Is neural activation within the rescued penumbra impeded by selective neuronal loss?

Brain

Volumn 136, Issue 6, 2013, Pages 1816-1829

  Carrera, Emmanuel ^a   Jones, P Simon ^a   Morris, Rhiannon S ^a   Alawneh, Josef ^a   Hong, Young T ^b   Aigbirhio, Franklin I ^b   Fryer, Tim D ^b   Adrian Carpenter, T ^b   Warburton, Elizabeth A ^a,c   Baron, Jean Claude ^a,d  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c ADDENBROOKE S HOSPITAL   (United Kingdom)

^d INSERM   (France)

Author keywords

brain activation; cerebral ischaemia; fMRI; PET; stroke

Indexed keywords

FLUMAZENIL C 11;

ADULT; AGED; ARTICLE; BRAIN INFARCTION; BRAIN MAPPING; CAROTID ARTERY DISEASE; CEREBRAL ARTERY DISEASE; CLINICAL ARTICLE; COMPUTED TOMOGRAPHY SCANNER; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; FEMALE; FOLLOW UP; FUNCTIONAL MAGNETIC RESONANCE IMAGING; FUNCTIONAL NEUROIMAGING; HUMAN; HYPOTHESIS; MAGNETIC RESONANCE ANGIOGRAPHY; MALE; NON INFARCTED PENUMBRA; NUCLEAR MAGNETIC RESONANCE SCANNER; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROSPECTIVE STUDY;

EID: 84878830382     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awt112     Document Type: Article

References (48)

