Mitochondrial trafficking in neurons

Cold Spring Harbor Perspectives in Medicine

Volumn 3, Issue 1, 2013, Pages

  Schwarz, Thomas L ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA;

EID: 84879005976     PISSN: None     EISSN: 21571422     Source Type: Journal    
DOI: None     Document Type: Article

References (115)

1. Amiri M., Hollenbeck PJ. 2008. Mitochondrial biogenesis in the axons of vertebrate peripheral neurons. DevNeurobiol 68: 1348-1361.
2. Aschrafi A., Natera-Naranjo O, Gioio AE, Kaplan BB. 2010. Regulation of axonal trafficking of cytochrome c oxidase IV mRNA. Mol Cell Neurosci 43: 422-430.
3. Aspenstrom P., Ruusala A, Pacholsky D. 2007. Taking Rho GTPases to the next level: The cellular functions of atypical Rho GTPases. Exp Cell Res 313: 3673-3679.
4. Baloh RH. 2007. Mitochondrial dynamics and peripheral neuropathy. Neuroscientist 14: 12-18.
5. Barkus R.V., Klyachko O, Horiuchi D, Dickson BJ, Saxton WM. 2008. Identification of an axonal kinesin-3 motor for fast anterograde vesicle transport that facilitates retrograde transport of neuropeptides. Mol Biol Cell 19: 274-283.
6. Beck M., Brickley K, Wilkinson HL, Sharma S, Smith M, Chazot P.L., Pollard S, Stephenson FA. 2002. Identification, molecular cloning, and characterization of a novel GABAAreceptor-associated protein, GRIF-1. J Biol Chem 277: 30079-30090.
7. Brickley K., Stephenson FA. 2011. Trafficking kinesin protein (TRAK)-mediated transport of mitochondria in axons of hippocampal neurons. J Biol Chem 286: 18079-18092.
8. Brickley K., Smith MJ, Beck M, Stephenson FA. 2005. GRIF-1 and OIP106, members of a novel gene family of coiledcoil domain proteins: Association in vivo and in vitro with kinesin. J Biol Chem 280: 14723-14732.
9. Brickley K., Pozo K, Stephenson FA. 2011. N-acetylglucosamine transferase is an integral component of a kinesindirected mitochondrial trafficking complex. Biochim Biophys Acta 1813: 269-281.
10. Cai Q., Gerwin C, Sheng ZH. 2005. Syntabulin-mediated anterograde transport of mitochondria along neuronal processes. J Cell Biol 170: 959-969.
11. Chada S.R., Hollenbeck PJ. 2003. Mitochondrial movement and positioning in axons: The role of growth factor signaling. J Exp Biol 206: 1985-1992.
12. Chada S.R., Hollenbeck PJ. 2004. Nerve growth factor signaling regulates motility and docking of axonal mitochondria. Curr Biol 14: 1272-1276.
13. Chan N.C., Salazar AM, Pham AH, Sweredoski MJ, Kolawa NJ, Graham RL, Hess S, Chan DC. 2011. Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy. Hum Mol Genet 20: 1726-1737.
14. Chang D.T., Honick AS, Reynolds IJ. 2006. Mitochondrial trafficking to synapses in cultured primary cortical neurons. J Neurosci 26: 7035-7045.
15. Chen H., McCaffery JM, Chan DC. 2007. Mitochondrial fusion protects against neurodegeneration in the cerebellum. Cell 130: 548-562.
16. Chen Y.M., Gerwin C, Sheng ZH. 2009. Dynein light chain LC8 regulates syntaphilin-mediated mitochondrial docking in axons. J Neurosci 29: 9429-9438.
17. Chen S., Owens GC, Makarenkova H, Edelman DB. 2010. HDAC6 regulates mitochondrial transport in hippocampal neurons. PLoS ONE 5: e10848.
18. Cho K.I., Cai Y, Yi H, Yeh A, Aslanukov A, Ferreira PA. 2007. Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function. Traffic 8: 1722-1735.
19. Clark I.E., Dodson MW, Jiang C, Cao JH, Huh JR, Seol JH, Yoo S.J., Hay BA, Guo M. 2006. Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. Nature 441: 1162-1166.
