T helper 17 polarization in familial Mediterranean fever

Genes and Immunity

Volumn 14, Issue 4, 2013, Pages 212-216

  Ovadia, A ^a,b   Livneh, A ^a,c,d   Feld, O ^c   Ben Zvi, I ^c   Kukuy, E ^c   Kivity, S ^c   Lidar, M ^c,d   Barda Saad, M ^b   Shinar, Y ^a  

^a HELLER INSTITUTE OF MEDICAL RESEARCH   (Israel)

^b BAR ILAN UNIVERSITY   (Israel)

^c SHEBA MEDICAL CENTER   (Israel)

^d TEL AVIV UNIVERSITY   (Israel)

Author keywords

autoinflammatory; familial Mediterranean fever (FMF); IL 17; T cell activation; Th17

Indexed keywords

RETINOID RELATED ORPHAN RECEPTOR ALPHA; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR T BET;

ADULT; ARTICLE; CD4+ T LYMPHOCYTE; CELL CULTURE; CELL POLARITY; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATIONAL STUDY; CYTOKINE RELEASE; FAMILIAL MEDITERRANEAN FEVER; GENE DELETION; GENOTYPE; HUMAN; NUCLEOTIDE SEQUENCE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REMISSION; TH1 CELL; TH17 CELL; TH2 CELL;

ADOLESCENT; ADULT; CASE-CONTROL STUDIES; CELLS, CULTURED; CYTOSKELETAL PROTEINS; FAMILIAL MEDITERRANEAN FEVER; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GATA3 TRANSCRIPTION FACTOR; HUMANS; INTERLEUKIN-17; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 1; T-LYMPHOCYTES, REGULATORY; TH17 CELLS; TRANSCRIPTION, GENETIC;

EID: 84878901509     PISSN: 14664879     EISSN: 14765470     Source Type: Journal    
DOI: 10.1038/gene.2013.6     Document Type: Article

References (30)

