A rapid analysis of plasma/serum ethylene and propylene glycol by headspace gas chromatography

SpringerPlus

Volumn 2, Issue 1, 2013, Pages 1-6

  Ehlers, Alexandra ^a   Morris, Cory ^a   Krasowski, Matthew D ^a  

^a UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

Author keywords

Ethylene glycol; Gas chromatography; Glycols; Propylene glycol; Toxicology

Indexed keywords

EID: 84878780237     PISSN: None     EISSN: 21931801     Source Type: Journal    
DOI: 10.1186/2193-1801-2-203     Document Type: Article

References (34)

1. Al-Khafaji AH, Dewhirst WE, Manning HL (2002) Propylene glycol toxicity associated with lorazepam infusion in a patient receiving continuous venovenous hemofiltration with dialysis. Anesth Analg 94:1583-1585
2. Almaghamsi AM, Yeung CK (1997) Osmolal gap in alcoholic ketoacidosis. Clin Nephrol 48:52-53
3. Arbour RB (1999) Propylene glycol toxicity related to high-dose lorazepam infusion: case report and discussion. Am J Crit Care 8:499-506
4. Balikova M, Kohlicek J (1988) Rapid determination of ethylene glycol at toxic levels in serum and urine. J Chromatogr 434:469-474
5. Barceloux DG, Krenzelok EP, Olson K, Watson W (1999) American Academy of Clinical Toxicology Practice Guidelines on the Treatment of Ethylene Glycol Poisoning. Ad Hoc Committee. J Toxicol Clin Toxicol 37:537-560
6. Braden GL, Strayhorn CH, Germain MJ, Mulhern JG, Skutches CL (1993) Increased osmolal gap in alcoholic acidosis. Arch Intern Med 153:2377-2380
7. Brooks DE, Wallace KL (2002) Acute propylene glycol ingestion. J Toxicol Clin Toxicol 40:513-516
8. Chicella M, Jansen P, Parthiban A, Marlowe KF, Bencsath FA, Krueger KP, Boerth R (2002) Propylene glycol accumulation associated with continuous infusion of lorazepam in pediatric intensive care patients. Crit Care Med 30:2752-2756. doi:10.1097/01.CCM.0000038279.25674.D4
9. Dursun H, Noyan A, Cengiz N, Attila G, Buyukcelik M, Soran M, Seydaoglu G, Bayazit AK, Anarat A (2007) Changes in osmolal gap and osmolality in children with chronic and end-stage renal failure. Nephron Physiol 105:p19-p21. doi:10.1159/000097604
10. Garcia-Morales EJ, Cariappa R, Parvin CA, Scott MG, Diringer MN (2004) Osmole gap in neurologic-neurosurgical intensive care unit: Its normal value, calculation, and relationship with mannitol serum concentrations. Crit Care Med 32:986-991
11. Gill GV, Osypiw JC, Shearer E, English PJ, Watson ID (2005) Critical illness with hyponatraemia and impaired cell membrane integrity-the sick cell syndrome revisited. Clin Biochem 38:1045-1048, 10.1016/j.clinbiochem.2005.07.014
12. Guglielminotti J, Pernet P, Maury E, Alzieu M, Vaubourdolle M, Guidet B, Offenstadt G (2002) Osmolar gap hyponatremia in critically ill patients: evidence for the sick cell syndrome? Crit Care Med 30:1051-1055
13. Houze P, Chaussard J, Harry P, Pays M (1993) Simultaneous determination of ethylene glycol, propylene glycol, 1,3-butylene glycol and 2,3-butylene glycol in human serum and urine by wide-bore column gas chromatography. J Chromatogr 619:251-257
14. Huff JS (1990) Acute mannitol intoxication in a patient with normal renal function. Am J Emerg Med 8:338-339
15. Jammalamadaka D, Raissi S (2010) Ethylene glycol, methanol and isopropyl alcohol intoxication. Am J Med Sci 339:276-281. doi:10.1097/ MAJ.0b013e3181c94601
