The effectiveness of modern antihistamines for treatment of allergic rhinitis - An IPD meta-analysis of 140,853 patients

Allergology International

Volumn 62, Issue 2, 2013, Pages 215-222

  Mösges, Ralph ^a   König, Volker ^a   Köberlein, Juliane ^b  

^a UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

^b UNIVERSITY OF WUPPERTAL   (Germany)

Author keywords

Allergic rhinitis; Desloratadine; Ebastine; Fexofenadine; Levocetirizine; Treatment

Indexed keywords

ANTIHISTAMINIC AGENT; BECLOMETASONE DIPROPIONATE; BUDESONIDE; CHLORPHENIRAMINE MALEATE; CORTICOSTEROID; DESLORATADINE; EBASTINE; FEXOFENADINE; FLUTICASONE PROPIONATE; LEVOCETIRIZINE; MOMETASONE FUROATE; PULNICORT; STEROID; TRIAMCINOLONE ACETONIDE; UNCLASSIFIED DRUG;

ADULT; AGED; ALLERGIC RHINITIS; ARTICLE; CHILD; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; GENERAL PRACTITIONER; GERMANY; HUMAN; INFORMATION PROCESSING; MAJOR CLINICAL STUDY; MALE; MEDICAL DOCUMENTATION; MEDICAL SPECIALIST; META ANALYSIS; MONOTHERAPY; PATIENT CODING; PREVALENCE; PRIORITY JOURNAL; PRIVATE PRACTICE; SCHOOL CHILD;

EID: 84878958970     PISSN: 13238930     EISSN: 14401592     Source Type: Journal    
DOI: 10.2332/allergolint.12-OA-0486     Document Type: Article

References (28)

1. Nathan RA, Meltzer EO, Derebery J et al. The prevalence of nasal symptoms attributed to allergies in the United States: findings from the burden of rhinitis in an America survey. Allergy Asthma Proc 2008;29:600-8.
2. Bauchau V, Durham SR. Prevalence and rate of diagnosis of allergic rhinitis in Europe. Eur Respir J 2004;24:758-64.
3. Asher MI, Montefort S, Bjorksten B et al. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry crosssectional surveys. Lancet 2006;368:733-43.
4. Heinrich J, Richter K, Frye C et al. [European Community Respiratory Health Survey in Adults (ECRHS)]. Pneumologie 2002;56:297-303(in German).
5. Janson C, Anto J, Burney P et al. The European Community Respiratory Health Survey: what are the main results so far? European Community Respiratory Health Survey II. Eur Respir J 2001;18:598-611.
6. Ring J, Fuchs T, Schultze-Werninghaus G. Weiβ buch Allergie, 2nd edn. Munich: Urban & Vogel, 2004;336.
7. Wang DY, Niti M, Smith JD, Yeoh KH, Ng TP. Rhinitis: do diagnostic criteria affect the prevalence and treatment? Allergy 2002;57:150-4.
8. Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee. Lancet 1998; 351:1225-32.
9. Maurer M, Zuberbier T. Undertreatment of rhinitis symptoms in Europe: findings from a cross-sectional questionnaire survey. Allergy 2007;62:1057-63.
10. Bousquet J, Khaltaev N, Cruz AA et al. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy 2008;63 (Suppl 86):8-160.
11. Benninger M, Farrar JR, Blaiss M et al. Evaluating approved medications to treat allergic rhinitis in the United States: an evidence-based review of efficacy for nasal symptoms by class. Ann Allergy Asthma Immunol 2010; 104:13-29.
12. Mosges R. On the benefit of breaking the rules. Curr Opin Allergy Clin Immunol 2005;5:211-3.
13. Wober W, Diez Crespo C, Bahre M. Efficacy and tolerability of azelastine nasal spray in the treatment of allergic rhinitis: large scale experience in community practice. Curr Med Res Opin 1997;13:617-26.
14. Wober W, Diez Crespo CD, Bahre M. Evaluation of the drug monitoring programme of azelastine hydrochloride nasal spray in the treatment of allergic rhinitis in children under 13 years of age. Arzneimittelforschung 1997;47:841-4.
15. Sutton AJ, Abrams KR, Jones DR, Sheldon TA, Song F. Methods of Meta-Analysis in Medical Research. Chichester, UK: John Wiley & Sons, 2000.
16. Friedenreich CM. Methods for pooled analyses of epidemiologic studies. Epidemiology 1993;4:295-305.
17. FDA. Allergic rhinitis: Clinical development programs for drug products. In: FDA (ed). Guidance for Industry. Rockville, USA: Center for Drug Evaluation and Research, 2000. Available at: http: www.fda.gov download s Drugs Guidance ComplianceRegulatory Information Guidances ucm071293.pdf. Accessed February 15, 2011.
18. Patou J, De Smedt H, van Cauwenberge P, Bachert C. Pathophysiology of nasal obstruction and meta-analysis of early and late effects of levocetirizine. Clin Exp Allergy 2006;36:972-81.
19. Staevska M, Popov TA, Kralimarkova T et al. The effectiveness of levocetirizine and desloratadine in up to 4 times conventional doses in difficult-to-treat urticaria. J Allergy Clin Immunol 2010;125:676-82.
20. Canonica GW, Tarantini F, Compalati E, Penagos M. Efficacy of desloratadine in the treatment of allergic rhinitis: a meta-analysis of randomized, double-blind, controlled trials. Allergy 2007;62:359-66.
21. Compalati E, Baena-Cagnani R, Penagos M et al. Systematic review on the efficacy of fexofenadine in seasonal allergic rhinitis: a meta-analysis of randomized, doubleblind, placebo-controlled clinical trials. Int Arch Allergy Immunol 2011;156:1-15.
22. Khianey R, Weinstein ME. Efficacy and tolerability of levocetirizine in improving symptoms and health-related quality of life in patients with allergic rhinitis: A metaanalysis [abstract]. J Allergy Clin Immunol 2011;127 (Suppl):A843.
23. Ratner P, Falques M, Chuecos F et al. Meta-analysis of the efficacy of ebastine 20 mg compared to loratadine 10 mg and placebo in the symptomatic treatment of seasonal allergic rhinitis. Int Arch Allergy Immunol 2005;138:312-8.
24. Mosges R, Konig V, Koberlein J. The effectiveness of levocetirizine in comparison with loratadine in treatment of allergic rhinitisa meta-analysis. Allergol Int 2011;60: 541-6.
25. Holgate S, Powell R, Jenkins M, Ali O. A treatment for allergic rhinitis: a view on the role of levocetirizine. Curr Med Res Opin 2005;21:1099-106.
26. Cohen J. A power primer. Psychol Bull 1992;112:155-9.
27. Robinson AC, Cherry JR, Daly S. Double-blind cross-over trial comparing beclomethasone dipropionate and terfenadine in perennial rhinitis. Clin Exp Allergy 1989;19:569-73.
28. Canonica GW, Fumagalli F, Guerra L et al. Levocetirizine in persistent allergic rhinitis: continuous or on-demand use? A pilot study. Curr Med Res Opin 2008;24:2829-39.