20. Cox R.T., Spradling AC. 2006. Milton controls the early acquisition of mitochondria by Drosophila oocytes. Development 133: 3371-3377.
21. Davis A.F., Clayton DA. 1996. In situ localization of mitochondrial DNA replication in intact mammalian cells. J Cell Biol 135: 883-893.
22. De Vos KJ, Grierson AJ, Ackerley S, Miller CC. 2008. Role of axonal transport in neurodegenerative diseases. Annu Rev Neurosci 31: 151-173.
23. Fransson A., Ruusala A, Aspenstrom P. 2003. Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis. J Biol Chem 278: 6495-6502.
24. Fransson S., Ruusala A, Aspenstrom P. 2006. The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking. Biochem Biophys Res Commun 344: 500-510.
25. Frederick R.L., Shaw JM. 2007. Moving mitochondria: Establishing distribution of an essential organelle. Traffic 8: 1668-1675.
26. Frederick R.L., McCaffery JM, Cunningham KW, Okamoto K, Shaw JM. 2004. Yeast Miro GTPase, Gem1p, regulates mitochondrial morphology via a novel pathway. J Cell Biol 167: 87-98.
27. Fujita T., Maturana AD, Ikuta J, Hamada J, Walchli S, Suzuki T, Sawa H, Wooten MW, Okajima T, Tatematsu K, et al. 2007. Axonal guidance protein FEZ1 associates with tubulin and kinesin motor protein to transport mitochondria in neurites of NGF-stimulated PC12 cells. Biochem Biophys Res Commun 361: 605-610.
28. Gauthier L.R., Charrin BC, Borrell-Pages M, Dompierre JP, Rangone H., Cordelieres FP, De Mey J, MacDonald ME, Lessmann V., Humbert S, et al. 2004. Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules. Cell 118: 127-138.
29. Gioio A.E., Eyman M, Zhang H, Lavina ZS, Giuditta A, Kaplan BB. 2001. Local synthesis of nuclear-encoded mitochondrial proteins in the presynaptic nerve terminal. J Neurosci Res 64: 447-453.
30. Glater E.E., Megeath LJ, Stowers RS, Schwarz TL. 2006. Axonal transport of mitochondria requires milton to recruit kinesin heavy chain and is light chain independent. J Cell Biol 173: 545-557.
31. Goldstein L.S., Gunawardena S. 2000. Flying through the Drosophila cytoskeletal genome. J Cell Biol 150: F63-F68.
32. Gorska-Andrzejak J, Stowers RS, Borycz J, Kostyleva R, Schwarz T.L., Meinertzhagen IA. 2003. Mitochondria are redistributed in Drosophila photoreceptors lacking milton, a kinesin-associated protein. J Comp Neurol 463: 372-388.
33. Greene J.C., Whitworth AJ, Kuo I, Andrews LA, Feany MB, Pallanck LJ. 2003. Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants. Proc Natl Acad Sci 100: 4078-4083.
34. + channel Kir2.1. J Biol Chem 281: 30104-30111.
35. Guo X., Macleod GT, Wellington A, Hu F, Panchumarthi S, Schoenfield M., Marin L, Charlton MP, Atwood HL, Zinsmaier KE. 2005. The GTPase dMiro is required for axonal transport of mitochondria to Drosophila synapses. Neuron 47: 379-393.
36. Hall D.H., Hedgecock EM. 1991. Kinesin-related gene unc-104 is required for axonal transport of synaptic vesicles in C. elegans. Cell 65: 837-847.
37. Hirokawa N. 1982. Cross-linker system between neurofilaments, microtubules, and membranous organelles in frog axons revealed by the quick-freeze, deep-etching method. J Cell Biol 94: 129-142.
38. Hollenbeck P.J., Saxton WM. 2005. The axonal transport of mitochondria. J Cell Sci 118: 5411-5419.
39. Holzbaur E. 2010. Axonal transport: CDKs as traffic signals for motor-ists along the axon? Curr Biol 20: R641-R642.
40. Hurd D.D., Saxton WM. 1996. Kinesin mutations cause motor neuron disease phenotypes by disrupting fast axonal transport in Drosophila. Genetics 144: 1075-1085.
