Pilicides inhibit the FGL chaperone/usher assisted biogenesis of the Dr fimbrial polyadhesin from uropathogenic Escherichia coli

BMC Microbiology

Volumn 13, Issue 1, 2013, Pages

  Piatek, Rafał ^a   Zalewska Piatek, Beata ^a   Dzierzbicka, Krystyna ^a   Makowiec, Sławomir ^a   Pilipczuk, Justyna ^a   Szemiako, Kasjan ^a   Cyranka Czaja, Anna ^b   Wojciechowski, Marek ^a  

^a GDANSK UNIVERSITY OF TECHNOLOGY   (Poland)

^b UNIVERSITY OF WROC AW   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; BACTERIAL PROTEIN; CHAPERONE; CHLORAMPHENICOL; DAF RECEPTOR PROTEIN; PILICIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIUM ADHERENCE; CHO CELL; CONTROLLED STUDY; DENSITOMETRY; FEMALE; FIMBRIA; GENE CLUSTER; HOST CELL; NONHUMAN; OPERON; POLYACRYLAMIDE GEL ELECTROPHORESIS; UROPATHOGENIC ESCHERICHIA COLI;

ADHESINS, ESCHERICHIA COLI; ANIMALS; ANTI-BACTERIAL AGENTS; CELL ADHESION; CHO CELLS; CRICETINAE; PYRIDONES; UROPATHOGENIC ESCHERICHIA COLI;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA;

EID: 84878815070     PISSN: None     EISSN: 14712180     Source Type: Journal    
DOI: 10.1186/1471-2180-13-131     Document Type: Article

References (37)