1. Alawneh JA, Jones PS, Mikkelsen IK, Cho TH, Siemonsen S, Mouridsen K, et al. Infarction of 'non-core-non-penumbral' tissue after stroke: multivariate modelling of clinical impact. Brain 2011; 134: 1765-76.
2. Astrup J, Siesjo BK, Symon L. Thresholds in cerebral ischemia-the ischaemic penumbra. Stroke 1981; 12: 723-5.
3. Baron JC. Mapping the ischaemic penumbra with PET: implications for acute stroke treatment. Cerebrovasc Dis 1999; 9: 193-201.
4. Baron JC. Mapping the ischaemic penumbra with PET: a new approach. Brain 2001; 124: 2-4.
5. Baron JC. How healthy is the acutely reperfused ischaemic penumbra Cerebrovasc Dis 2005; 20 (Suppl 2): 25-31.
6. Brett M, Leff AP, Rorden C, Ashburner J. Spatial normalization of brain images with focal lesions using cost function masking. Neuroimage 2001; 14: 486-500.
7. Cao Y, Vikingstad EM, George KP, Johnson AF, Welch KM. Cortical language activation in stroke patients recovering from aphasia with functional MRI. Stroke 1999; 30: 2331-40.
8. Cleij MC, Clark JC, Baron JC, Aigbirhio F. Rapid preparation of [11C] flumazenil: captive solvent synthesis combined with purification by analytical sized columns. J Label Comp Radiopharm 2007; 50: 19-24.
9. Cramer SC. Repairing the human brain after stroke: I. Mechanisms of spontaneous recovery. Ann Neurol 2008; 63: 272-87.
10. Cramer SC, Moore CI, Finklestein SP, Rosen BR. A pilot study of somatotopic mapping after cortical infarct. Stroke 2000; 31: 668-71.
11. Crinion J, Price CJ. Right anterior superior temporal activation predicts auditory sentence comprehension following aphasic stroke. Brain 2005; 128: 2858-71.
12. Damasio H. A computed tomographic guide to the identification of cerebral vascular territories. Arch Neurol 1983; 40: 138-42.
13. Dietrich WD, Ginsberg MD, Busto R. Effect of transient cerebral ischemia on metabolic activation of a somatosensory circuit. J Cereb Blood Flow Metab 1986; 6: 405-13.
14. Dijkhuizen RM, Singhal AB, Mandeville JB, Wu O, Halpern EF, Finklestein SP, et al. Correlation between brain reorganization, ischaemic damage, and neurologic status after transient focal cerebral ischemia in rats: a functional magnetic resonance imaging study. J Neurosci 2003; 23: 510-7.
15. Ejaz S, Williamson DJ, Ahmed T, Sitnikov S, Hong YT, Sawiak SJ, et al. Characterizing infarction and selective neuronal loss following temporary focal cerebral ischemia in the rat: a multi-modality imaging study. Neurobiol Dis 2013; 51: 120-32.
16. Furlan M, Marchal G, Viader F, Derlon JM, Baron JC. Spontaneous neurological recovery after stroke and the fate of the ischaemic penumbra. Ann Neurol 1996; 40: 216-26.
17. Gold G, Giannakopoulos P, Herrmann FR, Bouras C, Kovari E. Identification of Alzheimer and vascular lesion thresholds for mixed dementia. Brain 2007; 130: 2830-6.
18. Guadagno JV, Jones PS, Aigbirhio FI, Wang D, Fryer TD, Day DJ, et al. Selective neuronal loss in rescued penumbra relates to initial hypoperfusion. Brain 2008; 131: 2666-78.
19. Heiss WD. Ischaemic penumbra: evidence from functional imaging in man. J Cereb Blood Flow Metab 2000; 20: 1276-93.
20. Heiss WD, Grond M, Thiel A, Von Stockhausen HM, Rudolf J, Ghaemi M, et al. Tissue at risk of infarction rescued by early reperfusion: a positron emission tomography study in systemic recombinant tissue plasminogen activator thrombolysis of acute stroke. J Cereb Blood Flow Metab 1998; 18: 1298-307.
21. Heiss WD, Kessler J, Thiel A, Ghaemi M, Karbe H. Differential capacity of left and right hemispheric areas for compensation of poststroke aphasia. Ann Neurol 1999; 45: 430-8.
22. Hillis AE, Wityk RJ, Barker PB, Beauchamp NJ, Gailloud P, Murphy K, et al. Subcortical aphasia and neglect in acute stroke: the role of cortical hypoperfusion. Brain 2002; 125: 1094-104.
23. Hughes JL, Beech JS, Jones PS, Wang D, Menon DK, Baron JC. Mapping selective neuronal loss and microglial activation in the salvaged neocortical penumbra in the rat. Neuroimage 2010; 49: 19-31.
24. Ibanez V, Deiber MP, Sadato N, Toro C, Grissom J, Woods RP, et al. Effects of stimulus rate on regional cerebral blood flow after median nerve stimulation. Brain 1995; 118 (Pt 5): 1339-51.
25. Jaillard A, Martin CD, Garambois K, Lebas JF, Hommel M. Vicarious function within the human primary motor cortex A longitudinal fMRI stroke study. Brain 2005; 128: 1122-38.
26. Kleiser R, Wittsack HJ, Butefisch CM, Jorgens S, Seitz RJ. Functional activation within the PI-DWI mismatch region in recovery from ischaemic stroke: preliminary observations. Neuroimage 2005; 24: 515-23.
