Prescription opioids for back pain and use of medications for erectile dysfunction

Spine

Volumn 38, Issue 11, 2013, Pages 909-915

  Deyo, Richard A ^a   Smith, David H M ^b   Johnson, Eric S ^b   Tillotson, Carrie J ^c   Donovan, Marilee ^b   Yang, Xiuhai ^b   Petrik, Amanda ^b   Morasco, Benjamin J ^d   Dobscha, Steven K ^d  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b CENTER FOR HEALTH RESEARCH   (United States)

^c Public Health and Preventive Medicine   (United States)

^d PORTLAND VA MEDICAL CENTER   (United States)

Author keywords

Erectile dysfunction; Low back pain; Opioids; Sexual dysfunction

Indexed keywords

FLUOXYMESTERONE; HYPNOTIC SEDATIVE AGENT; METHYLTESTOSTERONE; OPIATE; OXANDROLONE; SILDENAFIL; TADALAFIL; TESTOSTERONE CIPIONATE; TESTOSTERONE DERIVATIVE; TESTOSTERONE ENANTATE; TESTOSTERONE PROPIONATE; VARDENAFIL;

ADULT; AGE DISTRIBUTION; AGED; ANDROGEN THERAPY; ARTICLE; BACKACHE; CHRONIC PAIN; COMORBIDITY; CROSS-SECTIONAL STUDY; DEPRESSION; DIABETES MELLITUS; DRUG USE; ELECTRONIC MEDICAL RECORD; ERECTILE DYSFUNCTION; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL DECISION MAKING; PRESCRIPTION; PRIORITY JOURNAL; RISK ASSESSMENT; SMOKING; TREATMENT DURATION;

ADULT; AGE FACTORS; AGED; ANALGESICS, OPIOID; ANDROGENS; BACK PAIN; CARBOLINES; COMORBIDITY; CROSS-SECTIONAL STUDIES; DEPRESSION; DRUG PRESCRIPTIONS; ERECTILE DYSFUNCTION; HORMONE REPLACEMENT THERAPY; HUMANS; IMIDAZOLES; INSURANCE, HEALTH; LOGISTIC MODELS; MALE; MIDDLE AGED; PIPERAZINES; PREVALENCE; PURINES; SMOKING; SULFONES; TESTOSTERONE; TRIAZINES; UNITED STATES; UROLOGICAL AGENTS;

EID: 84879079795     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/BRS.0b013e3182830482     Document Type: Article

References (39)

