Survey of human pharmaceuticals in drinking water in the Czech Republic

Journal of Water and Health

Volumn 11, Issue 1, 2013, Pages 84-97

  Kozisek, Frantisek ^a,b   Pomykacova, Ivana ^a   Jeligova, Hana ^a   Cadek, Vaclav ^a   Svobodova, Veronika ^a  

^a NATIONAL INSTITUTE OF PUBLIC HEALTH   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Czech Republic; Drinking water; Health risk; Human pharmaceuticals; Tap water

Indexed keywords

CARBAMAZEPINE; DICLOFENAC; DRINKING WATER; ETHINYLESTRADIOL; GROUND WATER; IBUPROFEN; NAPROXEN; SURFACE WATER; TAP WATER;

ASSESSMENT METHOD; DETECTION METHOD; DRINKING WATER; DRUG; HEALTH RISK; WASTEWATER; WATER TREATMENT;

ARTICLE; CONCENTRATION (PARAMETERS); CONSUMER; CONTROLLED STUDY; CZECH REPUBLIC; DRUG INDUSTRY; FOLLOW UP; HEALTH CARE SURVEY; HEALTH HAZARD; RISK ASSESSMENT; WASTE WATER TREATMENT PLANT; WATER SUPPLY;

CZECH REPUBLIC; DRINKING WATER; HUMANS; PHARMACEUTICAL PREPARATIONS; WATER POLLUTANTS, CHEMICAL;

CZECH REPUBLIC;

EID: 84878857186     PISSN: 14778920     EISSN: None     Source Type: Journal    
DOI: 10.2166/wh.2013.056     Document Type: Article

References (41)

