Impaired migration of IgA-secreting cells to colon adenocarcinomas

Cancer Immunology, Immunotherapy

Volumn 62, Issue 6, 2013, Pages 989-997

  Muthuswamy, Rangarajan V ^a   Sundström, Patrik ^a   Börjesson, Lars ^a   Gustavsson, Bengt ^a   Quiding Järbrink, Marianne ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

CCR10; Colon cancer; Human; IgA; Lymphocyte trafficking; Plasma cell

Indexed keywords

CD19 ANTIGEN; CD38 ANTIGEN; CHEMOKINE RECEPTOR CCR10; IMMUNOGLOBULIN A;

ADULT; AGED; ARTICLE; B LYMPHOCYTE; CELL MIGRATION; CLINICAL ARTICLE; COLON ADENOCARCINOMA; COLON MUCOSA; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOGLOBULIN PRODUCTION; MALE; PLASMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE;

ADENOCARCINOMA; AGED; AGED, 80 AND OVER; ANTIGENS, CD19; CHEMOKINES, CC; CHEMOTAXIS, LEUKOCYTE; COLONIC NEOPLASMS; FEMALE; HUMANS; IMMUNOGLOBULIN A, SECRETORY; IMMUNOPHENOTYPING; INTESTINAL MUCOSA; LYMPHOCYTE SUBSETS; MALE; MIDDLE AGED; NEOPLASM STAGING; PLASMA CELLS; RECEPTORS, CCR10;

EID: 84878843155     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-013-1410-1     Document Type: Article

References (50)

