Caffeic acid phenethyl ester inhibits endothelial tissue factor expression

Biological and Pharmaceutical Bulletin

Volumn 36, Issue 6, 2013, Pages 1032-1035

  Gebhard, Cathérine ^a,b   Stähli, Barbara Elisabeth ^a,b   Largiadèr, Stephanie ^a   Holy, Erik Walter ^a,b   Akhmedov, Alexander ^a   Camici, Giovanni Guido ^a   Lüscher, Thomas Felix ^a,b   Tanner, Felix Christoph ^a,b  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Coagulation; Endothelial function; Thrombosis

Indexed keywords

CAFFEIC ACID PHENETHYL ESTER; ENDOTHELIAL TISSUE FACTOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; THROMBOPLASTIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

AORTIC ENDOTHELIAL CELL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN PROCESSING; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

AORTA; CAFFEIC ACIDS; CELLS, CULTURED; ENDOTHELIAL CELLS; FIBRINOLYTIC AGENTS; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; PHENYLETHYL ALCOHOL; RNA, MESSENGER; THROMBOPLASTIN; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84878833769     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.b12-01039     Document Type: Article

References (16)

1. Libby P. Inflammation in atherosclerosis. Nature, 420, 868-874 (2002).
2. Steffel J, Lüscher TF, Tanner FC. Tissue factor in cardiovascular diseases: molecular mechanisms and clinical implications. Circulation, 113, 722-731 (2006).
3. Sud'ina GF, Mirzoeva OK, Pushkareva MA, Korshunova GA, Sumbatyan NV, Varfolomeev SD. Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties. FEBS Lett., 329, 21-24 (1993).
4. Mirzoeva OK, Calder PC. The effect of propolis and its components on eicosanoid production during the inflammatory response. Prostaglandins Leukot. Essent. Fatty Acids, 55, 441-449 (1996).
5. Chen TG, Lee JJ, Lin KH, Shen CH, Chou DS, Sheu JR. Antiplatelet activity of caffeic acid phenethyl ester is mediated through a cyclic GMP-dependent pathway in human platelets. Chin. J. Physiol., 50, 121-126 (2007).
6. Maffia P, Ianaro A, Pisano B, Borrelli F, Capasso F, Pinto A, Ialenti A. Beneficial effects of caffeic acid phenethyl ester in a rat model of vascular injury. Br. J. Pharmacol., 136, 353-360 (2002).
7. Hishikawa K, Nakaki T, Fujita T. Oral flavonoid supplementation attenuates atherosclerosis development in apolipoprotein E-deficient mice. Arterioscler. Thromb. Vasc. Biol., 25, 442-446 (2005).
8. Gebhard C, Breitenstein A, Akhmedov A, Gebhard CE, Camici GG, Lüscher TF, Tanner FC. Amphetamines induce tissue factor and impair tissue factor pathway inhibitor: role of dopamine receptor type 4. Eur. Heart J., 31, 1780-1791 (2010).
9. Gebhard C, Akhmedov A, Mocharla P, Angstenberger J, Sahbai S, Camici GG, Lüscher TF, Tanner FC. PDGF-CC induces tissue factor expression: role of PDGF receptor alpha/beta. Basic Res. Cardiol., 105, 349-356 (2010).
10. Steffel J, Akhmedov A, Greutert H, Lüscher TF, Tanner FC. Histamine induces tissue factor expression: implications for acute coronary syndromes. Circulation, 112, 341-349 (2005).
11. Holy EW, Forestier M, Richter EK, Akhmedov A, Leiber F, Camici GG, Mocharla P, Lüscher TF, Beer JH, Tanner FC. Dietary α-linolenic acid inhibits arterial thrombus formation, tissue factor expression, and platelet activation. Arterioscler. Thromb. Vasc. Biol., 31, 1772-1780 (2011).
12. Natarajan K, Singh S, Burke TR Jr, Grunberger D, Aggarwal BB. Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B. Proc. Natl. Acad. Sci. U.S.A., 93, 9090-9095 (1996).
13. Parlakpinar H, Tasdemir S, Polat A, Bay-Karabulut A, Vardi N, Ucar M, Acet A. Protective role of caffeic acid phenethyl ester (cape) on gentamicin-induced acute renal toxicity in rats. Toxicology, 207, 169-177 (2005).
14. Bierhaus A, Zhang Y, Deng Y, Mackman N, Quehenberger P, Haase M, Luther T, Müller M, Böhrer H, Greten J, Martin E, Baeuerle PA, Waldherr R, Kisiel W, Ziegler R, Stern DM, Nawroth PP. Mechanism of the tumor necrosis factor alpha-mediated induction of endothelial tissue factor. J. Biol. Chem., 270, 26419-26432 (1995).
15. Di Santo A, Mezzetti A, Napoleone E, Di Tommaso R, Donati MB, De Gaetano G, Lorenzet R. Resveratrol and quercetin down-regulate tissue factor expression by human stimulated vascular cells. J. Thromb. Haemost., 1, 1089-1095 (2003).
16. Stähli BE, Breitenstein A, Akhmedov A, Camici GG, Shojaati K, Bogdanov N, Steffel J, Ringli D, Lüscher TF, Tanner FC. Cardiac glycosides regulate endothelial tissue factor expression in culture. Arterioscler. Thromb. Vasc. Biol., 27, 2769-2776 (2007).