Epidemiology of Autism Spectrum Disorders

The Neuroscience of Autism Spectrum Disorders

Volumn , Issue , 2013, Pages 3-24

  French, Lisa R ^a   Bertone, Armando ^b,c   Hyde, Krista L ^a   Fombonne, Eric ^d  

^a RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c Perceptual Neuroscience Laboratory for Autism and Development   (Canada)

^d MONTREAL CHILDREN S HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84879046073     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-391924-3.00001-6     Document Type: Chapter

References (120)

1. Al-Farsi Y.M., Al-Sharbati M.M., Al-Farsi O.A., Al-Shafaee M.S., Brooks D.R., Waly M.I. Brief Report: Prevalence of Autistic Spectrum Disorders in the Sultanate of Oman. Journal of Autism and Developmental Disorders 2011, 41:821-825.
2. American Psychiatric Association (APA) Diagnostic and Statistical Manual of Mental Disorders 1980, American Psychiatric Association, Washington, DC. third ed.
3. American Psychiatric Association (APA) Diagnostic and Statistical Manual of Mental Disorders 1987, American Psychiatric Association, Washington, DC. third ed., rev.
4. American Psychiatric Association (APA) Diagnostic and statistical manual of mental disorders 1994, DSM-IV, American Psychiatric Association, Washington, DC. fourth ed.
5. Arvidsson T., Danielsson B., Forsberg P., Gillberg C., Johansson M., Kjellgren G. Autism in 3-6 year-olds in a suburb of Goteborg, Sweden. Autism 1997, 2:163-173.
6. Asperger H. Die 'autistischen psychopathen' im kindesalter (autistic psychopathology of childhood). Archiv für Psychiatrie und Nervenkrankheiten 1944, 177:76-136.
7. Baird G., Charman T., Baron-Cohen S., Cox A., Swettenham J., Wheelwright S., et al. A screening instrument for autism at 18 months of age: A 6-year follow-up study. Journal of the American Academy of Child and Adolescent Psychiatry 2000, 39:694-702.
8. Baird G., Simonoff E., Pickles A., Chandler S., Loucas T., Meldrum D., et al. Prevalence of disorders of the autism spectrum in a population cohort of children in South Thames: The special needs and autism project (SNAP). Lancet 2006, 368:210-215.
9. Barbaresi W.J., Katusic S.K., Colligan R.C., Weaver A.L., Jacobsen S.J. The incidence of autism in Olmsted County, Minnesota, 1976-1997: Results from a population-based study. Archives of Pediatrics & Adolescent Medicine 2005, 159:37-44.
10. Barnevik-Olsson M., Gillberg C., Fernell E. Clinical Letter: Prevalence of autism in children of Somali origin living in Stockholm: Brief report of an at-risk population. Developmental Medicine and Child Neurology 2010, 52:1167-1168.
11. Baron-Cohen S., Scott F.J., Allison C., Williams J., Bolton P., Matthews F.E., et al. Prevalence of autism-spectrum conditions: UK school-based population study. British Journal of Psychiatry 2009, 194:500-509.
12. Bertrand J., Mars A., Boyle C., Bove F., Yeargin-Allsopp M., Decoufle P. Prevalence of autism in a United States population: The Brick Township, New Jersey, investigation. Pediatrics 2001, 108:1155-1161.
13. Bishop D.V., Whitehouse A.J., Watt H.J., Line E.A. Autism and diagnostic substitution: Evidence from a study of adults with a history of developmental language disorder. Developmental Medicine and Child Neurology 2008, 50:341-345.
14. Bohman M., Bohman I., Bjorck P., Sjoholm E. Childhood psychosis in a northern Swedish county: Some preliminary findings from an epidemiological survey. Epidemiological Approaches in Child Psychiatry 1983, 164-173. Georg Thieme Verlag, Stuttgart. M. Schmidt, H. Remschmidt (Eds.).
15. Brask B. A prevalence investigation of childhood psychoses 1970, Paper presented at the Nordic Symposium on the Care of Psychotic Children, Oslo.
16. Brugha T.S., McManus S., Bankart J., Scott F., Purdon S., Smith J., et al. Epidemiology of Autism Spectrum Disorders in adults in the community in England. Archives of General Psychiatry 2011, 68:459-466.
