-
1
-
-
84255197842
-
Cancer immunotherapy comes of age
-
* Mellman I, Coukos G, Dranoff G. Cancer immunotherapy comes of age. Nature 2011;480:480-9.
-
(2011)
Nature
, vol.480
, pp. 480-489
-
-
Mellman, I.1
Coukos, G.2
Dranoff, G.3
-
2
-
-
77954801079
-
Improved survival with ipilimumab in patients with metastatic melanoma
-
** Hodi FS, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 2010;363:711-23.
-
(2010)
N Engl J Med
, vol.363
, pp. 711-723
-
-
Hodi, F.S.1
-
3
-
-
79959772576
-
Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
-
* Robert C, et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med 2011;364:2517-26.
-
(2011)
N Engl J Med
, vol.364
, pp. 2517-2526
-
-
Robert, C.1
-
4
-
-
84858766182
-
The blockade of immune checkpoints in cancer immunotherapy
-
* Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 2012;12:252-64.
-
(2012)
Nat Rev Cancer
, vol.12
, pp. 252-264
-
-
Pardoll, D.M.1
-
5
-
-
84859128199
-
Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape
-
Taube JM, et al. Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape. Sci Transl Med 2012;4:127-37.
-
(2012)
Sci Transl Med
, vol.4
, pp. 127-137
-
-
Taube, J.M.1
-
6
-
-
84862859820
-
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
-
** Topalian SL, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med 2012;366:2443-54.
-
(2012)
N Engl J Med
, vol.366
, pp. 2443-2454
-
-
Topalian, S.L.1
-
7
-
-
77954218212
-
BRAF as therapeutic target in melanoma
-
Wellbrock C, Hurlstone A. BRAF as therapeutic target in melanoma. Biochem Pharmacol 2010;80:561-7.
-
(2010)
Biochem Pharmacol
, vol.80
, pp. 561-567
-
-
Wellbrock, C.1
Hurlstone, A.2
-
9
-
-
27644575157
-
Coordinating ERK/MAPK signalling through scaffolds and inhibitors
-
DOI 10.1038/nrm1743, PII N1743
-
Kolch W. Coordinating ERK/MAPK signalling through scaffolds and inhibitors. Nat Rev Mol Cell Biol 2005;6:827-37. (Pubitemid 41568732)
-
(2005)
Nature Reviews Molecular Cell Biology
, vol.6
, Issue.11
, pp. 827-837
-
-
Kolch, W.1
-
10
-
-
80052358465
-
Treatment implications of the emerging molecular classification system for melanoma
-
* Romano E, Schwartz GK, Chapman PB, Wolchock JD, Carvajal RD. Treatment implications of the emerging molecular classification system for melanoma. Lancet Oncol 2011;12:913-22.
-
(2011)
Lancet Oncol
, vol.12
, pp. 913-922
-
-
Romano, E.1
Schwartz, G.K.2
Chapman, P.B.3
Wolchock, J.D.4
Carvajal, R.D.5
-
12
-
-
79959795786
-
Improved survival with vemurafenib in melanoma with BRAF V600E mutation
-
** Chapman PB, et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 2011;364:2507-16.
-
(2011)
N Engl J Med
, vol.364
, pp. 2507-2516
-
-
Chapman, P.B.1
-
13
-
-
84864285794
-
Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion
-
Straussman R, et al. Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion. Nature 2012;487:500-4.
-
(2012)
Nature
, vol.487
, pp. 500-504
-
-
Straussman, R.1
-
14
-
-
77953276524
-
Recovery of phospho-ERK activity allows melanoma cells to escape from BRAF inhibitor therapy
-
Paraiso KHT, et al. Recovery of phospho-ERK activity allows melanoma cells to escape from BRAF inhibitor therapy. Br J Cancer 2010;102:1724-30.
-
(2010)
Br J Cancer
, vol.102
, pp. 1724-1730
-
-
Paraiso, K.H.T.1
-
15
-
-
84863673204
-
Improved survival with mek inhibition in braf-mutated melanoma
-
** Flaherty KT, et al. Improved survival with mek inhibition in braf-mutated melanoma. N Engl J Med 2012;367:107-14.
-
(2012)
N Engl J Med
, vol.367
, pp. 107-114
-
-
Flaherty, K.T.1
-
16
-
-
84868224906
-
Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations
-
** Flaherty KT, et al. Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations. N Engl J Med 2012;367:1694-703.
-
(2012)
N Engl J Med
, vol.367
, pp. 1694-1703
-
-
Flaherty, K.T.1
|