41. Ikuta J., Maturana A, Fujita T, Okajima T, Tatematsu K, Tanizawa K, Kuroda S. 2007. Fasciculation and elongation protein z-1 (FEZ1) participates in the polarization of hippocampal neuron by controlling the mitochondrial motility. Biochem Biophys Res Commun 353: 127-132.
42. Iyer S.P., Akimoto Y, HartGW. 2003. Identification and cloning of a novel family of coiled-coil domain proteins that interact with O-GlcNAc transferase. J Biol Chem 278: 5399-5409.
43. Jakobs S. 2006. High resolution imaging of live mitochondria. Biochim Biophys 1763: 561-575.
44. Kang J.S., Tian JH, Pan PY, Zald P, Li C, Deng C, Sheng ZH. 2008. Docking of axonal mitochondria by syntaphilin controls their mobility and affects short-term facilitation. Cell 132: 137-148.
45. Khodjakov A., Lizunova EM, Minin AA, KoonceMP, Gyoeva FK. 1998. A specific light chain of kinesin associates with mitochondria in cultured cells. Mol Biol Cell 9: 333-343.
46. Kijima K., Numakura C, Izumino H, Umetsu K, Nezu A, Shiiki T., Ogawa M, Ishizaki Y, Kitamura T, Shozawa Y, et al. 2005. Mitochondrial GTPase mitofusin 2 mutation in Charcot-Marie-Tooth neuropathy type 2A. Human Genet 116: 23-27.
47. Kimura K., Ito M, Amano M, Chihara K, Fukata Y, Nakafuku M, Yamamori B, Feng J, Nakano T, Okawa K, et al. 1996. Regulation of myosin phosphatase by Rho and Rho-associated kinase (r-kinase). Science 273: 245-248.
48. Kirk E., Chin LS, Li L. 2006. GRIF1 binds Hrs and is a new regulator of endosomal trafficking. J Cell Sci 119: 4689-4701.
49. Kitada T., Asakawa S, Hattori N, Matsumine H, Yamamura Y, Minoshima S., Yokochi M, Mizuno Y, Shimizu N. 1998. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature 392: 605-608.
50. Lazarus B.D., Love DC, Hanover JA. 2009. O-GlcNAc cycling: Implications for neurodegenerative disorders. Int J Biochem Cell Biol 41: 2134-2146.
51. Li Y., Lim S, Hoffman D, Aspenstrom P, Federoff HJ, Rempe DA. 2009. HUMMR, a hypoxia-and HIF-1α-inducible protein, alters mitochondrial distribution and transport. J Cell Biol 185: 1065-1081.
52. Ligon L.A., Steward O. 2000a. Movement of mitochondria in the axons and dendrites of cultured hippocampal neurons. J Comp Neurol 427: 340-350.
53. Ligon L.A., Steward O. 2000b. Role of microtubules and actin filaments in the movement of mitochondria in the axons and dendrites of cultured hippocampal neurons. J Comp Neurol 427: 351-361.
54. Liu X., Weaver D, Shirihai O, Hajnoczky G. 2009. Mitochondrial "kiss-and-run": Interplay between mitochondrial motility and fusion-fission dynamics. EMBO J 28: 3074-3089.
55. Liu S., Sawada T, Lee S, YuW, Silverio G, Alapatt P, Millan I, Shen A., Saxton W, Kanao T, et al. 2012. Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria. PLoS Genet 8: e1002537.
56. Lopez-Domenech G, Serrat R, Mirra S, D'Aniello S, Somorjai I, Abad A, Vitureira N, Garcia-Arumi E, Alonso MT, Rodriguez-Prados M, et al. 2012. The Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro and Trak2. Nat Commun 3: 814.
57. Lyons D.A., Naylor SG, Mercurio S, Dominguez C, Talbot WS. 2008. KBP is essential for axonal structure, outgrowth and maintenance in zebrafish, providing insight into the cellular basis of Goldberg-Shprintzen syndrome. Development 135: 599-608.
58. Macaskill A.F., Rinholm JE, Twelvetrees AE, Arancibia-Carcamo IL, Muir J, Fransson A, Aspenstrom P, Attwell D, Kittler JT. 2009. Miro1 is a calcium sensor for glutamate receptor-dependent localization of mitochondria at synapses. Neuron 61: 541-555.