17. Bryson S.E., Clark B.S., Smith I.M. First report of a Canadian epidemiological study of autistic syndromes. Journal of Child Psychology and Psychiatry and Allied Disciplines 1988, 29:433-445.
18. Burd L., Fisher W., Kerbeshan J. A prevalance study of pervasive developmental disorders in North Dakota. Journal of the American Academy of Child and Adolescent Psychiatry 1987, 26:700-703.
19. California Department of Developmental Services (CDDS) Changes in the population of persons with autism and pervasive developmental disorders in California's Developmental Services System: 1987 through 1998. Report to the Legislature March 1, 1999, 19 pages 1999, March 1, Available at, <, > (accessed 14.05.12.). http://www.dds.ca.gov.
20. California Department of Developmental Services (CDDS) Autism Spectrum Disorders: Changes in the California Caseload - An Update 1999 Through 2002 2003, April, Available at <, > (accessed 18.05.12.). http://iier.isciii.es/autismo/pdf/aut_ar03.pdf.
21. California Department of Developmental Services (CDDS) Table 34 2007, December, Available at: <, > (accessed 28.01.09.). http://www.dds.ca.gov/FactsStats/docs/Dec07_QRTTBLS.pdf.
22. Census Bureau for the US Available at <, > (accessed 18.05.12.). http://www.census.gov/.
23. Centers for Disease Control (CDC) Prevalence of autism spectrum disorders-Autism and developmental disabilities monitoring network, six sites, United States, 2000. Morbidity and Mortality Weekly Report Surveillance Summary 2007, 56:1-11.
24. Centers for Disease Control (CDC) Prevalence of autism spectrum disorders-Autism and developmental disabilities monitoring network, 14 sites, United States, 2002. Morbidity and Mortality Weekly Report Surveillance Summary 2007, 56:12-28.
25. Centers for Disease Control (CDC) Prevalence of autism spectrum disorders-Autism and developmental disabilities monitoring network, United States, 2006. Morbidity and Mortality Weekly Report Surveillance Summary 2009, 58:1-14.
26. Chakrabarti S., Fombonne E. Pervasive developmental disorders in preschool children. Journal of the American Medical Association 2001, 285:3093-3099.
27. Chakrabarti S., Fombonne E. Pervasive developmental disorders in preschool children: Confirmation of high prevalence. American Journal of Psychiatry 2005, 162:1133-1141.
28. Cialdella P., Mamelle N. An epidemiological study of infantile autism in a French department (Rhone): A research note. Journal of Child Psychology and Psychiatry and Allied Disciplines 1989, 30:165-175.
29. Croen L.A., Grether J.K., Hoogstrate J., Selvin S. The changing prevalence of autism in California. Journal of Autism and Developmental Disorders 2002, 32:207-215.
30. Davidovitch M., Holtzman G., Tirosh E. Autism in the Haifa area: An epidemiological perspective. Israeli Medical Association Journal 2001, March, 3:188-189.
31. Durkin M.S., Maenner M.J., Meaney F.J., Levy S.E., DiGuiseppi C., Nicholas J.S., et al. Socioecnomic inequality in the prevalence of Autism Spectrum Disorder: Evidence from a U.S. cross-sectional study. PLoS ONE 2010, 5:e11551.
32. Eagle R.S. Commentary: Further commentary on the debate regarding increase in autism in California. Journal of Autism and Developmental Disorders 2004, 34:87-88.
33. Ehlers S., Gillberg C. The epidemiology of Asperger syndrome: A total population study. Journal of Child Psychology and Psychiatry and Allied Disciplines 1993, 34:1327-1350.
34. Ellefsen A., Kampmann H., Billstedt E., Gillberg I.C., Gillberg C. Autism in the Faroe islands: An epidemiological study. Journal of Autism and Developmental Disorders 2007, 37:437-444.
35. Elsabbagh M., Divan G., Koh Y.-J., Kim Y.S., Kauchali S., Marcin C., et al. Global Prevalence of Autism and other Pervasive Developmental Disorders 2012, Autism Research, John Wiley & Sons.