1. Alder, A. C., Bruchet, A., Carballa, M., Clara, M., Joss, A., Löffler, D., McArdell, C. S., Miksch, K., Omil, F., Tuhkanen, T. & Ternes, T. A. 2006 Consumption and occurrence. In: Human Pharmaceuticals, Hormones and Fragrances. The Challenge of Micropollutants in Urban Water Management (T. A. Ternes & A. Joss, eds). IWA Publishing, London, pp. 15-54.
2. Anonymous 2008 Anthropogenic Trace Elements in Water Cycle - Pharmaceuticals (Anthropogene Spurenstoffe im Wasserkreislauf, Arzneistoffe). Deutsche Vereinigung für Wasserwirtschaft, Abwasser und Abfall e.V., DWA, Hennef.
3. Anonymous 2011 Report on the national campaign for the analysis of pharmaceutical residues in water intended for human consumption (Rapport sur la campagne nationale d'occurrence des résidus de médicaments dans les eaux destinées à la consommation humaine). ANSES , Nancy. Available online at: http://www.anses.fr/Documents/LABO-Ra-EtudeMedicamentsEaux. pdf (accessed 30 December 2011).
4. Caldwell, D. J., Mastrocco, F., Nowak, E., Johnston, J., Yekel, H., Pfeiffer, D., Hoyt, M., DuPlessie, B. M. & Anderson, P. D. 2010 An assessment of potential exposure and risk from estrogens in drinking water. Environ. Health Persp. 118 ( 3), 338-344.
5. CSO (Czech Statistical Office) 2005 Census 2001 - Source Book . Czech Statistical Office, Prague.
6. Cunningham, V. L., Binks, S. P. & Olson, M. J. 2009 Human health risk assessment from the presence of human pharmaceuticals in the aquatic environment. Regul. Toxicol. Pharmacol. 53 ( 1), 39-45.
7. Dieter, H. H. & Mückter, H. 2007 Regulatory, health and aesthetic assessment of so called trace substances in drinking water with regard to pharmaceuticals (Regulatorische, gesundheitliche und ästhetische Bewertung sogenannter Spurenstoffe im Trinkwasser unter besonderer Berücksichtigung von Arzneimitteln). Bundesgesundheitsbl-Gesundheitsforsch- Gesundheitsschutz 50 ( 3), 322-331.
8. DWI 2007 Desk based review of current knowledge on pharmaceuticals in drinking water and estimation of potential levels . Final report prepared by Watts and Crane Associates for Drinking Water Inspectorate, Department for Environment, Food and Rural Affairs , London. Defra Project Code: CSA 7184/WT02046/DWI70/2/213. DWI, London. Available online at: http://dwi.defra. gov.uk/research/completed-research/reports/dwi70-2-213.pdf (accessed 20 October 2011).
9. EC (European Community) 1998 Council Directive 98/83/EC of 3 November 1998 on the quality of water intended for human consumption. Off. J. Eur. Communities No L 330, 32-54.
10. EEC (European Economic Community) 1975 Council Directive 75/440/EEC of 16 June 1975 concerning the quality required of surface water intended for the abstraction of drinking water in the Member States. Off. J. Eur. Communities No L 194, 26-31.
11. EFSA (European Food Safety Authority) 2005 Opinion of the Scientific Committee on a request from EFSA related to a harmonised approach for risk assessment of substances which are both genotoxic and carcinogenic. The EFSA J. 282, 1-31.
12. Fischhoff, B. 1995 Risk perception and communication unplugged: twenty years of process. Risk Anal. 15 ( 2), 137-145.
13. Halden, R. (ed.) 2010 Contaminants of Emerging Concern in the Environment: Ecological and Human Health Considerations. American Chemical Society, Washington, DC.
14. Hannah, R., D'Aco, V. J., Anderson, P. D., Buzby, M. E., Caldwell, D. J., Cunningham, V. L., Ericson, J. F., Johnson, A. C., Parke, N. J., Samuelian, J. H. & Sumpter, J. P. 2009 Exposure assessment of 17α-ethinylestradiol in surface waters of the United States and Europe. Environ. Toxicol. Chem. 28 ( 12), 2725-2732.
15. Hoffbuhr, J. 2009 The Truth About Pharmaceuticals & Personal Care Products in Your Water. American Water Work Association, Denver.
16. IWA 2004 The Bonn charter for safe drinking water . Available online at: http://www.iwahq.org/contentsuite/upload/iwa/ Document/BonnCharter-ENG.pdf (accessed 30 December 2011).
17. Kim, K. R. & Yoon, H. R. 1996 Rapid screening for acidic nonsteroidal anti-inflammatory drugs in urine by gas chromatography-mass spectrometry in the selected-ion monitoring mode. J. Chromatogr. B. Biomed. Sci. Appl. 682 ( 1), 55-66.
18. Kim, K. R., Shim, W. H., Shin, Y. J., Park, J., Myung, S. & Hong, J. 1993 Capillary gas chromatography of acidic non-steroidal antiinflammatory drugs as tert.-butyldimethylsilyl derivatives. J. Chromatogr. A 641 (2), 319-327. (Pubitemid 23200385)
19. KNAPPE (Knowledge and Need Assessment on Pharmaceutical Products in Environmental Waters) project 2008 Report D1.2: Proposal of an environmental indicator and classification system of PP residues for environmental management . Available online at: http://www.knappe-eu.org/fichiers/44-D1. 2%20environmental%20indicator%20final%20version.pdf (accessed 28 November 2011).
