Vitamin B12 deficiency in India: Mean corpuscular volume is an unreliable screening parameter

National Medical Journal of India

Volumn 25, Issue 6, 2012, Pages 336-338

  Bhatia, Puneeta ^a   Kulkarni, Jayashree D ^a   Pai, Sanjay A ^a  

^a Department of Gastroenterology and Liver Disease   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CYANOCOBALAMIN; FERRITIN; FOLIC ACID;

ADOLESCENT; ADULT; AGED; ANEMIA; ARTICLE; BETA THALASSEMIA; BONE MARROW BIOPSY; CLINICAL FEATURE; COMORBIDITY; CONTROLLED STUDY; CYANOCOBALAMIN DEFICIENCY; CYTOPENIA; ELECTROPHORESIS; FEMALE; FERRITIN BLOOD LEVEL; FOLIC ACID BLOOD LEVEL; FOLLOW UP; GASTROINTESTINAL BIOPSY; GASTROINTESTINAL SYMPTOM; GYNECOLOGIC DISEASE; HEMATOLOGICAL PARAMETERS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IRON DEFICIENCY; LEUKOPENIA; MAJOR CLINICAL STUDY; MALE; MEAN CORPUSCULAR VOLUME; NEUROLOGIC DISEASE; PANCYTOPENIA; THROMBOCYTOPENIA;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ERYTHROCYTE INDICES; FEMALE; HUMANS; INDIA; MALE; MIDDLE AGED; VITAMIN B 12 DEFICIENCY; YOUNG ADULT;

EID: 84878791020     PISSN: 0970258X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Carmel R. Efficiency and safety of fortification and supplementation with vitamin B12: Biochemical and physiological effects. Food Nutr Bull 2008;29 (2 Suppl): S177-S187
2. Hoffbrand AV. Megaloblastic anemias. In: Fauci SA, Kasper LD, Longo LD, Hauser LS, Jameson LJ, Loscalzo J (eds). Harrison's principles of internal medicine. Volume 1 18th ed. Pennsylvania:McGraw-Hill; 2012:862-872
3. Hoffbrand V, Moss PAH, Pettit JE. Megaloblastic anaemias. In: Essential haematology. 5th ed. Massachussetts:Wiley-Blackwell; 2006:44-57
4. Desai HG, Antia FP. Vitamin B12 malabsorption due to intrinsic factor deficiency in Indian subjects. Blood 1972;40:747-753
5. Sarode R, Garewal G, Marwaha N, Marwaha RK, Varma S, Ghosh K, et al. Pancytopenia in nutritional megaloblastic anemia: A study from north-west India. Trop Geogr Med 1989;41:331-336
6. Gomber S, Kela K, Dhingra N. Clinico-hematatological profile of megaloblastic anemia. Indian Pediatr 1998;35:55-58
7. Chandra J. Megaloblastic anemia: Back in focus. Indian J Pediatr 2010;77:795-799
8. Antony AC. Vegetarianism and vitamin B-12 (cobalamin) deficiency. Am J Clin Nutr 2003;78:3-6
9. Khanduri U, Sharma A, Joshi A. Occult cobalamin and folate deficiency in Indians. Natl Med J India 2005;18:182-183
10. Khanduri U, Sharma A. Megaloblastic anaemia: Prevalence and causative factors. Natl Med J India 2007;20:172-175
11. Allen L. Causes of vitamin B12 and folate deficiency. Food Nutr Bull 2008;29 (2 Suppl): S20-S34
12. Desai HG, Gupta PA. Helicobacter pylori link to pernicious anaemia. J Assoc Physicians India 2007;55:857-859
13. Molloy AM, Kirke PN, Troendle JF, Burke H, Sutton M, Brody LC, et al. Maternal vitamin B12 status and risk of neural tube defects in a population with high neural tube defect prevalence and no folic acid fortification. Pediatrics 2009;123:917-923
14. Muthayya S, Dwarkanath P, Mhaskar M, Mhaskar R, Thomas A, Duggan C, et al. The relationship of neonatal serum vitamin B12 status with birth weight. Asia Pac J Clin Nutr 2006;15:538-543
15. Muthayya S, Kurpad AV, Duggan CP, Bosch RJ, Dwarkanath P, Mhaskar A, et al. Low maternal vitamin B12 status is associated with intrauterine growth retardation in urban South Indians. Eur J Clin Nutr 2006;60:791-801
16. Pardo J, Peled Y, Bar J, Hod M, Sela BA, Rafael ZB, et al. Evaluation of low serum vitamin B (12) in the non-anaemic pregnant patient. Hum Reprod 2000;15:224-226
17. Hudson B. Vitamin-B12 deficiency. BMJ 2010;340:1245-1246
18. Wickramasinghe SN. Diagnosis of megaloblastic anaemias. Blood Rev 2006;20: 299-318
19. Sekhar J, Stabler S. Life threatening megaloblastic pancytopenia with normal mean cell volume: Case series. Eur J Intern Med 2007;18:548-550
20. Aitelli C, Wasson L, Page R. Pernicious anemia: Presentations mimicking acute leukaemia. South Med J 2004;97:295-297
21. Carmel R, Weiner JM, Johnson CS. Iron deficiency occurs frequently in patients with pernicious anemia. JAMA 1987;257:1081-1083
22. Chan JCW, Liu HSY, Kho BCS, Ma ESK, Ma KM, Choi PT. Megaloblastic anaemia in Chinese patients: A review of 52 cases. Hong Kong Med J 1998;4:269-274
23. Refsum H, Smith AD. Are we ready for mandatory fortification with vitamin -B12? Am J Clin Nutr 2008;88:253-254.