Comparative effectiveness research in cancer: What has been funded and what knowledge gaps remain?

Journal of the National Cancer Institute

Volumn 105, Issue 11, 2013, Pages 766-773

  Glasgow, Russell E ^a   Doria Rose, V Paul ^a   Khoury, Muin J ^a,c   Elzarrad, Mohammed ^a,b,d   Brown, Martin L ^a   Stange, Kurt C ^e  

^a NATIONAL CANCER INSTITUTE   (United States)

^b Cancer Prevention Fellowship Program   (United States)

^c NATIONAL CENTER ON BIRTH DEFECTS AND DEVELOPMENTAL DISABILITIES   (United States)

^d CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^e CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER CONTROL; CANCER PREVENTION; CANCER RESEARCH; CANCER SCREENING; CANCER SURVIVOR; COMPARATIVE EFFECTIVENESS; COST EFFECTIVENESS ANALYSIS; FUNDING; HEALTH CARE COST; HUMAN; MALIGNANT NEOPLASTIC DISEASE; NATIONAL HEALTH ORGANIZATION; NOTE; PERSONALIZED MEDICINE; PRACTICE GUIDELINE; PRIORITY JOURNAL; QUALITY ADJUSTED LIFE YEAR; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL (TOPIC); TRANSLATIONAL RESEARCH;

COMPARATIVE EFFECTIVENESS RESEARCH; FINANCING, GOVERNMENT; HEALTH KNOWLEDGE, ATTITUDES, PRACTICE; HUMANS; NATIONAL CANCER INSTITUTE (U.S.); NEOPLASMS; PATIENT SELECTION; PATIENT-CENTERED CARE; PUBLIC HEALTH; RESEARCH DESIGN; RESEARCH REPORT; RESEARCH SUPPORT AS TOPIC; SAMPLING STUDIES; UNITED STATES;

EID: 84878851028     PISSN: 00278874     EISSN: 14602105     Source Type: Journal    
DOI: 10.1093/jnci/djt066     Document Type: Note

References (64)

