Development and validation of highly selective and robust method for simultaneous estimation of pioglitazone, hydroxypioglitazone and metformin in human plasma by LC-MS/MS: Application to a pharmacokinetic study

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 930, Issue , 2013, Pages 136-145

  Jagadeesh, B ^a   Bharathi, D Vijaya ^a   Pankaj, C ^a   Narayana, V Satya ^a   Venkateswarulu, V ^a  

^a DR REDDY'S LABORATORIES LTD   (India)

Author keywords

Human plasma; Hydroxypioglitazone; LC MS MS; Metformin; Pharmacokinetics; Pioglitazone

Indexed keywords

HUMAN PLASMAS; HYDROXYPIOGLITAZONE; LC-MS/MS; METFORMINS; PIOGLITAZONE;

CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PHARMACOKINETICS; PLASMA (HUMAN);

DRUG PRODUCTS;

ACETONITRILE; DEUTERIUM; DRUG METABOLITE; HYDROXYPIOGLITAZONE; METFORMIN; PIOGLITAZONE; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; BLOOD SAMPLING; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; POSITIVE ION ELECTROSPRAY; PRECIPITATION; PRIORITY JOURNAL; REACTION ANALYSIS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SENSITIVITY AND SPECIFICITY; SINGLE DRUG DOSE; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

CHROMATOGRAPHY, LIQUID; DRUG STABILITY; HUMANS; MALE; METFORMIN; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; THIAZOLIDINEDIONES;

EID: 84878823751     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2013.04.024     Document Type: Article

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