISORDER; FEMALE; FIBROMYALGIA; FOLLOW UP; HEART FAILURE; HEART MUSCLE ISCHEMIA; HEMATOLOGIC MALIGNANCY; HODGKIN DISEASE; HUMAN; HUMAN TISSUE; LUNG FIBROSIS; MALE; MEDICAL RECORD REVIEW; MONOCLONAL IMMUNOGLOBULINEMIA; MOTOR NEUROPATHY; MULTIPLE CYCLE TREATMENT; MYELODYSPLASTIC SYNDROME; MYELOID LEUKEMIA; MYOSITIS; NEURODERMATITIS; OUTCOME ASSESSMENT; PHOTOTHERAPY; PRIORITY JOURNAL; PROSPECTIVE STUDY; PUVA; RAYNAUD PHENOMENON; REMISSION; RETINA MACULA EDEMA; RETROSPECTIVE STUDY; SCLEROMYXEDEMA; SENSORIMOTOR NEUROPATHY; SENSORY NEUROPATHY; SJOEGREN SYNDROME; SKIN MANIFESTATION; STEROID THERAPY; SYSTEMIC THERAPY; TREATMENT DURATION; TREATMENT RESPONSE; UNSPECIFIED SIDE EFFECT;

COMORBIDITY; FEMALE; GLUCOCORTICOIDS; HUMANS; IMMUNOGLOBULINS, INTRAVENOUS; IMMUNOLOGIC FACTORS; MALE; MIDDLE AGED; PARAPROTEINEMIAS; PROGNOSIS; PROSPECTIVE STUDIES; REMISSION INDUCTION; SCLEROMYXEDEMA; STREPTONIGRIN; TREATMENT OUTCOME;

EID: 84879105839     PISSN: 01909622     EISSN: 10976787     Source Type: Journal    
DOI: 10.1016/j.jaad.2013.01.007     Document Type: Article

References (28)