36. Fombonne E. Is there an epidemic of autism?. Pediatrics 2001, 107:411-413.
37. Fombonne E. Epidemiological surveys of autism and other pervasive developmental disorders: An update. Journal of Autism and Developmental Disorders 2003, 33:365-382.
38. Fombonne E. The prevalence of autism. Journal of the American Medical Association 2003, 289:1-3.
39. Fombonne E. Epidemiology of autistic disorder and other pervasive developmental disorders. Journal of Clinical Psychiatry 2005, 66:3-8.
40. Fombonne E. Epidemiology. Lewis's child and adolescent psychiatry: A comprehensive textbook 2007, 150-171. Lippincott, Williams, and Wilkins, Philadelphia. fourth ed. A. Martin, F. Volkmar (Eds.).
41. Fombonne E. Epidemiology of Pervasive Developmental Disorders. Pediatric Research 2009, 65:591-598.
42. Fombonne E. Commentary: On King and Bearman. International Journal of Epidemiology 2009, 38:1241-1242.
43. Fombonne E., du Mazaubrun C. Prevalence of infantile autism in four French regions. Social Psychiatry and Psychiatric Epidemiology 1992, 27:203-210.
44. Fombonne E., du Mazaubrun C., Cans C., Grandjean H. Autism and associated medical disorders in a French epidemiological survey. Journal of the American Academy of Child and Adolescent Psychiatry 1997, 36:1561-1569.
45. Fombonne E., Quirke S., Hagen A. Epidemiology of pervasive developmental disorders. Autism Spectrum Disorders 2011, Oxford University Press. D.G. Amaral, G. Dawson, D.H. Geschwind (Eds.).
46. Fombonne E., Simmons H., Ford T., Meltzer H., Goodman R. Prevalence of pervasive developmental disorders in the British nationwide survey of child mental health. Journal of the American Academy of Child and Adolescent Psychiatry 2001, 40:820-827.
47. Fombonne E., Zakarian R., Bennett A., Meng L., McLean-Heywood D. Pervasive developmental disorders in Montreal, Quebec, Canada: Prevalence and links with immunizations. Pediatrics 2006, 118:e139-150.
48. Ghanizadeh A. A preliminary study on screening prevalence of pervasive developmental disorder in school children in Iran. Journal of Autism and Developmental Disorders 2008, 38:759-763.
49. Gillberg C. Infantile autism and other childhood psychoses in a Swedish urban region: Epidemiological aspects. Journal of Child Psychology and Psychiatry and Allied Disciplines 1984, 25:35-43.
50. Gillberg C. Infantile autism in children of immigrant parents. A population-based study from Goteborg, Sweden. British Journal of Psychiatry 1987, 150:856-858.
51. Gillberg I.C., Gillberg C. Autism in immigrants: A population-based study from Swedish rural and urban areas. Journal of Intellectual Disability Research 1996, 40:24-31.
52. Gillberg C., Cederlund M., Lamberg K., Zeijlon L. Brief report: The autism epidemic. The registered prevalence of autism in a Swedish urban area. Journal of Autism and Developmental Disorders 2006, 36:429-435.
53. Gillberg C., Schaumann H., Gillberg I.C. Autism in immigrants: Children born in Sweden to mothers born in Uganda. Journal of Intellectual Disability Research 1995, 39:141-144.
54. Gillberg C., Steffenburg S., Schaumann H. Is autism more common now than ten years ago?. British Journal of Psychiatry 1991, 158:403-409.
55. Gurney J.G., Fritz M.S., Ness K.K., Sievers P., Newschaffer C.J., Shapiro E.G. Analysis of prevalence trends of autism spectrum disorder in Minnesota. Archives of Pediatrics and Adolescent Medicine 2003, 157:622-627.
56. Harrison M.J., O'Hare A.E., Campbell H., Adamson A., McNeillage J. Prevalence of autistic spectrum disorders in Lothian, Scotland: An estimate using the "capture-recapture" technique. Archives of Disease in Childhood 2006, 91:16-19.
57. Hertz-Picciotto I., Delwiche L. The rise in autism and the role of age at diagnosis. Epidemiology 2009, 38:84-90.
58. Honda H., Shimizu Y., Misumi K., Niimi M., Ohashi Y. Cumulative incidence and prevalence of childhood autism in children in Japan. British Journal of Psychiatry 1996, 169:228-235.