27. Logothetis NK, Pauls J, Augath M, Trinath T, Oeltermann A. Neurophysiological investigation of the basis of the fMRI signal. Nature 2001; 412: 150-7.
28. Maldjian JA, Laurienti PJ, Kraft RA, Burdette JH. An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. Neuroimage 2003; 19: 1233-9.
29. Manganotti P, Storti SF, Formaggio E, Acler M, Zoccatelli G, Pizzini FB, et al. Effect of median-nerve electrical stimulation on BOLD activity in acute ischaemic stroke patients. Clin Neurophysiol 2012; 123: 142-53.
30. Marchal G, Furlan M, Beaudouin V, Rioux P, Hauttement JL, Serrati C, et al. Early spontaneous hyperperfusion after stroke. A marker of favourable tissue outcome Brain 1996; 119 (Pt 2): 409-19.
31. Marchal G, Young AR, Baron JC. Early postischaemic hyperperfusion: pathophysiologic insights from positron emission tomography. J Cereb Blood Flow Metab 1999; 19: 467-82.
32. Markus HS, Harrison MJ. Estimation of cerebrovascular reactivity using transcranial Doppler, including the use of breath-holding as the vasodilatory stimulus. Stroke 1992; 23: 668-73.
33. Morris RS, Jones PS, Alawneh JA, Hong YT, Marrapu ST, Ferrari V, et al. Does inflammation cause selective neuronal loss in the penumbra A clinical PET study. Cerebrovasc Dis 2012; 33.
34. Nakagawara J, Sperling B, Lassen NA. Incomplete brain infarction of reperfused cortex may be quantitated with iomazenil. Stroke 1997; 28: 124-32.
35. Paus T, Zatorre RJ, Hofle N, Caramanos Z, Gotman J, Perides ME, et al. Time-related changes in neural systems underlying attention and arousal during the performance of an auditory vigilance task. J Cogn Neurosci 1997; 9: 392-408.
36. Pendlebury ST, Welch SJ, Cuthbertson FC, Mariz J, Mehta Z, Rothwell PM. Telephone assessment of cognition after transient ischaemic attack and stroke: modified telephone interview of cognitive status and telephone Montreal cognitive assessment versus face-toface Montreal cognitive assessment and neuropsychological battery. Stroke 2012; 44: 227-9.
37. Phan TG, Donnan GA, Wright PM, Reutens DC. A digital map of middle cerebral artery infarcts associated with middle cerebral artery trunk and branch occlusion. Stroke 2005; 36: 986-91.
38. Price CJ, Crinion J, Friston KJ. Design and analysis of fMRI studies with neurologically impaired patients. J Magn Reson Imaging 2006; 23: 816-26.
39. Rosen HJ, Petersen SE, Linenweber MR, Snyder AZ, White DA, Chapman L, et al. Neural correlates of recovery from aphasia after damage to left inferior frontal cortex. Neurology 2000; 55: 1883-94.
40. Saur D, Buchert R, Knab R, Weiller C, Rother J. Iomazenil-single-photon emission computed tomography reveals selective neuronal loss in magnetic resonance-defined mismatch areas. Stroke 2006; 37: 2713-9.
41. Sharma N, Jones PS, Carpenter TA, Baron JC. Mapping the involvement of BA 4a and 4p during Motor Imagery. Neuroimage 2008; 41: 92-9.
42. Sharma N, Simmons LH, Jones PS, Day DJ, Carpenter TA, Pomeroy VM, et al. Motor imagery after subcortical stroke: a functional magnetic resonance imaging study. Stroke 2009; 40: 1315-24.
43. Sicard KM, Henninger N, Fisher M, Duong TQ, Ferris CF. Differential recovery of multimodal MRI and behavior after transient focal cerebral ischemia in rats. J Cereb Blood Flow Metab 2006a; 26: 1451-62.
44. Sicard KM, Henninger N, Fisher M, Duong TQ, Ferris CF. Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats. Stroke 2006b; 37: 2593-600.
45. Signorini M, Paulesu E, Friston K, Perani D, Colleluori A, Lucignani G, et al. Rapid assessment of regional cerebral metabolic abnormalities in single subjects with quantitative and nonquantitative [18F]FDG PET: a clinical validation of statistical parametric mapping. Neuroimage 1999; 9: 63-80.
46. Warburton E, Price CJ, Swinburn K, Wise RJ. Mechanisms of recovery from aphasia: evidence from positron emission tomography studies. J Neurol Neurosurg Psychiatry 1999; 66: 155-61.
47. Wintermark M, Flanders AE, Velthuis B, Meuli R, Van Leeuwen M, Goldsher D, et al. Perfusion-CT assessment of infarct core and penumbra: receiver operating characteristic curve analysis in 130 patients suspected of acute hemispheric stroke. Stroke 2006; 37: 979-85.
48. Wintermark M, Meuli R, Browaeys P, Reichhart M, Bogousslavsky J, Schnyder P, et al. Comparison of CT perfusion and angiography and MRI in selecting stroke patients for acute treatment. Neurology 2007; 68: 694-7.