CT Pulmonary Angiography: Increasingly Diagnosing Less Severe Pulmonary Emboli

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Schissler, Andrew J ^a   Rozenshtein, Anna ^a   Kulon, Michal E ^a,c   Pearson, Gregory D N ^a   Green, Robert A ^a   Stetson, Peter D ^a   Brenner, David J ^a   D'Souza, Belinda ^a   Tsai, Wei Yann ^b   Schluger, Neil W ^a   Einstein, Andrew J ^a  

^a NewYork Presbyterian Hospital   (United States)

^b Columbia University ^*  (United States)

^c UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TROPONIN;

ADULT; AGE; ARTICLE; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; DIAGNOSTIC VALUE; DISEASE SEVERITY; FEMALE; HEART MUSCLE INJURY; HEART RIGHT VENTRICLE FAILURE; HUMAN; LUNG ANGIOGRAPHY; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; PROTEIN BLOOD LEVEL; RETROSPECTIVE STUDY; SEX DIFFERENCE; TRANSTHORACIC ECHOCARDIOGRAPHY; TREND STUDY;

ADULT; ANGIOGRAPHY; ECHOCARDIOGRAPHY; HUMANS; MULTIDETECTOR COMPUTED TOMOGRAPHY; NEW YORK; PULMONARY EMBOLISM; TROPONIN; VENTRICULAR DYSFUNCTION, RIGHT;

EID: 84878913396     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0065669     Document Type: Article

References (40)