59. Honda H., Shimizu Y., Rutter M. No effect of MMR withdrawal on the incidence of autism: A total population study. Journal of Child Psychology and Psychiatry and Allied Disciplines 2005, 46:572-579.
60. Hoshino Y., Kumashiro H., Yashima Y., Tachibana R., Watanabe M. The epidemiological study of autism in Fukushima-Ken. Folia Psychiatrica et Neurologica Japonica 1982, 36:115-124.
61. Icasiano F., Hewson P., Machet P., Cooper C., Marshall A. Childhood autism spectrum disorder in the Barwon region: A community based study. Journal of Paediatrics and Child Health 2004, 40:696-701.
62. Jick H., Kaye J.A., Black C. Epidemiology and possible causes of autism changes in risk of autism in the UK for birth cohorts 1990-1998. Pharmacotherapy 2003, 23:1524-1530.
63. Kadesjo B., Gillberg C., Hagberg B. Brief report: Autism and Asperger syndrome in seven-year-old children: A total population study. Journal of Autism and Developmental Disorders 1999, 29:327-331.
64. Kanner L. Autistic disturbances of affective contact. The Nervous Child 1943, 2:217-250.
65. Kawamura Y., Takahashi O., Ishii T. Reevaluating the incidence of pervasive developmental disorders: Impact of elevated rates of detection through implementation of an integrated system of screening in Toyota, Japan. Psychiatry and Clinical Neurosciences 2008, 62:152-159.
66. Kielinen M., Linna S.-L., Moilanen I. Autism in northern Finland. European Child and Adolescent Psychiatry 2000, 9:162-167.
67. Kim Y.S., Leventhal B.L., Koh Y.J., Fombonne E., Laska E., Lim E.C., et al. Prevalence of Autism Spectrum Disorders in a total population sample. American Journal of Psychiatry [Epub ahead of print] 2011.
68. King M., Bearman P. Diagnostic change and the increase in prevalence of autism. International Journal of Epidemiology 2009, 38:1224-1234.
69. Kogan M.D., Blumberg S.J., Schieve L.A., Boyle C.A., Perrin J.M., Ghandour R.M., et al. Prevalence of parent-reported diagnosis of autism spectrum disorder among children in the US, 2007. Pediatrics 2009, 124:1395-1403.
70. Latif A.H., Williams W.R. Diagnostic trends in autistic spectrum disorders in the South Wales valleys. Autism 2007, 11:479-487.
71. Lazoff T., Zhong L., Piperni T., Fombonne E. Prevalence rates of PDD among children in a Montreal School Board. The Canadian Journal of Child Psychiatry 2010, 55:715-720.
72. Le Couteur A., Rutter M., Lord C., Rios P., Robertson S., Holdgrafer M., et al. Autism diagnostic interview: A standardized investigator-based instrument. Journal of Autism and Developmental Disorders 1989, 19:363-387.
73. Leonard H., Glasson E., Nassar N., Whitehouse A., Bebbington A., Bourke J., et al. Autism and intellectual disability are differentially related to sociodemographic background at birth. PLoS ONE 2011, 6:e17875.
74. Lord C., Risi S., Lambrecht L., Cook E.H., Leventhal B.L., DiLavore P.C., et al. The Autism Diagnostic Observation Schedule-Generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders 2000, 30:205-223.
75. Lotter V. Epidemiology of autistic conditions in young children: I. Prevalence. Social Psychiatry 1966, 1:124-137.
76. Madsen K.M., Hviid A., Vestergaard M., Schendel D., Wohlfahrt J., Thorsen P., et al. A population-based study of measles, mumps, and rubella vaccination and autism. New England Journal of Medicine 2002, 347:1477-1482.
77. Magnússon P., Saemundsen E. Prevalence of autism in Iceland. Journal of Autism and Developmental Disorders 2001, 31:153-163.
78. Matsuishi T., Shiotsuki M., Yoshimura K., Shoji H., Imuta F., Yamashita F. High prevalence of infantile autism in Kurume city, Japan. Journal of Child Neurology 1987, 2:268-271.
79. McCarthy P., Fitzgerald M., Smith M. Prevalence of childhood autism in Ireland. Irish Medical Journal 1984, 77:129-130.