1. Lenfant C. Clinical research to clinical practice-lost in translation? N Engl J Med. 2003;349(9):868-874.
2. Parry C, Kent EE, Mariotto AB, Alfano CM, Rowland JH. Cancer survivors: a booming population. Cancer Epidemiol Biomarkers Prev. 2011;20(10):1996-2005.
3. Iglehart JK. Prioritizing comparative-effectiveness research-IOM recommendations. N Eng J Med. 2009;361(4):325-328.
4. Zerhouni EA. Transforming medicine through discovery. Major trends in biomedical research. Bull Acad Natl Med. 2007;191(8):1685-1694.
5. Khoury MJ, Gwinn ML, Glasgow RE, Kramer BS. A population approach to precision medicine. Am J Prev Med. 2012;42(6):639-645.
6. Hood L, Friend SH. Predictive, personalized, preventive, participatory (P4) cancer medicine. Nat Rev Clin Oncol. 2011;8(3):184-187.
7. Garber AM, Tunis SR. Does comparative-effectiveness research threaten personalized medicine? N Engl J Med. 2009;360(19):1925-1927.
8. Glasgow RE, Steiner JF. Comparative effectiveness research to accerlate translation: Recommendations for an emerging field of science. In: Brownson RC, Colditz G, Proctor E, eds. Dissemination and Implementation Research in Health: Translating Science and Practice. New York: Oxford University Press; 2012:72-93.
9. Glasgow RE, Chambers D. Developing robust, sustainable, implementation systems using rigorous, rapid and relevant science. Clin Transl Sci. 2012;5(1):48-55.
10. Institute of Medicine. Who Will Keep the Public Healthy? Washington, DC: National Academy Press; 2002.
11. Khoury MJ, Clauser SB, Freedman AN, et al. Population sciences, translational research, and the opportunities and challenges for genomics to reduce the burden of cancer in the 21st century. Cancer Epidemiol Biomarkers Prev. 2011;20(10):2105-2114.
12. Khoury MJ, Gwinn M, Joannidis JP. The emergence of translational epidemiology: from scientific discovery to population health impact. Am J Epidemiol. 2010;172(5):517-524.
13. Glasgow RE, Vinson C, Chambers D, et al. National Institutes of Health approaches to dissemination and implementation science: current and future directions. Am J Public Health. 2012;102(7):1274-1281.
14. McGlynn EA. Intended and unintended consequences: what should we really worry about? Med Care. 2007;45(1):3-5.
15. Safavi K. Unintended consequences: getting the most while avoiding the worst. J Healthc Manag. 2006;51(6):355-359. (Pubitemid 44788808)
16. Selby JV, Beal AC, Frank L. The Patient-Centered Outcomes Research Institute (PCORI) national priorities for research and initial research agenda. JAMA. 2012;307(15):1583-1584.
17. Hebert JR, Brandt HM, Armstead CA, Adams SA, Steck SE. Interdisciplinary, translational, and community-based participatory research: finding a common language to improve cancer research. Cancer Epidemiol Biomarkers Prev. 2009;18(4):1213-1217.
18. Cargo M, Mercer SL. The value and challenges of participatory research: strengthening its practice. Annu Rev Public Health. 2008;29:325-350. (Pubitemid 351600412)
19. Stange KC. The Journal of Participatory Medicine: Setting its sights on community of practice. J Participat Med. http://www.jopm.org/evidence/reviews/ 2009/10/21/the-journal-of-participatory-medicine-setting-itssights-on-a- community-of-practice/. Accessed October 26, 2012.
20. Stange KC, Breslau ES, Dietrich AJ, Glasgow RE. State-of-the-art and future directions in multilevel interventions across the cancer control continuum. J Natl Cancer Inst Monogr. 2012;2012(44):20-31.
21. Glasgow RE, Green LW, Taylor MV, Stange KC. An evidence integration triangle for aligning science with policy and practice. Am J Prev Med. 2012;42(6):646-654.
22. Tunis SR, Stryer DB, Clancey CM. Practical clinical trials: increasing the value of clinical research for decision making in clinical and health policy. JAMA. 2003;290:1624-1632. (Pubitemid 37430387)
23. Zwarenstein M, Treweek S, Gagnier JJ, et al. Improving the reporting of pragmatic trials: an extension of the CONSORT statement. BMJ. 2008;337:a2390.
24. Glasgow RE, Gaglio B, Bennett G, et al. Applying the PRECIS criteria to describe three effectiveness trials of weight loss in obese patients with comorbid conditions. Health Serv Res. 2012;47(3 Pt 1):1051-1067.
25. Gierisch JM, DeFrank JT, Bowling JM, et al. Finding the minimal intervention needed for sustained mammography adherence. Am J Prev Med. 2010;39(4):334-344.
26. Glasgow RE, Magid DJ, Beck A, Ritzwoller D, Estabrooks PA. Practical clinical trials for translating research to practice: design and measurement recommendations. Med Care. 2005;43(6):551-557. (Pubitemid 40847291)
27. Thorpe KE, Zwarenstein M, Oxman AD, et al. A pragmatic-explanatory continuum indicator summary (PRECIS): a tool to help trial designers. CMAJ. 2009;180(10):E47-E57.
28. Cresswell JW, Klassen AC, Plano Clark VL, Clegg Smith K. Best Practices for Mixed Models in the Health Sciences. Washington, DC: Office of Behavioral and Social Sciences Research; 2011.
29. Crabtree BF, Miller WL. Doing Qualitative Research. Thousand Oaks, CA: Sage Publications; 1999.
30. Kaplan RM. The significance of quality of life in health care. Qual Life Res. 2003;12(Suppl 1):3-16. (Pubitemid 36609835)
31. Goddard KA, Knaus WA, Whitlock E, et al. Building the evidence base for decision making in cancer genomic medicine using comparative effectiveness research. Genet Med. 2012;14(7):633-642.
32. Gold MR, Siegel JE, Russell LB, Weinstein MC. Cost-Effectiveness in Health and Medicine. New York: Oxford University Press; 2003.