59. Mandelkow E.M., Thies E, Trinczek B, Biernat J, Mandelkow E. 2004. MARK/PAR1 kinase is a regulator of microtubule-dependent transport in axons. J Cell Biol 167: 99-110.
60. Miller K.E., Sheetz MP. 2004. Axonal mitochondrial transport and potential are correlated. J Cell Sci 117: 2791-2804.
61. Milner D.J., Mavroidis M, Weisleder N, Capetanaki Y. 2000. Desmin cytoskeleton linked to muscle mitochondrial distribution and respiratory function. J Cell Biol 150: 1283-1298.
62. Minin A.A., Kulik AV, Gyoeva FK, Li Y, Goshima G, Gelfand VI. 2006. Regulation of mitochondria distribution by RhoA and formins. J Cell Sci 119: 659-670.
63. Mironov SL. 2007. ADP regulates movements of mitochondria in neurons. Biophys J 92: 2944-2952.
64. Mironov SL. 2009. Complexity of mitochondrial dynamics in neurons and its control by ADP produced during synaptic activity. Int J Biochem Cell Biol 41: 2005-2014.
65. Misgeld T., Kerschensteiner M, Bareyre FM, Burgess RW, Lichtman JW. 2007. Imaging axonal transport of mitochondria in vivo. Nature Methods 4: 559-561.
66. Misko A., Jiang S, Wegorzewska I, Milbrandt J, Baloh RH. 2010. Mitofusin 2 is necessary for transport of axonal mitochondria and interacts with the Miro/Milton complex. J Neurosci 30: 4232-4240.
67. Morfini G., Szebenyi G, Brown H, Pant HC, Pigino G, De-Boer S., Beffert U, Brady ST. 2004. A novel CDK5-dependent pathway for regulating GSK3 activity and kinesindriven motility in neurons. EMBO J 23: 2235-2245.
68. Morfini G., Pigino G, Szebenyi G, You Y, Pollema S, Brady ST. 2006. JNK mediates pathogenic effects of polyglutamineexpanded androgen receptor on fast axonal transport. Nat Neurosci 9: 907-916.
69. Morfini G.A., You YM, Pollema SL, Kaminska A, Liu K, Yoshioka K, Bjorkblom B, Coffey ET, Bagnato C, Han D, et al. 2009. Pathogenic Huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin. Nat Neurosci 12: 864-871.
70. Morris R.L., Hollenbeck PJ. 1993. The regulation of bidirectional mitochondrial transport is coordinated with axonal outgrowth. J Cell Sci 104: 917-927.
71. Nangaku M., Sato-Yoshitake R, Okada Y, Noda Y, Takemura R, Yamazaki H, Hirokawa N. 1994. KIF1B, a novel microtubule plus end-directed monomeric motor protein for transport of mitochondria. Cell 79: 1209-1220.
72. Narendra D., Walker JE, Youle R. 2012. Mitochondrial quality control mediated by PINK1 and Parkin: Links to Parkinsonism. Cold Spring Harb Perspect Biol 4: a011338.
73. Nekrasova O.E., Mendez MG, Chernoivanenko IS, Tyurin-Kuzmin P.A., Kuczmarski ER, Gelfand VI, Goldman RD, Minin AA. 2011. Vimentin intermediate filaments modulate the motility of mitochondria. Mol Biol Cell 22: 2282-2289.
74. Ohno N., Kidd GJ, Mahad D, Kiryu-Seo S, Avishai A, Komuro H, Trapp BD. 2011. Myelination and axonal electrical activity modulate the distribution and motility of mitochondria at CNS nodes of Ranvier. J Neurosci 31: 7249-7258.
75. Pack-Chung E, Kurshan PT, Dickman DK, Schwarz TL. 2007. A Drosophila kinesin required for synaptic bouton formation and synaptic vesicle transport. Nat Neurosci 10: 980-989.
76. Park J., Lee SB, Lee S, Kim Y, Song S, Kim S, Bae E, Kim J, Shong M., Kim JM, et al. 2006. Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin. Nature 441: 1157-1161.
77. Pathak D., Sepp KJ, Hollenbeck PJ. 2010. Evidence that myosin activity opposes microtubule-based axonal transport of mitochondria. J Neurosci 30: 8984-8992.
