Alterations of bone geometry, density, microarchitecture, and biomechanical properties in systemic lupus erythematosus on long-term glucocorticoid: A case-control study using HR-pQCT

Osteoporosis International

Volumn 24, Issue 6, 2013, Pages 1817-1826

  Tang, X L ^a   Qin, L ^b   Kwok, A W ^b   Zhu, T Y ^a   Kun, E W ^c   Hung, V W ^b   Griffith, J F ^b   Leung, P C ^b   Li, E K ^a   Tam, L S ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^c TAI PO HOSPITAL   (Hong Kong)

Author keywords

Biomechanical properties; Bone microarchitecture; Bone mineral density; FE analysis; HR pQCT; Systemic lupus erythematosus

Indexed keywords

GLUCOCORTICOID;

ADULT; ARTICLE; BIOMECHANICS; BONE DENSITOMETRY; BONE DENSITY; BONE STRESS; BONE STRUCTURE; CASE CONTROL STUDY; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CORTICAL THICKNESS (BONE); CORTICOSTEROID THERAPY; CROSS-SECTIONAL STUDY; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; FEMUR NECK; FINITE ELEMENT ANALYSIS; HIGH RESOLUTION PERIPHERAL QUANTITATIVE COMPUTED TOMOGRAPHY; HIP; HUMAN; LUMBAR SPINE; MAJOR CLINICAL STUDY; MICROFINITE ELEMENT ANALYSIS; POROSITY; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS; TRABECULAR BONE;

ABSORPTIOMETRY, PHOTON; ADULT; BIOMECHANICAL PHENOMENA; BONE DENSITY; BONE DISEASES, METABOLIC; CASE-CONTROL STUDIES; DRUG ADMINISTRATION SCHEDULE; FEMALE; FINITE ELEMENT ANALYSIS; GLUCOCORTICOIDS; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MIDDLE AGED; OSTEOPOROSIS; PREDNISOLONE; RADIUS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84878781795     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-012-2177-5     Document Type: Article

References (48)