16. Juenke JM, Hardy L, McMillin GA, Horowitz GL (2011) Rapid and specific quantification of ethylene glycol levels: adaptation of a commercial enzymatic assay to automated chemistry analyzers. Am J Clin Pathol 136:318-324.10.1309/AJCPOB9YPQIYKGLJ
17. Khajuria A, Krahn J (2005) Osmolality revisited-deriving and validating the best formula for calculated osmolality. Clin Biochem 38:514-519.10.1016/j. clinbiochem.2005.03.001
18. Krasowski MD, Wilcoxon RM, Miron J (2012) A retrospective analysis of glycol and toxic alcohol ingestion: utility of anion and osmolal gaps. BMC Clin Pathol 12:1, 10.1186/1472-6890-12-1
19. Kraut JA, Kurtz I (2008) Toxic alcohol ingestions: clinical features, diagnosis, and management. Clin J Am Soc Nephrol 3:208-225,10.2215/CJN.03220807
20. Lynd LD, Richardson KJ, Purssell RA, Abu-Laban RB, Brubacher JR, Lepik KJ, Sivilotti ML (2008) An evaluation of the osmole gap as a screening test for toxic alcohol poisoning. BMC Emerg Med 8:5,10.1186/1471-227X-8-5
21. Malandain H, Cano Y (1996) Interferences of glycerol, propylene glycol, and other diols in the enzymatic assay of ethylene glycol. Eur J Clin Chem Clin Biochem 34:651-654
22. Moreau CL, Kerns W 2nd, Tomaszewski CA, McMartin KE, Rose SR, Ford MD, Brent J (1998) Glycolate kinetics and hemodialysis clearance in ethylene glycol poisoning. META Study Group. J Toxicol Clin Toxicol 36:659-666
23. Parker MG, Fraser GL, Watson DM, Riker RR (2002) Removal of propylene glycol and correction of increased osmolar gap by hemodialysis in a patient on high dose lorazepam infusion therapy. Intensive Care Med 28:81-84
24. Porter WH (2012) Ethylene glycol poisoning: quintessential clinical toxicology; analytical conundrum. Clin Chim Acta 413:365-377, 10.1016/j.cca.2011.10.034
25. Porter WH, Auansakul A (1982) Gas-chromatographic determination of ethylene glycol in serum. Clin Chem 28:75-78
26. Porter WH, Rutter PW (2010) Improved GC-MS procedure for simultaneous measurement of ethylene glycol and glycolic acid. Clin Chem 56:1900-1902, 10.1373/clinchem.2010.152686
27. Porter WH, Rutter PW, Bush BA, Pappas AA, Dunnington JE (2001) Ethylene glycol toxicity: the role of serum glycolic acid in hemodialysis. J Toxicol Clin Toxicol 39:607-615
28. Rosano TG, Swift TA, Kranick CJ, Sikirica M (2009) Ethylene glycol and glycolic acid in postmortem blood from fatal poisonings. J Anal Toxicol 33:508-513
29. Sklar AH, Linas SL (1983) The osmolal gap in renal failure. Ann Intern Med 98:481-482
30. Smith NB (1984) Determination of serum ethylene glycol by capillary gas chromatography. Clin Chim Acta 144:269-272
31. Williams RH, Shah SM, Maggiore JA, Erickson TB (2000) Simultaneous detection and quantitation of diethylene glycol, ethylene glycol, and the toxic alcohols in serum using capillary column gas chromatography. J Anal Toxicol 24:621-626
32. Wilson KC, Reardon C, Theodore AC, Farber HW (2005) Propylene glycol toxicity: a severe iatrogenic illness in ICU patients receiving IV benzodiazepines: a case series and prospective, observational pilot study. Chest 128:1674-1681, 10.1378/chest.128.3.1674
33. Wu AH, Kelly T, McKay C, Ostheimer D, Forte E, Hill D (1995) Definitive identification of an exceptionally high methanol concentration in an intoxication of a surviving infant: methanol metabolism by first-order elimination kinetics. J Forensic Sci 40:315-320
34. Zar T, Graeber C, Perazella MA (2007) Recognition, treatment, and prevention of propylene glycol toxicity. Semin Dial 20:217-219, 10.1111/j.1525- 139X.2007.00280.x