1. Differentiation and developmental pathways of uropathogenic Escherichia coli in urinary tract pathogenesis. Justice SS, Hung C, Theriot JA, Fletcher DA, Anderson GG, Footer MJ, Hultgren SJ, Proc Natl Acad Sci USA 2004 101 1333 1338 10.1073/pnas.0308125100 14739341 (Pubitemid 38182689)
2. Development of intracellular bacterial communities of uropathogenic Escherichia coli depends on type 1 pili. Wright KJ, Seed PC, Hultgren SJ, Cell Microbiol 2007 9 2230 2241 10.1111/j.1462-5822.2007.00952.x 17490405 (Pubitemid 47250294)
3. Structural basis of chaperone function and pilus biogenesis. Sauer FG, Futterer K, Pinkner JS, Dodson KW, Hultgren SJ, Waksman G, Science 1999 285 1058 1061 10.1126/science.285.5430.1058 10446050 (Pubitemid 29385954)
4. X-ray structure of the FimC-FimH chaperone-adhesin complex from uropathogenic Escherichia coli. Choudhury D, Thompson A, Stojanoff V, Langermann S, Pinkner J, Hultgren SJ, Knight SD, Science 1999 285 1061 1066 10.1126/science.285.5430.1061 10446051 (Pubitemid 29385955)
5. Structure and biogenesis of the capsular F1 antigen from Yersinia pestis: preserved folding energy drives fiber formation. Zavialov AV, Berglund J, Pudney AF, Fooks LJ, Ibrahim TM, MacIntyre S, Knight SD, Cell 2003 113 587 596 10.1016/S0092-8674(03)00351-9 12787500 (Pubitemid 36694184)
6. Resolving the energy paradox of chaperone/usher-mediated fibre assembly. Zavialov AV, Tischenko VM, Fooks LJ, Brandsdal BO, Aqvist J, Zav'yalov VP, Macintyre S, Knight SD, Biochem J 2005 389 685 694 10.1042/BJ20050426 15799718 (Pubitemid 41117328)
7. PapD-like chaperones provide the missing information for folding of pilin proteins. Barnhart MM, Pinkner JS, Soto GE, Sauer FG, Langermann S, Waksman G, Frieden C, Hultgren SJ, Proc Natl Acad Sci USA 2000 97 7709 7714 10.1073/pnas.130183897 10859353 (Pubitemid 30460712)
8. Chaperone priming of pilus subunits facilitates a topological transition that drives fiber formation. Sauer FG, Pinkner JS, Waksman G, Hultgren SJ, Cell 2002 111 543 551 10.1016/S0092-8674(02)01050-4 12437927 (Pubitemid 35356559)
9. Donor-strand exchange in chaperone-assisted pilus assembly proceeds through a concerted beta strand displacement mechanism. Remaut H, Rose RJ, Hannan TJ, Hultgren SJ, Radford SE, Ashcroft AE, Waksman G, Mol Cell 2006 22 831 842 10.1016/j.molcel.2006.05.033 16793551
10. Fiber formation across the bacterial outer membrane by the chaperone/usher pathway. Remaut H, Tang C, Henderson NS, Pinkner JS, Wang T, Hultgren SJ, Thanassi DG, Waksman G, Li H, Cell 2008 133 640 652 10.1016/j.cell.2008.03.033 18485872 (Pubitemid 351636304)
11. Allosteric mechanism controls traffic in the chaperone/usher pathway. Di Yu X, Dubnovitsky A, Pudney AF, Macintyre S, Knight SDAVZ, Structure 2012 20 1861 1871 10.1016/j.str.2012.08.016 22981947
12. FGL chaperone-assembled fimbrial polyadhesins: anti-immune armament of Gram-negative bacterial pathogens. Zavialov A, Zav'yalova G, Korpela T, Zav'yalov V, FEMS Microbiol Rev 2007 31 478 514 10.1111/j.1574-6976.2007.00075.x 17576202 (Pubitemid 46920253)
13. Adhesive organelles of Gram-negative pathogens assembled with the classical chaperone/usher machinery: structure and function from a clinical standpoint. Zav'yalov V, Zavialov A, Zav'yalova G, Korpela T, FEMS Microb Rev 2010 34 317 378 10.1111/j.1574-6976.2009.00201.x
14. Crystal structure of enterotoxigenic Escherichia coli colonization factor CS6 reveals a novel type of functional assembly. Roy SP, Rahman MM, Yu XD, Tuittila M, Knight SD, Zavialov A, Mol Microbiol 2012 86 1100 1115 10.1111/mmi.12044 23046340
15. Molecular basis of two subfamilies of immunoglobulin-like chaperones. Hung DL, Knight SD, Woods RM, Pinkner JS, Hultgren SJ, EMBO J 1996 15 3792 3805 8670884 (Pubitemid 26289789)
16. Modelling of steric structure of a periplasmic molecular chaperone Caf1M of Yersinia pestis, a prototype member of a subfamily with characteristic structural and functional features. Zav'yalov VP, Zav'yalova GA, Denesyuk AI, Korpela T, FEMS Immunol Med Microbiol 1995 11 19 24 10.1111/j.1574-695X.1995. tb00074.x 7599600
17. Molecular aspects of biogenesis of Escherichia coli Dr Fimbriae: characterization of DraB-DraE complexes. Pia̧tek R, Zalewska B, Kolaj OMF, Nowicki B, Kur J, Infect Immun 2005 73 135 145 10.1128/IAI.73.1.135-145.2005 15618148 (Pubitemid 40041103)
18. Influence of the conserved disulphide bond, exposed to the putative binding pocket, on the structure and function of the immunoglobulin-like molecular chaperone Caf1M of Yersinia pestis. Zav'yalov VP, Chernovskaya TV, Chapman DA, Karlyshev AV, MacIntyre S, Zavialov AV, Vasiliev AM, Denesyuk AI, Zav'yalova GA, Dudich IV, et al. Biochem J 1997 324 571 578 9182720 (Pubitemid 27268004)
