Field effectiveness of combination antiretroviral prophylaxis for the prevention of mother-to-child HIV transmission in rural Zambia

AIDS

Volumn 27, Issue 8, 2013, Pages 1253-1262

  Gartland, Matthew G ^a,b   Chintu, Namwinga T ^b   Li, Michelle S ^b   Lembalemba, Mwila K ^c   Mulenga, Saziso N ^b   Bweupe, Maximillian ^c   Musonda, Patrick ^b,d   Stringer, Elizabeth M ^b,e   Stringer, Jeffrey S A ^b,e   Chi, Benjamin H ^b,c,e  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CENTRE FOR INFECTIOUS DISEASE RESEARCH IN ZAMBIA   (Zambia)

^c MINISTRY OF HEALTH   (Zambia)

^d UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^e UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Antiretroviral therapy; Breastfeeding; HIV; Prevention of mother to child transmission; Zambia

Indexed keywords

ABACAVIR PLUS LAMIVUDINE; ANTIRETROVIRUS AGENT; EFAVIRENZ; EFAVIRENZ PLUS LAMIVUDINE PLUS ZIDOVUDINE; LAMIVUDINE PLUS LOPINAVIR PLUS RITONAVIR; LAMIVUDINE PLUS NEVIRAPINE PLUS STAVUDINE; LAMIVUDINE PLUS NEVIRAPINE PLUS ZIDOVUDINE; LAMIVUDINE PLUS STAVUDINE; NEVIRAPINE; ZIDOVUDINE;

ADULT; ARTICLE; BREAST FEEDING; CD4 LYMPHOCYTE COUNT; COHORT ANALYSIS; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; GESTATIONAL AGE; HEALTH CARE QUALITY; HEALTH CENTER; HEALTH SERVICE; HIV TEST; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFANT MORTALITY; MAJOR CLINICAL STUDY; MOTHER CHILD RELATION; PERINATAL PERIOD; PREGNANCY; PREGNANT WOMAN; PRENATAL CARE; PRIMARY MEDICAL CARE; PRIORITY JOURNAL; PROPHYLAXIS; PROSPECTIVE STUDY; PUERPERIUM; RISK FACTOR; RURAL AREA; VIRUS TRANSMISSION; ZAMBIA;

ADULT; ANTI-HIV AGENTS; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; COHORT STUDIES; DRUG THERAPY, COMBINATION; FEMALE; HIV INFECTIONS; HUMANS; INFANT, NEWBORN; INFECTIOUS DISEASE TRANSMISSION, VERTICAL; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; PROSPECTIVE STUDIES; RURAL POPULATION; YOUNG ADULT; ZAMBIA;

EID: 84879080483     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0b013e32835e3937     Document Type: Article

References (27)