80. MIND Institute Report to the Legislature on the Principal Findings From the Epidemiology of Autism in California. A Comprehensive Pilot Study 2002, October 17, University of California, Davis.
81. Nicholas J.S., Charles J.M., Carpenter L.A., King L.B., Jenner W., Spratt E.G. Prevalence and characteristics of children with autism-spectrum disorders. Annals of Epidemiology 2008, 18:130-136.
82. Oliveira G., Ataide A., Marques C., Miguel T.S., Coutinho A.M., Mota-Vieira L., et al. Epidemiology of autism spectrum disorder in Portugal: Prevalence, clinical characterization, and medical conditions. Developmental Medicine and Child Neurology 2007, 49:726-733.
83. Palmer R.F., Walker T., Mandell D., Bayles B., Miller C.S. Explaining low rates of autism among Hispanic schoolchildren in Texas. American Journal of Public Health 2010, 100:270-272.
84. Parner E.T., Thorsen P., Dixon G., de Klerk N., Leonard H., Nassar N., et al. A comparison of autism prevalence trends in Denmark and Western Australia. Journal of Autism and Developmental Disorders 2011, 41:1601-1608.
85. Paula C.S., Ribeiro S., Fombonne E., Mercadante M.T. Brief report: Prevalence of pervasive developmental disorder in Brazil: A pilot study. Journal of Autism and Developmental Disorders 2011, 41:1738-1742.
86. Powell J., Edwards A., Edwards M., Pandit B., Sungum-Paliwal S., Whitehouse W. Changes in the incidence of childhood autism and other autistic spectrum disorders in preschool children from two areas of the West Midlands, UK. Developmental Medicine and Child Neurology 2000, 42:624-628.
87. Ritvo E., Freeman B., Pingree C., Mason-Brothers A., Jorde L., Jenson W.R., et al. The UCLA-University of Utah epidemiologic survey of autism: Prevalence. American Journal of Psychiatry 1989, 146:194-199.
88. Rutter M. Autistic children: Infancy to adulthood. Seminars in Psychiatry 1970, 2:435-450.
89. Samadi S.A., Mahmoodizadeh A., McConkey R. A national study of the prevalence of autism among five-year-old children in Iran. Sage Publications and The National Autistic Society 2011, 1-13.
90. Scott F.J., Baron-Cohen S., Bolton P., Brayne C. Brief report: Prevalence of autism spectrum conditions in children aged 5-11 years in Cambridgeshire, UK. Autism 2002, 6:231-237.
91. Shattuck P.T. The contribution of diagnostic substitution to the growing administrative prevalence of autism in US special education. Pediatrics 2006, 117:1028-1037.
92. Shattuck P.T., Durkin M., Maenner M., Newschaffer C., Mandell D.S., Wiggins L., et al. Timing of identification among children with an autism spectrum disorder: Findings from a population-based surveillance study. Journal of the American Academy of Child and Adolescent Psychiatry 2009, 48:474-483.
93. Sponheim E., Skjeldal O. Autism and related disorders: Epidemiological findings in a Norwegian study using icd-10 diagnostic criteria. Journal of Autism and Developmental Disorders 1998, 28:217-227.
94. Steffenburg S., Gillberg C. Autism and autistic-like conditions in Swedish rural and urban areas: a population study. The British Journal of Psychiatry 1986, 149:81-87.
95. Steinhausen H.-C., Gobel D., Breinlinger M., Wohlloben B. A community survey of infantile autism. Journal of the American Academy of Child Psychiatry 1986, 25:186-189.
96. Sugiyama T., Abe T. The prevalence of autism in Nagoya, Japan: A total population study. Journal of Autism and Developmental Disorders 1989, 19:87-96.
97. Tanoue Y., Oda S., Asano F., Kawashima K. Epidemiology of infantile autism in southern Ibaraki, Japan: Differences in prevalence in birth cohorts. Journal of Autism and Developmental Disorders 1988, 18:155-166.
98. Taylor B., Miller E., Farrington C., Petropoulos M.-C., Favot-Mayaud I., Li J., et al. Autism and measles, mumps, and rubella vaccine: No epidemiological evidence for a causal association. Lancet 1999, June 12, 353:2026-2029.