19. Fimbriae, pili, flagella and bacterial virulence. Jonson AB, Normark S, Rhen M, Contrib Microbiol 2005 12 67 89 15496777
20. Evolution of the chaperone/usher assembly pathway: fimbrial classification goes Greek. Nuccio SP, Bäumler AJ, Microbiol Mol Biol Rev 2007 71 551 575 10.1128/MMBR.00014-07 18063717 (Pubitemid 350309177)
21. Pilicides-small molecules targeting bacterial virulence. Aberg V, Almqvist F, Org Biomol Chem 2007 5 1827 1834 10.1039/b702397a 17551629 (Pubitemid 46884103)
22. Design and evaluation of pilicides: potential novel antibacterial agents directed against uropathogenic Escherichia coli. Svensson A, Larsson A, Emtenäs H, Hedenström M, Fex T, Hultgren SJ, Pinkner JS, Almqvist F, Kihlberg J, Chembiochem 2001 2 915 918 10.1002/1439-7633(20011203)2:12<915:: AID-CBIC915>3.0.CO;2-M 11948880 (Pubitemid 33722705)
23. Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria. Pinkner JS, Remaut H, Buelens F, Miller E, Aberg V, Pemberton N, Hedenström M, Larsson A, Seed P, Waksman G, et al. Proc Natl Acad Sci USA 2006 103 17897 17902 10.1073/pnas.0606795103 17098869 (Pubitemid 44852257)
24. Design and synthesis of C-2 substituted thiazolo and dihydrothiazolo ring-fused 2-pyridones: pilicides with increased antivirulence activity. Chorell E, Pinkner JS, Phan G, Edvinsson S, Buelens F, Remaut H, Waksman G, Hultgren SJ, Almqvist F, J Med Chem 2010 12 5690 5695
25. An atomic resolution model for assembly, architecture, and function of the Dr adhesins. Anderson KL, Billington J, Pettigrew D, Cota E, Simpson P, Roversi P, Chen HA, Urvil P, du Merle L, Barlow PN, et al. Mol Cell 2004 15 647 657 10.1016/j.molcel.2004.08.003 15327779 (Pubitemid 39141790)
26. Molecular cloning of the Escherichia coli O75X adhesin. Nowicki B, Barrish JP, Korhonen T, Hull RA, Hull SI, Infect Immun 1987 55 3168 3173 2890586 (Pubitemid 18008294)
27. Differential recognition of members of the carcinoembryonic antigen family by Afa/Dr adhesins of diffusely adhering Escherichia coli (Afa/Dr DAEC). Berger CN, Billker O, Meyer TF, Servin AL, Kansau I, Mol Microbiol 2004 52 963 983 10.1111/j.1365-2958.2004.04033.x 15130118 (Pubitemid 38916168)
28. A hemagglutinin of uropathogenic Escherichia coli recognizes the Dr blood group antigen. Nowicki B, Moulds J, Hull R, Hull S, Infect Immun 1988 56 1057 1060 2895740
29. The O75X adhesin of uropathogenic Escherichia coli is a type IV collagen-binding protein. Westerlund B, Kuusela P, Risteli J, Risteli L, Vartio T, Rauvala H, Virkola R, Korhonen TK, Mol Microbiol 1989 3 329 337 10.1111/j.1365-2958.1989.tb00178.x 2568575 (Pubitemid 19104814)
30. Pathogenesis of Afa/Dr diffusely adhering Escherichia coli. Servin AL, Int J Med Microbiol 2005 295 471 478 10.1016/j.ijmm.2005.07.001 16238021 (Pubitemid 41225458)
31. C-Terminal properties are important for ring-fused 2-pyridones that interfere with the chaperone function in uropathogenic E. coli. Aberg V, Hedenström M, Pinkner JS, Hultgren SJ, Almqvist F, Org Biomol Chem 2005 3 3886 3892 10.1039/b509376g 16240004 (Pubitemid 41640800)
32. Fimbria-like hemagglutinin of Escherichia coli O75 strains. Väisänen-Rhen V, Infect Immun 1984 46 401 407 6150006 (Pubitemid 15204611)
33. Phospholipid-anchored and transmembrane version of either decay-avvelerating factor or membrane cofactor protein show equal efficiency in protection from complement-mediated cell damage. Lublin DM, Coyne KE, J Exp Med 1991 174 35 10.1084/jem.174.1.35 1711565
34. Design, synthesis and evaluation of peptidomimetics based on substituted bicyclic 2-pyridones-targeting virulence of uropathogenic E. coli. Aberg V, Sellstedt M, Hedenström M, Pinkner JS, Hultgren SJ, Almqvist F, Bioorg Med Chem 2006 14 7563 7581 10.1016/j.bmc.2006.07.017 16904898 (Pubitemid 44486800)
35. Carboxylic acid isosteres improve the activity of ring-fused 2-pyridones that inhibit pilus biogenesis in E. coli. Aberg V, Das P, Chorell E, Hedenström M, Pinkner JS, Hultgren SJ, Almqvist F, Bioorg Med Chem Lett 2008 18 3536 3540 10.1016/j.bmcl.2008.05.020 18499455 (Pubitemid 351787568)
36. Pilicides regulate pili expression in E. coli without affecting the functional properties of the pilus rod. Aberg V, Fällman E, Axner O, Uhlin BE, Hultgren SJ, Almqvist F, Mol Biosyst 2007 3 214 218 10.1039/b613441f 17308668 (Pubitemid 46293328)
37. High resolution studies of the Afa/Dr adhesin DraE and its interaction with chloramphenicol. Pettigrew D, Anderson KL, Billington J, Cota E, Simpson P, Urvil P, Rabuzin F, Roversi P, Nowicki B, du Merle L, et al. J Biol Chem 2004 279 46851 46867 10.1074/jbc.M409284200 15331605 (Pubitemid 39518336)