1. Calder KK, Herbert M, Henderson SO, (2005) The mortality of untreated pulmonary embolus in emergency department patients. Ann Emerg Med 45: 302-310.
2. Wood KE, (2002) Major pulmonary embolism: review of a pathophysiologic approach to the golden hour of hemodynamically significant pulmonary embolism. Chest 121: 877-905.
3. Stein PD, Henry JW, Relyea B, (1995) Untreated patients with pulmonary embolism: outcome, clinical and laboratory assessment. Chest 107: 931-935.
4. Barritt DW, Jordan SC, (1960) Anticoagulant drugs in the treatment of pulmonary embolism. A controlled trial. Lancet 1(7138): 1309-12.
5. Weiss CR, Scatarige JC, Diette GB, Haponik EF, Merriman B, et al. (2006) CT pulmonary angiography is the first-line imaging test for acute pulmonary embolism: a survey of US clinicians. Acad Radiol 13(4): 434-46.
6. Perrier A, Roy PM, Sanchez O, Le Gal G, Meyer G, et al. (2005) Multidetector-row computed tomography in suspected pulmonary embolism. N Engl J Med 352(17): 1760-8.
7. Stein PD, Fowler SE, Goodman LR, Gottschalk A, Hales CA, et al. (2006) Multidetector computed tomography for acute pulmonary embolism. N Engl J Med 354(22): 2317-27.
8. Agnelli G, Becattini C, (2010) Acute pulmonary embolism. N Engl J Med 363(3): 266-74.
9. Goldhaber SZ, Bounameaux H, (2012) Pulmonary embolism and deep vein thrombosis. Lancet 379(9828): 1835-46.
10. Kocher KE, Meurer WJ, Fazel R, Scott PA, Krumholz HM, et al. (2011) National trends in use of computed tomography in the emergency department. Ann Emerg Med 58(5): 452-62.
11. Donohoo JH, Mayo-Smith WW, Pezzullo JA, Egglin TK, (2008) Utilization patterns and diagnostic yield of 3421 consecutive multidetector row computed tomography pulmonary angiograms in a busy emergency department. J Comput Assist Tomogr 32(3): 421-425.
12. Prologo JD, Gilkeson RC, Diaz M, Asaad J, (2004) CT pulmonary angiography: a comparative analysis of the utilization patterns in emergency department and hospitalized patients between 1998 and 2003. AJR Am J Roentgenol 183(4): 1093-6.
13. Raja AS, Ip IK, Prevedello LM, Sodickson AD, Farkas C, et al. (2012) Effect of computerized clinical decision support on the use and yield of CT pulmonary angiography in the emergency department. Radiology 262(2): 468-74.
14. Weir ID, Drescher F, Cousin D, Fraser ET, Lee R, et al. (2010) Trends in use and yield of chest computed tomography with angiography for diagnosis of pulmonary embolism in a Connecticut hospital emergency department. Conn Med 74(1): 5-9.
15. Wittram C, Meehan MJ, Halpern EF, Shepard JA, McLoud TC, et al. (2004) Trends in thoracic radiology over a decade at a large academic medical center. J ThoracImaging 19(3): 164-170.
16. Wiener RS, Schwartz LM, Woloshin S, (2011) Time trends in pulmonary embolism in the United States: evidence of overdiagnosis. Arch Intern Med 171(9): 831-7.
17. Burge AJ, Freeman KD, Klapper PJ, Haramati LB, (2008) Increased diagnosis of pulmonary embolism without a corresponding decline in mortality during the CT era. Clin Radiol 63(4): 381-6.
18. Sheh SH, Bellin E, Freeman KD, Haramati LB, (2012) Pulmonary embolism diagnosis and mortality with pulmonary CT angiography versus ventilation-perfusion scintigraphy: evidence of overdiagnosis with CT? AJR Am J Roentgenol 198(6): 1340-5.
19. Torbicki A, Perrier A, Konstantinides S, Agnelli G, Galiè N, et al. (2008) Guidelines on the diagnosis and management of acute pulmonary embolism: the Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC). Eur Heart J 29: 2276-315.
20. Wittram C, Kalra MK, Maher MM, Greenfield A, McLoud TC, et al. (2006) Acute and chronic pulmonary emboli: angiography-CT correlation. AJR Am J Roentgenol 186(6Suppl 2): S421-9.
21. (2003) Abbott AxSYM System Troponin-I [package insert]. Abbott Park, IL: Abbott Laboratories, Diagnostic Division.
22. (2006) Abbott AxSYM System Troponin-I ADV [package insert]. Abbott Park, IL: Abbott Laboratories, Diagnostic Division.
23. (2008) Stratus CS STAT Fluorometric Analyzer Acute Care CTNI TestPak [package insert]. Newark, DE: Siemens Healthcare Diagnostics Inc.
24. Fink DJ (2001) Core Laboratory Policy and Procedure Manual: Troponin I. New York, NY: Columbia University Medical Center.
25. Kreit JW, (2004) The impact of right ventricular dysfunction on the prognosis and therapy of normotensive patients with pulmonary embolism. Chest 125(4): 1539-45.
26. Kucher N, Rossi E, De Rosa M, Goldhaber SZ, (2005) Prognostic role of echocardiography among patients with acute pulmonary embolism and a systolic arterial pressure of 90 mm Hg or higher. Arch Intern Med 165(15): 1777-81.
27. Konstantinides S, Geibel A, Olschewski M, Kasper W, Hruska N, et al. (2002) Importance of cardiac troponins I and T in risk stratification of patients with acute pulmonary embolism. Circulation 106(10): 1263-8.
28. La Vecchia L, Ottani F, Favero L, Spadaro GL, Rubboli A, et al. (2004) Increased cardiac troponin I on admission predicts in-hospital mortality in acute pulmonary embolism. Heart 90(6): 633-7.
29. Stein PD, Janjua M, Matta F, Pathak PK, Jaweesh F, et al. (2011) Prognosis based on creatine kinase isoenzyme MB, cardiac troponin I, and right ventricular size in stable patients with acute pulmonary embolism. Am J Cardiol 107(5): 774-7.
30. Furlan A, Aghayev A, Chang CC, Patil A, Jeon KN, et al. (2012) Short-term Mortality in Acute Pulmonary Embolism: Clot Burden and Signs of Right Heart Dysfunction at CT Pulmonary Angiography. Radiology 265(1): 283-93.
31. Morris MF, Gardner BA, Gotway MB, Thomsen KM, Harmsen WS, et al. (2012) CT findings and long-term mortality after pulmonary embolism. AJR Am J Roentgenol 198(6): 1346-52.
32. Araoz PA, Haramati LB, Mayo JR, Barbosa EJ Jr, Rybicki FJ, et al. (2012) Panel Discussion: Pulmonary Embolism Imaging and Outcomes. AJR Am J Roentgenol 198(6): 1313-9.
33. Heit JA, Silverstein MD, Mohr DN, Petterson TM, Lohse CM, et al. (2001) The epidemiology of venous thromboembolism in the community. Thromb Haemost 86(1): 452-63.
34. Wells PS, Anderson DR, Rodger M, Stiell I, Dreyer JF, et al. (2001) Excluding pulmonary embolism at the bedside without diagnostic imaging: management of patients with suspected pulmonary embolism presenting to the emergency department by using a simple clinical model and d-dimer. Ann Intern Med 135(2): 98-107.
35. Wang JH, Christino MA, Thakur NA, Palumbo MA, Daniels AH, (2013) Evaluation of the utility of the Wells score in predicting pulmonary embolism in patients admitted to a spine surgery service. Hosp Pract (1995) 41(1): 122-8.
36. Wicki J, Perneger TV, Junod AF, Bounameaux H, Perrier A, (2001) Assessing clinical probability of pulmonary embolism in the emergency ward: a simple score. Arch Intern Med 161(1): 92-7.
37. Becattini C, Vedovati MC, Agnelli G, (2007) Prognostic value of troponins in acute pulmonary embolism: a meta-analysis. Circulation 116(4): 427-33.
38. Meyer M, Fink C, Roeger S, Apfaltrer P, Haghi D, et al. (2012) Benefit of combining quantitative cardiac CT parameters with troponin I for predicting right ventricular dysfunction and adverse clinical events in patients with acute pulmonary embolism. Eur J Radiol 81(11): 3294-9.
39. Onyedika C, Glaser JE, Freeman LM, (2013) Pulmonary embolism: role of ventilation-perfusion scintigraphy. Semin Nucl Med 43(2): 82-7.
40. Kluge A, Luboldt W, Bachmann G, (2006) Acute pulmonary embolism to the subsegmental level: diagnostic accuracy of three MRI techniques compared with 16-MDCT. AJR Am J Roentgenol 187(1): W7-14.