A treatment planning comparison of four target volume contouring guidelines for locally advanced pancreatic cancer radiotherapy

Radiotherapy and Oncology

Volumn 107, Issue 2, 2013, Pages 200-206

  Fokas, Emmanouil ^a,b   Eccles, Cynthia ^a   Patel, Neel ^a   Chu, Kwun Ye ^a   Warren, Samantha ^a   McKenna, W Gillies ^a   Brunner, Thomas B ^a,c  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b GOETHE UNIVERSITY   (Germany)

^c UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Dosimetric comparison; Four contouring methods; Pancreatic cancer; Radiotherapy

Indexed keywords

ADVANCED CANCER; ARTICLE; CANCER RADIOTHERAPY; CANCER SIZE; CELIAC ARTERY; CHEMORADIOTHERAPY; CLINICAL ARTICLE; COMMON BILE DUCT; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CYSTIC DUCT; HUMAN; INFERIOR CAVA VEIN; INFERIOR MESENTERIC ARTERY; LIVER PARENCHYMA; LYMPHATIC DRAINAGE; ORGANS AT RISK; PANCREAS ADENOCARCINOMA; PARAAORTIC LYMPH NODE; PHASE 2 CLINICAL TRIAL; PORTAL VEIN; PRACTICE GUIDELINE; PRIMARY TUMOR; PRIORITY JOURNAL; RADIATION DOSE DISTRIBUTION; RADIATION DOSE REDUCTION; RANDOMIZED CONTROLLED TRIAL; SUPERIOR MESENTERIC ARTERY; SUPERIOR MESENTERIC VEIN; TREATMENT PLANNING;

ADENOCARCINOMA; CARCINOMA, PANCREATIC DUCTAL; HUMANS; ORGANS AT RISK; PANCREATIC NEOPLASMS; PRACTICE GUIDELINES AS TOPIC; RADIOTHERAPY DOSAGE; RADIOTHERAPY PLANNING, COMPUTER-ASSISTED; TUMOR BURDEN;

EID: 84879030998     PISSN: 01678140     EISSN: 18790887     Source Type: Journal    
DOI: 10.1016/j.radonc.2013.04.010     Document Type: Article

References (20)

1. B. Asiyanbola, A. Gleisner, and J.M. Herman Determining pattern of recurrence following pancreaticoduodenectomy and adjuvant 5-flurouracil-based chemoradiation therapy: effect of number of metastatic lymph nodes and lymph node ratio J Gastrointest Surg 13 2009 752 759
2. E. Ben-Josef, and T.S. Lawrence Radiotherapy: the importance of local control in pancreatic cancer Nat Rev Clin Oncol 9 2012 9 10
3. E. Ben-Josef, M. Schipper, and I.R. Francis Phase I/II radiation dose-escalation trial of intensity-modulated radiotherapy (IMRT) with concurrent fixed dose-rate gemcitabine (FDR-G) for unresectable pancreatic cancer Int J Radiat Oncol Biol Phys 81 2011 127 128
4. T.B. Brunner, U. Baum, G.G. Grabenbauer, R. Sauer, and U. Lambrecht Large topographic variability of upper abdominal lymphatics and the consequences for radiation treatment planning Radiother Oncol 81 2006 190 195 (Pubitemid 44780783)
5. T.B. Brunner, G.G. Grabenbauer, and P. Klein Phase I trial of strictly time-scheduled gemcitabine and cisplatin with concurrent radiotherapy in patients with locally advanced pancreatic cancer Int J Radiat Oncol Biol Phys 55 2003 144 153 (Pubitemid 36020354)
6. T.B. Brunner, S. Merkel, and G.G. Grabenbauer Definition of elective lymphatic target volume in ductal carcinoma of the pancreatic head based on histopathologic analysis Int J Radiat Oncol Biol Phys 62 2005 1021 1029 (Pubitemid 40884413)
7. T.B. Brunner, and M. Scott-Brown The role of radiotherapy in multimodal treatment of pancreatic carcinoma Radiat Oncol 5 2010 64
8. W. Eppinga, F. Lagerwaard, W. Verbakel, B. Slotman, and S. Senan Volumetric modulated arc therapy for advanced pancreatic cancer Strahlenther Onkol 186 2010 382 387
9. S. Gillen, T. Schuster, C. Meyer Zum Buschenfelde, H. Friess, and J. Kleeff Preoperative/neoadjuvant therapy in pancreatic cancer: a systematic review and meta-analysis of response and resection percentages PLoS Med 7 2010 e1000267
10. K.A. Goodman, W.F. Regine, and L.A. Dawson Radiation Therapy Oncology Group consensus panel guidelines for the delineation of the clinical target volume in the postoperative treatment of pancreatic head cancer Int J Radiat Oncol Biol Phys 83 2012 901 908
11. C.A. Iacobuzio-Donahue, B. Fu, and S. Yachida DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer J Clin Oncol 27 2009 1806 1813
12. P.J. Loehrer Sr., Y. Feng, and H. Cardenes Gemcitabine alone versus gemcitabine plus radiotherapy in patients with locally advanced pancreatic cancer: an Eastern Cooperative Oncology Group trial J Clin Oncol 29 2011 4105 4112
13. J.D. Murphy, S. Adusumilli, and K.A. Griffith Full-dose gemcitabine and concurrent radiotherapy for unresectable pancreatic cancer Int J Radiat Oncol Biol Phys 68 2007 801 808 (Pubitemid 46818734)
14. T. Nagakawa, H. Kobayashi, K. Ueno, T. Ohta, M. Kayahara, and I. Miyazaki Clinical study of lymphatic flow to the paraaortic lymph nodes in carcinoma of the head of the pancreas Cancer 73 1994 1155 1162 (Pubitemid 24061609)
15. M. Niedergethmann, M. Rexin, and R. Hildenbrand Prognostic implications of routine, immunohistochemical, and molecular staging in resectable pancreatic adenocarcinoma Am J Surg Pathol 26 2002 1578 1587 (Pubitemid 35407402)
16. A.C. Spalding, K.W. Jee, and K. Vineberg Potential for dose-escalation and reduction of risk in pancreatic cancer using IMRT optimization with lexicographic ordering and gEUD-based cost functions Med Phys 34 2007 521 529 (Pubitemid 46185131)
17. A. Stathis, and M.J. Moore Advanced pancreatic carcinoma: current treatment and future challenges Nat Rev Clin Oncol 7 2010 163 172
18. W. Sun, C.N. Leong, Z. Zhang, and J.J. Lu Proposing the lymphatic target volume for elective radiation therapy for pancreatic cancer: a pooled analysis of clinical evidence Radiat Oncol 5 2010 28
19. J.L. Van Laethem, P. Hammel, and F. Mornex Adjuvant gemcitabine alone versus gemcitabine-based chemoradiotherapy after curative resection for pancreatic cancer: a randomized EORTC-40013-22012/FFCD-9203/GERCOR phase II study J Clin Oncol 28 2010 4450 4456
20. L. Zhao, M. Chen, and R. Ten Haken Three-dimensional conformal radiation may deliver considerable dose of incidental nodal irradiation in patients with early stage node-negative non-small cell lung cancer when the tumor is large and centrally located Radiother Oncol 82 2007 153 159 (Pubitemid 46275141)