A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation

Nature Structural and Molecular Biology

Volumn 20, Issue 6, 2013, Pages 728-734

  Schellenberg, Matthew J ^a,c   Wu, Tao ^a   Ritchie, Dustin B ^a,c   Fica, Sebastian ^b   Staley, Jonathan P ^b   Atta, Karim A ^a   Lapointe, Paul ^a   Macmillan, Andrew M ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF CHICAGO   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; MESSENGER RNA; METAL ION; METALLOPROTEIN; PRP8 PROTEIN; SMALL NUCLEAR RNA; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; BINDING SITE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN STRUCTURE; SPLICEOSOME;

CRYSTALLOGRAPHY, X-RAY; IONS; LIGATION; METALS; MODELS, MOLECULAR; PROTEIN CONFORMATION; RIBONUCLEASE H; RIBONUCLEOPROTEIN, U4-U6 SMALL NUCLEAR; RIBONUCLEOPROTEIN, U5 SMALL NUCLEAR; RNA PRECURSORS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EUKARYOTA;

EID: 84878910487     PISSN: 15459993     EISSN: 15459985     Source Type: Journal    
DOI: 10.1038/nsmb.2556     Document Type: Article

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