Improving the diagnosis and treatment of CRPS: Insights from a clinical immunologist's personal experience with an underrecognized neuroinflammatory disorder

Journal of Neuroimmune Pharmacology

Volumn 8, Issue 3, 2013, Pages 477-488

  Binkley, Karen E ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

CRPS

Indexed keywords

ACETYLCYSTEINE; BACLOFEN; BISPHOSPHONIC ACID DERIVATIVE; CALCITONIN; CAPSAICIN; CORTICOSTEROID; IMMUNOGLOBULIN; KETAMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NALTREXONE; PREDNISONE; PREGABALIN; SUBSTANCE P;

BEDTIME DOSAGE; BLOOD PRESSURE; BONE NECROSIS; COMPLEX REGIONAL PAIN SYNDROME; DELAYED DIAGNOSIS; DRUG DOSE REDUCTION; DRUG MEGADOSE; HALLUCINATION; HEALTH CARE ACCESS; HUMAN; INSOMNIA; LOW DRUG DOSE; MOTOR DYSFUNCTION; NAUSEA; NERVOUS SYSTEM INFLAMMATION; NEUROPATHIC PAIN; PHYSIOTHERAPY; PRIORITY JOURNAL; RANGE OF MOTION; REVIEW; SIDE EFFECT; SOCIAL PSYCHOLOGY; VOMITING;

COMPLEX REGIONAL PAIN SYNDROMES; FEMALE; FRACTURES, BONE; HUMANS; PHYSICIAN'S ROLE; TIME FACTORS; TOE PHALANGES; TREATMENT OUTCOME;

EID: 84878776907     PISSN: 15571890     EISSN: 15571904     Source Type: Journal    
DOI: 10.1007/s11481-012-9376-x     Document Type: Review

References (32)