1. Bultink IE (2012) Osteoporosis and fractures in systemic lupus erythematosus. Arthritis Care Res (Hoboken) 64:2-8
2. Ammann P, Rizzoli R (2003) Bone strength and its determinants. Osteoporos Int 14(Suppl 3):S13-S18
3. Seeman E, Delmas PD (2006) Bone quality - the material and structural basis of bone strength and fragility. N Engl J Med 354:2250-2261
4. Harrington JT, Ste-Marie LG, Brandi ML, Civitelli R, Fardellone P, Grauer A, Barton I, Boonen S (2004) Risedronate rapidly reduces the risk for nonvertebral fractures in women with postmenopausal osteoporosis. Calcif Tissue Int 74:129-135
5. Van Staa TP, Laan RF, Barton IP, Cohen S, Reid DM, Cooper C (2003) Bone density threshold and other predictors of vertebral fracture in patients receiving oral glucocorticoid therapy. Arthritis Rheum 48:3224-3229
6. van Staa TP, Leufkens HG, Cooper C (2002) The epidemiology of corticosteroid-induced osteoporosis: a meta-analysis. Osteoporos Int 13:777-787
7. Li EK, Tam LS, Griffith JF et al (2009) High prevalence of asymptomatic vertebral fractures in Chinese women with systemic lupus erythematosus. J Rheumatol 36:1646-1652
8. Lee C, Almagor O, Dunlop DD, Manzi S, Spies S, Ramsey-Goldman R (2007) Self-reported fractures and associated factors in women with systemic lupus erythematosus. J Rheumatol 34:2018-2023
9. Yee CS, Crabtree N, Skan J, Amft N, Bowman S, Situnayake D, Gordon C (2005) Prevalence and predictors of fragility fractures in systemic lupus erythematosus. Ann Rheum Dis 64:111-113
10. Borba VZ, Matos PG, da Silva Viana PR, Fernandes A, Sato EI, Lazaretti-Castro M (2005) High prevalence of vertebral deformity in premenopausal systemic lupus erythematosus patients. Lupus 14:529-533
11. Bultink IE, Lems WF, Kostense PJ, Dijkmans BA, Voskuyl AE (2005) Prevalence of and risk factors for low bone mineral density and vertebral fractures in patients with systemic lupus erythematosus. Arthritis Rheum 52:2044-2050
12. Kaji H, Yamauchi M, Yamaguchi T, Sugimoto T (2010) Urinary deoxypyridinoline is a BMD-independent marker for prevalent vertebral fractures in postmenopausal women treated with glucocorticoid. Osteoporos Int 21:1585-1590
13. MacNeil JA, Boyd SK (2007) Accuracy of high-resolution peripheral quantitative computed tomography for measurement of bone quality. Med Eng Phys 29:1096-1105
14. Sornay-Rendu E, Boutroy S, Munoz F, Delmas PD (2007) Alterations of cortical and trabecular architecture are associated with fractures in postmenopausal women, partially independent of decreased BMD measured by DXA: the OFELY study. J Bone Miner Res 22:425-433
15. Hansen S, Beck Jensen JE, Rasmussen L, Hauge EM, Brixen K (2010) Effects on bone geometry, density, and microarchitecture in the distal radius but not the tibia in women with primary hyperparathyroidism: a case-control study using HR-pQCT. J Bone Miner Res 25:1941-1947
16. Hansen S, Brixen K, Gravholt CH (2012) Compromised trabecular microarchitecture and lower finite element estimates of radius and tibia bone strength in adults with turner syndrome: a cross-sectional study using high-resolution-pQCT. J Bone Miner Res 27:1794-1803
17. Li EK, Zhu TY, Tam LS et al (2010) Bone microarchitecture assessment by high-resolution peripheral quantitative computed tomography in patients with systemic lupus erythematosus taking corticosteroids. J Rheumatol 37:1473-1479
18. Li EK, Zhu TY, Hung VY et al (2010) Ibandronate increases cortical bone density in patients with systemic lupus erythematosus on long-term glucocorticoid. Arthritis Res Ther 12:R198
19. Bombardier C, Gladman DD, Urowitz MB, Caron D, Chang CH (1992) Derivation of the SLEDAI. A disease activity index for lupus patients. The Committee on Prognosis Studies in SLE. Arthritis Rheum 35:630-640
20. Ibanez D, Gladman DD, Urowitz MB (2005) Adjusted mean Systemic Lupus Erythematosus Disease Activity Index-2K is a predictor of outcome in SLE. J Rheumatol 32:824-827
21. Gladman D, Ginzler E, Goldsmith C et al (1996) The development and initial validation of the Systemic Lupus International Collaborating Clinics/American College of Rheumatology damage index for systemic lupus erythematosus. Arthritis Rheum 39:363-369
22. Lynn HS, Lau EM, Au B, Leung PC (2005) Bone mineral density reference norms for Hong Kong Chinese. Osteoporos Int 16:1663-1668
23. Boutroy S, Bouxsein ML, Munoz F, Delmas PD (2005) In vivo assessment of trabecular bone microarchitecture by high-resolution peripheral quantitative computed tomography. J Clin Endocrinol Metab 90:6508-6515
24. Liu XS, Cohen A, Shane E et al (2010) Bone density, geometry, microstructure, and stiffness: Relationships between peripheral and central skeletal sites assessed by DXA, HR-pQCT, and cQCT in premenopausal women. J Bone Miner Res 25:2229-2238
25. Buie HR, Campbell GM, Klinck RJ, MacNeil JA, Boyd SK (2007) Automatic segmentation of cortical and trabecular compartments based on a dual threshold technique for in vivo micro-CT bone analysis. Bone 41:505-515
