Expression of RACGAP1 in high grade meningiomas: A potential role in cancer progression

Journal of Neuro-Oncology

Volumn 113, Issue 2, 2013, Pages 327-332

  Ke, Hong Lin ^a   Ke, Rong Hu ^a   Li, Shi Ting ^a   Li, Bin ^a   Lu, Hai Tao ^a   Wang, Xiao Qiang ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Meningioma; MIB 1; Prognosis; qRT PCR; RACGAP1; Western blot

Indexed keywords

GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; KI 67 ANTIGEN; MESSENGER RNA; RAC GTPASE ACTIVATING PROTEIN 1; RACGAP1; UNCLASSIFIED DRUG; MGCRACGAP; TUMOR MARKER;

ADULT; ARTICLE; CANCER GRADING; CANCER PATIENT; CANCER SURVIVAL; CLINICAL ARTICLE; CLINICAL FEATURE; DISEASE COURSE; FEMALE; HISTOPATHOLOGY; HUMAN; KAPLAN MEIER METHOD; LABELING INDEX; MALE; MENINGIOMA; PROGNOSIS; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; TUMOR CLASSIFICATION; TUMOR GROWTH; TUMOR VOLUME; WESTERN BLOTTING; AGED; ENZYME IMMUNOASSAY; FOLLOW UP; GENETICS; METABOLISM; MIDDLE AGED; MORTALITY; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SURVIVAL RATE; TUMOR RECURRENCE;

ADULT; AGED; BLOTTING, WESTERN; DISEASE PROGRESSION; FEMALE; FOLLOW-UP STUDIES; GTPASE-ACTIVATING PROTEINS; HUMANS; IMMUNOENZYME TECHNIQUES; MALE; MENINGEAL NEOPLASMS; MENINGIOMA; MIDDLE AGED; NEOPLASM GRADING; NEOPLASM RECURRENCE, LOCAL; PROGNOSIS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SURVIVAL RATE; TUMOR MARKERS, BIOLOGICAL;

EID: 84879088878     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/s11060-013-1121-7     Document Type: Article

References (25)

