Design, synthesis and biological evaluation of novel aminothiazoles as antiviral compounds acting against human rhinovirus

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 13, 2013, Pages 3841-3847

  Décor, Anne ^a,c   Grand Maître, Chantal ^a   Hucke, Oliver ^a,d   O'Meara, Jeff ^a,e   Kuhn, Cyrille ^a,f   Forget, Léa Constantineau ^b   Brochu, Christian ^a   Malenfant, Eric ^a   Bertrand Laperle, Mégan ^a,g   Bordeleau, Josée ^a   Ghiro, Elise ^a   Pesant, Marc ^a   Fazal, Gulrez ^a   Gorys, Vida ^a   Little, Michael ^a   Boucher, Colette ^a   Bordeleau, Sylvain ^a   Turcotte, Pascal ^a   Guo, Tim ^a   Garneau, Michel ^a   Spickler, Catherine ^a   Gauthier, Annick ^a   more..

^a BOEHRINGER INGELHEIM CANADA LTD   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c BAYER AG   (Germany)

^d BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^e Alphora Research Inc   (Canada)

^f BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^g Fabbrica Italiana Sintetici   (Canada)

Author keywords

Aminothiazoles; Design of experiment; DOE; HRV; Human rhinovirus; Library design; PI4KIII

Indexed keywords

AMINOTHIAZOLE DERIVATIVE; ANTIVIRUS AGENT; PHOSPHATIDYLINOSITOL KINASE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TOLERABILITY; HUMAN; HUMAN CELL; HUMAN RHINOVIRUS; MOLECULAR WEIGHT; NONHUMAN; STRUCTURE ACTIVITY RELATION; VIRUS REPLICATION;

ANTIVIRAL AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; RHINOVIRUS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

HUMAN RHINOVIRUS SP.; MUS;

EID: 84878837146     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.04.077     Document Type: Article

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