1. Ballow M (2011) The IgG molecule as a biological immune response modifier: mechanisms of action of intravenous immune serum globulin in autoimmune and inflammatory disorders. J Allergy Clin Immunol 127(2):315-323
2. Bernateck M, Karst M, Gratz KF, Meyer GJ, Fischer MJ, Knapp WH, Koppert W, Brunkhorst T (2010) The first scintigraphic detection of tumor necrosis factor-alpha in patients with complex regional pain syndrome type. Anesth Analg 110(1):211-215
3. Bianchi C, Rossi S, Turi S, Brambilla A, Felisari G, Mascheri D (2006) Long-term functional outcome measures in corticosteroid-treated complex regional pain syndrome. Eura Medicophys 42(2):103-111
4. Cappello ZJ, Kasdan ML, Louis DS (2012) Meta-analysis of the imaging techniques for the diagnosis of complex regional pain syndrome Type I. J Hand Surg Am 37(2):288-296
5. De Bosscher K (2010) Selective glucocorticoid receptor modulators. J Steroid Biochem Mol Biol 120:96-104
6. Goebel A (2010) Immunoglobulin responsive chronic pain. J Clin Immunol 30(Suppl 1):S103-S108
7. Goebel A, Baranowski A, Maurer K, Ghiai A, McCabe C, Ambler G (2010) Intravenous immunoglobulin treatment of the complex regional pain syndrome: a randomized trial. Ann Intern Med 152(3):152-158
8. Goldberg ME, Domsky R, Scaringe D, Hirsh R, Dotson J, Sharaf I, Torjman MC, Schwartzman RJ (2005) Multi-day low dose ketamine infusion for the treatment of complex regional pain syndrome. Pain Physician 8(2):175-179
9. Goldberg ME, Torjman MC, Schwartzman RJ, Mager DE, Wainer IW (2010) Pharmacodynamic profiles of ketamine (R)- and (S)- with 5-day inpatient infusion for the treatment of complex regional pain syndrome. Pain Physician 13(4):379-387
10. Harden RN (ed) (2006) Complex regional pain syndrome: treatment guidelines. RSDSA Press, Milford CT
11. Hocking G, Cousins MJ (2003) Ketamine in chronic pain management: an evidence based review. Anesth Analg 97:1730-1739
12. Hutchinson MR, Zhang Y, Brown K, Coats BD, Shridhar M, Sholar PW, Patel SJ, Crysdale NY, Harrison JA, Maier SF, Rice KC, Watkins LR (2008) Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4). Eur J Neurosci 28(1):20-29
13. Huygen FJ, Niehof S, Zijlstra FJ, van Hagen PM, van Daele PL (2004) Successful treatment of CRPS 1 with anti-TNF. J Pain Symptom Manage 27(2):101-103
14. Inchiosa MA Jr, Kizelshteyn G (2008) Treatment of complex regional pain syndrome type I with oral phenoxybenzamine: rationale and case reports. Pain Pract 8(2):125-132
15. Ingelfinger JR, Drazen JM (2011) Patient organizations and research on rare diseases. N Engl J Med 364:1670-1671
16. Jensen MP, Gammaitoni AR, Bolognese JA, Alon A, Smugar SS, Galer BS, Hewitt DJ (2011 Dec 7) The pain quality response profile of pregabalin in the treatment of neuropathic pain. Clin J Pain. [Epub ahead of print]
17. Kiefer RT, Rohr P, Ploppa A, Dieterich HJ, Grothusen J, Koffler S, Altemeyer KH, Unertl K, Schwartzman RJ (2008) Efficacy of ketamine in anesthetic dosage for the treatment of refractory complex regional pain syndrome: an open-label phase II study. Pain Med 9(8):1173-1201
18. Kohr D, Singh P, Tschernatsch M, Kaps M, Pouokam E, Diener M, Kummer W, Birklein F, Vincent A, Goebel A, Wallukat G, Blaes F (2011) Autoimmunity against the β(2) adrenergic receptor and muscarinic-2 receptor in complex regional pain syndrome. Pain 152(12):2690-2700
19. Kozin F, Ryan LM, Carerra GF, Soin JS, Wortmann RL (1981) The reflex sympathetic dystrophy syndrome (RSDS). III. Scintigraphic studies, further evidence for the therapeutic efficacy of systemic corticosteroids, and proposed diagnostic criteria. Am J Med 70(1):23-30
20. Legge J, Ball N, Elliot DP (2006) The potential role of ketamine in hospice analgesia: a literature review. Consult Pharm 21:51-57
21. Maihöfner C, Seifert F, Markovic K (2010) Complex regional pain syndromes: new pathophysiological concepts and therapies. Eur J Neurol 17(5):649-660
22. McCabe CS, Haigh RC, Blake DR (2008) Mirror visual feedback for the treatment of complex regional pain syndrome (type 1). Curr Pain Headache Rep 12(2):103-107
23. Netherlands Society of Rehabilitation Specialists, Netherlands Society of Anaesthesiologists. Complex regional pain syndrome type I guidelines, 2006. (Available online http://www.rsds.org/clinical-guidelines.html)
24. Perez RS, Zuurmond WW, Bezemer PD, Kuik DJ, van Loenen AC, de Lange JJ, Zuidhof AJ (2003) The treatment of complex regional pain syndrome type I with free radical scavengers: a randomized controlled study. Pain 102(3):297-307
25. Ribbers GM, Stam HJ (2001) Complex regional pain syndrome type I treated with topical capsaicin: a case report. Arch Phys Med Rehabil 82(6):851-852
26. Schwartzman RJ, Alexander GM, Grothusen JR, Paylor T, Reichenberger E, Perreault M (2009) Outpatient intravenous ketamine for the treatment of complex regional pain syndrome: a double-blind placebo controlled study. Pain 147(1-3):107-115
27. Sinis N, Birbaumer N, Schwarz A, Gustin S, Unertl K, Schaller HE, Haerle M (2006) Memantine and Complex Regional Pain Syndrome (CRPS): effects of treatment and cortical reorganisation. Handchir Mikrochir Plast Chir 38(3):164-171
28. Sinis N, Birbaumer N, Gustin S, Schwarz A, Bredanger S, Becker ST, Unertl K, Schaller HE, Haerle M (2007) Memantine treatment of complex regional pain syndrome: a preliminary report of six cases. Clin J Pain 23(3):237-243
29. Soderquist RG, Sloane EM, Loram LC, Harrison JA, Dengler EC, Johnson SM, Amer LD, Young CS, Lewis MT, Poole S, Frank MG, Watkins LR, Milligan ED, Mahoney MJ (2010) Release of plasmid DNA-encoding IL-10 from PLGA microparticles facilitates long-term reversal of neuropathic pain following a single intrathecal administration. Pharm Res 27(5):841-857
30. van Rijn MA, Marinus J, Putter H, Bosselaar SR, Moseley GL, van Hilten JJ (2011) Spreading of complex regional pain syndrome: not a random process. J Neural Transm 118(9):1301-1309
31. Villanueva-Perez VL, Cerdá-Olmedo G, Samper JM, Mínguez A, Monsalve V, Bayona MJ, De Andrés JA (2007) Oral ketamine for the treatment of type I complex regional pain syndrome. Pain Pract 7(1):39-43
32. Zollinger PE, Tuinebreijer WE, Breederveld RS, Kreis RW (2007) Can vitamin C prevent complex regional pain syndrome in patients with wrist fractures? A randomized, controlled, multicenter dose-response study. J Bone Joint Surg Am 89(7):1424-1431