78. Poole A.C., Thomas RE, Andrews LA, McBride HM, Whitworth AJ, Pallanck LJ. 2008. The PINK1/Parkin pathway regulates mitochondrial morphology. Proc Natl Acad Sci 105: 1638-1643.
79. Poole A.C., Thomas RE, Yu S, Vincow ES, Pallanck L. 2010. The mitochondrial fusion-promoting factor mitofusin is a substrate of the PINK1/parkin pathway. PLoS ONE 5: e10054.
80. Quintero O.A., DiVito MM, Adikes RC, KortanMB, Case LB, Lier A.J., Panaretos NS, Slater SQ, Rengarajan M, Feliu M, et al. 2009. Human Myo19 is a novel myosin that associates with mitochondria. Curr Biol 19: 2008-2013.
81. Ratner N., Bloom GS, Brady ST. 1998. A role for cyclindependent kinase(s) in the modulation of fast anterograde axonal transport: Effects defined by olomoucine and the APC tumor suppressor protein. J Neurosci 18: 7717-7726.
82. Reipert S., Steinbock F, Fischer I, Bittner RE, Zeold A, Wiche G. 1999. Association of mitochondria with plectin and desmin intermediate filaments in striated muscle. Exp Cell Res 252: 479-491.
83. Rezniczek G.A., Abrahamsberg C, Fuchs P, Spazierer D, Wiche G. 2003. Plectin 5'-transcript diversity: Short alternative sequences determine stability of gene products, initiation of translation and subcellular localization of isoforms. Human Mol Genet 12: 3181-3194.
84. Rintoul G.L., Filiano AJ, Brocard JB, Kress GJ, Reynolds IJ. 2003. Glutamate decreases mitochondrial size and movement in primary forebrain neurons. J Neurosci 23: 7881-7888.
85. Russo G.J., Louie K, Wellington A, Macleod GT, Hu F, Panchumarthi S, Zinsmaier KE. 2009. Drosophila Miro is required for both anterograde and retrograde axonal mitochondrial transport. J Neurosci 29: 5443-5455.
86. 2+-dependent control of mitochondrial dynamics by the Miro GTPase. Proc Natl Acad Sci 105: 20728-20733.
87. Smith M.J., Pozo K, Brickley K, Stephenson FA. 2006. Mapping the GRIF-1 binding domain of the kinesin, KIF5C, substantiates a role for GRIF-1 as an adaptor protein in the anterograde trafficking of cargoes. J Biol Chem 281: 27216-27228.
88. Stowers R.S., Megeath LJ, Gorska-Andrzejak J, Meinertzhagen IA, Schwarz TL. 2002. Axonal transport of mitochon-dria to synapses depends on milton, a novel Drosophila protein. Neuron 36: 1063-1077.
89. Sturmer K., Baumann O, Walz B. 1995. Actin-dependent light-induced translocation of mitochondria and ER cisternae in the photoreceptor cells of the locust Schistocerca gregaria. J Cell Sci 108: 2273-2283.
90. 2+ signaling. Biochim Biophys Acta 1763: 442-449.
91. Tanaka Y., Kanai Y, Okada Y, Nonaka S, Takeda S, Harada A, Hirokawa N. 1998. Targeted disruption of mouse conventional kinesin heavy chain, kif5B, results in abnormal perinuclear clustering of mitochondria. Cell 93: 1147-1158.
92. Tanaka A., Cleland MM, Xu S, Narendra DP, Suen DF, Karbowski M, Youle RJ. 2010. Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin. J Cell Biol 191: 1367-1380.
93. Tanaka K., Sugiura Y, Ichishita R, Mihara K, Oka T. 2011. KLP6: A newly identified kinesin that regulates the morphology and transport of mitochondria in neuronal cells. J Cell Sci 124: 2457-2465.
94. Tao G.Z., Looi KS, Toivola DM, Strnad P, Zhou Q, Liao J, Wei Y., Habtezion A, Omary MB. 2009. Keratins modulate the shape and function of hepatocyte mitochondria: A mechanism for protection from apoptosis. J Cell Sci 122: 3851-3855.
