Serum levels of soluble platelet endothelial cell adhesion molecule-1 and vascular cell adhesion molecule-1 are decreased in subjects with autism spectrum disorder

Molecular Autism

Volumn 4, Issue 1, 2013, Pages

  Kameno, Yosuke ^a   Iwata, Keiko ^b   Matsuzaki, Hideo ^b   Miyachi, Taishi ^c   Tsuchiya, Kenji J ^a   Matsumoto, Kaori ^a   Iwata, Yasuhide ^a   Suzuki, Katsuaki ^a   Nakamura, Kazuhiko ^d   Maekawa, Masato ^a   Tsujii, Masatsugu ^a,e   Sugiyama, Toshirou ^a   Mori, Norio ^a  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF FUKUI   (Japan)

^c NAGOYA CITY UNIVERSITY HOSPITAL   (Japan)

^d HIROSAKI UNIVERSITY   (Japan)

^e CHUKYO UNIVERSITY   (Japan)

Author keywords

Adhesion molecules; Autism; Endothelial selectin; Human serum; Intracellular adhesion molecule 1; Platelet selectin; Platelet endothelial adhesion molecule 1; Vascular cell adhesion molecule 1

Indexed keywords

CD31 ANTIGEN; PADGEM PROTEIN; VASCULAR CELL ADHESION MOLECULE 1;

ADOLESCENT; ARTICLE; AUTISM; BLOOD SAMPLING; BODY MASS; CHILD; CLINICAL ARTICLE; FEMALE; HUMAN; IMMUNOASSAY; INTERVIEW; MALE; MOLECULE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN FUNCTION; REPRODUCIBILITY; SCHOOL CHILD; SENSITIVITY ANALYSIS;

EID: 84879061420     PISSN: None     EISSN: 20402392     Source Type: Journal    
DOI: 10.1186/2040-2392-4-19     Document Type: Article

References (22)

