Pharmacological Activation of Sirt1 Ameliorates Polyglutamine-Induced Toxicity through the Regulation of Autophagy

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Shin, Bae Hyun ^a   Lim, Yunki ^a   Oh, Hye Jin ^a   Park, Sang Min ^a   Lee, Sun Kyung ^b   Ahnn, Joohong ^b   Kim, Do Han ^a   Song, Woo Keun ^a   Kwak, Tae Hwan ^c   Park, Woo Jin ^a  

^a Gwangju Institute of Science and Technology (GIST)   (South Korea)

^b Hanyang University   (South Korea)

^c Mazence Inc   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOPHAGY PROTEIN 5; BETA LAPACHONE; GREEN FLUORESCENT PROTEIN; HUNTINGTIN; POLYGLUTAMINE; SHORT HAIRPIN RNA; SIRTINOL; SIRTUIN 1; TRANSCRIPTION FACTOR FKHR;

APOPTOSIS; ARTICLE; AUTOLYSOSOME; AUTOPHAGY; CAENORHABDITIS ELEGANS; CELL PROTECTION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DEACETYLATION; DRUG EFFICACY; DRUG MECHANISM; EXON; HUMAN; HUMAN CELL; HUNTINGTON CHOREA; NERVE CELL; NEUROBLASTOMA CELL; NONHUMAN; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RNA INTERFERENCE;

ADENINE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; APOPTOSIS; AUTOPHAGY; BLOTTING, WESTERN; CAENORHABDITIS ELEGANS; CELL MOVEMENT; CELL PROLIFERATION; GREEN FLUORESCENT PROTEINS; HUMANS; IMMUNOENZYME TECHNIQUES; IMMUNOPRECIPITATION; MICROSCOPY, FLUORESCENCE; NAPHTHOQUINONES; NERVE TISSUE PROTEINS; NEUROBLASTOMA; PEPTIDES; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE INHIBITORS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; SIRTUIN 1;

CAENORHABDITIS ELEGANS;

EID: 84878870713     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0064953     Document Type: Article

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