26. Sell CA, Masi JN, Burghardt A, Newitt D, Link TM, Majumdar S (2005) Quantification of trabecular bone structure using magnetic resonance imaging at 3 Tesla-calibration studies using microcomputed tomography as a standard of reference. Calcif Tissue Int 76:355-364
27. Boutroy S, Van Rietbergen B, Sornay-Rendu E, Munoz F, Bouxsein ML, Delmas PD (2008) Finite element analysis based on in vivo HR-pQCT images of the distal radius is associated with wrist fracture in postmenopausal women. J Bone Miner Res 23:392-399
28. Pistoia W, van Rietbergen B, Lochmuller EM, Lill CA, Eckstein F, Ruegsegger P (2002) Estimation of distal radius failure load with micro-finite element analysis models based on three-dimensional peripheral quantitative computed tomography images. Bone 30:842-848
29. Pons F, Peris P, Guanabens N, Font J, Huguet M, Espinosa G, Ingelmo M, Munoz-Gomez J, Setoain J (1995) The effect of systemic lupus erythematosus and long-term steroid therapy on bone mass in pre-menopausal women. Br J Rheumatol 34:742-746
30. Li EK, Tam LS, Young RP, Ko GT, Li M, Lau EM (1998) Loss of bone mineral density in Chinese pre-menopausal women with systemic lupus erythematosus treated with corticosteroids. Br J Rheumatol 37:405-410
31. Kipen Y, Buchbinder R, Forbes A, Strauss B, Littlejohn G, Morand E (1997) Prevalence of reduced bone mineral density in systemic lupus erythematosus and the role of steroids. J Rheumatol 24:1922-1929
32. Korczowska I, Olewicz-Gawlik A, Hrycaj P, Lacki J (2003) The effect of long-term glucocorticoids on bone metabolism in systemic lupus erythematosus patients: the prevalence of its anti-inflammatory action upon bone resorption. Yale J Biol Med 76:45-54
33. Gilboe IM, Kvien TK, Haugeberg G, Husby G (2000) Bone mineral density in systemic lupus erythematosus: comparison with rheumatoid arthritis and healthy controls. Ann Rheum Dis 59:110-115
34. Lee C, Almagor O, Dunlop DD, Manzi S, Spies S, Chadha AB, Ramsey-Goldman R (2006) Disease damage and low bone mineral density: an analysis of women with systemic lupus erythematosus ever and never receiving corticosteroids. Rheumatology (Oxford) 45:53-60
35. Van Staa TP, Leufkens HG, Abenhaim L, Zhang B, Cooper C (2000) Use of oral corticosteroids and risk of fractures. J Bone Miner Res 15:993-1000
36. Macdonald HM, Nishiyama KK, Kang J, Hanley DA, Boyd SK (2011) Age-related patterns of trabecular and cortical bone loss differ between sexes and skeletal sites: a population-based HR-pQCT study. J Bone Miner Res 26:50-62
37. Melton LJ 3rd, Riggs BL, van Lenthe GH, Achenbach SJ, Muller R, Bouxsein ML, Amin S, Atkinson EJ, Khosla S (2007) Contribution of in vivo structural measurements and load/strength ratios to the determination of forearm fracture risk in postmenopausal women. J Bone Miner Res 22:1442-1448
38. Crabtree N, Loveridge N, Parker M, Rushton N, Power J, Bell KL, Beck TJ, Reeve J (2001) Intracapsular hip fracture and the region-specific loss of cortical bone: analysis by peripheral quantitative computed tomography. J Bone Miner Res 16:1318-1328
39. Voide R, Schneider P, Stauber M, Wyss P, Stampanoni M, Sennhauser U, van Lenthe GH, Muller R (2009) Time-lapsed assessment of microcrack initiation and propagation in murine cortical bone at submicrometer resolution. Bone 45:164-173
40. Pistoia W, van Rietbergen B, Ruegsegger P (2003) Mechanical consequences of different scenarios for simulated bone atrophy and recovery in the distal radius. Bone 33:937-945
41. Tsugeno H, Tsugeno H, Fujita T, Goto B, Sugishita T, Hosaki Y, Ashida K, Mitsunobu F, Tanizaki Y, Shiratori Y (2002) Vertebral fracture and cortical bone changes in corticosteroid-induced osteoporosis. Osteoporos Int 13:650-656
42. Sornay-Rendu E, Cabrera-Bravo JL, Boutroy S, Munoz F, Delmas PD (2009) Severity of vertebral fractures is associated with alterations of cortical architecture in postmenopausal women. J Bone Miner Res 24:737-743
43. Kaji H, Yamauchi M, Chihara K, Sugimoto T (2008) Glucocorticoid excess affects cortical bone geometry in premenopausal, but not postmenopausal, women. Calcif Tissue Int 82:182-190
44. Lakshminarayanan S, Walsh S, Mohanraj M, Rothfield N (2001) Factors associated with low bone mineral density in female patients with systemic lupus erythematosus. J Rheumatol 28:102-108
45. Tang XL, Zhu TY, Hung VW, Qin L, Wong CK, Kun EW, Tam LS, Li EK (2012) Increased organ damage associated with deterioration in volumetric bone density and bone microarchitecture in patients with systemic lupus erythematosus on longterm glucocorticoid therapy. J Rheumatol 39:1955-1963
46. Weinstein RS (2011) Clinical practice. Glucocorticoid-induced bone disease. N Engl J Med 365:62-70
47. Dalle Carbonare L, Arlot ME, Chavassieux PM, Roux JP, Portero NR, Meunier PJ (2001) Comparison of trabecular bone microarchitecture and remodeling in glucocorticoid-induced and postmenopausal osteoporosis. J Bone Miner Res 16:97-103
48. Formiga F, Moga I, Nolla JM, Pac M, Mitjavila F, Roig-Escofet D (1995) Loss of bone mineral density in premenopausal women with systemic lupus erythematosus. Ann Rheum Dis 54:274-276