1. Liang PS, Chen TY, Giovannucci E (2009) Cigarette smoking and colorectal cancer incidence and mortality: systematic review and meta-analysis. Int J Cancer 124:2406-2415. doi: 10.1002/ijc.24191
2. Ullman TA, Itzkowitz SH (2011) Intestinal inflammation and cancer. Gastroenterology 140:1807-1816
3. Lund EK, Belshaw NJ, Elliott GO, Johnson IT (2011) Recent advances in understanding the role of diet and obesity in the development of colorectal cancer. Proc Nutr Soc 70:194-204
4. Sobhani I, Tap J, Roudot-Thoraval F, Roperch JP, Letulle S, Langella P, Corthier G, Tran Van Nhieu J, Furet JP (2011) Microbial dysbiosis in colorectal cancer (CRC) patients. PLoS One 6:e16393. doi: 10.1371/journal.pone.0016393
5. Wang T, Cai G, Qiu Y, Fei N, Zhang M, Pang X, Jia W, Cai S, Zhao L (2012) Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers. ISME J 6:320-329. doi: 10.1038/ismej.2011.109
6. Rothwell PM, Wilson M, Elwin CE, Norrving B, Algra A, Warlow CP, Meade TW (2010) Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials. Lancet 376:1741-1750
7. Liao X, Lochhead P, Nishihara R et al (2012) Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival. N Engl J Med 367:1596-1606. doi: 10.1056/NEJMoa1207756
8. Macpherson AJ, McCoy KD, Johansen FE, Brandtzaeg P (2008) The immune geography of IgA induction and function. Mucosal Immunol 1:11-22
9. Quiding-Jarbrink M, Nordstrom I, Granstrom G, Kilander A, Jertborn M, Butcher EC, Lazarovits AI, Holmgren J, Czerkinsky C (1997) Differential expression of tissue-specific adhesion molecules on human circulating antibody-forming cells after systemic, enteric, and nasal immunizations. A molecular basis for the compartmentalization of effector B cell responses. J Clin Invest 99:1281-1286. doi: 10.1172/JCI119286
10. Kantele A, Kantele JM, Savilahti E, Westerholm M, Arvilommi H, Lazarovits A, Butcher EC, Makela PH (1997) Homing potentials of circulating lymphocytes in humans depend on the site of activation: oral, but not parenteral, typhoid vaccination induces circulating antibody-secreting cells that all bear homing receptors directing them to the gut. J Immunol 158:574-579
11. Briskin MJ, Rott L, Butcher EC (1996) Structural requirements for mucosal vascular addressin binding to its lymphocyte receptor alpha 4 beta 7. Common themes among integrin-Ig family interactions. J Immunol 156:719-726
12. Kunkel EJ, Kim CH, Lazarus NH, Vierra MA, Soler D, Bowman EP, Butcher EC (2003) CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells. J Clin Invest 111:1001-1010. doi: 10.1172/JCI17244
13. Lazarus NH, Kunkel EJ, Johnston B, Wilson E, Youngman KR, Butcher EC (2003) A common mucosal chemokine (mucosae-associated epithelial chemokine/CCL28) selectively attracts IgA plasmablasts. J Immunol 170:3799-3805
14. Pan J, Kunkel EJ, Gosslar U et al (2000) A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues. J Immunol 165:2943-2949
15. Wang W, Soto H, Oldham ER et al (2000) Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2). J Biol Chem 275:22313-22323. doi: 10.1074/jbc.M001461200
16. Sundstrom P, Lundin SB, Nilsson LA, Quiding-Jarbrink M (2008) Human IgA-secreting cells induced by intestinal, but not systemic, immunization respond to CCL25 (TECK) and CCL28 (MEC). Eur J Immunol 38:3327-3338. doi: 10.1002/eji.200838506
17. Reiss Y, Proudfoot AE, Power CA, Campbell JJ, Butcher EC (2001) CC chemokine receptor (CCR)4 and the CCR10 ligand cutaneous T cell-attracting chemokine (CTACK) in lymphocyte trafficking to inflamed skin. J Exp Med 194:1541-1547
18. Pasquier B, Launay P, Kanamaru Y et al (2005) Identification of FcalphaRI as an inhibitory receptor that controls inflammation: dual role of FcRgamma ITAM. Immunity 22:31-42
19. Staff C, Magnusson CG, Hojjat-Farsangi M, Mosolits S, Liljefors M, Frodin JE, Wahren B, Mellstedt H, Ullenhag GJ (2012) Induction of IgM, IgA and IgE antibodies in colorectal cancer patients vaccinated with a recombinant CEA protein. J Clin Immunol 32:855-865. doi: 10.1007/s10875-012-9662-7
20. Valerius T, Stockmeyer B, van Spriel AB et al (1997) FcalphaRI (CD89) as a novel trigger molecule for bi-specific antibody therapy. Blood 90:4485-4492
21. Huls G, Heijnen IA, Cuomo E, van der Linden J, Boel E, van de Winkel JG, Logtenberg T (1999) Antitumor immune effector mechanisms recruited by phage display-derived fully human IgG1 and IgA1 monoclonal antibodies. Cancer Res 59:5778-5784
22. Lohse S, Derer S, Beyer T, Klausz K, Peipp M, Leusen JH, van de Winkel JG, Dechant M, Valerius T (2011) Recombinant dimeric IgA antibodies against the epidermal growth factor receptor mediate effective tumor cell killing. J Immunol 186:3770-3778. doi: 10.4049/jimmunol.1003082
23. Svensson H, Olofsson V, Lundin S, Yakkala C, Bjorck S, Borjesson L, Gustavsson B, Quiding-Jarbrink M (2012) Accumulation of CCR4(+)CTLA-4 FOXP3(+)CD25(hi) regulatory T cells in colon adenocarcinomas correlate to reduced activation of conventional T cells. PLoS ONE 7:e30695. doi: 10.1371/journal.pone.0030695
24. Dimberg J, Hugander A, Wagsater D (2006) Protein expression of the chemokine, CCL28, in human colorectal cancer. Int J Oncol 28:315-319
25. Rognum TO, Brandtzaeg P, Orjasaeter H, Elgjo K, Hognestad J (1980) Immunohistochemical study of secretory component, secretory IgA and carcinoembryonic antigen in large bowel carcinomas. Pathol Res Pract 170:126-145