20. Kroes, R., Renwick, A. G., Cheeseman, M., Kleiner, J., Mangelsdorf, I., Piersma, A., Schiller, B., Schlatter, J., van Schothorst, F., Vos, J. G. & Würtzen, G. 2004 Structure-based thresholds of toxicological concern (TTC): guidance for application to substances present at low levels in the diet. Food Chem. Toxicol. 42 (1), 65-83. (Pubitemid 37421327)
21. Kümmerer, K. (ed.) 2004 Pharmaceuticals in the Environment: Sources, Fate, Effects and Risks. Springer, Heidelberg.
22. Kümmerer, K. & Al-Ahmad, A. 2010 Estimation of the cancer risk to humans resulting from the presence of cyclophosphamide and ifosfamide in surface water. Environ. Sci. Pollut. Res. 17 ( 2), 486-496.
23. MoA (Ministry of Agriculture) 2011 Water Supply and Sewerage Systems in the Czech Republic 2010. The Statistical Yearbook (Vodovody a kanalizace ČR 2010. Ročenka). Ministry of Agriculture of the Czech Republic, Prague.
24. Moldavan, Z., Schmutzer, G., Tusa, F., Calin, R. & Alder, A. C. 2007 An overview of pharmaceuticals and personal care products contamination along the river Somes watershed, Romania. J. Environ. Monit. 9 (9), 986-993. (Pubitemid 47340664)
25. NIPH (National Institute of Public Health) 2011 Report on Drinking Water Quality in the Czech Republic in 2010 (Zpráva o kvalitě pitné vody v ČR za rok 2010) . NIPH, Prague. Available online at: http://www.szu.cz/uploads/documents/chzp/voda/pdf/monit/voda-10.pdf (accessed 30 August 2012).
26. NRMMC, EPHC & NHMRC 2008 Australian Guidelines for Water Recycling: Managing Health and Environmental Risks (PHASE 2). Augmentation of Drinking Water Supplies . Natural Resource Management Ministerial Council, Environment Protection and Heritage Council and National Health and Medical Research Council, Canberra.
27. Pomati, F., Orlandi, C., Clerici, M., Luciani, F. & Zuccatom, E. 2008 Effects and interactions in an environmentally relevant mixture of pharmaceuticals. Toxicol. Sci. 102 (1), 129-137. (Pubitemid 351250475)
28. Pomykacova, I., Cadek, V., Svobodova, V., Kozisek, F. & Jeligova, H. 2012 GC-MS determination of trace amounts of pharmaceuticals in drinking water (Stanoveni stopovych mnozstvi leciv v pitnych vodach metodou GC/MS). Chem. Listy 106 ( 2), 143-148.
29. Schulman, L. J., Sargent, E. V., Naumann, B. D., Faria, E. C., Dolan, D. G. & Wargo, J. P. 2002 A human health risk assessment of pharmaceuticals in the aquatic environment. Human Ecol. Risk Assess. 8 (4), 657-680. (Pubitemid 41002721)
30. Schwab, B. W., Hayes, E. P., Fiori, J. M., Mastrocco, F. J., Roden, N. M., Cragin, D., Meyerhoff, R. D., D'Aco, V. J. & Anderson, P. D. 2005 Human pharmaceuticals in US surface water: a human health risk assessment. Regul. Toxicol. Pharmacol. 42 (3), 296-312. (Pubitemid 41021979)
31. Snyder, S. A., Trenholm, R. A., Snyder, E. M., Bruce, G. M., Pleus, R. C. & Hemming, J. D. C. 2008 Toxicological Relevance of EDCs and Pharmaceuticals in Drinking Water. AWWA Research Foundation, Denver.
32. SOVAK CR (Water Supply and Sewerage Association of the Czech Republic) 2012 Expert opinion, 30.08.2012.
33. Stanford, B. D., Trenholm, R. A., Holady, J. C., Vanderford, B. J. & Snyder, S. A. 2010 Estrogenic activity of US drinking waters: a relative exposure comparison. J. AWWA 102 ( 11), 55-65.
34. SUKL (State Institute for Drug Control) 2008 Consumption of Selected Drugs in the Czech Republic in 2007 . Communication of the SUKL press office, Prague, 29.2.2008.
35. SUKL 2011 Medicinal products database . Available online at: http://www.sukl.eu/modules/medication/search.php?lang=2 (accessed 30 November 2011).
36. Ternes, T. A. & Joss, A. (eds) 2006 Human Pharmaceuticals, Hormones and Fragrances. The Challenge of Micropollutants in Urban Water Management . IWA Publishing, London.
37. Webb, S., Ternes, T., Gibert, M. & Olejniczak, K. 2003 Indirect human exposure to pharmaceuticals via drinking water. Toxicol. Lett. 142 (3), 157-167. (Pubitemid 36412006)
38. WHO 2011a Pharmaceuticals in Drinking Water . WHO/HSE/WSH/11.05. World Health Organization, Geneva.
39. WHO 2011b Guidelines for Drinking-water Quality, 4th edn. World Health Organization, Geneva.
40. Wuijts, S., Rutjes, S. A., van der Aa, N. G. F. M., Mendizabal, I. & de Roda Husman, A. M. 2008 The Influence of Human and Animal Sources on Groundwater Abstraction. From Field Study to Protection Policy (Invloed humane en animale verontreinigingen op Grondwaterwinningen. Van veldonderzoek naar beschermingsbeleid) . Report No. 734301031/2008. RIVM , Bilthoven. Available online at: http://www.rivm.nl/bibliotheek/rapporten/734301031.pdf (accessed 30 December 2011).
41. Yu, Z., Peldszus, S. & Huck, P. M. 2007 Optimizing gas chromatographic-mass spectrometric analysis of selected pharmaceuticals and endocrine-disrupting substances in water using factorial experimental design. J. Chromatogr. A 1148 (1), 65-77. (Pubitemid 46498865)