Defective ATM-Kap-1-mediated chromatin remodeling impairs DNA repair and accelerates senescence in progeria mouse model

Aging Cell

Volumn 12, Issue 2, 2013, Pages 316-318

  Liu, Baohua ^a,b   Wang, Zimei ^a,c   Ghosh, Shrestha ^a   Zhou, Zhongjun ^a,b  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY OF HONG KONG   (China)

^c Shenzhen University   (China)

Author keywords

ATM; Cellular senescence; Chromatin remodeling; DNA repair; KAP 1; Progeria; Zmpste24

Indexed keywords

ATM PROTEIN; BUTYRIC ACID; KAP 1 PROTEIN; PROTEIN; TRICHOSTATIN A; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHROMATIN ASSEMBLY AND DISASSEMBLY; DNA DAMAGE; DNA REPAIR; EMBRYO; FIBROBLAST; GENE SILENCING; HETEROCHROMATIN; HISTONE ACETYLATION; MOUSE; NONHUMAN; PREMATURE AGING; PRIORITY JOURNAL; PROGERIA; PROTEIN PHOSPHORYLATION;

ANIMALS; CELL CYCLE PROTEINS; CHROMATIN ASSEMBLY AND DISASSEMBLY; DNA; DNA DAMAGE; DNA REPAIR; DNA-BINDING PROTEINS; FIBROBLASTS; GENE EXPRESSION REGULATION; MEMBRANE PROTEINS; METALLOENDOPEPTIDASES; MICE; MICE, KNOCKOUT; NUCLEAR PROTEINS; PHOSPHORYLATION; PROGERIA; PROTEIN-SERINE-THREONINE KINASES; REPRESSOR PROTEINS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEINS;

MUS;

EID: 84878944714     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12035     Document Type: Article

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