1. Kuhn L, Aldrovandi GM, Sinkala M, Kankasa C., Mwiya M, Thea DM Potential impact of new WHO criteria for antiretroviral treatment for prevention of mother-to-child HIV transmission. AIDS 2010; 24:1374-1377.
2. UNAIDS. Global plan towards the elimination of new HIV infections among children by 2015 and keeping their mothers alive. 2011; 1-48. http://www.unaids.org/en/media/unaids/contentassets/documents/unaidspublication/ 2011/20110609-JC2137-Global-Plan-Elimination-HIV-Children-en.pdf. [Accessed 8 September 2012].
3. Shapiro RL, Hughes MD, Ogwu A, Kitch D., Lockman S, Moffat C, et al Antiretroviral regimens in pregnancy and breast-feeding in Botswana. N Engl J Med 2010; 362:2282-2294.
4. Thomas TK, Masaba R, Borkowf C.B., Ndivo R., Zeh C, Misore A, et al Triple-antiretroviral prophylaxis to prevent mother-to-child HIV transmission through breastfeeding-The Kisumu Breastfeeding Study, Kenya: a clinical trial. PLoS Med 2011; 8:e1001015.
5. Chasela CS, Hudgens MG, Jamieson D.J., Kayira D., Hosseinipour MC, Kourtis AP, et al Maternal or infant antiretroviral drugs to reduce HIV-1 transmission. N Engl J Med 2010; 362:2271-2281.
6. Peltier CA, Ndayisaba GF, Lepage P, van Griensven J, Leroy V, Pharm C.O., et al. Breastfeeding with maternal antiretroviral therapy or formula feeding to prevent HIV postnatal mother-to-child transmission in Rwanda. AIDS 2009; 23:2415-2423.
7. Kilewo C, Karlsson K, Ngarina M., Massawe A, Lyamuya E, Swai A., et al. Prevention of mother-to-child transmission of HIV-1 through breastfeeding by treating mothers with triple antiretroviral therapy in Dar es Salaam, Tanzania: the Mitra Plus study. J Acquir Immune Defic Syndr 2009; 52:406-416.
8. Palombi L, Marazzi MC, Voetberg A, Magid NA Treatment acceleration program and the experience of the DREAM program in prevention of mother-to-child transmission of HIV. AIDS 2007; 21 (SUPPL. 4):S65-71.
9. Kesho Bora Study Group, de Vincenzi I. Triple antiretroviral compared with zidovudine and single-dose nevirapine prophylaxis during pregnancy and breastfeeding for prevention of mother-to-child transmission of HIV-1 (Kesho Bora study): a randomised controlled trial. Lancet Infectious Diseases 2011; 11:171-180.
10. World Health Organization. Antiretroviral drugs for treating pregnant women and preventing HIV infection in infants. Guidelines on care, treatment and support for women living with HIV/AIDS and their children in resource-constrained settings. Geneva: World Health Organization; 2010. http://whqlibdoc.who.int/publications/2010/9789241599818-eng.pdf [Accessed 10 January 2013].
11. World Health Organization. Use of Antiretroviral Drugs for Treating Pregnant Women and Preventing HIV Infections in Infants: Executive Summary. 2012:1-7. http://www.who.int/hiv/PMTCT-update.pdf. [Accessed 8 September 2012].
12. Stringer EM, Ekouevi DK, Coetzee D, Tih P.M., Creek TL, Stinson K, et al Coverage of nevirapine-based services to prevent mother-to-child HIV transmission in 4 African countries. JAMA 2010; 304:293-302.
13. Clouse K, Maskew M, Fox M.P., Bassett J., Larson B. Delayed diagnosis of HIV and high rates of loss to follow-up among pregnant women receiving antenatal services at a primary healthcare clinic in Johannesburg, South Africa [Abstract 1004]. Paper presented at: 19th Conference on Retroviruses and Opportunistic Infections 2012; Seattle, WA; 2012:1-1.
14. Kaplan R, Orrell C, Zwane E., Bekker L-G, Wood R. Loss to follow-up and mortality among pregnant women referred to a community clinic for antiretroviral treatment. AIDS 2008; 22:1679-1681.
15. Nachega JB, Uthman OA, Anderson J, Peltzer K., Wampold S, Cotton MF, et al Adherence to antiretroviral therapy during and after pregnancy in low-, middle and high income countries. AIDS 2012; 26:2039-2052.
16. Myer L, Cornell M, Fox M.P., Garone D., Wood R, Prozesky HW, et al Loss to Follow-up and Mortality among Pregnant and Nonpregnant Women Initiating ART: South Africa [Paper 22]. Paper presented at: 19th Conference on Retroviruses and Opportunistic Infections 2012; Seattle, WA; 2012:1-1.
17. Republic of Zambia Central Statistical Office. Zambia 2010 Census of Population and Housing: Preliminary Population Figures. 2011; 1-71. http://unstats.un.org/unsd/demographic/sources/census/2010-phc/Zambia/ PreliminaryReport.pdf. [Accessed 10 January 2013].
18. Ministry of Health Zambia. National Protocol Guidelines Integrated Prevention of Mother-to-child Transmission of HIV/AIDS. 2007; 1-51. http://www.aidstar-one.com/sites/default/files/treatment-documents/ hiv-treatment-guidelines-zambia-pmtct-2007.pdf. [Accessed 10 January 2013].
19. Hitti J, Frenkel LM, Stek A.M., Nachman SA, Baker D, Gonzalez-Garcia A, et al Maternal toxicity with continuous nevirapine in pregnancy: results from PACTG 1022. J Acquir Immune Defic Syndr 2004; 36:772-776.
20. Jamisse L, Balkus J, Hitti J., Gloyd S, Manuel R, Osman N., et al. Antiretroviral-associated toxicity among HIV-1-seropositive pregnant women in Mozambique receiving nevirapine-based regimens. J Acquir Immune Defic Syndr 2007; 44:371-376.
21. Ssali F, Stöhr W, Munderi P., Reid A, Walker AS, Gibb D.M., et al. Prevalence, incidence and predictors of severe anaemia with zidovudine- containing regimens in African adults with HIV infection within the DART trial. Antivir Ther (Lond) 2006; 11:741-749.
22. Chi BH, Cantrell RA, Zulu I, Mulenga L.B., Levy JW, Tambatamba BC, et al Adherence to first-line antiretroviral therapy affects nonvirologic outcomes among patients on treatment for more than 12 months in Lusaka, Zambia. Int J Epidemiol 2009; 38:746-756.
23. Jamisse L, Balkus J, Farquhar C., Osman N, Djedje M, Hitti J. Perinatal HIV transmission with highly active antiretroviral therapy during late pregnancy and postpartum. In: 14th Conference on Retroviruses and Opportunistic Infections 2007; Los Angeles, CA 2007: 1-1.
24. Jackson JB, Musoke P, Fleming T., Guay LA, Bagenda D, Allen M, et al Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: 18-month follow-up of the HIVNET 012 randomised trial. Lancet 2003; 362:859-868.
25. Hayes RJ, Bennett S. Simple sample size calculation for cluster-randomized trials. Int J Epidemiol 1999; 28:319-326.
26. Alioum A, Cortina-Borja M, Dabis F., Dequae-Merchadou L, Haverkamp G, Hughes J., et al. Estimating the efficacy of interventions to prevent mother-to-child transmission of human immunodeficiency virus in breastfeeding populations: comparing statistical methods. Am J Epidemiol 2003; 158:596-605.
27. Schouten EJ, Jahn A, Midiani D., Makombe SD, Mnthambala A, Chirwa Z, et al Prevention of mother-to-child transmission of HIV and the health-related Millennium Development Goals: time for a public health approach. Lancet 2011; 378:282-284.