1. Caudill-Slosberg MA, Schwartz LM, Woloshin S. Office visits and analgesic prescriptions for musculoskeletal pain in US: 1980 vs. 2000. Pain 2004; 109: 514-9.
2. Martin BI, Deyo RA, Mirza SK, et al. Expenditures and health status among adults with back and neck problems. JAMA 2008; 299: 656-64.
3. Franklin GM, Mai J, Wickizer T, et al. Opioid dosing trends and mortality in Washington State workers' compensation, 1996-2002. Am J Ind Med 2005; 48: 91-9.
4. Luo X, Pietrobon R, Hey L. Patterns and trends in opioid use among individuals with back pain in the United States. Spine 2004; 29: 884-91.
5. Zerzan JT, Morden NE, Soumerai S, et al. Trends and geographic variation of opiate medication use in state Medicaid fee-for-service programs, 1996 to 2002. Med Care 2006; 44: 1005-10.
6. Compton WM, Volkow ND. Major increases in opioid analgesic abuse in the United States: concerns and strategies. Drug Alcohol Depend 2006; 81: 103-7.
7. Martell BA, O'Connor PG, Kerns RD, et al. Systematic review: opioid treatment for chronic back pain: prevalence, efficacy, and association with addiction. Ann Intern Med 2007; 146: 116-27.
8. Ambler N, Williams AC, Hill P, et al. Sexual difficulties of chronic pain patients. Clin J Pain 2001; 17: 138-45.
9. Daniell HW. Hypogonadism in men consuming sustained-action oral opioids. J Pain 2002; 3: 377-84.
10. Daniell HW. Opioid endocrinopathy in women consuming prescribed sustained-action opioids for control of nonmalignant pain. J Pain 2008; 9: 28-36.
11. Makhlouf A, Kparker A, Niederberger CS. Depression and erectile dysfunction. Urol Clin N Am 2007; 34: 565-74.
12. Edlund MJ, Steffick D, Hudson T, et al. Risk factors for clinically recognized opioid abuse and dependence among veterans using opioids for chronic non-cancer pain. Pain 2007; 129: 355-62.
13. Wasan AD, Davar G, Jamison R. The association between negative affect and opioid analgesia in patients with discogenic low back pain. Pain 2005; 117: 450-61.
14. Hermos JA, Young MM, Gagnon DR, et al. Characterizations of long-term oxycodone/acetaminophen prescriptions in veteran patients. Arch Intern Med 2004; 164: 2361-6.
15. Sullivan MD, Edlund MJ, Zhang L, et al. Association between mental health disorders, problem drug use, and regular prescription opioid use. Arch Intern Med 2006; 166: 2087-93.
16. Deyo RA, Smith DHM, Johnson ES, et al. Opioids for back pain patients: primary care prescribing patterns and use of services. J Am Board Fam Med 2011; 24: 717-27.
17. Gades NM, Nehra A, Jacobson DJ, et al. Association between smoking and erectile dysfunction: a population-based study. Am J Epidemiol 2005; 161: 346-51.
18. McVary KT, Carrier S, Wessells H, et al. Smoking and erectile dysfunction: evidence based analysis. J Urol 2001; 166: 1624-32.
19. MacDonald AA, Herbison GP, Showell M, et al. The impact of body mass index on semen parameters and reproductive hormones in human males: a systematic review with meta-analysis. Human Reprod Update 2010; 16: 293-311.
20. Mammi C, Calanchini M, Antelmi A, et al. Androgens and adipose tissue in males: a complex and reciprocal interplay. Int J Endocrinol 2012; 2012: 789653.
21. Fraser LA, Morrison D, Morley-Forster P, et al. Oral Opioids for chronic non-cancer pain: higher prevalence of hypogonadism in men than in women. Exp Clin Endocrinol Diabetes 2009; 117: 38-43.
22. Daniell HW. DHEAS deficiency during consumption of sustainedaction prescribed opioids: evidence for opioid-induced inhibition of adrenal androgen production. J Pain 2006; 7: 901-7.
23. Chou R, Ballantyne JC, Fanciullo GJ, et al. Research gaps on use of opioids for chronic noncancer pain: findings from a review of the evidence for an American Pain Society and American Academy of Pain Medicine clinical practice guideline. J Pain 2009; 10: 147-59.
24. Cicero TJ, Schainker BA, Meyer ER. Endogenous opioids participate in the regulation of the hypothalamus-pituitary-luteinizing hormone axis and testosterone's negative feedback control of luteinizing hormone. Endocrinology 1979; 104: 1286-91.
25. Kalra PS, Sahu A, Kalra SP. Opiate-induced hypersensitivity to testosterone feedback: pituitary involvement. Endocrinology 1988; 122: 997-1003.
26. Yuong C, Van Uum SHM, O'Dell LE, et al. The effects of opioids and opioid analogs on animal and human endocrine systems. Endocr Rev 2010; 31: 98-132.
27. Steggall MJ. Erectile dysfunction: physiology, causes and patient management. Nurs Stand 2007; 21: 49-56.
28. Kubin M, Wagner G, Fugl-Meyer AR. Epidemiology of erectile dysfunction. Int J Impotence Res 2003; 15: 63-71.
29. Tsertsvadze A, Fink HA, Yazdi F, et al. Oral Phosphodiesterase-5 inhibitors and hormonal treatments for erectile dysfunction: a systematic review and meta-analysis. Ann Intern Med 2009; 151: 650-61.
30. Hudson TJ, Edlund MJ, Steffick DE, et al. Epidemiology of regular prescribed opioid use: results from a national, population-based survey. J Pain Symptom Manage 2008; 36: 280-8.
31. Cherkin DC, Deyo RA, Volinn E, et al. Use of the International Classification of Diseases (ICD-9-CM) to identify hospitalizations for mechanical low back problems in administrative databases. Spine 1992; 17: 817-25.
32. Von Korff M, Saunders K, Ray GT, et al. De facto long-term opioid therapy for noncancer pain. Clin J Pain 2008; 24: 521-7.
33. Master Drug Data Base v 2.5 (MDDB). Available at: http://www. medispan.com/master-drug-database.aspx. Accessed July 15, 2010.
34. American Society of Health-System Pharmacists. AHFS Drug Information. Available at: http://www.ahfsdruginformation.com/products-services/di-ahfs.aspx. Accessed January 12, 2013.
35. Fishman PA, Goodman MJ, Hornbrook MC, et al. Risk adjustment using automated ambulatory pharmacy data: the RxRisk model. Med Care 2003; 41: 84-99.
36. Farley FJ, Harley CR, Devine JW. A comparison of comorbidity measurements to predict healthcare expenditures. Am J Manag Care 2006; 12: 110-7.
37. Reddy RG, Aung T, Karavitaki N, et al. Opioid induced hypogonadism. BMJ 2010; 341: c4462.
38. Morasco BJ, Duckart JP, Carr TP, et al. Clinical characteristics of veterans prescribed high doses of opioid medications for chronic non-cancer pain. Pain 2010; 151: 625-32.
39. Daniell HW, Lentz R, Mazer NA. Open-label pilot study of testosterone patch therapy in men with opioid-induced androgen deficiency. J Pain 2006; 7: 200-10.