99. Tebruegge M., Nandini V., Ritchie J. Does routine child health surveillance contribute to the early detection of children with pervasive developmental disorders? An epidemiological study in Kent, UK. BMC Pediatrics 2004, 4:4.
100. Treffert D.A. Epidemiology of infantile autism. Archives of General Psychiatry 1970, 22:431-438.
101. van Balkom I.D.C., Bresnahan M., Vogtländer M.F., van Hoeken D., Minderaa R., Susser E., et al. Prevalence of treated autism spectrum disorders in Aruba. Journal of Neurodevelopmental Disorders 2009, 1:197-204.
102. Wazana A., Bresnahan M., Kline J. The autism epidemic: Fact or artifact?. Journal of the American Academy of Child and Adolescent Psychiatry 2007, 46:721-730.
103. Webb E., Lobo S., Hervas A., Scourfield J., Fraser W. The changing prevalence of autistic disorder in a Welsh health district. Developmental Medicine and Child Neurology 1997, 39:150-152.
104. Webb E., Morey J., Thompsen W., Butler C., Barber M., Fraser W.I. Prevalence of autistic spectrum disorder in children attending mainstream schools in a Welsh education authority. Developmental Medicine and Child Neurology 2003, 45:377-384.
105. Wignyosumarto S., Mukhlas M., Shirataki S. Epidemiological and clinical study of autistic children in Yogyakarta, Indonesia. Kobe Journal of Medical Sciences 1992, 38:1-19.
106. Williams J.G., Brayne C.E., Higgins J.P. Systematic review of prevalence studies of autism spectrum disorders. Archives of Disease in Childhood 2006, 91:8-15.
107. Williams E., Thomas K., Sidebotham H., Emond A. Prevalence and characteristics of autistic spectrum disorders in the ALSPAC cohort. Developmental Medicine and Child Neurology 2008, 50:672-677.
108. Wing L. Childhood autism and social class: A question of selection?. British Journal of Psychiatry 1980, 137:410-417.
109. Wing L. The definition and prevalence of autism: A review. European Child and Adolescent Psychiatry 1993, 2:61-74.
110. Wing L., Gould J. Severe impairments of social interaction and associated abnormalities in children: Epidemiology and classification. Journal of Autism and Developmental Disorders 1979, 9:11-29.
111. Wing L., Yeates S., Brierly L., Gould J. The prevalence of early childhood autism: Comparison of administrative and epidemiological studies. Psychological Medicine 1976, 6:89-100.
112. Wolff S., Barlow A. Schizoid personality in childhood: A comparative study of schizoid, autistic and normal children. Journal of Child Psychology and Psychiatry 1979, 20:29-46.
113. Wong V.C., Hui S.L. Epidemiological study of autism spectrum disorder in China. Journal of Child Neurology 2008, 23:67-72.
114. ICD-10 The ICD-9 Classification of Mental and Behavioural Disorders: Clinical Descriptions and Diagnostic Guidelines 1977, World Health Organization, Geneva.
115. ICD-10 The ICD-10 Classification of Mental and Behavioural Disorders: Clinical Descriptions and Diagnostic Guidelines 1992, World Health Organization, Geneva.
116. Yeargin-Allsopp M., Rice C., Karapurkar T., Doernberg N., Boyle C., Murphy C. Prevalence of autism in a US metropolitan area. Journal of the American Medical Association 2003, 289:49-55. [comment].
117. Centers for Disease Control Prevalence of autism spectrum disorders - autism and developmental disabilities monitoring network, United States, 2006. Morbidity and Mortality Weekly Report Surveillance Summary 2009, 58:1-14.
118. Chakrabarti S., Fombonne E. Pervasive developmental disorders in preschool children. Journal of the American Medical Association 2001, 285:3093-3099.
119. Fombonne E. Epidemiology. Lewis's Child and Adolescent Psychiatry: A Comprehensive Textbook 2007, 150-171. Lippincott, Williams, and Wilkins. fourth ed. A. Martin, F. Volkmar (Eds.).
120. Shattuck P.T. The contribution of diagnostic substitution to the growing administrative prevalence of autism in US special education. Pediatrics 2006, 117:1028-1037.