26. Koretz K, Schlag P, Quentmeier A, Moller P (1994) Evaluation of the secretory component as a prognostic variable in colorectal carcinoma. Int J Cancer 57:365-370
27. Chalkias A, Nikotian G, Koutsovasilis A, Bramis J, Manouras A, Mystrioti D, Katergiannakis V (2011) Patients with colorectal cancer are characterized by increased concentration of fecal hb-hp complex, myeloperoxidase, and secretory IgA. Am J Clin Oncol 34:561-566. doi: 10.1097/COC.0b013e3181f9457e
28. Lundgren A, Stromberg E, Sjoling A et al (2005) Mucosal FOXP3-expressing CD4 + CD25high regulatory T cells in Helicobacter pylori-infected patients. Infect Immun 73:523-531
29. Hansson M, Hermansson M, Svensson H, Elfvin A, Hansson LE, Johnsson E, Sjoling A, Quiding-Jarbrink M (2008) CCL28 is increased in human Helicobacter pylori-induced gastritis and mediates recruitment of gastric immunoglobulin A-secreting cells. Infect Immun 76:3304-3311
30. Czerkinsky C, Moldoveanu Z, Mestecky J, Nilsson LA, Ouchterlony O (1988) A novel two colour ELISPOT assay. I. Simultaneous detection of distinct types of antibody-secreting cells. J Immunol Methods 115:31-37
31. Mattsson A, Lonroth H, Quiding-Jarbrink M, Svennerholm AM (1998) Induction of B cell responses in the stomach of Helicobacter pylori- infected subjects after oral cholera vaccination. J Clin Invest 102:51-56. doi: 10.1172/JCI22
32. Bjerke K, Brandtzaeg P, Rognum TO (1986) Distribution of immunoglobulin producing cells is different in normal human appendix and colon mucosa. Gut 27:667-674
33. Jertborn M, Nordstrom I, Kilander A, Czerkinsky C, Holmgren J (2001) Local and systemic immune responses to rectal administration of recombinant cholera toxin B subunit in humans. Infect Immun 69:4125-4128. doi: 10.1128/IAI.69.6.4125-4128.2001
34. Quiding-Jarbrink M, Sundstrom P, Lundgren A et al (2009) Decreased IgA antibody production in the stomach of gastric adenocarcinoma patients. Clin Immunol 131:463-471. doi: 10.1016/j.clim.2009.01.010
35. Jones SL, Pihl E, Cuthbertson AM, Hughes ES, Johnson WR, Rollo AJ (1983) Immunoglobulins intrinsic to colorectal carcinoma: an unfavourable prognostic association with IgM. J Natl Cancer Inst 71:469-472
36. Svennevig JL, Lunde OC, Holter J (1982) In situ analysis of the inflammatory cell infiltrates in colon carcinomas and in the normal colon wall. Acta Pathol Microbiol Immunol Scand A 90:131-137
37. Johansson C, Ahlstedt I, Furubacka S, Johnsson E, Agace WW, Quiding-Jarbrink M (2005) Differential expression of chemokine receptors on human IgA+ and IgG + B cells. Clin Exp Immunol 141:279-287. doi: 10.1111/j.1365-2249.2005.02843.x
38. Ghadjar P, Rubie C, Aebersold DM, Keilholz U (2009) The chemokine CCL20 and its receptor CCR6 in human malignancy with focus on colorectal cancer. International journal of cancer. J Int du Cancer 125:741-745. doi: 10.1002/ijc.24468
39. Ogawa H, Iimura M, Eckmann L, Kagnoff MF (2004) Regulated production of the chemokine CCL28 in human colon epithelium. Am J Physiol Gastrointest Liver Physiol 287:G1062-G1069. doi: 10.1152/ajpgi.00162.2004
40. O'Gorman MT, Jatoi NA, Lane SJ, Mahon BP (2005) IL-1beta and TNF-alpha induce increased expression of CCL28 by airway epithelial cells via an NFkappaB-dependent pathway. Cell Immunol 238:87-96. doi: 10.1016/j.cellimm.2006. 02.003
41. Facciabene A, Peng X, Hagemann IS et al (2011) Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells. Nature 475:226-230. doi: 10.1038/nature10169
42. Mickanin CS, Bhatia U, Labow M (2001) Identification of a novel beta-chemokine, MEC, down-regulated in primary breast tumors. Int J Oncol 18:939-944
43. Liu GX, Lan J, Sun Y, Hu YJ, Jiang GS (2012) Expression of the chemokine CCL28 in pleomorphic adenoma and adenolymphoma of the human salivary glands. Exp Ther Med 4:65-69. doi: 10.3892/etm.2012.544
44. Hieshima K, Ohtani H, Shibano M et al (2003) CCL28 has dual roles in mucosal immunity as a chemokine with broad-spectrum antimicrobial activity. J Immunol 170:1452-1461
45. Le Gouvello S, Bastuji-Garin S, Aloulou N et al (2008) High prevalence of Foxp3 and IL17 in MMR-proficient colorectal carcinomas. Gut 57:772-779. doi: 10.1136/gut.2007.123794
46. Tosolini M, Kirilovsky A, Mlecnik B et al (2011) Clinical impact of different classes of infiltrating T cytotoxic and helper cells (Th1, Th2, Treg, Th17) in patients with colorectal cancer. Cancer Res 71:1263-1271. doi: 10.1158/0008-5472.CAN-10-2907
47. Chae WJ, Gibson TF, Zelterman D, Hao L, Henegariu O, Bothwell AL (2010) Ablation of IL-17A abrogates progression of spontaneous intestinal tumorigenesis. Proc Natl Acad Sci USA 107:5540-5544. doi: 10.1073/pnas. 0912675107
48. Ladoire S, Martin F, Ghiringhelli F (2011) Prognostic role of FOXP3 + regulatory T cells infiltrating human carcinomas: the paradox of colorectal cancer. Cancer Immun Immunother 60:909-918. doi: 10.1007/s00262-011-1046-y
49. Frey DM, Droeser RA, Viehl CT et al (2010) High frequency of tumor-infiltrating FOXP3(+) regulatory T cells predicts improved survival in mismatch repair-proficient colorectal cancer patients. Int J Cancer 126:2635-2643. doi: 10.1002/ijc.24989
50. Salama P, Phillips M, Grieu F, Morris M, Zeps N, Joseph D, Platell C, Iacopetta B (2009) Tumor-infiltrating FOXP3 + T regulatory cells show strong prognostic significance in colorectal cancer. J Clin Oncol 27:186-192. doi: 10.1200/JCO.2008.18.7229