95. Trejo H.E., Lecuona E, Grillo D, Szleifer I, Nekrasova OE, Gelfand V.I., Sznajder JI. 2010. Role of kinesin light chain-2 of kinesin-1 in the traffic of Na, K-ATPase-containing vesicles in alveolar epithelial cells. FASEB J 24: 374-382.
96. Vale RD. 2003. The molecular motor toolbox for intracellular transport. Cell 112: 467-480.
97. Valente E.M., Abou-Sleiman PM, Caputo V, Muqit MM, Harvey K., Gispert S, Ali Z, Del Turco D, Bentivoglio AR, Healy DG, et al. 2004. Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science 304: 1158-1160.
98. van Spronsen M, Mikhaylova M, Lipka J, Schlager MA, van den Heuvel DJ, Kuijpers M, Wulf PS, Keijzer N, Demmers J, Kapitein LC, et al. 2013. TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking to axons and dendrites. Neuron 77: 485-502.
99. Verburg J., Hollenbeck PJ. 2008. Mitochondrial membrane potential in axons increases with local nerve growth factor or semaphorin signaling. J Neurosci 28: 8306-8315.
100. Wagner O.I., Lifshitz J, Janmey PA, Linden M, McIntosh TK, Leterrier JF. 2003. Mechanisms of mitochondria-neurofilament interactions. J Neurosci 23: 9046-9058.
101. 2+-dependent regulation of kinesin-mediated mitochondrial motility. Cell 136: 163-174.
102. Wang X., Winter D, Ashrafi G, Schlehe J, Wong YL, Selkoe D, Rice S., Steen J, LaVoie MJ, Schwarz TL. 2011. PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility. Cell 147: 893-906.
103. Watanabe N., Madaule P, Reid T, Ishizaki T, Watanabe G, Kakizuka A., Saito Y, Nakao K, Jockusch BM, Narumiya S. 1997. p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin. EMBO J 16: 3044-3056.
104. Weihofen A., Thomas KJ, Ostaszewski BL, Cookson MR, Selkoe DJ. 2009. Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking. Biochemistry 48: 2045-2052.
105. Whitworth A.J., Pallanck LJ. 2009. The PINK1/Parkin pathway: A mitochondrial quality control system? J Bioenerg Biomembr 41: 499-503.
106. Winter L., Abrahamsberg C, Wiche G. 2008. Plectin isoform 1b mediates mitochondrion-intermediate filament network linkage and controls organelle shape. J Cell Biol 181: 903-911.
107. Wozniak M.J., Melzer M, Dorner C, Haring HU, Lammers R. 2005. The novel protein KBP regulates mitochondria localization by interactionwith a kinesin-like protein. BMC Cell Biol 6: 35.
108. 2+ release in permeabilised rat ventricularmyocytes. J Physiol 523: 29-44.
109. Yang Y., Gehrke S, Imai Y, Huang Z, Ouyang Y, WangJW, Yang L, Beal MF, Vogel H, Lu B. 2006. Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin. Proc Natl Acad Sci 103: 10793-10798.
110. Yi M., Weaver D, Hajnoczky G. 2004. Control of mitochondrial motility and distribution by the calcium signal: A homeostatic circuit. J Cell Biol 167: 661-672.
111. Yonekawa Y., Harada A, Okada Y, Funakoshi T, Kanai Y, Takei Y, Terada S, Noda T, Hirokawa N. 1998. Defect in synaptic vesicle precursor transport and neuronal cell death in KIF1A motor protein-deficient mice. J Cell Biol 141: 431-441.
112. Yoon B.C., Jung H, Dwivedy A, O'Hare CM, Zivraj KH, Holt CE. 2012. Local translation of extranuclear lamin B promotes axon maintenance. Cell 148: 752-764.
113. Youle R.J., Narendra DP. 2011. Mechanisms of mitophagy. Nat Rev Mol Cell Biol 12: 9-14.
114. Zhu X.H., Qiao H, Du F, Xiong Q, Liu X, Zhang X, Ugurbil K, Chen W. 2012. Quantitative imaging of energy expenditure in human brain. Neuroimage 60: 2107-2117.
115. Zuchner S., Mersiyanova IV, Muglia M, Bissar-Tadmouri N, Rochelle J., Dadali EL, Zappia M, Nelis E, Patitucci A, Senderek J., et al. 2004. Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A. Nat Genet 36: 449-451.