1. F. Rongioletti, and A. Rebora Updated classification of papular mucinosis, lichen myxedematosus, and scleromyxedema J Am Acad Dermatol 44 2001 273 281
2. F. Rongioletti, and A. Rebora Mucinoses J. Bolognia, J.L. Jorizzo, J.V. Schaffer, Dermatology 3rd ed. 2012 Elsevier Saunders Philadelphia, PA 687 698
3. A.M. Dinneen, and C.H. Dicken Scleromyxedema J Am Acad Dermatol 33 1995 37 43
4. M. Blum, F.M. Wigley, and L.K. Hummers Scleromyxedema: a case series highlighting long-term outcomes of treatment with intravenous immunoglobulin (IVIG) Medicine (Baltimore) 87 2008 10 20
5. M. Le Moigne, J. Mazereeuw-Hautier, J.M. Bonnetblanc, L. Astudillo, M. D'Incan, and D. Bessis Clinical characteristics, outcome of scleromyxedema: a retrospective multicenter study [in French] Ann Dermatol Venereol 137 2010 782 788
6. F. Rongioletti, E. Cozzani, and A. Parodi Scleromyxedema with an interstitial granulomatous-like pattern: a rare histologic variant mimicking granuloma annulare J Cutan Pathol 37 2010 1084 1087
7. P. Gholam, M. Hartmann, and A. Enk Arndt-Gottron scleromyxedema: successful therapy with intravenous immunoglobulins Br J Dermatol 157 2007 1058 1060
8. M.P. Binitha, G. Nandakumar, and D. Thomas Suspected cardiac toxicity to intravenous immunoglobulin used for treatment of scleromyxedema Indian J Dermatol Venereol Leprol 74 2008 248 250
9. A. Samuelsson, T.L. Towers, and J.V. Ravetch Anti-inflammatory activity of IVIG mediated through the inhibitory Fc receptor Science 291 2001 484 486
10. Y.C. Lin, H.C. Wang, and J.L. Shen Scleromyxedema: an experience using treatment with systemic corticosteroid and review of the published work J Dermatol 33 2006 207 210
11. J. Cañueto, J. Labrador, C. Román, A. Santos-Briz, T. Contreras, and N.C. Gutiérrez The combination of bortezomib and dexamethasone is an efficient therapy for relapsed/refractory scleromyxedema: a rare disease with new clinical insights Eur J Haematol 88 2012 450 454
12. A. Kreuter, and P. Altmeyer High-dose dexamethasone in scleromyxedema: report of 2 additional cases J Am Acad Dermatol 53 2005 739 740
13. J.C. Sansbury, B. Cocuroccia, B.L. Jorizzo, E. Gubinelli, P. Gisondi, and G. Girolomoni Treatment of recalcitrant scleromyxedema with thalidomide in 3 patients J Am Acad Dermatol 51 2004 126 131
14. M.L. Donato, A.M. Feasel, D.M. Weber, V.G. Prieto, S.A. Giralt, and R.E. Champlin Scleromyxedema: role of high-dose melphalan with autologous stem cell transplantation Blood 107 2006 463 466
15. K.E. Fleming, D. Virmani, E. Sutton, R. Langley, J. Corbin, and S. Pasternak Scleromyxedema and the dermato-neuro syndrome: case report and review of the literature J Cutan Pathol 39 2012 508 517
16. F. Rongioletti, A. Hazini, and A. Rebora Coma associated with scleromyxedema and interferon alfa therapy: full recovery after steroids and cyclophosphamide combined with plasmapheresis Br J Dermatol 144 2001 1283 1284
17. N.M. Fett, M.B. Toporcer, J. Dalmau, M.M. Shinohara, and D.T. Vogl Scleromyxedema and dermato-neuro syndrome in a patient with multiple myeloma effectively treated with dexamethasone and bortezomib Am J Hematol 86 2011 893 896
18. J.B. Rey, and R.B. Luria Treatment of scleromyxedema and the dermatoneuro syndrome with intravenous immunoglobulin J Am Acad Dermatol 60 2009 1037 1041
19. J. Gonzalez, M. Palangio, J. Schwartz, A.S. Klainer, and E. Bisaccia Scleromyxedema with dermato-neuro syndrome J Am Acad Dermatol 42 2000 927 928
20. A. Godby, P.R. Bergstresser, B. Chaker, and A.G. Pandya Fatal scleromyxedema: report of a case and review of the literature J Am Acad Dermatol 38 1998 289
21. C. De Simone, M. Castriota, A. Carbone, P. Marini Bettolo, M. Pieroni, and F. Rongioletti Cardiomyopathy in scleromyxedema: report of a fatal case Eur J Dermatol 20 2010 852 853
22. B. Loggini, R. Pingitore, A. Avvenente, G. Giuliano, and P. Barachini Lichen myxedematosus with systemic involvement: clinical and autopsy findings J Am Acad Dermatol 45 2001 606 608
23. R. Giménez Garcia, S.G. Garcia, D. Suarez Vilela, and M.J. Moro Sanchez Scleromyxedema associated with non-Hodgkin lymphoma Int J Dermatol 28 1989 670 671
24. C.D. Cokonis Georgakis, G. Falasca, A. Georgakis, and W.R. Heymann Scleromyxedema Clin Dermatol 24 2006 493 497
25. R. Harper, and J. Rispler Lichen myxedematosus serum stimulates human skin fibroblast proliferation Science 199 1978 545 547
26. F. Rongioletti, G. Cattarini, E. Sottofattori, and A. Rebora Granulomatous reaction after intradermal injections of hyaluronic acid gel Arch Dermatol 139 2003 815 816
27. J. Alijotas-Reig, V. Garcia-Gimenez, E. Llurba, and M. Vilardell-Tarrés Autoimmune/inflammatory syndrome (ASIA) induced by biomaterials injection other than silicone medical grade Lupus 21 2012 1326 1334
28. R.A. Hardie, J.A. Hunter, S. Urbaniak, and J.A. Habeshaw Spontaneous resolution of lichen myxedematosus Br J Dermatol 100 1979 727 730