Practical limitations to estimating heritability in pharmacogenetic studies

Pharmacogenomics

Volumn 14, Issue 8, 2013, Pages 851-852

  Song, Kijoung ^a   Mosteller, Michael ^a   Lawson, Michael ^a   Nelson, Matthew R ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EFFECT SIZE; GENETIC ASSOCIATION; GENETIC MODEL; GENETIC VARIABILITY; GENOTYPE; HUMAN; LETTER; NORMAL DISTRIBUTION; PHARMACOGENETICS; PHENOTYPIC VARIATION; SAMPLE SIZE; SIMULATION; SINGLE NUCLEOTIDE POLYMORPHISM;

GENOME-WIDE ASSOCIATION STUDY; HUMANS; MODELS, STATISTICAL; QUANTITATIVE TRAIT, HERITABLE; SAMPLE SIZE;

EID: 84878885788     PISSN: 14622416     EISSN: 17448042     Source Type: Journal    
DOI: 10.2217/pgs.13.86     Document Type: Letter

References (3)

1. Marshall SL, Guennel T, Kohler J, Man M, Fossceco S. Estimating heritability in pharmacogenetic studies. Pharmacogenomics 14(4), 369-377 (2013).
2. Firmann M, Mayor V, Marques VP et al. The CoLaus study: a population-based study to investigate the epidemiology and genetic determinants of cardiovascular risk factors and metabolic syndrome. BMC Cardiovasc. Disord. 8, 6 (2008).
3. Yang J, Lee SH, Goddard ME and Visscher PM. GCTA: a tool for genome-wide complex trait analysis. Am. J. Hum. Genet. 88(1), 76-82 (2011).