1. Lidar M, Livneh A. Familial Mediterranean fever: clinical, molecular and management advancements. Neth J Med 2007; 65: 318-324. (Pubitemid 350011355)
2. Gang N, Drenth JP, Langevitz P, Zemer D, Brezniak N, Pras M et al. Activation of the cytokine network in familial Mediterranean fever. J Rheumatol 1999; 26: 890-897. (Pubitemid 29195678)
3. Baykal Y, Saglam K, Taslipinar A, Inal A. Serum sIL-2r, IL-6, IL-10 and TNF-alpha level in familial Mediterranean fever patients. Clin Rheumatol 2003; 22: 99-101. (Pubitemid 36748856)
4. Oktem S, Yavuzsen TU, Sengu l B, Akhunlar H, Akar S, Tunca M. Levels of interleukin-6 (IL-6) and its soluble receptor (sIL-6R) in familial Mediterranean fever (FMF) patients and their first degree relatives. Clin Exp Rheumatol 2004; 22 (Suppl 34): 34-36.
5. Meinzer U, Quartier P, Alexandra JF, Hentgen V, Retornaz F, Kone-Paut I. Interleukin-1 targeting drugs in familial Mediterranean fever: a case series and a review of the literature. Semin Arthritis Rheum 2011; 41: 265-271.
6. Chae JJ, Aksentijevich I, Kastner DL. Advances in the understanding of familial Mediterranean fever and possibilities for targeted therapy. Br J Haematol 2009; 146: 467-478.
7. Zielinski CE, Mele F, Aschenbrenner D, Jarrossay D, Ronchi F, Gattorno M et al. Pathogen-induced human TH17 cells produce IFN-g or IL-10 and are regulated by IL-1b. Nature 2012; 484: 514-518.
8. Acosta-Rodriguez EV, Napolitani G, Lanzavecchia A, Sallusto F. Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol 2007; 8: 942-949. (Pubitemid 47300008)
9. Roussel L, Houle F, Chan C, Yao Y, Berube J, Olivenstein R et al. IL-17 promotes p38 MAPK-dependent endothelial activation enhancing neutrophil recruitment to sites of inflammation. J Immunol 2010; 184: 4531-4537.
10. Ivanov II, McKenzie BS, Zhou L, Tadokoro CE, Lepelley A, Lafaille JJ et al. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17 T helper cells. Cell 2006; 126: 1121-1133. (Pubitemid 44380299)
11. Liang SC, Long AJ, Bennett F, Whitters MJ, Karim R, Collins M et al. An IL-17F/A heterodimer protein is produced by mouse Th17 cells and induces airway neutrophil recruitment. J Immunol 2007; 179: 7791-7799.
12. Haznedaroglu S, Oztu rk MA, Sancak B, Goker B, Onat AM, Bukan N et al. Serum interleukin 17 and interleukin 18 levels in familial Mediterranean fever. Clin Exp Rheumatol 2005; 23(Suppl 38): 77-80.
13. Manukyan GP, Ghazaryan KA, ZhA Ktsoyan, Tatyan MV, Khachatryan ZA, Hakobyan GS et al. Cytokine profile of Armenian patients with Familial Mediterranean fever. Clin Biochem 2008; 41: 920-922.
14. Manukyan G, Ghazaryan K, Ktsoyan Z, Khachatryan Z, Kelly D, Tatyan M et al. Comparative analysis of cytokine profiles in autoinflammatory and autoimmune conditions. Cytokine 2010; 50: 146-151.
15. Shinar Y, Livneh A, Langevitz P, Zaks N, Aksentijevich I, Koziol DE et al. Genotypephenotype assessment of common genotypes among patients with familial Mediterranean fever. J Rheumatol 2000; 27: 1703-1707. (Pubitemid 30462815)
16. Sutton CE, Lalor SJ, Sweeney CM, Brereton CF, Lavelle EC et al. Interleukin-1 and IL-23 induce innate IL-17 production from gd T cells, amplifying Th17 responses and autoimmunity. Immunity 2009; 31: 331-341.
17. Perry JSA, Han S, Xu Q, Herman ML, Kennedy LB, Csako G et al. Inhibition of LTi cell development by CD25 blockade is associated with decreased intrathecal inflammation in multiple sclerosis. Sci Trans Med 2012; 4: 145ra106.
18. Hoffman HM, Mueller JL, Broide DH, Wanderer AA, Kolodner RD. Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. Nat Genet 2001; 29: 301-305. (Pubitemid 33096455)
19. Meng G, Zhang F, Fuss I, Kitani A, Strober W. A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses. Immunity 2009; 30: 860-874.
20. Brydges SD, Mueller JL, McGeouGh MD, Pena CA, Misaghi A, Gandhi C et al. Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity. Immunity 2009; 30: 875-887.
21. Lasiglie D, Traggiai E, Federici S, Alessio M, Buoncompagni A, Accogli A et al. Role of IL-1 beta in the development of human T(H)17 cells: lesson from NLPR3 mutated patients. PLoS One 2011; 6: e20014.
22. Puel A, Cypowyj S, Bustamante J, Wright JF, Liu L, Lim HK. Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity. Science 2011; 332: 65-68.
23. Chamilos G, Ganguly D, Lande R, Gregorio J, Meller S, Goldman WE et al. Generation of IL-23 producing dendritic cells (DCs) by airborne fungi regulates fungal pathogenicity via the Induction of TH-17 responses. PLoS One 2010; 5: e12955.
24. Shinar Y, Livneh A, Villa Y, Pinhasov A, Zeitoun I, Kogan A et al. Common mutations in the familial Mediterranean fever gene associate with rapid progression to disability in non-Ashkenazi Jewish multiple sclerosis patients. Genes Immun 2003; 4: 197-203. (Pubitemid 38967597)
25. Rabinovich E, Livneh A, Langevitz P, Brezniak N, Shinar E, Pras M et al. Severe disease in patients with rheumatoid arthritis carrying a mutation in the Mediterranean fever gene. Ann Rheum Dis 2005; 64: 1009-1014. (Pubitemid 40909514)
26. Yahalom G, Kivity S, Lidar M, Vaknin-Dembinsky A, Karussis D, Flechter S et al. Familial Mediterranean fever (FMF) and multiple sclerosis: an association study in one of the world's largest FMF cohorts. Eur J Neurol 2011; 18: 1146-1150.
27. Hemdan NY, Birkenmeier G, Wichmann G, Abu El-Saad AM, Krieger T, Conrad K et al. Interleukin-17-producing T helper cells in autoimmunity. Autoimmun Rev 2010; 9: 785-792.
28. Livneh A, Langevitz P, Zemer D, Zaks N, Kees S, Lidar T et al. Criteria for the diagnosis of familial Mediterranean fever. Arthritis Rheum 1997; 40: 1879-1885. (Pubitemid 27452541)
29. Dheda K, Huggett JF, Bustin SA, Johnson MA, Rook G, Zumla A. Validation of housekeeping genes for normalizing RNA expression in real-time PCR. Bio Techniques 2004; 37: 112-119. (Pubitemid 38902668)
30. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001; 25: 402-408. (Pubitemid 34164012)