33. Ritzwoller DP, Sukhanova A, Gaglio B, Glasgow RE. Costing behavioral interventions: a practical guide to enhance translation. Ann Behav Med. 2009;37(2):218-227.
34. Neumann PJ, Weinstein MC. Legislating against use of cost-effectiveness information. N Engl J Med. 2010;363(16):1495-1497.
35. Wilkerson J. PCORI Head Vows Not To Do Cost-Effectiveness Studies, But Notes Gray Areas. http://insidehealthpolicy com/Inside-Health-General/Public- Content/pcori-head-vows-not-to-do-cost-effectiveness-studies-butnotes-gray- areas/menu-id-869 html. Accessed July 7, 2012.
36. Mercer SW, Watt GC. The inverse care law: clinical primary care encounters in deprived and affluent areas of Scotland. Ann Fam Med. 2007;5(6):503-510. (Pubitemid 350248581)
37. Wolff M, Bates T, Beck B, et al. Cancer prevention in underserved African American communities: barriers and effective strategies-a review of the literature. WMJ. 2003;102(5):36-40. (Pubitemid 37266746)
38. Wasson JH, Ahles T, Johnson D, et al. Resource planning for patientcentered, collaborative care. J Ambul Care Manage. 2006;29(3):207-214. (Pubitemid 44492237)
39. Asch SM, Kerr EA, Keesey J, et al. Who is at greatest risk for receiving poor-quality health care? N Engl J Med. 2006;354(11):1147-1156.
40. Kessler RS, Purcell EP, Glasgow RE, et al. What does it mean to "employ" the RE-AIM model? Eval Health Prof. 2012;36(1):44-46.
41. Pawson R, Greenhalgh T, Harvey G, Walshe K. Realist review: a new method of systematic review designed for complex policy interventions. J Health Serv Res Policy. 2005;10(S1):S21-S39.
42. Glasgow RE, Strycker LA, Kurz D, et al. Recruitment for an internetbased diabetes self-management program: scientific and ethical implications. Ann Behav Med. 2010;40(1):40-48.
43. Stange KC, Glasgow RE. Considering and reporting important contextual factors. In: Agency for Health Care Research and Quality, eds. Methods Brief for the AHRQ Initiative in Patient-Centered Medical Home (PCMH). Rockville, MD: Agency for Healthcare Research and Quality, 2012.
44. Kessler R, Glasgow RE. A proposal to speed translation of healthcare research into practice: dramatic change is needed. Am J Prev Med. 2011; 40(6):637-644.
45. Diez Roux AV. Complex systems thinking and current impasses in health disparities research. Am J Public Health. 2011;101(9):1627-1634.
46. Weiner SJ, Schwartz A, Weaver F, et al. Contextual errors and failures in individualizing patient care: a multicenter study. Ann Intern Med. 2010; 153(2):69-75.
47. Homer JB, Hirsch GB. System dynamics modeling for public health: background and opportunities. Am J Public Health. 2006;96(3):452-458. (Pubitemid 43320691)
48. Auchincloss AH, Diez Roux AV. A new tool for epidemiology: the usefulness of dynamic-agent models in understanding place effects on health. Am J Epidemiol. 2008;168(1):1-8. (Pubitemid 351881895)
49. Gilbert N. Agent-Based Models. London: Sage Publications; 2007.
50. Mabry PL, Olster DH, Morgan GD, Abrams DB. Interdisciplinarity and systems science to improve population health: a view from the NIH Office of Behavioral and Social Sciences Research. Am J Prev Med. 2008;35(2 Suppl):S211-S224. (Pubitemid 351932081)
51. Hovmand PS, Brennan L, Chalise N. Whose model is it anyway? Paper presented at the 29th International Conference of the System Dynamics Society; July 25-29, 2011; Washington, DC.
52. Rose J, Riolo R, Hovmand P, et al. Modeling the paradox of primary care. In: Martin C, Sturmberg J, eds. Handbook on Systems and Complexity in Health. New York: Springer Press; 2012.
53. Rouwette E, Vennix JAM, Mullekom TV. Group model building effectiveness: a review of assessment studies. Syst Dyn Rev. 2006;18(1):5-45.
54. Huberman AM, Crandall DP. Fitting words to numbers: Multisite/multimethod research in educational dissemination. Am Behav Sci. 1982;26(1): 62-83.
55. Stange KC, Crabtree BF, Miller WL. Publishing multimethod research. Ann Fam Med. 2006;4(4):292-294. (Pubitemid 44198455)
56. Stokols D. Toward a science of transdisciplinary action research. Am J Community Psychol. 2006;38(1-2):63-77. (Pubitemid 44483351)
57. Syme SL. The science of team science: assessing the value of transdisciplinary research. Am J Prev Med. 2008;35(2 Suppl):S94-S95. (Pubitemid 351932080)
58. Stange KC, Miller WL, Crabtree BF, O'Connor PJ, Zyzanski SJ. Multimethod research: approaches for integrating qualitative and quantitative methods. J Gen Intern Med. 1994;9(5):278-282.
59. Louis KS. Multisite/multimethod studies: an introduction. Am Behav Sci. 1982;26(1):6-22.
60. Chesla CA. When qualitative and quantitative findings do not converge. West J Nurs Res. 1992;14(5):681-685.
61. Stange KC, Zyzanski SJ. Integrating qualitative and quantitative research methods. Fam Med. 1989;21(6):448-451. (Pubitemid 20046614)
62. Creswell JW. Research Design: Qualitative, Quantitative, and Mixed Methods Approaches. 2nd ed. Thousand Oaks, CA: Sage Publications; 2003.
63. Samuel-Hodge CD, Garcia BA, Johnston LF, et al. Rationale, design, and sample characteristics of a practical randomized trial to assess a weight loss intervention for low-income women: the Weight-Wise II Program. Contemp Clin Trials. 2011;33(1):93-103.
64. Des Jarlais DC, Lyles C, Crepaz N, TREND Group. Improving the reporting quality of nonrandomized evaluations of behavioral and public health interventions: the TREND statement. Am J Public Health. 2004;94(3):361-366. (Pubitemid 38269486)