1. Perry A, Gutmann DH, Reifenberger G (2004) Molecular pathogenesis of meningiomas. J Neurooncol 70:183-202. doi: 10.1007/s11060-004-2749-0
2. Adegbite AB, Khan MI, Paine KW, Tan LK (1983) The recurrence of intracranial meningiomas after surgical treatment. J Neurosurg 58:51-56. doi: 10.3171/jns.1983.58.1.0051
3. Jaaskelainen J, Haltia M, Laasonen E, Wahlstrom T, Valtonen S (1985) The growth rate of intracranial meningiomas and its relation to histology. An analysis of 43 patients. Surg Neurol 24:165-172
4. Maier H, Ofner D, Hittmair A, Kitz K, Budka H (1992) Classic, atypical, and anaplastic meningioma: three histopathological subtypes of clinical relevance. J Neurosurg 77:616-623. doi: 10.3171/jns.1992.77.4.0616
5. Perry A, Scheithauer BW, Stafford SL, Lohse CM, Wollan PC (1999) "Malignancy" in meningiomas: a clinicopathologic study of 116 patients, with grading implications. Cancer 85:2046-2056. doi: 10.1002/(SICI)1097-0142(19990501)85:9<2046:AID-CNCR23>3.0.CO;2-M
6. Jantsch-Plunger V, Gonczy P, Romano A, Schnabel H, Hamill D, Schnabel R, Hyman AA, Glotzer M (2000) CYK-4: A Rho family gtpase activating protein (GAP) required for central spindle formation and cytokinesis. J Cell Biol 149:1391-1404
7. Toure A, Dorseuil O, Morin L, Timmons P, Jegou B, Reibel L, Gacon G (1998) MgcRacGAP, a new human GTPase-activating protein for Rac and Cdc42 similar to Drosophila rotundRacGAP gene product, is expressed in male germ cells. J Biol Chem 273:6019-6023
8. Kamijo K, Ohara N, Abe M, Uchimura T, Hosoya H, Lee JS, Miki T (2006) Dissecting the role of Rho-mediated signaling in contractile ring formation. Mol Biol Cell 17:43-55. doi: 10.1091/mbc.E05-06-0569
9. Niiya F, Xie X, Lee KS, Inoue H, Miki T (2005) Inhibition of cyclin-dependent kinase 1 induces cytokinesis without chromosome segregation in an ECT2 and MgcRacGAP-dependent manner. J Biol Chem 280:36502-36509. doi: 10.1074/jbc.M508007200
10. Yamada T, Hikida M, Kurosaki T (2006) Regulation of cytokinesis by mgcRacGAP in B lymphocytes is independent of GAP activity. Exp Cell Res 312:3517-3525. doi: 10.1016/j.yexcr.2006.07.026
11. Kawashima T, Hirose K, Satoh T, Kaneko A, Ikeda Y, Kaziro Y, Nosaka T, Kitamura T (2000) MgcRacGAP is involved in the control of growth and differentiation of hematopoietic cells. Blood 96:2116-2124
12. Hirose K, Kawashima T, Iwamoto I, Nosaka T, Kitamura T (2001) MgcRacGAP is involved in cytokinesis through associating with mitotic spindle and midbody. J Biol Chem 276:5821-5828. doi: 10.1074/jbc.M007252200
13. Tonozuka Y, Minoshima Y, Bao YC, Moon Y, Tsubono Y, Hatori T, Nakajima H, Nosaka T, Kawashima T, Kitamura T (2004) A GTPase-activating protein binds STAT3 and is required for IL-6-induced STAT3 activation and for differentiation of a leukemic cell line. Blood 104:3550-3557. doi: 10.1182/blood-2004-03-1066
14. Wang SM, Ooi LL, Hui KM (2011) Upregulation of Rac GTPase-activating protein 1 is significantly associated with the early recurrence of human hepatocellular carcinoma. Clin Cancer Res 17:6040-6051. doi: 10.1158/1078-0432.CCR-11-0557
15. Perry A, Stafford SL, Scheithauer BW, Suman VJ, Lohse CM (1997) Meningioma grading: an analysis of histologic parameters. Am J Surg Pathol 21:1455-1465
16. Zorludemir S, Scheithauer BW, Hirose T, Van Houten C, Miller G, Meyer FB (1995) Clear cell meningioma. A clinicopathologic study of a potentially aggressive variant of meningioma. Am J Surg Pathol 19:493-505
17. Jain D, Sharma MC, Sarkar C, Suri V, Garg A, Singh M, Sharma BS, Mahapatra AK (2007) Clear cell meningioma, an uncommon variant of meningioma: a clinicopathologic study of nine cases. J Neurooncol 81:315-321. doi: 10.1007/s11060-006-9237-7
18. Wang XQ, Jiang CC, Zhao L, Gong Y, Hu J, Chen H (2012) Clinical features and treatment of World Health Organization grade II and III meningiomas in childhood: report of 23 cases. J Neurosurg Pediatr 10:423-433. doi: 10.3171/2012.7.PEDS12179
19. Lee JS, Kamijo K, Ohara N, Kitamura T, Miki T (2004) MgcRacGAP regulates cortical activity through RhoA during cytokinesis. Exp Cell Res 293:275-282
20. Zhao WM, Fang G (2005) MgcRacGAP controls the assembly of the contractile ring and the initiation of cytokinesis. Proc Natl Acad Sci USA 102:13158-13163. doi: 10.1073/pnas.0504145102
21. Lu KH, Patterson AP, Wang L, Marquez RT, Atkinson EN, Baggerly KA, Ramoth LR, Rosen DG, Liu J, Hellstrom I, Smith D, Hartmann L, Fishman D, Berchuck A, Schmandt R, Whitaker R, Gershenson DM, Mills GB, Bast RC Jr (2004) Selection of potential markers for epithelial ovarian cancer with gene expression arrays and recursive descent partition analysis. Clin Cancer Res 10:3291-3300. doi: 10.1158/1078-0432.CCR-03-0409
22. Rosty C, Sheffer M, Tsafrir D, Stransky N, Tsafrir I, Peter M, de Cremoux P, de La Rochefordiere A, Salmon R, Dorval T, Thiery JP, Couturier J, Radvanyi F, Domany E, Sastre-Garau X (2005) Identification of a proliferation gene cluster associated with HPV E6/E7 expression level and viral DNA load in invasive cervical carcinoma. Oncogene 24:7094-7104. doi: 10.1038/sj.onc.1208854
23. Ma XJ, Salunga R, Tuggle JT, Gaudet J, Enright E, McQuary P, Payette T, Pistone M, Stecker K, Zhang BM, Zhou YX, Varnholt H, Smith B, Gadd M, Chatfield E, Kessler J, Baer TM, Erlander MG, Sgroi DC (2003) Gene expression profiles of human breast cancer progression. Proc Natl Acad Sci USA 100:5974-5979. doi: 10.1073/pnas.0931261100
24. Yuce O, Piekny A, Glotzer M (2005) An ECT2-centralspindlin complex regulates the localization and function of RhoA. J Cell Biol 170:571-582. doi: 10.1083/jcb.200501097
25. Grewal S, Carver JG, Ridley AJ, Mardon HJ (2008) Implantation of the human embryo requires Rac1-dependent endometrial stromal cell migration. Proc Natl Acad Sci USA 105:16189-16194. doi: 10.1073/pnas.0806219105