1. Autism: a window onto the development of the social and the analytic brain. Baron-Cohen S, Belmonte MK, Annu Rev Neurosci 2005 28 109 126 10.1146/annurev.neuro.27.070203.144137 16033325 (Pubitemid 41098901)
2. Autism. Volkmar FR, Pauls D, Lancet 2003 362 1133 1141 10.1016/S0140-6736(03)14471-6 14550703 (Pubitemid 37222341)
3. Immunological findings in autism. Cohly HH, Panja A, Int Rev Neurobiol 2005 71 317 341 16512356 (Pubitemid 43580939)
4. Brief report: immune factors in autism: a critical review. Krause I, He XS, Gershwin ME, Shoenfeld Y, J Autism Dev Disord 2002 32 337 345 10.1023/A:1016391121003 12199139 (Pubitemid 37490184)
5. Immunity, neuroglia and neuroinflammation in autism. Pardo CA, Vargas DL, Zimmerman AW, Int Rev Psychiatry 2005 17 485 495 10.1080/02646830500381930 16401547 (Pubitemid 43086675)
6. Adhesion molecule expression and regulation on cells of the central nervous system. Lee SJ, Benveniste EN, J Neuroimmunol 1999 98 77 88 10.1016/S0165-5728(99)00084-3 10430040 (Pubitemid 29317533)
7. Adhesion molecules and atherosclerosis. Blankenberg S, Barbaux S, Tiret L, Atherosclerosis 2003 170 191 203 10.1016/S0021-9150(03)00097-2 14612198 (Pubitemid 37377790)
8. Biosynthesis and processing of the cell adhesion molecule PECAM-1 includes production of a soluble form. Goldberger A, Middleton KA, Oliver JA, Paddock C, Yan HC, DeLisser HM, Albelda SM, Newman PJ, J Biol Chem 1994 269 17183 17191 8006026 (Pubitemid 24204041)
9. Serum levels of P-selectin in men with high-functioning autism. Iwata Y, Tsuchiya KJ, Mikawa S, Nakamura K, Takai Y, Suda S, Sekine Y, Suzuki K, Kawai M, Sugihara G, Matsuzaki H, Hashimoto K, Tsujii M, Sugiyama T, Takei N, Mori N, Br J Psychiatry 2008 193 338 339 10.1192/bjp.bp.107.043497 18827301
10. Decreased serum levels of platelet-endothelial adhesion molecule (PECAM-1) in subjects with high-functioning autism: a negative correlation with head circumference at birth. Tsuchiya KJ, Hashimoto K, Iwata Y, Tsujii M, Sekine Y, Sugihara G, Matsuzaki H, Suda S, Kawai M, Nakamura K, Minabe Y, Yagi A, Iyo M, Takei N, Mori N, Biol Psychiatry 2007 62 1056 1058 10.1016/j.biopsych.2006. 12.018 17509538 (Pubitemid 47562363)
11. Levels of soluble platelet endothelial cell adhesion molecule-1 and P-selectin are decreased in children with autism spectrum disorder. Onore CE, Nordahl CW, Young GS, Van de Water JA, Rogers SJ, Ashwood P, Biol Psychiatry 2012 72 1020 1025 10.1016/j.biopsych.2012.05.004 22717029
12. Sex-specific serum biomarker patterns in adults with Asperger's syndrome. Schwarz E, Guest PC, Rahmoune H, Wang L, Levin Y, Ingudomnukul E, Ruta L, Kent L, Spain M, Baron-Cohen S, Bahn S, Mol Psychiatry 2011 16 1213 1220 10.1038/mp.2010.102 20877284
13. Network- and attribute-based classifiers can prioritize genes and pathways for autism spectrum disorders and intellectual disability. Kou Y, Betancur C, Xu H, Buxbaum JD, Ma'ayan A, Am J Med Genet C Semin Med Genet 2012 160C 130 142 10.1002/ajmg.c.31330 22499558
14. Plasma cytokine profiles in subjects with high-functioning autism spectrum disorders. Suzuki K, Matsuzaki H, Iwata K, Kameno Y, Shimmura C, Kawai S, Yoshihara Y, Wakuda T, Takebayashi K, Takagai S, Matsumoto K, Tsuchiya KJ, Iwata Y, Nakamura K, Tsujii M, Sugiyama T, Mori N, PLoS One 2011 6 20470 10.1371/journal.pone.0020470 21647375
15. Reliability and validity of Autism Diagnostic Interview-Revised, Japanese Version. Tsuchiya KJ, Matsumoto K, Yagi A, Inada N, Kuroda M, Inokuchi E, Koyama T, Kamio Y, Tsujii M, Sakai S, Mohri I, Taniike M, Iwanaga R, Ogasahara K, Miyachi T, Nakajima S, Tani I, Ohnishi M, Inoue M, Nomura K, Hagiwara T, Uchiyama T, Ichikawa H, Kobayashi S, Miyamoto K, Nakamura K, Suzuki K, Mori N, Takei N, J Autism Dev Disord 2013 43 643 662 10.1007/s10803-012-1606-9 22806002
16. A review of research trends in physiological abnormalities in autism spectrum disorders: immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and environmental toxicant exposures. Rossignol DA, Frye RE, Mol Psychiatry 2012 17 389 401 10.1038/mp.2011.165 22143005
17. The role of PECAM-1 (CD31) in leukocyte emigration: studies in vitro and in vivo. Muller WA, J Leukoc Biol 1995 57 523 528 7722409
18. Altered vascular permeability and early onset of experimental autoimmune encephalomyelitis in PECAM-1-deficient mice. Graesser D, Solowiej A, Bruckner M, Osterweil E, Juedes A, Davis S, Ruddle NH, Engelhardt B, Madri JA, J Clin Invest 2002 109 383 392 11827998 (Pubitemid 34141812)
19. Genetic evidence for functional redundancy of Platelet/Endothelial cell adhesion molecule-1 (PECAM-1): CD31-deficient mice reveal PECAM-1-dependent and PECAM-1-independent functions. Duncan GS, Andrew DP, Takimoto H, Kaufman SA, Yoshida H, Spellberg J, de la Pompa JL, Elia A, Wakeham A, Karan-Tamir B, Muller WA, Senaldi G, Zukowski MM, Mak TW, J Immunol 1999 162 3022 3030 10072554 (Pubitemid 29309332)
20. Microglial activation in young adults with autism spectrum disorder. Suzuki K, Sugihara G, Ouchi Y, Nakamura K, Futatsubashi M, Takebayashi K, Yoshihara Y, Omata K, Matsumoto K, Tsuchiya KJ, Iwata Y, Tsujii M, Sugiyama T, Mori N, JAMA Psychiatry 2013 70 49 58 23404112
21. Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome. Ashwood P, Krakowiak P, Hertz-Picciotto I, Hansen R, Pessah I, Van de Water J, Brain Behav Immun 2011 25 40 45 10.1016/j.bbi.2010.08.003 20705131
22. Selected neurotrophins, neuropeptides, and cytokines: developmental trajectory and concentrations in neonatal blood of children with autism or Down syndrome. Nelson PG, Kuddo T, Song EY, Dambrosia JM, Kohler S, Satyanarayana G, Vandunk C, Grether JK, Nelson KB, Int J Dev Neurosci 2006 24 73 80 10.1016/j.ijdevneu.2005.10.003 16289943 (Pubitemid 43287950)